Fredrik Lanner

The Lanner lab aims to:
1. Uncover the fundamental principles underlying how the first cell types established in the early human embryo from totipotent morula, to blastocyst, implantation and gastrulation. For this we are utilising embryo culture and stem cell based embryo models.

2. Develop embryonic stem cell based strategies. We have establish a first
clinically compliant good manufacturing practice (GMP) grade human embryonic
stem cell line, KARO1.

3. Treatment of Diabetes. We are actively working to establish methodology to efficiently produce glucose responsive pancreatic islets with correct cellular composition.

4. Treatment of age-related macula degeneration (AMD). During collaborative agreement with St. Erik Eye Hospital and Novo Nordisk A/S we have
manufacture hESC-RPE cells according to our developed protocol and performed preclinical toxicology and functionality testing. With support from The Erling Person foundation we are planning to perform first in human clinical trial aiming to treat AMD.

5. Treatment of retinopathy we are now establishing efficient methods to establish photoreceptors to be transplanted alone or together with RPE cells.

Current Lab members:
Dr. Elisabeth Moussaud, Research Coordinator Lanner and Damdimopoulou labs

Dr. Cheng Zhao, Research Specialist shared with Sophie Petropoulos. Bioinformatics in embryo and stem cell biology.

Dr. Sanjiv Risal, Research Specialist at the unit, working with reproductive medicine.
Dr. Shivam Chandel, Postdoc. Developing insulin producing stem cell derived islets.
Dr. Mathilde Bergamelli, Postdoc shared with Andres Salumets. Using blastoids to mimic embryo implantation biology.
Dr. Jing Lyu, Postdoc performing epigenetic studies or early human embryos.

Dr. Kristina Kiisholts, Postdoc studying Human Endometrium and Embryo interaction

Dr. Laura Baque Vidal, Research Assistant. Treatment of AMD with stem cell derived RPE cells.
Sara Saietz, PhD student. Embryonic stem cell-based treatment of retinal degenerative disease
Frederik Bär, PhD student. Individualized iPSC-based treatment of blindness

Celia Mesias Casares, PhD student. Building the early human embryo

Eda Erbil, PhD student. Developing insulin producing stem cell derived islets.

*Past Lab members*
Dr. Sophie Petroploulos, PI at KI and University of Montreal
Dr. Sebastian Hildebrand, Postdoc. Now working at Tecan
Dr. Liselotte Antonsson, Now working at Stockholm University
Dr. Sarita Panula, Postdoc. Now working at Procella Therapeutics.
Dr. Sandra Petrus-Reurer, PhD and Postdoc, now working at Cambridge University.
Dr. Sara Padrell Sánchez, PhD student now Director of Business Development at Akron Biotech
Dr. John Paul Schell. PhD and then Postdoc in Professor Ken Chiens laboratory, KI
Dr. Paschalis Efstathopoulos, Industrial Postdoc now working as Research scientist at Novo Nordisk
Dr. Leni Wagner, PhD and Postdoc.
Dr. Alvaro Plaza Reyes, PhD and Postdoc. Currently working at CABIMER, Spain
Dr. Pankaj Kumar, Postdoc. Currently working as Senior Scientist at Strand Life Sciences, Begaluru
Dr. Nicholas Ortega-Linard, Postdoc. Currently working as Business Development Manager at Olink, Sweden
Dr. Heather Main, ATMP Sweden
Dr Jere Weltner, Postdoc. Currently at University of Helsinki
Dr. Breniere-Letuffe, Postdoc
Hazel Reilly, Currently PhD student at Karolinska Institutet, Sweden
Nerges Winblad, PhD student. Currently working at Karolinska University Hospital
Mona Hedenskog, Previous lab manager, currently enjoying life.
Nefeli Eirini Beri, Previous MSc student, Regulatory Affairs Postgraduate at Novartis
Hugo Metzger, Previous Erasmus student
Nashwan Jalal Markus, now working at the productive Unit Karolinska Hospital
Haojiang Lu
Philipp Schenk
Angelos Gkikas
Nariman Gharari