Fredrik Lanner

Fredrik Lanner

Professor
Telephone: +46852483671
Visiting address: Hälsovägen, Enheten för obstetrik och gynekologi C1:77, 14181 Stockholm
Postal address: H9 Klinisk vetenskap, intervention och teknik, H9 CLT Obstetrik o gynekologi Lanner, 141 52 Huddinge
Part of:

Research

  • The Lanner lab aims to:
    1. Uncover the fundamental principles underlying how the first cell types established in the early human embryo from totipotent morula, to blastocyst, implantation and gastrulation. For this we are utilising embryo culture and stem cell based embryo models.

    2. Develop embryonic stem cell based strategies. We have establish a first
    clinically compliant good manufacturing practice (GMP) grade human embryonic
    stem cell line, KARO1.

    3. Treatment of Diabetes. We are actively working to establish methodology to efficiently produce glucose responsive pancreatic islets with correct cellular composition.

    4. Treatment of age-related macula degeneration (AMD). During collaborative agreement with St. Erik Eye Hospital and Novo Nordisk A/S we have
    manufacture hESC-RPE cells according to our developed protocol and performed preclinical toxicology and functionality testing. With support from The Erling Person foundation we are planning to perform first in human clinical trial aiming to treat AMD.

    5. Treatment of retinopathy we are now establishing efficient methods to establish photoreceptors to be transplanted alone or together with RPE cells.

    Current Lab members:
    Dr. Elisabeth Moussaud, Research Coordinator Lanner and Damdimopoulou labs

    Dr. Cheng Zhao, Research Specialist shared with Sophie Petropoulos. Bioinformatics in embryo and stem cell biology.

    Dr. Sanjiv Risal, Research Specialist at the unit, working with reproductive medicine.
    Dr. Shivam Chandel, Postdoc. Developing insulin producing stem cell derived islets.
    Dr. Mathilde Bergamelli, Postdoc shared with Andres Salumets. Using blastoids to mimic embryo implantation biology.
    Dr. Jing Lyu, Postdoc performing epigenetic studies or early human embryos.

    Dr. Kristina Kiisholts, Postdoc studying Human Endometrium and Embryo interaction

    Dr. Laura Baque Vidal, Research Assistant. Treatment of AMD with stem cell derived RPE cells.
    Sara Saietz, PhD student. Embryonic stem cell-based treatment of retinal degenerative disease
    Frederik Bär, PhD student. Individualized iPSC-based treatment of blindness

    Celia Mesias Casares, PhD student. Building the early human embryo

    Eda Erbil, PhD student. Developing insulin producing stem cell derived islets.

    *Past Lab members*
    Dr. Sophie Petroploulos, PI at KI and University of Montreal
    Dr. Sebastian Hildebrand, Postdoc. Now working at Tecan
    Dr. Liselotte Antonsson, Now working at Stockholm University
    Dr. Sarita Panula, Postdoc. Now working at Procella Therapeutics.
    Dr. Sandra Petrus-Reurer, PhD and Postdoc, now working at Cambridge University.
    Dr. Sara Padrell Sánchez, PhD student now Director of Business Development at Akron Biotech
    Dr. John Paul Schell. PhD and then Postdoc in Professor Ken Chiens laboratory, KI
    Dr. Paschalis Efstathopoulos, Industrial Postdoc now working as Research scientist at Novo Nordisk
    Dr. Leni Wagner, PhD and Postdoc.
    Dr. Alvaro Plaza Reyes, PhD and Postdoc. Currently working at CABIMER, Spain
    Dr. Pankaj Kumar, Postdoc. Currently working as Senior Scientist at Strand Life Sciences, Begaluru
    Dr. Nicholas Ortega-Linard, Postdoc. Currently working as Business Development Manager at Olink, Sweden
    Dr. Heather Main, ATMP Sweden
    Dr Jere Weltner, Postdoc. Currently at University of Helsinki
    Dr. Breniere-Letuffe, Postdoc
    Hazel Reilly, Currently PhD student at Karolinska Institutet, Sweden
    Nerges Winblad, PhD student. Currently working at Karolinska University Hospital
    Mona Hedenskog, Previous lab manager, currently enjoying life.
    Nefeli Eirini Beri, Previous MSc student, Regulatory Affairs Postgraduate at Novartis
    Hugo Metzger, Previous Erasmus student
    Nashwan Jalal Markus, now working at the productive Unit Karolinska Hospital
    Haojiang Lu
    Philipp Schenk
    Angelos Gkikas
    Nariman Gharari

Articles

All other publications

Grants

  • Ming Wai Lau Centre for Reparative Medicine (MWLC)
    1 January 2024 - 31 December 2026
  • Swedish Research Council
    1 December 2023 - 30 November 2028
    Understanding fundamental principles that regulate the early human embryo has clinical value for reproductive technologies, congenital disease, and regenerative medicine. My lab and others have begun to uncover the molecular mechanisms controlling the first week of development but following implantation, we have very poor understanding beyond historic histological characterisations. We have learned a lot from the mouse, but human post-implantation development is very distinct from mouse. One example, following implantation a primate specific cell type fills the blastocoel cavity prior to gastrulation, the extra embryonic mesenchyme. This cell type is completely lacking in the mouse.New opportunities to study post-implantation development has emerged through extended blastocyst cultures and stem cell-based embryo models. In this project we will build a comprehensive spatial single cell transcriptional atlas of implantation, describing the cell types and the genes that control them. This resource will be critical to validate blastoids and post-implantation embryo models. Functionally we will use the transcriptional information and validated embryo models, together with genome editing to dissect regulators of the implantation event and lineage specification of the extra embryonic mesenchyme and amnion. Lastly, we will extend our recent studies of the epigenetic control through Polycomb Repressive Complex 2, histone deacetylation and X-chromosome inactivation in female embryos.
  • Knut and Alice Wallenberg Foundation
    1 January 2015 - 1 January 2020
  • Swedish Research Council
    1 January 2014 - 31 December 2018
  • Mammalian preimplantation development and pluripotency –Man is not a mouse
    Ragnar Söderberg Foundation
    1 January 2014 - 31 December 2018
  • Uncovering early mammalian development and pluripotency
    Swedish Foundation for Strategic Research
    1 September 2013 - 31 August 2016
  • Swedish Research Council
    1 July 2012 - 30 June 2013
  • Studies on how pluripotent stem cells are regulated in the early embryo
    Swedish Research Council
    1 July 2009 - 30 June 2011

Employments

  • Professor, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 2025-
  • Principal Researcher, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 2022-2025

Degrees and Education

  • Degree Of Doctor Of Philosophy, Department of Cell and Molecular Biology, Karolinska Institutet, 2008

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