Fredrik Lanner
Principal Researcher
E-mail: fredrik.lanner@ki.se
Telephone: +46852483671
Visiting address: Hälsovägen, Enheten för obstetrik och gynekologi C1:77, 14181 Stockholm
Postal address: H9 Klinisk vetenskap, intervention och teknik, H9 CLT Obstetrik o gynekologi Lanner, 171 77 Stockholm
Research
- The Lanner lab aims to:
1. Uncover the fundamental principles underlying how the first cell types established in the early human embryo from totipotent morula, to blastocyst, implantation and gastrulation. For this we are utilising embryo culture and stem cell based embryo models.
2. Develop embryonic stem cell based strategies. We have establish a first
clinically compliant good manufacturing practice (GMP) grade human embryonic
stem cell line, KARO1.
3. Treatment of Diabetes. We are actively working to establish methodology to efficiently produce glucose responsive pancreatic islets with correct cellular composition.
4. Treatment of age-related macula degeneration (AMD). During collaborative agreement with St. Erik Eye Hospital and Novo Nordisk A/S we have
manufacture hESC-RPE cells according to our developed protocol and performed preclinical toxicology and functionality testing. With support from The Erling Person foundation we are planning to perform first in human clinical trial aiming to treat AMD.
5. Treatment of retinopathy we are now establishing efficient methods to establish photoreceptors to be transplanted alone or together with RPE cells.
Current Lab members:
Dr. Elisabeth Moussaud, Research Coordinator Lanner and Damdimopoulou labs
Dr. Shivam Chandel, Postdoc. Developing insulin producing stem cell derived islets.
Dr. Mathilde Bergamelli, Postdoc shared with Andres Salumets. Using blastoids to mimic embryo implantation biology.
Dr. Jing Lyu, Postdoc performing epigenetic studies or early human embryos.
Dr. Cheng Zhao, Research Specialist shared with Sophie Petropoulos. Bioinformatics in embryo and stem cell biology.
Laura Baque Vidal, PhD student. Treatment of AMD with stem cell derived RPE cells.
Sara Saietz, PhD student. Embryonic stem cell-based treatment of retinal degenerative disease
Frederik Bär, PhD student. Individualized iPSC-based treatment of blindness
*Past Lab members*
Dr. Sophie Petroploulos, PI at KI and University of Montreal
Dr. Sebastian Hildebrand, Postdoc. Now working at Tecan
Dr. Liselotte Antonsson, Now working at Stockholm University
Dr. Sarita Panula, Postdoc. Now working at Procella Therapeutics.
Dr. Sandra Petrus-Reurer, PhD and Postdoc, now working at Cambridge University.
Dr. Sara Padrell Sánchez, PhD student now Director of Business Development at Akron Biotech
Dr. John Paul Schell. PhD and then Postdoc in Professor Ken Chiens laboratory, KI
Dr. Paschalis Efstathopoulos, Industrial Postdoc now working as Research scientist at Novo Nordisk
Dr. Leni Wagner, PhD and Postdoc.
Dr. Alvaro Plaza Reyes, PhD and Postdoc. Currently working at CABIMER, Spain
Dr. Pankaj Kumar, Postdoc. Currently working as Senior Scientist at Strand Life Sciences, Begaluru
Dr. Nicholas Ortega-Linard, Postdoc. Currently working as Business Development Manager at Olink, Sweden
Dr. Heather Main, ATMP Sweden
Dr Jere Weltner, Postdoc. Currently at University of Helsinki
Dr. Breniere-Letuffe, Postdoc
Hazel Reilly, Currently PhD student at Karolinska Institutet, Sweden
Nerges Winblad, PhD student. Currently working at Karolinska University Hospital
Mona Hedenskog, Previous lab manager, currently enjoying life.
Nefeli Eirini Beri, Previous MSc student, Regulatory Affairs Postgraduate at Novartis
Hugo Metzger, Previous Erasmus student
Nashwan Jalal Markus, now working at the productive Unit Karolinska Hospital
Haojiang Lu
Philipp Schenk
Angelos Gkikas
Nariman Gharari
Articles
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Article: CYTOTHERAPY. 2024;26(4):340-350
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Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2024;12:1341373
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Article: NATURE. 2023;622(7983):562-573
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Article: COMMUNICATIONS BIOLOGY. 2023;6(1):969
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Article: HUMAN REPRODUCTION OPEN. 2022;2022(4):hoac043
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Article: STEM CELL REPORTS. 2022;17(6):1458-1475
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Article: NATURE CELL BIOLOGY. 2022;24(6):845-857
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Article: NATURE COMMUNICATIONS. 2021;12(1):5126
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Article: NATURE CELL BIOLOGY. 2021;23(1):49-60
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Article: STEM CELLS TRANSLATIONAL MEDICINE. 2020;9(8):936-953
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Article: STEM CELL RESEARCH. 2020;45:101810
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Article: STEM CELL REPORTS. 2020;14(4):648-662
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Article: NATURE COMMUNICATIONS. 2020;11(1):1609
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Article: NATURE COMMUNICATIONS. 2020;11(1):1357
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Article: NATURE COMMUNICATIONS. 2020;11(1):1147
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Article: HUMAN REPRODUCTION. 2019;34(11):2297-2310
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Article: NATURE COMMUNICATIONS. 2019;10(1):1636
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Article: DEVELOPMENTAL BIOLOGY. 2019;447(1):3-13
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Journal article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2018;(131)
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Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2018;(131)
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Article: SCIENTIFIC REPORTS. 2017;7(1):9540
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Article: CELL STEM CELL. 2017;20(6):874-890.e7
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Article: CELL REPORTS. 2017;19(6):1101-1109
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Article: ELIFE. 2017;6:e22906
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Article: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2017;58(2):1314-1322
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Article: NATURE BIOTECHNOLOGY. 2016;34(12):1264-1266
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Article: DEVELOPMENT. 2016;143(19):3459-3469
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Article: GENOME RESEARCH. 2016;26(10):1342-1354
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Article: SCIENTIFIC REPORTS. 2016;6:28995
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Article: CELL. 2016;165(4):1012-1026
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Article: STEM CELL REPORTS. 2016;6(1):9-17
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Article: DEVELOPMENT. 2013;140(22):4533-4543
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Article: DEVELOPMENT. 2013;140(14):2961-2971
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Article: STEM CELLS AND DEVELOPMENT. 2013;22(9):1360-1369
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Article: CELL. 2013;152(5):1008-1020
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Article: DEVELOPMENTAL CELL. 2012;22(4):887-901
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Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011;413(3):426-431
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Article: EMBO JOURNAL. 2011;30(9):1778-1789
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Article: DEVELOPMENTAL BIOLOGY. 2010;348(2):153-166
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Journal article: DEVELOPMENT. 2010;137(18):e1
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Article: JOURNAL OF CELL SCIENCE. 2010;123(17):2931-2942
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Article: DEVELOPMENT. 2010;137(5):715-724
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Article: STEM CELLS. 2010;28(2):191-200
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Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;391(1):24-27
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Article: GENE. 2009;437(1-2):54-59
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Article: INTERNATIONAL JOURNAL OF CANCER. 2008;123(2):389-394
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Article: CIRCULATION RESEARCH. 2008;102(12):1483-1491
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Article: STEM CELLS. 2007;25(12):2987-2995
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Article: ENDOCRINE-RELATED CANCER. 2007;14(1):125-134
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Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2007;27(3):487-493
- Show more
All other publications
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Editorial comment: STEM CELLS. 2023;41(2):105-110
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Letter: STEM CELLS. 2023;41(2):205-206
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Editorial comment: NATURE. 2021;600(7888):223-224
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Editorial comment: CELL STEM CELL. 2021;28(9):1503-1504
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Review: STEM CELL REPORTS. 2021;16(5):1117-1141
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Preprint: BIORXIV. 2021
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Editorial comment: OBSTETRICAL & GYNECOLOGICAL SURVEY. 2020;75(6):354-355
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Review: CURRENT OPINION IN GENETICS & DEVELOPMENT. 2018;52:1-6
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Editorial comment: CELL STEM CELL. 2018;23(2):155-157
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Editorial comment: NATURE. 2017;548(7668):398-400
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Review: DEVELOPMENT. 2017;144(1):3-7
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Corrigendum: CELL. 2016;167(1):285
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Corrigendum: SCIENTIFIC REPORTS. 2016;6:32053
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Review: JOURNAL OF INTERNAL MEDICINE. 2016;280(3):252-264
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Editorial comment: OBSTETRICAL & GYNECOLOGICAL SURVEY. 2016;71(1):29-30
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Letter: NATURE MEDICINE. 2015;21(10):1116-1118
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Review: EXPERIMENTAL CELL RESEARCH. 2014;321(1):32-39
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Review: DEVELOPMENT. 2010;137(20):3351-3360
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Thesis / dissertation: 2008
Grants
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Knut and Alice Wallenberg Foundation1 January 2015 - 1 January 2020
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Mammalian preimplantation development and pluripotency –Man is not a mouseRagnar Söderberg Foundation1 January 2014 - 31 December 2018
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Swedish Research Council1 January 2014 - 31 December 2018
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Uncovering early mammalian development and pluripotencySwedish Foundation for Strategic Research1 September 2013 - 31 August 2016
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Swedish Research Council1 July 2012 - 30 June 2013
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Understanding the stem cell state and lineage specification of the early embryoSwedish Research Council1 July 2009 - 30 June 2011
Employments
- Principal Researcher, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 2022-
Degrees and Education
- Degree Of Doctor Of Philosophy, Department of Cell and Molecular Biology, Karolinska Institutet, 2008