Psychiatric epidemiology – Paul Lichtenstein's research group

We study causes, consequences and comorbidities for psychiatric conditions primarily among children and adolescents. We combine national health data with clinical data, use advanced family and twin design, and have large national and international collaborations.

Part of the Department of Medical Epidemiology and Biostatistics

Our research

The work in my group is primarily concerned with using genetically informative samples (twins, families) to understand genetic and environmental influences on both health and behavior. The studies are usually based on the Swedish Twin Registry (comprising more than 200 000 twins) and other Swedish Registries such as the Multi-Generational Register (comprising all individuals born in Sweden since 1931).

My group performs quantitative genetic studies - that is, evaluate the relative importance of genes and environments for a phenotype - and "cotwin-control"-studies, where the importance of an exposure is evaluated after controlling for genetic predisposition for the disease. The research is interdisciplinary and includes, among others, medical, genetic, epidemiological, sociological and psychological research questions.

Publications

All publications from group members

Staff and contact

Group leader

All members of the group

Visiting address

Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Nobels väg 12A, Stockholm, 171 77, Sweden

Postal address

Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, PO Box 281, Stockholm, 171 77, Sweden

Causes and consequences of criminality and psychiatric disorders

The database with genetically informative psychiatric data from the entire Swedish population is very complex, and we have developed new statistical models to analyze causality and to understand how genes and environments influence intergenerational transmission. Using these methods we have shown that smoking during pregnancy is not causally related to offspring criminality and school achievements, that there is a common genetic etiology between schizophrenia and bipolar disorder, and that ADHD medication seems to be protective against criminality, traffic accidents, and drug abuse.

At least 41 completed and 16 ongoing PhD theses and 230 papers have been published based on our family study.

Project leader

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Paul Lichtenstein

Professor
+46852487424

Partners

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Brian D'Onofrio

Seena Fazel

University of Oxford

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Zheng Chang

Principal Researcher
+46852482412
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David Mataix-Cols

Professor/Psychologist
+46852481042
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Henrik Larsson

Affiliated to Research
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Catarina Almqvist Malmros

Professor/Senior Physician
+46852482220
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Cynthia Bulik

Professor
+46852482419
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Patrick Sullivan

Professor
+46852482326
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Agnieszka Butwicka

Principal Researcher
+46852482428
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Erik Pettersson

Principal Researcher
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Ralf Kuja-Halkola

Statistician
+46852482306
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Lotfi Khemiri

Affiliated to Research
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Antti Latvala

Affiliated to Research

Scientific publications

Risk of Subjection to Violence and Perpetration of Violence in Persons With Psychiatric Disorders in Sweden.
Sariaslan A, Arseneault L, Larsson H, Lichtenstein P, Fazel S
JAMA Psychiatry 2020 Jan;():

Comparison of suicide risk and other outcomes among boys and girls who self-harm.
Ohlis A, Bjureberg J, Lichtenstein P, D'Onofrio BM, Fruzzetti AE, Cederlöf M, et al
Eur Child Adolesc Psychiatry 2020 Feb;():

Evaluating the Impact of Nonrandom Mating: Psychiatric Outcomes Among the Offspring of Pairs Diagnosed With Schizophrenia and Bipolar Disorder.
Nordsletten AE, Brander G, Larsson H, Lichtenstein P, Crowley JJ, Sullivan PF, et al
Biol. Psychiatry 2020 Feb;87(3):253-262

Harmonizing behavioral outcomes across studies, raters, and countries: application to the genetic analysis of aggression in the ACTION Consortium.
Luningham JM, Hendriks AM, Krapohl E, Fung Ip H, van Beijsterveldt CEM, Lundström S, et al
J Child Psychol Psychiatry 2020 Jan;():

Association of parental substance use disorder with offspring cognition: a population family-based study.
Khemiri L, Larsson H, Kuja-Halkola R, D'Onofrio BM, Lichtenstein P, Jayaram-Lindström N, et al
Addiction 2020 Feb;115(2):326-336

Genetic and environmental contributions to diagnostic fluctuation in anorexia nervosa and bulimia nervosa.
Yao S, Larsson H, Norring C, Birgegård A, Lichtenstein P, DʼOnofrio BM, et al
Psychol Med 2019 Oct;():1-8

Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders: A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches.
Yao S, Kuja-Halkola R, Martin J, Lu Y, Lichtenstein P, Norring C, et al
Biol. Psychiatry 2019 Oct;86(8):577-586

Comorbidity of substance misuse with anxiety-related and depressive disorders: a genetically informative population study of 3 million individuals in Sweden.
Virtanen S, Kuja-Halkola R, Mataix-Cols D, Jayaram-Lindström N, D'Onofrio BM, Larsson H, et al
Psychol Med 2019 Jul;():1-10

Maternal prescribed opioid analgesic use during pregnancy and associations with adverse birth outcomes: A population-based study.
Sujan AC, Quinn PD, Rickert ME, Wiggs KK, Lichtenstein P, Larsson H, et al
PLoS Med. 2019 12;16(12):e1002980

Stress related disorders and risk of cardiovascular disease: population based, sibling controlled cohort study.
Song H, Fang F, Arnberg FK, Mataix-Cols D, Fernández de la Cruz L, Almqvist C, et al
BMJ 2019 04;365():l1255

Stress related disorders and subsequent risk of life threatening infections: population based sibling controlled cohort study.
Song H, Fall K, Fang F, Erlendsdóttir H, Lu D, Mataix-Cols D, et al
BMJ 2019 10;367():l5784

Is depression more likely following childbirth? A population-based study.
Silverman ME, Reichenberg A, Lichtenstein P, Sandin S
Arch Womens Ment Health 2019 04;22(2):253-258

Genetic and environmental sources of familial coaggregation of obsessive-compulsive disorder and suicidal behavior: a population-based birth cohort and family study.
Sidorchuk A, Kuja-Halkola R, Runeson B, Lichtenstein P, Larsson H, Rück C, et al
Mol. Psychiatry 2019 Apr;():

Maternal anxiety, depression and asthma and adverse pregnancy outcomes - a population based study.
Rejnö G, Lundholm C, Öberg S, Lichtenstein P, Larsson H, D'Onofrio B, et al
Sci Rep 2019 Sep;9(1):13101

Associations of mental health and family background with opioid analgesic therapy: a nationwide Swedish register-based study.
Quinn PD, Rickert ME, Franck J, Sariaslan A, Boersma K, Lichtenstein P, et al
Pain 2019 11;160(11):2464-2472

Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls.
Pettersson E, Lichtenstein P, Larsson H, Song J, , Agrawal A, et al
Psychol Med 2019 05;49(7):1166-1173

Association of Fetal Growth With General and Specific Mental Health Conditions.
Pettersson E, Larsson H, D'Onofrio B, Almqvist C, Lichtenstein P
JAMA Psychiatry 2019 May;76(5):536-543

Exploring the Association of Sex Differences and Exposure to Maternal Smoking With Low Fetal Growth-Reply.
Pettersson E, D'Onofrio B, Lichtenstein P
JAMA Psychiatry 2019 Jul;76(7):767-768

Hypogonadotrophic hypogonadism, delayed puberty and risk for neurodevelopmental disorders.
Ohlsson Gotby V, Söder O, Frisén L, Serlachius E, Bölte S, Almqvist C, et al
J. Neuroendocrinol. 2019 Nov;31(11):e12803

Sex differences in predicting ADHD clinical diagnosis and pharmacological treatment.
Mowlem FD, Rosenqvist MA, Martin J, Lichtenstein P, Asherson P, Larsson H
Eur Child Adolesc Psychiatry 2019 Apr;28(4):481-489

Data Integration Methods for Phenotype Harmonization in Multi-Cohort Genome-Wide Association Studies With Behavioral Outcomes.
Luningham JM, McArtor DB, Hendriks AM, van Beijsterveldt CEM, Lichtenstein P, Lundström S, et al
Front Genet 2019 ;10():1227

Antidepressant prescription patterns and CNS polypharmacy with antidepressants among children, adolescents, and young adults: a population-based study in Sweden.
Lagerberg T, Molero Y, D'Onofrio BM, Fernández de la Cruz L, Lichtenstein P, Mataix-Cols D, et al
Eur Child Adolesc Psychiatry 2019 Aug;28(8):1137-1145

Reproductive stoppage in autism spectrum disorder in a population of 2.5 million individuals.
Kuja-Halkola R, Larsson H, Lundström S, Sandin S, Chizarifard A, Bölte S, et al
Mol Autism 2019 ;10():45

Increased schizophrenia family history burden and reduced premorbid IQ in treatment-resistant schizophrenia: a Swedish National Register and Genomic Study.
Kowalec K, Lu Y, Sariaslan A, Song J, Ploner A, Dalman C, et al
Mol. Psychiatry 2019 Nov;():

Attention-Deficit/Hyperactivity Disorder, School Performance, and Effect of Medication.
Jangmo A, Stålhandske A, Chang Z, Chen Q, Almqvist C, Feldman I, et al
J Am Acad Child Adolesc Psychiatry 2019 Apr;58(4):423-432

Association of chronic and acute inflammation of the mucosa-associated lymphoid tissue with psychiatric disorders and suicidal behavior.
Isung J, Isomura K, Almqvist C, Lichtenstein P, Larsson H, Wester T, et al
Transl Psychiatry 2019 09;9(1):227

Methylphenidate and the risk of psychosis in adolescents and young adults: a population-based cohort study.
Hollis C, Chen Q, Chang Z, Quinn PD, Viktorin A, Lichtenstein P, et al
Lancet Psychiatry 2019 08;6(8):651-658

Suicide Immediately After Discharge From Psychiatric Inpatient Care: A Cohort Study of Nearly 2.9 Million Discharges.
Haglund A, Lysell H, Larsson H, Lichtenstein P, Runeson B
J Clin Psychiatry 2019 02;80(2):

Parental asthma and risk of autism spectrum disorder in offspring: A population and family-based case-control study.
Gong T, Lundholm C, Rejnö G, Bölte S, Larsson H, D'Onofrio BM, et al
Clin. Exp. Allergy 2019 Jun;49(6):883-891

Maternal infection requiring hospitalization during pregnancy and attention-deficit hyperactivity disorder in offspring: a quasi-experimental family-based study.
Ginsberg Y, D'Onofrio BM, Rickert ME, Class QA, Rosenqvist MA, Almqvist C, et al
J Child Psychol Psychiatry 2019 02;60(2):160-168

The relation between the age at diagnosis of problem behaviors related to aggression and distal outcomes in Swedish children.
Campbell I, Lundstrom S, Larsson H, Lichtenstein P, Lubke G
Eur Child Adolesc Psychiatry 2019 Jul;28(7):899-911

No association between urbanisation, neighbourhood deprivation and IBD: a population-based study of 4 million individuals.
Butwicka A, Sariaslan A, Larsson H, Halfvarson J, Myrelid PE, Olén O, et al
Gut 2019 05;68(5):947-948

Association of Childhood-Onset Inflammatory Bowel Disease With Risk of Psychiatric Disorders and Suicide Attempt.
Butwicka A, Olén O, Larsson H, Halfvarson J, Almqvist C, Lichtenstein P, et al
JAMA Pediatr 2019 Aug;():

Medication treatment for attention-deficit/hyperactivity disorder and the risk of acute seizures in individuals with epilepsy.
Brikell I, Chen Q, Kuja-Halkola R, D'Onofrio BM, Wiggs KK, Lichtenstein P, et al
Epilepsia 2019 Feb;60(2):284-293

A population-based family clustering study of tic-related obsessive-compulsive disorder.
Brander G, Kuja-Halkola R, Rosenqvist MA, Rück C, Serlachius E, Fernández de la Cruz L, et al
Mol. Psychiatry 2019 Oct;():

Adolescent self-harm with and without suicidality: cross-sectional and longitudinal analyses of a Swedish regional register.
Bjureberg J, Ohlis A, Ljótsson B, D'Onofrio BM, Hedman-Lagerlöf E, Jokinen J, et al
J Child Psychol Psychiatry 2019 Mar;60(3):295-304

Epilepsy, antiepileptic drugs, and serious transport accidents: A nationwide cohort study.
Sundelin H, Chang Z, Larsson H, Lichtenstein P, Almqvist C, Tomson T, et al
Neurology 2018 Mar;90(13):e1111-e1118

Specificity in Etiology of Subtypes of Bipolar Disorder: Evidence From a Swedish Population-Based Family Study.
Song J, Kuja-Halkola R, Sjölander A, Bergen S, Larsson H, Landén M, et al
Biol. Psychiatry 2018 Dec;84(11):810-816

The association between body mass index and postpartum depression: A population-based study.
Silverman M, Smith L, Lichtenstein P, Reichenberg A, Sandin S
J Affect Disord 2018 11;240():193-198

Is depression more likely following childbirth? A population-based study.
Silverman M, Reichenberg A, Lichtenstein P, Sandin S
Arch Womens Ment Health 2019 Apr;22(2):253-258

Benzodiazepine prescribing for children, adolescents, and young adults from 2006 through 2013: A total population register-linkage study.
Sidorchuk A, Isomura K, Molero Y, Hellner C, Lichtenstein P, Chang Z, et al
PLoS Med. 2018 08;15(8):e1002635

Has the attention deficit hyperactivity disorder phenotype become more common in children between 2004 and 2014? Trends over 10 years from a Swedish general population sample.
Rydell M, Lundström S, Gillberg C, Lichtenstein P, Larsson H
J Child Psychol Psychiatry 2018 Aug;59(8):863-871

Adverse Pregnancy Outcomes in Asthmatic Women: A Population-Based Family Design Study.
Rejnö G, Lundholm C, Larsson K, Larsson H, Lichtenstein P, D'Onofrio B, et al
J Allergy Clin Immunol Pract ;6(3):916-922.e6

Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls.
Pettersson E, Lichtenstein P, Larsson H, Song J, , Agrawal A, et al
Psychol Med 2018 Sep;():1-8

Criterion Validity and Utility of the General Factor of Psychopathology in Childhood: Predictive Associations With Independently Measured Severe Adverse Mental Health Outcomes in Adolescence.
Pettersson E, Lahey B, Larsson H, Lichtenstein P
J Am Acad Child Adolesc Psychiatry 2018 Jun;57(6):372-383

Maternal and infant outcomes associated with lithium use in pregnancy: an international collaborative meta-analysis of six cohort studies.
Munk-Olsen T, Liu X, Viktorin A, Brown H, Di Florio A, D'Onofrio B, et al
Lancet Psychiatry 2018 08;5(8):644-652

Sex differences in predicting ADHD clinical diagnosis and pharmacological treatment.
Mowlem F, Rosenqvist M, Martin J, Lichtenstein P, Asherson P, Larsson H
Eur Child Adolesc Psychiatry 2019 Apr;28(4):481-489

Parental nicotine replacement therapy and offspring bronchitis/bronchiolitis and asthma - a nationwide population-based cohort study.
Molero Y, Zetterqvist J, Lichtenstein P, Almqvist C, Ludvigsson J
Clin Epidemiol 2018 ;10():1339-1347

A total-population multigenerational family clustering study of autoimmune diseases in obsessive-compulsive disorder and Tourette's/chronic tic disorders.
Mataix-Cols D, Frans E, Pérez-Vigil A, Kuja-Halkola R, Gromark C, Isomura K, et al
Mol. Psychiatry 2018 07;23(7):1652-1658

A Genetic Investigation of Sex Bias in the Prevalence of Attention-Deficit/Hyperactivity Disorder.
Martin J, Walters R, Demontis D, Mattheisen M, Lee S, Robinson E, et al
Biol. Psychiatry 2018 Jun;83(12):1044-1053

Artistic creativity and risk for schizophrenia, bipolar disorder and unipolar depression: a Swedish population-based case-control study and sib-pair analysis.
MacCabe JH, Sariaslan A, Almqvist C, Lichtenstein P, Larsson H, Kyaga S
Br J Psychiatry 2018 06;212(6):370-376

Do borderline personality disorder and attention-deficit/hyperactivity disorder co-aggregate in families? A population-based study of 2 million Swedes.
Kuja-Halkola R, Lind Juto K, Skoglund C, Rück C, Mataix-Cols D, Pérez-Vigil A, et al
Mol. Psychiatry 2018 Oct;():

Metabolic and Cardiovascular Complications in Obsessive-Compulsive Disorder: A Total Population, Sibling Comparison Study With Long-Term Follow-up.
Isomura K, Brander G, Chang Z, Kuja-Halkola R, Rück C, Hellner C, et al
Biol. Psychiatry 2018 Sep;84(5):324-331

The familial co-aggregation of ASD and ADHD: a register-based cohort study.
Ghirardi L, Brikell I, Kuja-Halkola R, Freitag CM, Franke B, Asherson P, et al
Mol. Psychiatry 2018 02;23(2):257-262

Outcome-dependent associations between short interpregnancy interval and offspring psychological and educational problems: a population-based quasi-experimental study.
Class QA, Rickert ME, Larsson H, Öberg AS, Sujan AC, Almqvist C, et al
Int J Epidemiol 2018 08;47(4):1159-1168

The relation between the age at diagnosis of problem behaviors related to aggression and distal outcomes in Swedish children.
Campbell I, Lundstrom S, Larsson H, Lichtenstein P, Lubke G
Eur Child Adolesc Psychiatry 2018 Nov;():

No association between urbanisation, neighbourhood deprivation and IBD: a population-based study of 4 million individuals.
Butwicka A, Sariaslan A, Larsson H, Halfvarson J, Myrelid P, Olén O, et al
Gut 2019 05;68(5):947-948

Longitudinal depression or anxiety in mothers and offspring asthma: a Swedish population-based study.
Brew B, Lundholm C, Viktorin A, Lichtenstein P, Larsson H, Almqvist C
Int J Epidemiol 2018 02;47(1):166-174

Perinatal risk factors in Tourette's and chronic tic disorders: a total population sibling comparison study.
Brander G, Rydell M, Kuja-Halkola R, Fernández de la Cruz L, Lichtenstein P, Serlachius E, et al
Mol. Psychiatry 2018 05;23(5):1189-1197

Risk of being convicted of theft and other crimes in anorexia nervosa and bulimia nervosa: A prospective cohort study in a Swedish female population.
Yao S, Kuja-Halkola R, Thornton L, Norring C, Almqvist C, D'Onofrio B, et al
Int J Eat Disord 2017 09;50(9):1095-1103

The Risk of Treatment-Emergent Mania With Methylphenidate in Bipolar Disorder.
Viktorin A, Rydén E, Thase ME, Chang Z, Lundholm C, D'Onofrio BM, et al
Am J Psychiatry 2017 04;174(4):341-348

A Family-Based Study of the Association Between Labor Induction and Offspring Attention-Deficit Hyperactivity Disorder and Low Academic Achievement.
Wiggs KK, Rickert ME, Hernandez-Diaz S, Bateman BT, Almqvist C, Larsson H, et al
Behav. Genet. 2017 07;47(4):383-393

Associations of Maternal Antidepressant Use During the First Trimester of Pregnancy With Preterm Birth, Small for Gestational Age, Autism Spectrum Disorder, and Attention-Deficit/Hyperactivity Disorder in Offspring.
Sujan AC, Rickert ME, Öberg AS, Quinn PD, Hernández-Díaz S, Almqvist C, et al
JAMA 2017 04;317(15):1553-1562

Suicidal Behavior During Lithium and Valproate Treatment: A Within-Individual 8-Year Prospective Study of 50,000 Patients With Bipolar Disorder.
Song J, Sjölander A, Joas E, Bergen S, Runeson B, Larsson H, et al
Am J Psychiatry 2017 08;174(8):795-802

The risk factors for postpartum depression: A population-based study.
Silverman M, Reichenberg A, Savitz D, Cnattingius S, Lichtenstein P, Hultman C, et al
Depress Anxiety 2017 02;34(2):178-187

Neighborhood Influences on Violent Reoffending Risk in Released Prisoners Diagnosed With Psychotic Disorders.
Sariaslan A, Larsson H, Lichtenstein P, Fazel S
Schizophr Bull 2017 09;43(5):1011-1020

The Heritability of Autism Spectrum Disorder.
Sandin S, Lichtenstein P, Kuja-Halkola R, Hultman C, Larsson H, Reichenberg A
JAMA 2017 09;318(12):1182-1184

Association Between Deliberate Self-harm and Violent Criminality.
Sahlin H, Kuja-Halkola R, Bjureberg J, Lichtenstein P, Molero Y, Rydell M, et al
JAMA Psychiatry 2017 06;74(6):615-621

Association Between Maternal Smoking During Pregnancy and Severe Mental Illness in Offspring.
Quinn P, Rickert M, Weibull C, Johansson A, Lichtenstein P, Almqvist C, et al
JAMA Psychiatry 2017 06;74(6):589-596

ADHD Medication and Substance-Related Problems.
Quinn P, Chang Z, Hur K, Gibbons R, Lahey B, Rickert M, et al
Am J Psychiatry 2017 09;174(9):877-885

Risk of eating disorders in immigrant populations.
Mustelin L, Hedman AM, Thornton LM, Kuja-Halkola R, Keski-Rahkonen A, Cantor-Graae E, et al
Acta Psychiatr Scand 2017 08;136(2):156-165

Association Between Medication Use and Performance on Higher Education Entrance Tests in Individuals With Attention-Deficit/Hyperactivity Disorder.
Lu Y, Sjölander A, Cederlöf M, D'Onofrio B, Almqvist C, Larsson H, et al
JAMA Psychiatry 2017 08;74(8):815-822

Neurodegenerative and psychiatric diseases among families with amyotrophic lateral sclerosis.
Longinetti E, Mariosa D, Larsson H, Ye W, Ingre C, Almqvist C, et al
Neurology 2017 Aug;89(6):578-585

Physical and cognitive fitness in young adulthood and risk of amyotrophic lateral sclerosis at an early age.
Longinetti E, Mariosa D, Larsson H, Almqvist C, Lichtenstein P, Ye W, et al
Eur. J. Neurol. 2017 01;24(1):137-142

Pharmacological treatment and risk of psychiatric hospital admission in bipolar disorder.
Joas E, Karanti A, Song J, Goodwin G, Lichtenstein P, Landén M
Br J Psychiatry 2017 03;210(3):197-202

Paternal age at childbirth and eating disorders in offspring.
Javaras K, Rickert M, Thornton L, Peat C, Baker J, Birgegård A, et al
Psychol Med 2017 Feb;47(3):576-584

Suicide in obsessive-compulsive disorder: a population-based study of 36 788 Swedish patients.
Fernández de la Cruz L, Rydell M, Runeson B, D'Onofrio B, Brander G, Rück C, et al
Mol. Psychiatry 2017 11;22(11):1626-1632

Suicide in Tourette's and Chronic Tic Disorders.
Fernández de la Cruz L, Rydell M, Runeson B, Brander G, Rück C, D'Onofrio B, et al
Biol. Psychiatry 2017 07;82(2):111-118

Identification of low risk of violent crime in severe mental illness with a clinical prediction tool (Oxford Mental Illness and Violence tool [OxMIV]): a derivation and validation study.
Fazel S, Wolf A, Larsson H, Lichtenstein P, Mallett S, Fanshawe T
Lancet Psychiatry 2017 06;4(6):461-468

The Familial Co-Aggregation of Attention-Deficit/Hyperactivity Disorder and Intellectual Disability: A Register-Based Family Study.
Faraone S, Ghirardi L, Kuja-Halkola R, Lichtenstein P, Larsson H
J Am Acad Child Adolesc Psychiatry 2017 Feb;56(2):167-174.e1

Shared familial risk factors between attention-deficit/hyperactivity disorder and overweight/obesity - a population-based familial coaggregation study in Sweden.
Chen Q, Kuja-Halkola R, Sjölander A, Serlachius E, Cortese S, Faraone SV, et al
J Child Psychol Psychiatry 2017 Jun;58(6):711-718

Familial aggregation of attention-deficit/hyperactivity disorder.
Chen Q, Brikell I, Lichtenstein P, Serlachius E, Kuja-Halkola R, Sandin S, et al
J Child Psychol Psychiatry 2017 03;58(3):231-239

Association Between Medication Use for Attention-Deficit/Hyperactivity Disorder and Risk of Motor Vehicle Crashes.
Chang Z, Quinn PD, Hur K, Gibbons RD, Sjölander A, Larsson H, et al
JAMA Psychiatry 2017 06;74(6):597-603

Increased Risk for Substance Use-Related Problems in Autism Spectrum Disorders: A Population-Based Cohort Study.
Butwicka A, Långström N, Larsson H, Lundström S, Serlachius E, Almqvist C, et al
J Autism Dev Disord 2017 Jan;47(1):80-89

Parental and perinatal risk factors for sexual offending in men: a nationwide case-control study.
Babchishin KM, Seto MC, Sariaslan A, Lichtenstein P, Fazel S, Långström N
Psychol Med 2017 01;47(2):305-315

Familial Liability for Eating Disorders and Suicide Attempts: Evidence From a Population Registry in Sweden.
Yao S, Kuja-Halkola R, Thornton LM, Runfola CD, D'Onofrio BM, Almqvist C, et al
JAMA Psychiatry 2016 Mar;73(3):284-91

Heritability of Perinatal Depression and Genetic Overlap With Nonperinatal Depression.
Viktorin A, Meltzer-Brody S, Kuja-Halkola R, Sullivan PF, Landén M, Lichtenstein P, et al
Am J Psychiatry 2016 Feb;173(2):158-65

Selective serotonin re-uptake inhibitor use during pregnancy: association with offspring birth size and gestational age.
Viktorin A, Lichtenstein P, Lundholm C, Almqvist C, D'Onofrio BM, Larsson H, et al
Int J Epidemiol 2016 Feb;45(1):170-7

Autism and epilepsy: A population-based nationwide cohort study.
Sundelin HE, Larsson H, Lichtenstein P, Almqvist C, Hultman CM, Tomson T, et al
Neurology 2016 07;87(2):192-7

A Genetically Informed Study of the Associations Between Maternal Age at Childbearing and Adverse Perinatal Outcomes.
Sujan AC, Rickert ME, Class QA, Coyne CA, Lichtenstein P, Almqvist C, et al
Behav. Genet. 2016 05;46(3):431-56

Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder.
Song J, Bergen SE, Di Florio A, Karlsson R, Charney A, Ruderfer DM, et al
Mol. Psychiatry 2016 09;21(9):1290-7

Triggers for Violent Criminality in Patients With Psychotic Disorders.
Sariaslan A, Lichtenstein P, Larsson H, Fazel S
JAMA Psychiatry 2016 08;73(8):796-803

Suicide risk after nonfatal self-harm: a national cohort study, 2000-2008.
Runeson B, Haglund A, Lichtenstein P, Tidemalm D
J Clin Psychiatry 2016 02;77(2):240-6

Understanding the covariation of tics, attention-deficit/hyperactivity, and obsessive-compulsive symptoms: A population-based adult twin study.
Pinto R, Monzani B, Leckman JF, Rück C, Serlachius E, Lichtenstein P, et al
Am. J. Med. Genet. B Neuropsychiatr. Genet. 2016 10;171(7):938-47

Common psychiatric disorders share the same genetic origin: a multivariate sibling study of the Swedish population.
Pettersson E, Larsson H, Lichtenstein P
Mol. Psychiatry 2016 May;21(5):717-21

Patterns of Nonrandom Mating Within and Across 11 Major Psychiatric Disorders.
Nordsletten AE, Larsson H, Crowley JJ, Almqvist C, Lichtenstein P, Mataix-Cols D
JAMA Psychiatry 2016 Apr;73(4):354-61

Killing the mother of one's child: psychiatric risk factors among male perpetrators and offspring health consequences.
Lysell H, Dahlin M, Långström N, Lichtenstein P, Runeson B
J Clin Psychiatry 2016 Mar;77(3):342-7

Association of Resting Heart Rate and Blood Pressure in Late Adolescence With Subsequent Mental Disorders: A Longitudinal Population Study of More Than 1 Million Men in Sweden.
Latvala A, Kuja-Halkola R, Rück C, D'Onofrio BM, Jernberg T, Almqvist C, et al
JAMA Psychiatry 2016 Dec;73(12):1268-1275

Cognitive ability and risk for substance misuse in men: genetic and environmental correlations in a longitudinal nation-wide family study.
Latvala A, Kuja-Halkola R, D'Onofrio BM, Larsson H, Lichtenstein P
Addiction 2016 10;111(10):1814-22

Premature mortality in autism spectrum disorder.
Hirvikoski T, Mittendorfer-Rutz E, Boman M, Larsson H, Lichtenstein P, Bölte S
Br J Psychiatry 2016 Mar;208(3):232-8

Age at fatherhood: heritability and associations with psychiatric disorders.
Frans EM, Lichtenstein P, Hultman CM, Kuja-Halkola R
Psychol Med 2016 10;46(14):2981-2988

Prediction of violent reoffending on release from prison: derivation and external validation of a scalable tool.
Fazel S, Chang Z, Fanshawe T, Långström N, Lichtenstein P, Larsson H, et al
Lancet Psychiatry 2016 Jun;3(6):535-43

Association Between Prescription of Major Psychotropic Medications and Violent Reoffending After Prison Release.
Chang Z, Lichtenstein P, Långström N, Larsson H, Fazel S
JAMA 2016 Nov;316(17):1798-1807

Medication for Attention-Deficit/Hyperactivity Disorder and Risk for Depression: A Nationwide Longitudinal Cohort Study.
Chang Z, D'Onofrio BM, Quinn PD, Lichtenstein P, Larsson H
Biol. Psychiatry 2016 12;80(12):916-922

Nationwide population-based cohort study of psychiatric disorders in individuals with Ehlers-Danlos syndrome or hypermobility syndrome and their siblings.
Cederlöf M, Larsson H, Lichtenstein P, Almqvist C, Serlachius E, Ludvigsson JF
BMC Psychiatry 2016 07;16():207

Association of Perinatal Risk Factors With Obsessive-Compulsive Disorder: A Population-Based Birth Cohort, Sibling Control Study.
Brander G, Rydell M, Kuja-Halkola R, Fernández de la Cruz L, Lichtenstein P, Serlachius E, et al
JAMA Psychiatry 2016 Nov;73(11):1135-1144

The association between childhood relocations and subsequent risk of suicide attempt, psychiatric problems, and low academic achievement.
Bramson LM, Rickert ME, Class QA, Sariaslan A, Almqvist C, Larsson H, et al
Psychol Med 2016 Apr;46(5):969-79

Mental illness and suicide after self-harm among young adults: long-term follow-up of self-harm patients, admitted to hospital care, in a national cohort.
Beckman K, Mittendorfer-Rutz E, Lichtenstein P, Larsson H, Almqvist C, Runeson B, et al
Psychol Med 2016 12;46(16):3397-3405

Improving risk assessment in schizophrenia: epidemiological investigation of criminal history factors.
Witt K, Lichtenstein P, Fazel S
Br J Psychiatry 2015 May;206(5):424-30

Age-specific suicide mortality following non-fatal self-harm: national cohort study in Sweden.
Tidemalm D, Beckman K, Dahlin M, Vaez M, Lichtenstein P, Långström N, et al
Psychol Med 2015 Jun;45(8):1699-707

Bipolar disorder and its relation to major psychiatric disorders: a family-based study in the Swedish population.
Song J, Bergen SE, Kuja-Halkola R, Larsson H, Landén M, Lichtenstein P
Bipolar Disord 2015 Mar;17(2):184-93

Attention-deficit/hyperactivity disorder and risk for substance use disorders in relatives.
Skoglund C, Chen Q, Franck J, Lichtenstein P, Larsson H
Biol. Psychiatry 2015 May;77(10):880-6

Validity and reliability of chronic tic disorder and obsessive-compulsive disorder diagnoses in the Swedish National Patient Register.
Rück C, Larsson KJ, Lind K, Perez-Vigil A, Isomura K, Sariaslan A, et al
BMJ Open 2015 Jun;5(6):e007520

Congenital Adrenal Hyperplasia, Polycystic Ovary Syndrome and criminal behavior: A Swedish population based study.
Ohlsson Gotby A, Nordenström A, Falhammar H, Nordenskjöld A, Linden Hirschberg A, Frisén L, et al
Psychiatry Res 2015 Oct;229(3):953-9

Selective Serotonin Reuptake Inhibitors and Violent Crime: A Cohort Study.
Molero Y, Lichtenstein P, Zetterqvist J, Gumpert CH, Fazel S
PLoS Med. 2015 Sep;12(9):e1001875

Varenicline and risk of psychiatric conditions, suicidal behaviour, criminal offending, and transport accidents and offences: population based cohort study.
Molero Y, Lichtenstein P, Zetterqvist J, Gumpert CH, Fazel S
BMJ 2015 Jun;350():h2388

Familial Risks of Tourette Syndrome and Chronic Tic Disorders. A Population-Based Cohort Study.
Mataix-Cols D, Isomura K, Pérez-Vigil A, Chang Z, Rück C, Larsson KJ, et al
JAMA Psychiatry 2015 Aug;72(8):787-93

Paternal antisocial behavior and sons' cognitive ability: a population-based quasiexperimental study.
Latvala A, Kuja-Halkola R, Långström N, Lichtenstein P
Psychol Sci 2015 Jan;26(1):78-88

A Longitudinal Study of Resting Heart Rate and Violent Criminality in More Than 700 000 Men.
Latvala A, Kuja-Halkola R, Almqvist C, Larsson H, Lichtenstein P
JAMA Psychiatry 2015 Oct;72(10):971-8

Sexual offending runs in families: A 37-year nationwide study.
Långström N, Babchishin KM, Fazel S, Lichtenstein P, Frisell T
Int J Epidemiol 2015 Apr;44(2):713-20

Bipolar disorder and leadership--a total population study.
Kyaga S, Lichtenstein P, Boman M, Landén M
Acta Psychiatr Scand 2015 Feb;131(2):111-9

Sex- and age-specific incidence of healthcare-register-recorded eating disorders in the complete swedish 1979-2001 birth cohort.
Javaras KN, Runfola CD, Thornton LM, Agerbo E, Birgegård A, Norring C, et al
Int J Eat Disord 2015 Dec;48(8):1070-81

Depression and violence: a Swedish population study.
Fazel S, Wolf A, Chang Z, Larsson H, Goodwin GM, Lichtenstein P
Lancet Psychiatry 2015 Mar;2(3):224-32

Depression and violence—what do we really know? – Authors' reply.
Fazel S, Goodwin GM, Lichtenstein P
Lancet Psychiatry 2015 Jun;2(6):492

Congenital adrenal hyperplasia and risk for psychiatric disorders in girls and women born between 1915 and 2010: A total population study.
Engberg H, Butwicka A, Nordenström A, Hirschberg AL, Falhammar H, Lichtenstein P, et al
Psychoneuroendocrinology 2015 Oct;60():195-205

Substance use disorders, psychiatric disorders, and mortality after release from prison: a nationwide longitudinal cohort study.
Chang Z, Lichtenstein P, Larsson H, Fazel S
Lancet Psychiatry 2015 May;2(5):422-430

Variation in mortality risk of people released from prison - Authors' reply.
Chang Z, Lichtenstein P, Larssen H, Fazel S
Lancet Psychiatry 2015 Aug;2(8):681-682

Psychiatric disorders and violent reoffending: a national cohort study of convicted prisoners in Sweden.
Chang Z, Larsson H, Lichtenstein P, Fazel S
Lancet Psychiatry 2015 Oct;2(10):891-900

Hypospadias and increased risk for neurodevelopmental disorders.
Butwicka A, Lichtenstein P, Landén M, Nordenvall AS, Nordenström A, Nordenskjöld A, et al
J Child Psychol Psychiatry 2015 Feb;56(2):155-61

Risks of psychiatric disorders and suicide attempts in children and adolescents with type 1 diabetes: a population-based cohort study.
Butwicka A, Frisén L, Almqvist C, Zethelius B, Lichtenstein P
Diabetes Care 2015 Mar;38(3):453-9

Psychiatric disorders and suicide attempts in Swedish survivors of the 2004 southeast Asia tsunami: a 5 year matched cohort study.
Arnberg FK, Gudmundsdóttir R, Butwicka A, Fang F, Lichtenstein P, Hultman CM, et al
Lancet Psychiatry 2015 Sep;2(9):817-24

Suboptimal psychosocial outcomes in patients with congenital adrenal hyperplasia: epidemiological studies in a nonbiased national cohort in Sweden.
Strandqvist A, Falhammar H, Lichtenstein P, Hirschberg AL, Wedell A, Norrby C, et al
J. Clin. Endocrinol. Metab. 2014 Apr;99(4):1425-32

Familial confounding of the association between maternal smoking during pregnancy and ADHD in offspring.
Skoglund C, Chen Q, D'Onofrio BM, Lichtenstein P, Larsson H
J Child Psychol Psychiatry 2014 Jan;55(1):61-8

The association between schizophrenia and rheumatoid arthritis: a nationwide population-based Swedish study on intraindividual and familial risks.
Sellgren C, Frisell T, Lichtenstein P, Landèn M, Askling J
Schizophr Bull 2014 Nov;40(6):1552-9

Childhood family income, adolescent violent criminality and substance misuse: quasi-experimental total population study.
Sariaslan A, Larsson H, D'Onofrio B, Långström N, Lichtenstein P
Br J Psychiatry 2014 Oct;205(4):286-90

The heritability of clinically diagnosed attention deficit hyperactivity disorder across the lifespan.
Larsson H, Chang Z, D'Onofrio BM, Lichtenstein P
Psychol Med 2014 Jul;44(10):2223-9

Multiple sclerosis and psychiatric disorders: comorbidity and sibling risk in a nationwide Swedish cohort.
Johansson V, Lundholm C, Hillert J, Masterman T, Lichtenstein P, Landén M, et al
Mult. Scler. 2014 Dec;20(14):1881-91

Suicide after release from prison: a population-based cohort study from Sweden.
Haglund A, Tidemalm D, Jokinen J, Långström N, Lichtenstein P, Fazel S, et al
J Clin Psychiatry 2014 Oct;75(10):1047-53

Antipsychotics, mood stabilisers, and risk of violent crime.
Fazel S, Zetterqvist J, Larsson H, Långström N, Lichtenstein P
Lancet 2014 Sep;384(9949):1206-14

Fetal growth and psychiatric and socioeconomic problems: population-based sibling comparison.
Class QA, Rickert ME, Larsson H, Lichtenstein P, D'Onofrio BM
Br J Psychiatry 2014 Nov;205(5):355-61

Stimulant ADHD medication and risk for substance abuse.
Chang Z, Lichtenstein P, Halldner L, D'Onofrio B, Serlachius E, Fazel S, et al
J Child Psychol Psychiatry 2014 Aug;55(8):878-85

Examining and interpreting the female protective effect against autistic behavior.
Robinson EB, Lichtenstein P, Anckarsäter H, Happé F, Ronald A
Proc. Natl. Acad. Sci. U.S.A. 2013 Mar;110(13):5258-62

Fecundity of patients with schizophrenia, autism, bipolar disorder, depression, anorexia nervosa, or substance abuse vs their unaffected siblings.
Power RA, Kyaga S, Uher R, MacCabe JH, Långström N, Landen M, et al
JAMA Psychiatry 2013 Jan;70(1):22-30

Population-based, multigenerational family clustering study of obsessive-compulsive disorder.
Mataix-Cols D, Boman M, Monzani B, Rück C, Serlachius E, Långström N, et al
JAMA Psychiatry 2013 Jul;70(7):709-17

Mental illness, suicide and creativity: 40-year prospective total population study.
Kyaga S, Landén M, Boman M, Hultman CM, Långström N, Lichtenstein P
J Psychiatr Res 2013 Jan;47(1):83-90

Time to hospitalization for suicide attempt by the timing of parental suicide during offspring early development.
Kuramoto SJ, Runeson B, Stuart EA, Lichtenstein P, Wilcox HC
JAMA Psychiatry 2013 Feb;70(2):149-57

ADHD and criminality: could treatment benefit prisoners with ADHD who are at higher risk of reoffending?
Ginsberg Y, Långström N, Larsson H, Lichtenstein P
Expert Rev Neurother 2013 Apr;13(4):345-8

Autism risk across generations: a population-based study of advancing grandpaternal and paternal age.
Frans EM, Sandin S, Reichenberg A, Långström N, Lichtenstein P, McGrath JJ, et al
JAMA Psychiatry 2013 May;70(5):516-21

Maternal age at first birth and offspring criminality: using the children of twins design to test causal hypotheses.
Coyne CA, Långström N, Rickert ME, Lichtenstein P, D'Onofrio BM
Dev. Psychopathol. 2013 Feb;25(1):17-35

The association between teenage motherhood and poor offspring outcomes: a national cohort study across 30 years.
Coyne CA, Långström N, Lichtenstein P, D'Onofrio BM
Twin Res Hum Genet 2013 Jun;16(3):679-89

Maternal stress and infant mortality: the importance of the preconception period.
Class QA, Khashan AS, Lichtenstein P, Långström N, D'Onofrio BM
Psychol Sci 2013 Jul;24(7):1309-16

Familial aggregation of schizophrenia: the moderating effect of age at onset, parental immigration, paternal age and season of birth.
Svensson AC, Lichtenstein P, Sandin S, Öberg S, Sullivan PF, Hultman CM
Scand J Public Health 2012 Feb;40(1):43-50

Family history of schizophrenia and bipolar disorder as risk factors for autism.
Sullivan PF, Magnusson C, Reichenberg A, Boman M, Dalman C, Davidson M, et al
Arch. Gen. Psychiatry 2012 Nov;69(11):1099-1103

A novel approach to determining violence risk in schizophrenia: developing a stepped strategy in 13,806 discharged patients.
Singh JP, Grann M, Lichtenstein P, Långström N, Fazel S
PLoS ONE 2012 ;7(2):e3172722359622

Medication for attention deficit-hyperactivity disorder and criminality.
Lichtenstein P, Halldner L, Zetterqvist J, Sjölander A, Serlachius E, Fazel S, et al
N. Engl. J. Med. 2012 Nov;367(21):2006-14

Advancing paternal age and offspring violent offending: a sibling-comparison study.
Kuja-Halkola R, Pawitan Y, D'Onofrio BM, Långström N, Lichtenstein P
Dev. Psychopathol. 2012 Aug;24(3):739-53

Poor school performance in offspring of patients with schizophrenia: what are the mechanisms?
Jundong J, Kuja-Halkola R, Hultman C, Långström N, D'Onofrio BM, Lichtenstein P
Psychol Med 2012 Jan;42(1):111-23

Heritability, assortative mating and gender differences in violent crime: results from a total population sample using twin, adoption, and sibling models.
Frisell T, Pawitan Y, Långström N, Lichtenstein P
Behav. Genet. 2012 Jan;42(1):3-18

Perinatal risk factors in offenders with severe personality disorder: a population-based investigation.
Fazel S, Bakiyeva L, Cnattingius S, Grann M, Hultman CM, Lichtenstein P, et al
J. Pers. Disord. 2012 Oct;26(5):737-50

Disentangling the relationships between maternal smoking during pregnancy and co-occurring risk factors.
Ellingson JM, Rickert ME, Lichtenstein P, Långström N, D'Onofrio BM
Psychol Med 2012 Jul;42(7):1547-57

Familial confounding of the association between maternal smoking during pregnancy and offspring substance use and problems.
D'Onofrio BM, Rickert ME, Langström N, Donahue KL, Coyne CA, Larsson H, et al
Arch. Gen. Psychiatry 2012 Nov;69(11):1140-50

The impact of birth mode of delivery on childhood asthma and allergic diseases--a sibling study.
Almqvist C, Cnattingius S, Lichtenstein P, Lundholm C
Clin. Exp. Allergy 2012 Sep;42(9):1369-76

Violent offending and IQ level as predictors of suicide in schizophrenia: national cohort study.
Webb RT, Långström N, Runeson B, Lichtenstein P, Fazel S
Schizophr. Res. 2011 Aug;130(1-3):143-7

Familial clustering of suicide risk: a total population study of 11.4 million individuals.
Tidemalm D, Runeson B, Waern M, Frisell T, Carlström E, Lichtenstein P, et al
Psychol Med 2011 Dec;41(12):2527-34

A genetically informed study of associations between family functioning and child psychosocial adjustment.
Schermerhorn AC, D'Onofrio BM, Turkheimer E, Ganiban JM, Spotts EL, Lichtenstein P, et al
Dev Psychol 2011 May;47(3):707-25

Increased suicide risk in coeliac disease--a Swedish nationwide cohort study.
Ludvigsson JF, Sellgren C, Runeson B, Långström N, Lichtenstein P
Dig Liver Dis 2011 Aug;43(8):616-22

Does maternal weight gain in pregnancy have long-term effects on offspring adiposity? A sibling study in a prospective cohort of 146,894 men from 136,050 families.
Lawlor DA, Lichtenstein P, Fraser A, Långström N
Am. J. Clin. Nutr. 2011 Jul;94(1):142-8

Creativity and mental disorder: family study of 300,000 people with severe mental disorder.
Kyaga S, Lichtenstein P, Boman M, Hultman C, Långström N, Landén M
Br J Psychiatry 2011 Nov;199(5):373-9

Alcohol use disorders in schizophrenia: a national cohort study of 12,653 patients.
Jones RM, Lichtenstein P, Grann M, Långström N, Fazel S
J Clin Psychiatry 2011 Jun;72(6):775-9; quiz 878-9

Advancing paternal age and risk of autism: new evidence from a population-based study and a meta-analysis of epidemiological studies.
Hultman CM, Sandin S, Levine SZ, Lichtenstein P, Reichenberg A
Mol. Psychiatry 2011 Dec;16(12):1203-12

Violent crime runs in families: a total population study of 12.5 million individuals.
Frisell T, Lichtenstein P, Långström N
Psychol Med 2011 Jan;41(1):97-105

Advanced paternal and grandpaternal age and schizophrenia: a three-generation perspective.
Frans EM, McGrath JJ, Sandin S, Lichtenstein P, Reichenberg A, Långström N, et al
Schizophr. Res. 2011 Dec;133(1-3):120-4

Risk of violent crime in individuals with epilepsy and traumatic brain injury: a 35-year Swedish population study.
Fazel S, Lichtenstein P, Grann M, Långström N
PLoS Med. 2011 Dec;8(12):e1001150

Maternal bereavement and childhood asthma-analyses in two large samples of Swedish children.
Fang F, Höglund CO, Arck P, Lundholm C, Långström N, Lichtenstein P, et al
PLoS ONE 2011 ;6(11):e27202

D'Onofrio BM, Langstrom N, Lichtenstein P. The Need for Family Research Using Multiple Approaches and Methods. Natl Symp Fam Iss 2011:149-59.

Long-term follow-up of transsexual persons undergoing sex reassignment surgery: cohort study in Sweden.
Dhejne C, Lichtenstein P, Boman M, Johansson AL, Långström N, Landén M
PLoS ONE 2011 Feb;6(2):e16885

Timing of prenatal maternal exposure to severe life events and adverse pregnancy outcomes: a population study of 2.6 million pregnancies.
Class QA, Lichtenstein P, Långström N, D'Onofrio BM
Psychosom Med 2011 Apr;73(3):234-41

Psychiatric morbidity, violent crime, and suicide among children and adolescents exposed to parental death.
Wilcox HC, Kuramoto SJ, Lichtenstein P, Långström N, Brent DA, Runeson B
J Am Acad Child Adolesc Psychiatry 2010 May;49(5):514-23; quiz 530

Method of attempted suicide as predictor of subsequent successful suicide: national long term cohort study.
Runeson B, Tidemalm D, Dahlin M, Lichtenstein P, Långström N
BMJ 2010 Jul;341():c3222

Maternal or paternal suicide and offspring's psychiatric and suicide-attempt hospitalization risk.
Kuramoto SJ, Stuart EA, Runeson B, Lichtenstein P, Långström N, Wilcox HC
Pediatrics 2010 Nov;126(5):e1026-32

Prenatal smoking exposure and offspring stress coping in late adolescence: no causal link.
Kuja-Halkola R, D'Onofrio BM, Iliadou AN, Långström N, Lichtenstein P
Int J Epidemiol 2010 Dec;39(6):1531-40

Bipolar disorder and violent crime: new evidence from population-based longitudinal studies and systematic review.
Fazel S, Lichtenstein P, Grann M, Goodwin GM, Långström N
Arch. Gen. Psychiatry 2010 Sep;67(9):931-8

Bipolar disorder and violent crime: time at risk reanalysis.
Fazel S, Lichtenstein P, Frisell T, Grann M, Goodwin G, Långström N
Arch. Gen. Psychiatry 2010 Dec;67(12):1325-6

A quasi-experimental study of maternal smoking during pregnancy and offspring academic achievement.
D'Onofrio BM, Singh AL, Iliadou A, Lambe M, Hultman CM, Neiderhiser JM, et al
Child Dev ;81(1):80-100

Familial confounding of the association between maternal smoking during pregnancy and offspring criminality: a population-based study in Sweden.
D'Onofrio BM, Singh AL, Iliadou A, Lambe M, Hultman CM, Grann M, et al
Arch. Gen. Psychiatry 2010 May;67(5):529-38

Svensson et al. respond to "Maternal genes and environment in preterm birth".
Svensson AC, Sandin S, Cnattingius S, Reilly M, Pawitan Y, Hultman CM, et al
Am. J. Epidemiol. 2009 Dec;170(11):1386-7

Maternal effects for preterm birth: a genetic epidemiologic study of 630,000 families.
Svensson AC, Sandin S, Cnattingius S, Reilly M, Pawitan Y, Hultman CM, et al
Am. J. Epidemiol. 2009 Dec;170(11):1365-72

Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study.
Lichtenstein P, Yip BH, Björk C, Pawitan Y, Cannon TD, Sullivan PF, et al
Lancet 2009 Jan;373(9659):234-9

Schizophrenia, substance abuse, and violent crime.
Fazel S, Långström N, Hjern A, Grann M, Lichtenstein P
JAMA 2009 May;301(19):2016-23

Risk factors for violent crime in Schizophrenia: a national cohort study of 13,806 patients.
Fazel S, Grann M, Carlström E, Lichtenstein P, Långström N
J Clin Psychiatry 2009 Mar;70(3):362-9

Familial aggregation of amyotrophic lateral sclerosis.
Fang F, Kamel F, Lichtenstein P, Bellocco R, Sparén P, Sandler DP, et al
Ann. Neurol. 2009 Jul;66(1):94-9

Covariance component models for multivariate binary traits in family data analysis.
Yip BH, Björk C, Lichtenstein P, Hultman CM, Pawitan Y
Stat Med 2008 Mar;27(7):1086-105

Risk of suicide after suicide attempt according to coexisting psychiatric disorder: Swedish cohort study with long term follow-up.
Tidemalm D, Långström N, Lichtenstein P, Runeson B
BMJ 2008 Nov;337():a2205

Schizophrenia and offspring's risk for adverse pregnancy outcomes and infant death.
Nilsson E, Hultman CM, Cnattingius S, Olausson PO, Björk C, Lichtenstein P
Br J Psychiatry 2008 Oct;193(4):311-5

Advancing paternal age and bipolar disorder.
Frans EM, Sandin S, Reichenberg A, Lichtenstein P, Långström N, Hultman CM
Arch. Gen. Psychiatry 2008 Sep;65(9):1034-40

Fertility of first-degree relatives of patients with schizophrenia: a three generation perspective.
Svensson AC, Lichtenstein P, Sandin S, Hultman CM
Schizophr. Res. 2007 Mar;91(1-3):238-45

Adverse pregnancy outcomes in mothers with affective psychosis.
MacCabe JH, Martinsson L, Lichtenstein P, Nilsson E, Cnattingius S, Murray RM, et al
Bipolar Disord 2007 May;9(3):305-9

Familial aggregation of small-for-gestational-age births: the importance of fetal genetic effects.
Svensson AC, Pawitan Y, Cnattingius S, Reilly M, Lichtenstein P
Am. J. Obstet. Gynecol. 2006 Feb;194(2):475-9

Recurrence risks for schizophrenia in a Swedish national cohort.
Lichtenstein P, Björk C, Hultman CM, Scolnick E, Sklar P, Sullivan PF
Psychol Med 2006 Oct;36(10):1417-25

Pawitan Y, Reilly M, Nilsson E, Cnattingius S, Lichtenstein P. Estimation of genetic and environmental factors for binary traits using family data - by Y. Pawitan, M. Reilly, E. Nilsson, S. Cnattingius and P. Lichtenstein, statistics in medicine 2004; 23 : 449-465 - Authors' reply. Statistics in medicine 2005;24:1617-8.

Fetal growth restriction and schizophrenia: a Swedish twin study.
Nilsson E, Stålberg G, Lichtenstein P, Cnattingius S, Olausson PO, Hultman CM
Twin Res Hum Genet 2005 Aug;8(4):402-8

Estimation of genetic and environmental factors for binary traits using family data.
Pawitan Y, Reilly M, Nilsson E, Cnattingius S, Lichtenstein P
Stat Med 2004 Feb;23(3):449-65

The importance of genetic and environmental effects for pre-eclampsia and gestational hypertension: a family study.
Nilsson E, Salonen Ros H, Cnattingius S, Lichtenstein P
BJOG 2004 Mar;111(3):200-6

Maternal and fetal genetic factors account for most of familial aggregation of preeclampsia: a population-based Swedish cohort study.
Cnattingius S, Reilly M, Pawitan Y, Lichtenstein P
Am. J. Med. Genet. A 2004 Nov;130A(4):365-71

Genetic influence on dystocia.
Algovik M, Nilsson E, Cnattingius S, Lichtenstein P, Nordenskjöld A, Westgren M
Acta Obstet Gynecol Scand 2004 Sep;83(9):832-7

Women with schizophrenia: pregnancy outcome and infant death among their offspring.
Nilsson E, Lichtenstein P, Cnattingius S, Murray RM, Hultman CM
Schizophr. Res. 2002 Dec;58(2-3):221-9

Theses

  1. Salonen Ros H. Preeclampsia and other circulatory diseases during pregnancy - etiological aspects and impact on female offspring [Doctoral Dissertation]. Stockholm, Sweden: Karolinska Institutet; 2001.
  2. Nilsson E. Genetic epidemiological studies of adverse pregnancy outcomes and the role of schizophrenia. Stockholm: Karolinska Institutet; 2006.
  3. Lindström LS. Population-based family studies: Genetic contribution to cancer development and survival? Stockholm: Karolinska Institutet; 2008.
  4. Yip BH. Statistical Genetics Analysis of family data. Stockholm: Karolinska Institutet; 2008.
  5. Algovik M. Genetic and epidemiological studies of Dystocia : Difficult labour. Stockholm: Karolinska Institutet; 2009.
  6. Svensson A. Family studies of schizophrenia and pregnancy outcomes. Stockholm: Karolinska Institutet; 2009.
  7. Fang F. Epidemiologic studies of emyotrophic lateral sclerosis. Stockholm: Karolinska Institutet; 2010.
  8. Tidemalm D. Suicide and mortality related to mental disorder in three Swedish cohorts. Stockholm: Karolinska Institutet; 2010.
  9. Kuramoto J. Suicidal ideation among inner-city drug users: Association with social support networks and polydrug use. Maryland, Baltimore, USA: Johns Hopkins Bloomberg School of Public Health; 2011.
  10. Donahue K. Quasi-experimental approaches to understanding the causes and consequences of adolescent sexual behavior: Indiana University; 2012.
  11. Frisell T. Violent crime: addressing causation with family-based methods. Stockholm: Karolinska Institutet; 2012.
  12. Jundong J. Schizophrenia: Risk Factors and Outcomes. Singapore: National University of Singapore; 2012.
  13. Chang Z. The Origins and Consequences of Attention Deficit Hyperactivity Disorder. Stockholm: Karolinska Institutet; 2013.
  14. Frans E. High paternal age and risk of psychiatric disorders in offspring. Stockholm: Karolinska Institutet; 2013.
  15. Ljung T. Parental characteristics and offspring internalizing behaviors : understanding the associations using quantitative genetics. Stockholm: Karolinska Institutet; 2013.
  16. Coyne C. Quasi-experimental approaches to understanding the causes and consequences of early childbirth: Indiana University; 2014.
  17. Kuja-Halkola R. Twin and family studies on the development of cognitive and externalizing problems. Stockholm: Karolinska Institutet; 2014.
  18. Kyaga S. Creativity and psychopathology. Stockholm: Karolinska Institutet; 2014.
  19. Power RA. Genetic and environmental predictors of psychiatric disorders and related traits London: King's College London, University of London; 2014.
  20. Sellgren C. On neuroinflammation in psychotic disorders. Stockholm: Karolinska Institutet; 2014.
  21. Westerlind H. Modeling genetic susceptibility to multiple sclerosis. Stockholm: Karolinska Institutet; 2014.
  22. Class Q. Testing causal hypotheses and associations between perinatal risk factors and offspring morbidity and mortality: Indiana University; 2015.
  23. Haglund A. Suicidal behaviour in three high-risk populations : epidemiological and clinical cohort studies. Stockholm: Karolinska Institutet; 2015.
  24. Johansson V. Cerebrospinal fluid biomarkers in twins with schizophrenia and bipolar disorder. Stockholm: Karolinska Institutet; 2015.
  25. Sariaslan A. Exploring the causal nature of neighborhood influences on violent criminality, substance misuse and psychiatric morbidity. Stockholm: Karolinska Institutet; 2015.
  26. Skoglund C. When ADHD and substance use disorders coexist : etiology and pharmacological treatment. Stockholm: Karolinska Institutet; 2015.
  27. Viktorin A. Mood disorders and consequences of pharmacological treatment. Stockholm: Karolinska Institutet; 2015.
  28. Cederlöf M. Risks, correlates, and consequences of the extended psychosis phenotype. Stockholm: Karolinska Institutet; 2016.
  29. Chen Q. What can genetically informative designs add to the understanding of ADHD? Stockholm: Karolinska Institutet; 2016.
  30. Gong T. Epidemiological studies of asthma and neurodevelopmental disorders in children. Stockholm: Karolinska Institutet; 2016.
  31. Dhejne C. On gender dysphoria. Stockholm: Karolinska Institutet; 2017.
  32. Song J. Bipolar disorder and lithium treatment : etiologies and consequences. Stockholm: Karolinska Institutet; 2017.
  33. Wolf A. Violence in severe mental illness: Risk factors, risk assessment, and prevention. Oxford: University of Oxford; 2017.
  34. Zetterqvist J. Statistical methods for twin and sibling designs. Stockholm: Karolinska Institutet; 2017.
  35. Brikell I. ADHD, epilepsy, and related childhood psychopathology: understanding shared genetic risk, developmental trajectories, and pharmacological treatment safety. Stockholm: Karolinska Institutet; 2018.
  36. Rejno G. Asthma, anxiety and depression in pregnancy : the impact on pregnancy, delivery and perinatal outcomes  Stockholm: Karolinska Institutet; 2018.
  37. Yao S. Genetic and environmental influences on eating disorders and associated adversities and comorbidities. Stockholm: Karolinska Institutet; 2018.
  38. Brander G. Risk factors and health consequences of obsessive-compulsive and chronic tic disorders. Stockholm: Karolinska Institutet; 2019.
  39. Ghirardi L. The comorbidity between attention-deficit/hyperactivity disorder and other neurodevelopmental disorders: aetiology, treatment and outcomes. Stockholm: Karolinska Institutet; 2019.
  40. Khemiri L. Cognitive deficits in alcohol use disorder : etiology and treatment. Stockholm: Karolinska Institutet; 2019.
  41. Karanti A. Bipolar disorders: subtypes, treatments, and health inequalities. Göteborg: Sahlgrenska Academy, Göteborg University; 2020.

Twin Study of Child and Adolescent Development - TCHAD

A paper that describes the study was published in 2007 (Lichtenstein, Tuvblad, Larsson, Carlström, 2007, Twin Research and Human Genetics). At least 15 PhD theses and more than 80 papers/reports have been published based on data from this study.

Project description

We have studied how genetic and environmental effects contribute to the development of mental health problems over time. For example, we have identified persistent “combined” and subtype-specific genetic influences (i.e., “hyperactive-impulsive” and “inattentive”) suggesting a genetic basis for the DSM-IV classification of ADHD (Larsson, Lichtenstein et al. 2006) and that genetic effects are more stable for ADHD (Chang, Lichtenstein et al. 2013) compared to internalizing problems (e.g., fears, anxiety) (Kendler, Gardner et al. 2008).

With the large population-based sample of twins, followed prospectively from childhood to emerging adulthood, the study is unique also in an international perspective. The data include a broad spectrum of measures of environments as well as internalizing and externalizing problems behaviors from both twins and parents. The study is designed to address the interplay between genes and environments, comorbidity, and the development into adult psychopathology. We will continue our studies of antisocial behavior, ADHD, eating problems, fears and phobias, and relationships.

Project leader

Profile image

Paul Lichtenstein

Professor
+46852487424

Partners

Inst för barn- och ungdomspsykiatri, Astrid Lindgrens Barnsjukhus, Karolinska Sjukhuset; Inst of Psychiatry, London; Centre for Violence Prevention, Karolinska Institutet, Center for developmental studies, Örebro universitet; Center for Family Research, George Washington University, Washington.

Main financing: Vetenskapsrådet, FAS, FORTE

References

The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins.
Silventoinen K, Jelenkovic A, Yokoyama Y, Sund R, Sugawara M, Tanaka M, et al
Twin Res Hum Genet 2019 Jul;():1-9

Parental Education and Genetics of BMI from Infancy to Old Age: A Pooled Analysis of 29 Twin Cohorts.
Silventoinen K, Jelenkovic A, Latvala A, Yokoyama Y, Sund R, Sugawara M, et al
Obesity (Silver Spring) 2019 05;27(5):855-865

Testing Bidirectional Associations Between Childhood Aggression and BMI: Results from Three Cohorts.
Derks IPM, Bolhuis K, Yalcin Z, Gaillard R, Hillegers MHJ, Larsson H, et al
Obesity (Silver Spring) 2019 05;27(5):822-829

Association between pharmacotherapy for ADHD in offspring and depression-related specialty care visits by parents with a history of depression.
Chen Q, Larsson H, Almqvist C, Chang Z, Lichtenstein P, D'Onofrio BM, et al
BMC Psychiatry 2019 07;19(1):224

Body dissatisfaction in adolescent boys.
Baker JH, Higgins Neyland MK, Thornton LM, Runfola CD, Larsson H, Lichtenstein P, et al
Dev Psychol 2019 Jul;55(7):1566-1578

Illicit Drug Use, Cigarette Smoking, and Eating Disorder Symptoms: Associations in an Adolescent Twin Sample.
Baker JH, Johnson NK, Munn-Chernoff MA, Lichtenstein P, Larsson H, Maes HH, et al
J Stud Alcohol Drugs 2018 Sep;79(5):720-724

Associations Between Alcohol Involvement and Drive for Thinness and Body Dissatisfaction in Adolescent Twins: A Bivariate Twin Study.
Baker JH, Brosof LC, Munn-Chernoff MA, Lichtenstein P, Larsson H, Maes HH, et al
Alcohol. Clin. Exp. Res. 2018 Nov;42(11):2214-2223

Association Between Childhood to Adolescent Attention Deficit/Hyperactivity Disorder Symptom Trajectories and Late Adolescent Disordered Eating.
Yilmaz Z, Javaras KN, Baker JH, Thornton LM, Lichtenstein P, Bulik CM, et al
J Adolesc Health 2017 Aug;61(2):140-146

Education in Twins and Their Parents Across Birth Cohorts Over 100 years: An Individual-Level Pooled Analysis of 42-Twin Cohorts.
Silventoinen K, Jelenkovic A, Latvala A, Sund R, Yokoyama Y, Ullemar V, et al
Twin Res Hum Genet 2017 10;20(5):395-405

A Genetic Epidemiological Mega Analysis of Smoking Initiation in Adolescents.
Maes HH, Prom-Wormley E, Eaves LJ, Rhee SH, Hewitt JK, Young S, et al
Nicotine Tob. Res. 2017 Apr;19(4):401-409

Predictive validity of parent- and self-rated ADHD symptoms in adolescence on adverse socioeconomic and health outcomes.
Du Rietz E, Kuja-Halkola R, Brikell I, Jangmo A, Sariaslan A, Lichtenstein P, et al
Eur Child Adolesc Psychiatry 2017 Jul;26(7):857-867

Shared familial risk between bulimic symptoms and alcohol involvement during adolescence.
Baker JH, Munn-Chernoff MA, Lichtenstein P, Larsson H, Maes H, Kendler KS
J Abnorm Psychol 2017 Jul;126(5):506-518

Relative Immaturity in Childhood and Attention-Deficit/Hyperactivity Disorder Symptoms From Childhood to Early Adulthood: Exploring Genetic and Environmental Overlap Across Development.
Brikell I, Kuja-Halkola R, Larsson JO, Lahey BB, Kuntsi J, Lichtenstein P, et al
J Am Acad Child Adolesc Psychiatry 2016 10;55(10):886-95

The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits.
Silventoinen K, Jelenkovic A, Sund R, Honda C, Aaltonen S, Yokoyama Y, et al
Twin Res Hum Genet 2015 Aug;18(4):348-60

A genetically informed study of the longitudinal relation between irritability and anxious/depressed symptoms.
Savage J, Verhulst B, Copeland W, Althoff RR, Lichtenstein P, Roberson-Nay R
J Am Acad Child Adolesc Psychiatry 2015 May;54(5):377-84

Is Physical Activity Causally Associated With Symptoms of Attention-Deficit/Hyperactivity Disorder?
Rommel AS, Lichtenstein P, Rydell M, Kuja-Halkola R, Asherson P, Kuntsi J, et al
J Am Acad Child Adolesc Psychiatry 2015 Jul;54(7):565-70

Longitudinal Stability of Genetic and Environmental Influences on Irritability: From Childhood to Young Adulthood.
Roberson-Nay R, Leibenluft E, Brotman MA, Myers J, Larsson H, Lichtenstein P, et al
Am J Psychiatry 2015 Jul;172(7):657-64

Risk for self-reported anorexia or bulimia nervosa based on drive for thinness and negative affect clusters/dimensions during adolescence: A three-year prospective study of the TChAD cohort.
Peñas-Lledó E, Bulik CM, Lichtenstein P, Larsson H, Baker JH
Int J Eat Disord 2015 Sep;48(6):692-9

Codevelopment of ADHD and externalizing behavior from childhood to adulthood.
Kuja-Halkola R, Lichtenstein P, D'Onofrio BM, Larsson H
J Child Psychol Psychiatry 2015 Jun;56(6):640-7

Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age: A Study of the CODATwins Project.
Jelenkovic A, Yokoyama Y, Sund R, Honda C, Bogl LH, Aaltonen S, et al
Twin Res Hum Genet 2015 Oct;18(5):557-70

Accounting for genetic and environmental confounds in associations between parent and child characteristics: a systematic review of children-of-twins studies.
McAdams TA, Neiderhiser JM, Rijsdijk FV, Narusyte J, Lichtenstein P, Eley TC
Psychol Bull 2014 Jul;140(4):1138-73

Psychotic experiences as a predictor of the natural course of suicidal ideation: a Swedish cohort study.
Kelleher I, Cederlöf M, Lichtenstein P
World Psychiatry 2014 Jun;13(2):184-8

Genetic innovation and stability in externalizing problem behavior across development: a multi-informant twin study.
Wichers M, Gardner C, Maes HH, Lichtenstein P, Larsson H, Kendler KS
Behav. Genet. 2013 May;43(3):191-201

Genetic and environmental risk factors in males for self-report externalizing traits in mid-adolescence and criminal behavior through young adulthood.
Kendler KS, Patrick CJ, Larsson H, Gardner CO, Lichtenstein P
Psychol Med 2013 Oct;43(10):2161-8

Developmental twin study of attention problems: high heritabilities throughout development.
Chang Z, Lichtenstein P, Asherson PJ, Larsson H
JAMA Psychiatry 2013 Mar;70(3):311-8

Variation in the oxytocin receptor gene is associated with pair-bonding and social behavior.
Walum H, Lichtenstein P, Neiderhiser JM, Reiss D, Ganiban JM, Spotts EL, et al
Biol. Psychiatry 2012 Mar;71(5):419-26

Genetic and environmental influences on the association between pubertal maturation and internalizing symptoms.
Marceau K, Neiderhiser JM, Lichtenstein P, Reiss D
J Youth Adolesc 2012 Sep;41(9):1111-26

Genetic and environmental contributions to weight, height, and BMI from birth to 19 years of age: an international study of over 12,000 twin pairs.
Dubois L, Ohm Kyvik K, Girard M, Tatone-Tokuda F, Pérusse D, Hjelmborg J, et al
PLoS ONE 2012 ;7(2):e30153

Genetic variance of body mass index from childhood to early adulthood.
Dellava JE, Lichtenstein P, Kendler KS
Behav. Genet. 2012 Jan;42(1):86-95

The effects of childhood ADHD symptoms on early-onset substance use: a Swedish twin study.
Chang Z, Lichtenstein P, Larsson H
J Abnorm Child Psychol 2012 Apr;40(3):425-35

Pubertal development predicts eating behaviors in adolescence.
Baker JH, Thornton LM, Lichtenstein P, Bulik CM
Int J Eat Disord 2012 Nov;45(7):819-26

Shared genetic effects between age at menarche and disordered eating.
Baker JH, Thornton LM, Bulik CM, Kendler KS, Lichtenstein P
J Adolesc Health 2012 Nov;51(5):491-6

The genetic and environmental etiology of antisocial behavior from childhood to emerging adulthood.
Tuvblad C, Narusyte J, Grann M, Sarnecki J, Lichtenstein P
Behav. Genet. 2011 Sep;41(5):629-40

Parental criticism and externalizing behavior problems in adolescents: the role of environment and genotype-environment correlation.
Narusyte J, Neiderhiser JM, Andershed AK, D'Onofrio BM, Reiss D, Spotts E, et al
J Abnorm Psychol 2011 May;120(2):365-76

Association between childhood asthma and ADHD symptoms in adolescence--a prospective population-based twin study.
Mogensen N, Larsson H, Lundholm C, Almqvist C
Allergy 2011 Sep;66(9):1224-30

Internalizing behavior in adolescent girls affects parental emotional overinvolvement: a cross-lagged twin study.
Moberg T, Lichtenstein P, Forsman M, Larsson H
Behav. Genet. 2011 Mar;41(2):223-33

Developmental trajectories of DSM-IV symptoms of attention-deficit/hyperactivity disorder: genetic effects, family risk and associated psychopathology.
Larsson H, Dilshad R, Lichtenstein P, Barker ED
J Child Psychol Psychiatry 2011 Sep;52(9):954-63

The impact of environmental experiences on symptoms of anxiety and depression across the life span.
Kendler KS, Eaves LJ, Loken EK, Pedersen NL, Middeldorp CM, Reynolds C, et al
Psychol Sci 2011 Oct;22(10):1343-52

Early environmental influences contribute to covariation between internalizing symptoms and alcohol intoxication frequency across adolescence.
Edwards AC, Larsson H, Lichtenstein P, Kendler KS
Addict Behav 2011 Mar;36(3):175-82

Study on the possible association of brain-derived neurotrophic factor polymorphism with the developmental course of symptoms of attention deficit and hyperactivity.
Bergman O, Westberg L, Lichtenstein P, Eriksson E, Larsson H
Int. J. Neuropsychopharmacol. 2011 Nov;14(10):1367-76

Sex differences and developmental stability in genetic and environmental influences on psychoactive substance consumption from early adolescence to young adulthood.
Baker JH, Maes HH, Larsson H, Lichtenstein P, Kendler KS
Psychol Med 2011 Sep;41(9):1907-16

Heritability of dental fear.
Ray J, Boman UW, Bodin L, Berggren U, Lichtenstein P, Broberg AG
J. Dent. Res. 2010 Mar;89(3):297-301

A longitudinal twin study of the direction of effects between psychopathic personality and antisocial behaviour.
Forsman M, Lichtenstein P, Andershed H, Larsson H
J Child Psychol Psychiatry 2010 Jan;51(1):39-47

High sense of coherence in adolescence is a protective factor in the longitudinal development of ADHD symptoms.
Edbom T, Malmberg K, Lichtenstein P, Granlund M, Larsson JO
Scand J Caring Sci 2010 Sep;24(3):541-7

Genetic risk factors for disordered eating in adolescent males and females.
Baker JH, Maes HH, Lissner L, Aggen SH, Lichtenstein P, Kendler KS
J Abnorm Psychol 2009 Aug;118(3):576-86

Intrauterine testosterone exposure and risk for disordered eating.
Baker JH, Lichtenstein P, Kendler KS
Br J Psychiatry 2009 Apr;194(4):375-6

Testing different types of genotype-environment correlation: an extended children-of-twins model.
Narusyte J, Neiderhiser JM, D'Onofrio BM, Reiss D, Spotts EL, Ganiban J, et al
Dev Psychol 2008 Nov;44(6):1591-603

ADHD and Disruptive Behavior scores - associations with MAO-A and 5-HTT genes and with platelet MAO-B activity in adolescents.
Malmberg K, Wargelius HL, Lichtenstein P, Oreland L, Larsson JO
BMC Psychiatry 2008 Apr;8():28

A developmental twin study of symptoms of anxiety and depression: evidence for genetic innovation and attenuation.
Kendler KS, Gardner CO, Lichtenstein P
Psychol Med 2008 Nov;38(11):1567-75

A longitudinal twin study of fears from middle childhood to early adulthood: evidence for a developmentally dynamic genome.
Kendler KS, Gardner CO, Annas P, Neale MC, Eaves LJ, Lichtenstein P
Arch. Gen. Psychiatry 2008 Apr;65(4):421-9

The development of fears from early adolesence to young adulthood: a multivariate study.
Kendler KS, Gardner CO, Annas P, Lichtenstein P
Psychol Med 2008 Dec;38(12):1759-69

Genetic effects explain the stability of psychopathic personality from mid- to late adolescence.
Forsman M, Lichtenstein P, Andershed H, Larsson H
J Abnorm Psychol 2008 Aug;117(3):606-17

Aggression as a mediator of genetic contributions to the association between negative parent-child relationships and adolescent antisocial behavior.
Narusyte J, Andershed AK, Neiderhiser JM, Lichtenstein P
Eur Child Adolesc Psychiatry 2007 Mar;16(2):128-37

The Swedish Twin study of CHild and Adolescent Development: the TCHAD-study.
Lichtenstein P, Tuvblad C, Larsson H, Carlström E
Twin Res Hum Genet 2007 Feb;10(1):67-73

A common genetic factor explains the association between psychopathic personality and antisocial behavior.
Larsson H, Tuvblad C, Rijsdijk FV, Andershed H, Grann M, Lichtenstein P
Psychol Med 2007 Jan;37(1):15-26

Birth weight and attention-deficit/hyperactivity symptoms in childhood and early adolescence: a prospective Swedish twin study.
Hultman CM, Torrång A, Tuvblad C, Cnattingius S, Larsson JO, Lichtenstein P
J Am Acad Child Adolesc Psychiatry 2007 Mar;46(3):370-7

Forsman M, Larsson H, Andershed H, Lichtenstein P. The association between persistent disruptive childhood behaviour and the psychopathic personality constellation in adolescence: A twin study. Brit J Dev Psychol. 2007;25:383-98.

Heritability for adolescent antisocial behavior differs with socioeconomic status: gene-environment interaction.
Tuvblad C, Grann M, Lichtenstein P
J Child Psychol Psychiatry 2006 Jul;47(7):734-43

Genetic contributions to the development of ADHD subtypes from childhood to adolescence.
Larsson H, Lichtenstein P, Larsson JO
J Am Acad Child Adolesc Psychiatry 2006 Aug;45(8):973-81

A genetic factor explains most of the variation in the psychopathic personality.
Larsson H, Andershed H, Lichtenstein P
J Abnorm Psychol 2006 May;115(2):221-30

Long-term relationships between symptoms of Attention Deficit Hyperactivity Disorder and self-esteem in a prospective longitudinal study of twins.
Edbom T, Lichtenstein P, Granlund M, Larsson JO
Acta Paediatr. 2006 Jun;95(6):650-7

The development of antisocial behaviour from childhood to adolescence. A longitudinal twin study.
Tuvblad C, Eley TC, Lichtenstein P
Eur Child Adolesc Psychiatry 2005 Jul;14(4):216-25

Genetic and environmental contributions to stability and change of ADHD symptoms between 8 and 13 years of age: a longitudinal twin study.
Larsson JO, Larsson H, Lichtenstein P
J Am Acad Child Adolesc Psychiatry 2004 Oct;43(10):1267-75

A longitudinal behavioral genetic analysis of the etiology of aggressive and nonaggressive antisocial behavior.
Eley TC, Lichtenstein P, Moffitt TE
Dev. Psychopathol. 2003 ;15(2):383-402

Genetic and environmental influences on problematic masturbatory behavior in children: a study of same-sex twins.
Långström N, Grann M, Lichtenstein P
Arch Sex Behav 2002 Aug;31(4):343-50

Heritability and prevalence of specific fears and phobias in childhood.
Lichtenstein P, Annas P
J Child Psychol Psychiatry 2000 Oct;41(7):927-37

Parents' perception of mental development and behavioural problems in 8 to 9-year-old children.
Larsson JO, Lichtenstein P, Fried I, El-Sayed E, Rydelius PA
Acta Paediatr. 2000 Dec;89(12):1469-73

Genetic and environmental influences on recurrent headaches in eight to nine-year-old twins.
Svensson DA, Larsson B, Bille B, Lichtenstein P
Cephalalgia 1999 Dec;19(10):866-72

Steffensson B, Larsson JO, Fried I, El-Sayed E, Rydelius PA, Lichtenstein P. Genetic disposition for global maturity: An explanation for genetic effects on parental report on ADHD. International Journal of Behavioral Development. 1999;23(2):357-74.

Sex differences in the etiology of aggressive and nonaggressive antisocial behavior: results from two twin studies.
Eley TC, Lichtenstein P, Stevenson J
Child Dev ;70(1):155-68

Lichtenstein P, Svartengren M. Genes, environments, and sex: factors of importance in atopic diseases in 7-9-year-old Swedish twins. Allergy 1997;52:1079-86.