Sanjiv Risal

About me
Publications
Public outreach and news

About me

I am research specialist in reproductive medicine and germ cell biology at
the Department of Clinical Science, Intervention and Technology (CLINTEC)
and Division of Obstetrics and Gynecology (Karolinska University
Hospital).
Selected publications
1) /Cell Rep Med./ 2023 May 16
4(5):101035. doi: 10.1016/j.xcrm.2023.101035.
Epub 2023 May 5.PMID: 37148878
2) /Transl Psychiatry. 2021/ Jan 13
11(1):45. doi:
10.1038/s41398-020-01183-9.PMID: 33441551
3) /Nat Med. 2019 /Dec
25 (12):1894-1904. doi: 10.1038/s41591-019-0666-1.
Epub 2019 Dec 2.PMID: 31792459
4) /Cell Discov./ 2017 Feb 7
3:16052. doi: 10.1038/celldisc.2016.52.
eCollection 2017.PMID: 28224044
*Postdoctoral Fellow*, FyFa, Karolinska Institutet, Sweden, *2017*-*2021*
*Doctor of Philosophy, *University of Gothenburg, Sweden, *2011*-*2016 *

Research

Translational medical research, mainly focusing on regenerative medicine in
infertility.

Articles

Journal article: ADVANCED SCIENCE. 2024;11(36):e2309429
Dissecting the Impact of Maternal Androgen Exposure on Developmental Programming through Targeting the Androgen Receptor
Lu H; Jiang H; Li C; Derisoud E; Zhao A; Eriksson G; Lindgren E; Pui H-P; Risal S; Pei Y; Maxian T; Ohlsson C; Benrick A; Haider S; Stener-Victorin E; Deng Q
Article: ADVANCED SCIENCE. 2024;11(28):e2401772
Androgens Modulate the Immune Profile in a Mouse Model of Polycystic Ovary Syndrome
Torstensson S; Ascani A; Risal S; Lu H; Zhao A; Espinosa A; Lindgren E; Johansson MH; Eriksson G; Barakat M; Karlsson MCI; Svensson C; Benrick A; Stener-Victorin E
Article: ELIFE. 2023;12:e86454
The role of B cells in immune cell activation in polycystic ovary syndrome
Ascani A; Torstensson S; Risal S; Lu H; Eriksson G; Li C; Teschl S; Menezes J; Sandor K; Ohlsson C; Svensson CI; Karlsson MCI; Stradner MH; Obermayer-Pietsch B; Stener-Victorin E
Journal article: HUMAN REPRODUCTION. 2023;38(Supplement_1)
P-593 developmental programming by maternal androgen excess is mediated by androgen receptor pathways
Lu H; Jiang H; Li C; Pui HP; Lindgren E; Risal S; Torstensson S; Eriksson G; Ohlsson C; Benrick A; Stener-Victorin E; Deng Q
Article: CELL REPORTS MEDICINE. 2023;4(5):101035
Transgenerational transmission of reproductive and metabolic dysfunction in the male progeny of polycystic ovary syndrome
Risal S; Li C; Luo Q; Fornes R; Lu H; Eriksson G; Manti M; Ohlsson C; Lindgren E; Crisosto N; Maliqueo M; Echiburu B; Recabarren S; Petermann TS; Benrick A; Brusselaers N; Qiao J; Deng Q; Stener-Victorin E
Journal article: ENDOCRINE ABSTRACTS. 2023
Mapping endometrial cell-type-specific disease signatures and endometrial organoids in polycystic ovary syndrome
Eriksson G; Li C; Risal S; Pui H-P; Torstensson S; Linden AH; Petropoulos S; Deng Q; Stener-Victorin E
Article: COMMUNICATIONS BIOLOGY. 2023;6(1):69
Transcriptomic survey of key reproductive and metabolic tissues in mouse models of polycystic ovary syndrome
Pei Y; Risal S; Jiang H; Lu H; Lindgren E; Stener-Victorin E; Deng Q
Journal article: ENDOCRINE ABSTRACTS. 2022
Is there a link between polycystic ovary syndrome and transgenerational transmission of a reproductive and metabolic function in male offspring?
Risal S; Li C; Luo Q; Fornes R; Manti M; Lu H; Eriksson G; Ohlsson C; Lindgren E; Crisosto N; Maliqueo M; Echiburu B; Recabarren S; Sir PT; Benrick A; Brusselaers N; Qiao J; Deng Q; Stener-Victorin E
Journal article: ENDOCRINE ABSTRACTS. 2022
The effect of dihydrotestosterone on the immune profile in a mouse model of Polycystic Ovary Syndrome
Torstensson S; Ascani A; Lu H; Risal S; Eriksson G; Li C; Benrick A; Obermayer-Pietsch B; Stener-Victorin E
Journal article: ENDOCRINE ABSTRACTS. 2022
The role of B cells in immune cell activation in polycystic ovary syndrome
Ascani A; Torstensson S; Risal S; Lu H; Teschl S; Eriksson G; Li C; Menezes J; Sandor K; Svensson C; Stradner M; Obermayer-Pietsch B; Stener-Victorin E
Journal article: ENDOCRINE ABSTRACTS. 2022
Common and unique transcriptional regulation in target tissues and oocytes across polycystic ovary syndrome-like mouse models
Deng Q; Pei Y; Risal S; Jiang H; Stener-Victorin E
Journal article: ENDOCRINE ABSTRACTS. 2022
Endometrial cell-type-specific disease signatures and endometrial organoids in polycystic ovary syndrome
Eriksson G; Li C; Pui H-P; Risal S; Hirschberg ALN; Petropoulos S; Deng Q; Stener-Victorin E
Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):45
Prenatal androgen exposure causes a sexually dimorphic transgenerational increase in offspring susceptibility to anxiety disorders
Risal S; Manti M; Lu H; Fornes R; Larsson H; Benrick A; Deng Q; Cesta CE; Rosenqvist MA; Stener-Victorin E
Article: FASEB JOURNAL. 2020;34(11):14440-14457
Excess of ovarian nerve growth factor impairs embryonic development and causes reproductive and metabolic dysfunction in adult female mice
Manti M; Pui H-P; Edstrom S; Risal S; Lu H; Lindgren E; Ohlsson C; Jerlhag E; Benrick A; Deng Q; Stener-Victorin E
Journal article: JOURNAL OF THE ENDOCRINE SOCIETY. 2020;4(Supplement_1):mon-035
MON-035 Does Androgen Exposure Result in Germline Transmission of PCOS-Like Phenotypes and Can It Be Reversed?
Lu H; Manti M; Risal S; Lindgren E; Benrick A; Deng Q; Stener-Victorin E
Article: NATURE MEDICINE. 2019;25(12):1894-1904
Prenatal androgen exposure and transgenerational susceptibility to polycystic ovary syndrome
Risal S; Pei Y; Lu H; Manti M; Fornes R; Pui H-P; Zhao Z; Massart J; Ohlsson C; Lindgren E; Crisosto N; Maliqueo M; Echiburu B; de Guevara AL; Sir-Petermann T; Larsson H; Rosenqvist MA; Cesta CE; Benrick A; Deng Q; Stener-Victorin E
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(3):592-597
Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation
Tu Z; Bayazit MB; Liu H; Zhang J; Busayavalasa K; Risal S; Shao J; Satyanarayana A; Coppola V; Tessarollo L; Singh M; Zheng C; Han C; Chen Z; Kaldis P; Gustafsson J-A; Liu K
Article: CELL DISCOVERY. 2017;3:16052
MASTL is essential for anaphase entry of proliferating primordial germ cells and establishment of female germ cells in mice
Risal S; Zhang J; Adhikari D; Liu X; Shao J; Hu M; Busayavalasa K; Tu Z; Chen Z; Kaldis P; Liu K
Article: CELL RESEARCH. 2016;26(11):1212-1225
Inhibitory phosphorylation of Cdk1 mediates prolonged prophase I arrest in female germ cells and is essential for female reproductive lifespan
Adhikari D; Busayavalasa K; Zhang J; Hu M; Risal S; Bayazit MB; Singh M; Diril MK; Kaldis P; Liu K
Article: METHODS IN MOLECULAR BIOLOGY. 2016;1336:155-166
Animal Models for Studying the In Vivo Functions of Cell Cycle CDKs.
Risal S; Adhikari D; Liu K
Article: CURRENT BIOLOGY. 2014;24(21):2501-2508
Somatic Cells Initiate Primordial Follicle Activation and Govern the Development of Dormant Oocytes in Mice
Zhang H; Risal S; Gorre N; Busayavalasa K; Li X; Shen Y; Bosbach B; Brannstrom M; Liu K
Article: JOURNAL OF CELL BIOLOGY. 2014;206(7):843-853
Mastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II
Adhikari D; Diril MK; Busayavalasa K; Risal S; Nakagawa S; Lindkvist R; Shen Y; Coppola V; Tessarollo L; Kudo NR; Kaldis P; Liu K
Article: HUMAN MOLECULAR GENETICS. 2014;23(4):920-928
Two classes of ovarian primordial follicles exhibit distinct developmental dynamics and physiological functions
Zheng W; Zhang H; Gorre N; Risal S; Shen Y; Liu K
Article: PLOS ONE. 2013;8(1):e53810
Pharmacological Inhibition of mTORC1 Prevents Over-Activation of the Primordial Follicle Pool in Response to Elevated PI3K Signaling
Adhikari D; Risal S; Liu K; Shen Y
Article: PLOS ONE. 2012;7(6):e39034
The Safe Use of a PTEN Inhibitor for the Activation of Dormant Mouse Primordial Follicles and Generation of Fertilizable Eggs
Adhikari D; Gorre N; Risal S; Zhao Z; Zhang H; Shen Y; Liu K
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All other publications

Preprint: BIORXIV. 2024
Androgens modulate the immune profile in a mouse model of polycystic ovary syndrome
Torstensson S; Ascani A; Risal S; Lu H; Zhao A; Espinosa A; Lindgren E; Johansson M; Eriksson G; Barakat M; Karlsson MCI; Svensson C; Benrick A; Stener-Victorin E
Preprint: BIORXIV. 2023
Dissecting the Impact of Maternal Androgen Exposure on Offspring Health through Targeting the Androgen Receptor in Developmental Programming
Lu H; Jiang H; Li C; Derisoud E; Zhao A; Eriksson G; Lindgren E; Pui H-P; Risal S; Pei Y; Maxian T; Ohlsson C; Benrick A; Haider S; Stener-Victorin E; Deng Q
Conference publication: JOURNAL OF THE ENDOCRINE SOCIETY. 2023;7(Supplement_1):bvad114.1587
FRI393 Mapping Endometrial Cell-type-specific Disease Signatures A nd Endometrial Organoids In Polycystic Ovary Syndrome
Eriksson G; Li C; Risal S; Pui H-P; Torstensson S; Hirschberg AL; Petropoulos S; Deng Q; Stener-Victorin E
Preprint: BIORXIV. 2023
The role of B cells in immune cell activation in polycystic ovary syndrome
Ascani A; Torstensson S; Risal S; Lu H; Eriksson G; Li C; Teshl S; Menezes J; Sandor K; Ohlsson C; Svensson C; Karlsson MCI; Stradner MH; Obermayer-Pietsch B; Stener-Victorin E
Conference publication: HUMAN REPRODUCTION. 2023;38
developmental programming by maternal androgen excess is mediated by androgen receptor pathways
Lu H; Jiang H; Li C; Pui HP; Lindgren E; Risal S; Torstensson S; Eriksson G; Ohlsson C; Benrick A; Stener-Victorin E; Deng Q
Preprint: RESEARCH SQUARE. 2022
Transcriptomic mapping of key reproductive and metabolic tissues and oocytes in mouse models of polycystic ovary syndrome
Deng Q; Pei Y; Risal S; Jiang H; Lu J; Lindgren E; Stener-Victorin E
Preprint: SSRN ELECTRONIC JOURNAL. 2022
Transgenerational Transmission of Reproductive and Metabolic Dysfunction in the Male Progeny of Polycystic Ovary Syndrome
Risal S; Li C; Luo Q; Fornes R; Lu H; Eriksson G; Manti M; Ohlsson C; Lindgren E; Crisosto N; Maliqueo M; Echiburú B; Recabarren S; Petermann TS; Benrick A; Brusselaers N; Qiao J; Deng Q; Stener-Victorin E
Review: MEDICAL SCIENCES. 2019;7(8):E86-86
Origins and Impact of Psychological Traits in Polycystic Ovary Syndrome.
Stener-Victorin E; Manti M; Fornes R; Risal S; Lu H; Benrick A
Editorial comment: OBSTETRICAL & GYNECOLOGICAL SURVEY. 2016;71(1):29-30
Adult Human and Mouse Ovaries Lack DDX4-Expressing Functional Oogonial Stem Cells EDITORIAL COMMENT
Zhang H; Panula S; Petropoulos S; Edsgard D; Busayavalasa K; Liu L; Li X; Risal S; Shen Y; Shao J; Liu M; Li S; Zhang D; Zhang X; Gerner RR; Sheikhi M; Damdimopoulou P; Sandberg R; Douagi I; Gustafsson J-A; Liu L; Lanner F; Hovatta O; Liu K
Letter: NATURE MEDICINE. 2015;21(10):1116-1118
Adult human and mouse ovaries lack DDX4-expressing functional oogonial stem cells
Zhang H; Panula S; Petropoulos S; Edsgard D; Busayavalasa K; Liu L; Li X; Risal S; Shen Y; Shao J; Liu M; Li S; Zhang D; Zhang X; Gerner RR; Sheikhi M; Damdimopoulou P; Sandberg R; Douagi I; Gustafsson J-A; Liu L; Lanner F; Hovatta O; Liu K

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