Agnieszka Butwicka
About me
Child and adolescent psychiatrist and Research group leader at MEB with a focus on the Interplay of Somatic, Mental, and Neurodevelopmental Conditions (SOMIND group).
2024 Principal investigator, Karolinska Institutet
2023 Senior Researcher, Division of Mental Health Services, Akershus University Hospital, Lørenskog, Norway
2023 Professor II of Medicine (Psychiatry), Institute of Clinical Medicine, University of Oslo, Oslo, Norway
2022 Associate Professor (Docent) in Child and Adolescent Psychiatry2018-2023 Assistant professor, Karolinska Institutet
2012-2018 Postdoctoral position at the Dept. of Medical Epidemiology and Biostatistics, Karolinska Institute
2014 Specialist in Child and Adolescent Psychiatry (licensed in Poland, Sweden, and Norway)
2011 PhD. Medicine. Medical University of Lodz, Poland
2007 MD. Medical University of Lodz, PolandFunding:
Nordforsk
Swedish Research Council for Health, Working life and Welfare
Swedish Research Council
Karolinska Institutet's foundations and funds
Stockholm County Council (SLL/ALF)Medical Research Agency, Poland
Articles
- Article: JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY. 2025;66(8):1170-1181Martini MI; Kuja-Halkola R; Butwicka A; Du Rietz E; Kanina A; Brikell I; Chang Z; Larsson H; Lichtenstein P; Bolte S; Happe F; Taylor MJ
- Article: ACTA PAEDIATRICA. 2025Kanina A; Li Z; Rosenqvist M; Butwicka A; Larsson H; Johansson S; Rado MK; Martini MI; Taylor MJ
- Article: BMJ MEDICINE. 2025;4(1):e001129Hu K; Nguyen T-D; Borges K; Kuja-Halkola R; Butwicka A; Brikell I; Crowley JJ; Chang Z; D'Onofrio BM; Larsson H; Lichtenstein P; Rueck C; Bulik C; Sullivan P; Fang F; Lu Y
- Article: LANCET REGIONAL HEALTH-EUROPE. 2025;53:101301Haskell E; Sigmarsdottir B; Thorisdottir IE; Valborgarson A; Aparicio EB; Kiviruusu O; Suvisaari J; Chang Z; Ystrom E; Butwicka A; Asgeirsdottir BB; Valdimarsdottir HB; Sigfusdottir ID; Allegrante JP; Halldorsdottir T
- Journal article: JCPP ADVANCES. 2025Kanina A; Sjolander A; Martini MI; Butwicka A; Larsson H; Hughes AM; Rado MK; Taylor MJ; Havdahl A; Ask H; Rosenqvist MA
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2025;:dgaf121Kanina A; Stener-Victorin E; Butwicka A; Oberg AS; Rosenqvist MA; Cesta CE
- Article: NORDIC JOURNAL OF PSYCHIATRY. 2025;79(2):136-145Kusmierczyk-Koziel H; Michalak A; Chrzanowski J; Blaziak K; Mianowska B; Szadkowska A; Chobot A; Jarosz-Chobot P; Mysliwiec M; Makowska I; Kalenik A; Rzeszutek M; Zamarlik M; Rusak E; Kaczmarek A; Nowak A; Polaniecka M; Musial-Pazdzior M; Szmigiel K; Sobota-Krawczyk A; Rutkowska M; Wolanczyk T; Fendler W; Butwicka A
- Article: AMERICAN JOURNAL OF GASTROENTEROLOGY. 2024;119(12):2516-2525Bergman D; Roelstraete B; Sun J; Ebrahimi F; Butwicka A; Pardi DS; Ludvigsson JF
- Article: BMJ MENTAL HEALTH. 2024;27(1):e301195Dong Z; Zhang L; Li L; Liu S; Brikell I; Kuja-Halkola R; D'Onofrio BM; Butwicka A; Gudbjornsdottir S; Larsson H; Chang Z; Du Rietz E
- Article: JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY. 2024;65(9):1135-1144Martini MI; Butwicka A; Du Rietz E; Kanina A; Rosenqvist MA; Larsson H; Lichtenstein P; Taylor MJ
- Article: JCPP ADVANCES. 2024;4(2):e12225Pahlsson-Notini A; Liu S; Tideman M; Latvala A; Serlachius E; Larsson H; Hirvikoski T; Taylor MJ; Kuja-Halkola R; Lichtenstein P; Butwicka A
- Article: BMJ OPEN. 2023;13(12):e078112Michalak A; Chrzanowski J; Kusmierczyk-Koziel H; Klejman E; Blaziak K; Mianowska B; Szadkowska A; Chobot AP; Jarosz-Chobot P; Mysliwiec M; Makowska I; Kalenik A; Zamarlik M; Wolanczyk T; Fendler W; Butwicka A
- Article: JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY. 2023;62(12):1316-1325Ahlberg R; Garcia-Argibay M; Du Rietz E; Butwicka A; Cortese S; D'Onofrio BM; Ludvigsson JF; Larsson H
- Article: JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY. 2023;64(11):1608-1616Taylor MJ; Martin J; Butwicka A; Lichtenstein P; D'Onofrio B; Lundstrom S; Larsson H; Rosenqvist MA
- Article: JAMA NETWORK OPEN. 2023;6(10):e2336621Liu S; Lagerberg T; Ludvigsson JF; Taylor MJ; Chang Z; D'Onofrio BM; Larsson H; Lichtenstein P; Gudbjornsdottir S; Kuja-Halkola R; Butwicka A
- Article: ECLINICALMEDICINE. 2023;63:102170Khemiri L; Kuja-Halkola R; Larsson H; Butwicka A; Tideman M; DOnofrio BM; Latvala A; Lichtenstein P
- Article: TRANSLATIONAL PSYCHIATRY. 2023;13(1):282Kanina A; Larsson H; Sjolander A; Butwicka A; Taylor MJJ; Martini MII; Lichtenstein P; Lundberg FEE; Onofrio BMD; Rosenqvist MAA
- Article: BMJ MENTAL HEALTH. 2023;26(1):e300809Ahlberg R; Garcia-Argibay M; Taylor M; Lichtenstein P; D'Onofrio BM; Butwicka A; Hill C; Cortese S; Larsson H; Du Rietz E
- Article: LANCET HEALTHY LONGEVITY. 2023;4(7):e307-e315Liu S; Larsson H; Kuja-Halkola R; Lichtenstein P; Butwicka A; Taylor MJ
- Article: JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY. 2023;64(7):1027-1036Leone M; Kuja-Halkola R; Lagerberg T; Bjureberg J; Butwicka A; Chang Z; Larsson H; D'Onofrio BM; Leval A; Bergen SE
- Article: PSYCHOLOGICAL MEDICINE. 2023;53(9):3817-3825Latvala A; Tideman M; Sondenaa E; Larsson H; Butwicka A; Fazel S; Lichtenstein P
- Journal article: DIABETES. 2023;72Liu S; Lagerberg T; Ludvigsson JF; Taylor M; Donofrio B; Lichtenstein P; Gudbjornsdottir S; Butwicka A
- Article: JAMA NETWORK OPEN. 2023;6(4):e238135Liu S; Ludvigsson JF; Lichtenstein P; Gudbjornsdottir S; Taylor MJ; Larsson H; Kuja-Halkola R; Butwicka A
- Article: JOURNAL OF AFFECTIVE DISORDERS. 2023;325:817-823Andersson A; Garcia-Argibay M; Viktorin A; Ghirardi L; Butwicka A; Skoglund C; Madsen KB; D'onofrio BM; Lichtenstein P; Tuvblad C; Larsson H
- Article: DIABETES CARE. 2022;45(12):2950-2956Liu S; Leone M; Ludvigsson JF; Lichtenstein P; Gudbjoernsdottir S; Landen M; Bergen SE; Taylor MJ; Larsson H; Kuja-Halkola R; Butwicka A
- Article: JAMA PSYCHIATRY. 2022;79(12):1188-1198Martini MI; Kuja-Halkola R; Butwicka A; Du Rietz E; D'Onofrio BM; Happe F; Kanina A; Larsson H; Lundstrom S; Martin J; Rosenqvist MA; Lichtenstein P; Taylor MJ
- Article: ACTA PAEDIATRICA. 2022;111(11):2131-2141Liu S; Larsson H; Lichtenstein P; Ludvigsson JF; Gudbjornsdottir S; Serlachius E; Kuja-Halkola R; Butwicka A
- Article: JOURNAL OF THE ACADEMY OF CONSULTATION-LIAISON PSYCHIATRY. 2022;63(6):548-556Michalak A; Szadkowska A; Mlynarski W; Mysliwiec M; Deja G; Skala-Zamorowska E; Jarosz-Chobot P; Borowiec M; Zalepa A; Musial-Pazdzior M; Gierak A; Kazmierczak-Mytkowska A; Wolanczyk T; Fendler W; Butwicka A
- Article: AMERICAN JOURNAL OF PSYCHIATRY. 2022;179(11):824-832Leone M; Kuja-Halkola R; Leval A; Butwicka A; Skov J; Zhang R; Liu S; Larsson H; Bergen SE
- Article: JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY. 2022;63(9):1092-1102Familial risk and heritability of intellectual disability: a population-based cohort study in SwedenLichtenstein P; Tideman M; Sullivan PF; Serlachius E; Larsson H; Kuja-Halkola R; Butwicka A
- Article: DIABETES CARE. 2022;45(9):1987-1993Liu S; Leone M; Ludvigsson JF; Lichtenstein P; D'Onofrio B; Svensson A-M; Gudbjornsdottir S; Bergen SE; Larsson H; Kuja-Halkola R; Butwicka A
- Article: PSYCHIATRIA POLSKA. 2022;56(4):889-902Kazmierczak-Mytkowska A; Butwicka A; Lucci K; Wolanczyk T; Brynska A
- Article: AMERICAN JOURNAL OF GASTROENTEROLOGY. 2022;117(7):1046-1055Rojler L; Garber JJ; Butwicka A; Roelstraete B; Ludvigsson JF
- Article: PSYCHIATRIA POLSKA. 2022;56(3):535-549Kazmierczak-Mytkowska A; Butwicka A; Lucci KD; Wolanczyk T; Brynska A
- Article: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY. 2022;51(3):898-909Hegvik T-A; Chen Q; Kuja-Halkola R; Klungsoyr K; Butwicka A; Lichtenstein P; Almqvist C; Faraone SV; Haavik J; Larsson H
- Article: JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY. 2022;63(3):315-323Taylor MJ; Larsson H; Lundstrom S; Lichtenstein P; Butwicka A
- Article: TRANSLATIONAL PSYCHIATRY. 2022;12(1):73Carlsson T; Rosenqvist M; Butwicka A; Larsson H; Lundstrom S; Pan P-Y; Lundin Remnelius K; Taylor MJ; Bolte S
- Article: JOURNAL OF CROHNS & COLITIS. 2021;15(11):1824-1836Ludvigsson JF; Olen O; Larsson H; Halfvarson J; Almqvist C; Lichtenstein P; Butwicka A
- Article: JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY. 2021;62(11):1274-1284Ghirardi L; Kuja-Halkola R; Butwicka A; Martin J; Larsson H; D'Onofrio BM; Lichtenstein P; Taylor MJ
- Article: JOURNAL OF NEURODEVELOPMENTAL DISORDERS. 2021;13(1):51Avdic HB; Butwicka A; Nordenstrom A; Almqvist C; Nordenskjold A; Engberg H; Frisen L
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2021;106(11):e4459-e4470Liu S; Kuja-Halkola R; Larsson H; Lichtenstein P; Ludvigsson JF; Svensson A-M; Gudbjornsdottir S; Tideman M; Serlachius E; Butwicka A
- Article: CLINICAL GASTROENTEROLOGY AND HEPATOLOGY. 2021;19(10):2093-2101.e13Lebwohl B; Haggard L; Emilsson L; Soderling J; Roelstraete B; Butwicka A; Green PHR; Ludvigsson JF
- Journal article: LANCET PSYCHIATRY. 2021;8(9):774-783Du Rietz E; Brikell I; Butwicka A; Leone M; Chang Z; Cortese S; D'Onofrio BM; Hartman CA; Lichtenstein P; Faraone SV; Kuja-Halkola R; Larsson H
- Article: LANCET PSYCHIATRY. 2021;8(9):774-783Du Rietz E; Brikell I; Butwicka A; Leone M; Chang Z; Cortese S; D'Onofrio BM; Hartman CA; Lichtenstein P; Faraone SV; Kuja-Halkola R; Larsson H
- Article: JOURNAL OF ATTENTION DISORDERS. 2021;25(11):1519-1528Zhang L; Reif A; Du Rietz E; Lagerberg T; Butwicka A; D'Onofrio BM; Johnell K; Pedersen NL; Larsson H; Chang Z
- Article: JAMA NETWORK OPEN. 2021;4(6):e2113014Hirvikoski T; Boman M; Tideman M; Lichtenstein P; Butwicka A
- Article: DIABETES CARE. 2021;44(5):1143-1150Tate AE; Liu S; Zhang R; Yilmaz Z; Larsen JT; Petersen LV; Bulik CM; Svensson A-M; Gudbjornsdottir S; Larsson H; Butwicka A; Kuja-Halkola R
- Article: DIABETOLOGIA. 2021;64(4):767-777Liu S; Kuja-Halkola R; Larsson H; Lichtenstein P; Ludvigsson JF; Svensson A-M; Gudbjornsdottir S; Tideman M; Serlachius E; Butwicka A
- Journal article: GASTROENTEROLOGY. 2020;158(6):s-825Paulsson L; Garber JJ; Butwicka A; Roelstraete B; Ludvigsson JF
- Article: JAMA PEDIATRICS. 2019;173(10):969-978Butwicka A; Olen O; Larsson H; Halfvarson J; Almqvist C; Lichtenstein P; Serlachius E; Frisen L; Ludvigsson JF
- Journal article: 2018H E; A S; A N; A B; A N; AL H; L F
- Article: JOURNAL OF PSYCHOSOMATIC RESEARCH. 2017;101:122-127Engberg H; Strandqvist A; Nordenstrom A; Butvvicka A; Nordenskjold A; Hirschberg AL; Frisen L
- Article: JOURNAL OF PEDIATRICS. 2017;184:87-93.e1Butwicka A; Lichtenstein P; Frisen L; Almqvist C; Larsson H; Ludvigsson JF
- Article: PSYCHIATRIA POLSKA. 2017;51(2):231-246Jagielska G; Przedlacki J; Bartoszewicz Z; Kondracka A; Butwicka A; Racicka E; Rowinski O; Brzewski R; Wolanczyk T; Tomaszewicz-Libudzic C; Szymanska U
- Article: PLOS ONE. 2017;12(4):e0174923Nordenvall AS; Norrby C; Butwicka A; Frisen L; Nordenstrom A; Almqvist C; Nordenskjold A
- Article: CLINICAL ENDOCRINOLOGY. 2017;86(3):317-324Nordenström A; Butwicka A; Lindén Hirschberg A; Almqvist C; Nordenskjöld A; Falhammar H; Frisén L
- Article: JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS. 2017;47(1):80-89Butwicka A; Långström N; Larsson H; Lundström S; Serlachius E; Almqvist C; Frisén L; Lichtenstein P
- Article: PSYCHOSOMATICS. 2016;57(2):185-193Butwicka A; Fendler W; Zalepa A; Szadkowska A; Zawodniak-Szalapska M; Gmitrowicz A; Mlynarski W
- Article: PSYCHONEUROENDOCRINOLOGY. 2015;60:195-205Engberg H; Butwicka A; Nordenstrom A; Hirschberg AL; Falhammar H; Lichtenstein P; Nordenskjold A; Frisen L; Landen M
- Article: LANCET PSYCHIATRY. 2015;2(9):817-824Arnberg FK; Gudmundsdóttir R; Butwicka A; Fang F; Lichtenstein P; Hultman CM; Valdimarsdóttir UA
- Article: DIABETES CARE. 2015;38(3):453-459Butwicka A; Frisén L; Almqvist C; Zethelius B; Lichtenstein P
- Article: JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY. 2015;56(2):155-161Butwicka A; Lichtenstein P; Landén M; Nordenvall AS; Nordenström A; Nordenskjöld A; Frisén L
- Article: EUROPEAN JOURNAL OF PEDIATRICS. 2014;173(12):1639-1642Butwicka A; Krystyna S; Retka W; Wolanczyk T
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2014;99(3):E554-E560Falhammar H; Butwicka A; Landen M; Lichtenstein P; Nordenskjold A; Nordenstrom A; Frisen L
- Article: PEDIATRIC DIABETES. 2013;14(4):288-294Butwicka A; Zalepa A; Fendler W; Szadkowska A; Mlynarski W
- Article: DIABETES CARE. 2012;35(11):2133-2139Butwicka A; Fendler W; Zalepa A; Szadkowska A; Mianowska B; Gmitrowicz A; Mlynarski W
- Article: PEDIATRIC DIABETES. 2011;12(4):424-428Butwicka A; Fendler WM; Zalepa A; Szadkowska A; Gmitrowicz A; Mlynarski WM
- Article: EUROPEAN CHILD & ADOLESCENT PSYCHIATRY. 2010;19(4):365-370Butwicka A; Gmitrowicz A
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All other publications
- Corrigendum: TRANSLATIONAL PSYCHIATRY. 2023;13(1):299Kanina A; Larsson H; Sjolander A; Butwicka A; Taylor MJ; Martini MI; Lichtenstein P; Lundberg FE; Onofrio BMD; Rosenqvist MA
- Letter: JAMA PSYCHIATRY. 2023;80(4):401-402Martini MI; Butwicka A; Taylor M
- Review: LAKARTIDNINGEN. 2022;119:21098Du Rietz E; Butwicka A; Lundström S; Larsson H
- Letter: EPIDEMIOLOGY. 2022;33(1):e5-e6Thordardottir EB; Song H; Arnberg FK; Hauksdottir A; Fang F; Butwicka A; Lichtenstein P; Hultman CM; Valdimarsdottir U
- Book: 2021Srebrnicki T; Dąbkowska M; Siwiec A; Wilczyński K; Janas-Kozik M; Tyszkiewicz-Nwafor M; Pałasz A; Szymańska U; Urbanek K; Cichoń L; Hyrnik J; Kaźmierczak-Mytkowska A; Klecka M; Jagielska G; Kacperska I; Butwicka A; Bryńska A; Wolańczyk T; Szamburska-Lewandowska K; Zielińska A; Józefik B; Pilecki M; Remberk B; Wiśniewski A; Rybakowski F
- Review: CNS DRUGS. 2020;34(7):731-747Li L; Sujan AC; Butwicka A; Chang Z; Cortese S; Quinn P; Viktorin A; Oberg AS; D'Onofrio BM; Larsson H
- Letter: GUT. 2019;68(5):947-948Butwicka A; Sariaslan A; Larsson H; Halfvarson J; Myrelid PE; Olen O; Frisen L; Lichtenstein P; Ludvigsson JF
- Corrigendum: DIABETES CARE. 2016;39(3):495Butwicka A; Frisen L; Almqvist C; Zethelius B; Lichtenstein P
- Letter: ARCHIVES OF MEDICAL SCIENCE. 2015;11(6):1361-1362Determinants of quality of life in patients with breast cancer undergoing external beam radiotherapyChalubinska-Fendler J; Butwicka A; Kazmierczak P; Jalocha-Kaczka A; Fendler W; Fijuth J
- Editorial comment: DIABETOLOGE. 2015;11(5):366Butwicka A
- Review: POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ. 2006;60:387-396Marciniak K; Butwicka A; Nowak JZ
Grants
- Swedish Research Council1 January 2024 - 31 December 2026Purpose and aims: There is so much comorbidity among psychiatric conditions that one can combine them into a single general psychopathology index. Although general psychopathology predicts adverse outcomes, it remains unknown if it responds to intervention. Therefore, we will estimate the causal effect of psychosocial interventions and psychotropic medications on general psychopathology. Method: We will apply casual inference designs (children-of-siblings designco-twin control/within-individual designinstrumental variableand front-door criterion) to data from the Swedish Twin Register and Swedish population registers to estimate the effect of childrearing conditions (year 1), psychotherapy (years 2-3), and psychotropic medication (years 1-5) on general psychopathology (derived from self/parent-reported symptoms and psychiatric diagnoses). The principal investigator will devote 50% of his time to this project, and he is supported by experts in epidemiology, psychotherapy, and psychiatry. Importance: Even though comorbidity is the rule rather than exception in psychiatry, most randomized clinical trials exclude individuals with several disorders. Therefore, there is a lack of knowledge of the effect of treatment on comorbidity. By applying innovative causal inference designs to large observational data, we aim to study the effect of treatment on general psychopathology in the best conceivable way. This could open a new area of research into transdiagnostic treatments.
- Swedish Research Council1 January 2024 - 31 December 2026Autism is a common lifelong condition. Autistic individuals are at a high risk of somatic disorders, such as epilepsy, and are at an increased risk for premature mortality. A better understanding of co-occurring somatic disorders in autistic individuals is thus critical from the perspective of improving public health in marginalized groups, yet existing research is limited by a descriptive focus. Our overall aim is to identify risk factors for somatic disorders in autistic individuals. We will optimize Swedish registry data, including linkage with a large genotyped sample, using powerful longitudinal study designs. First, we will test whether genetic factors account for the association between autism and somatic disorders. We will triangulate three family-based designs, and utilize contemporary molecular genetic approaches to assess genetic links between autism and somatic disorders. Second, we will assess whether the psychosocial adversity faced by autistic individuals impact on their health using longitudinal cohort designs. Finally, real-world data will allow us to circumvent the challenges of conducting randomized controlled trials to examine the impact of psychotropic medication use on somatic health in autistic individuals. This project will guide the field of somatic health in autistic individuals from descriptive epidemiology towards a mechanistic understanding, which will ultimately lead to improved prevention, detection, and treatment of these disorders.
- Swedish Research Council for Health Working Life and Welfare1 January 2024 - 31 December 2026Research problem and specific questions: About one quarter of all children have parents with mental health problems. These children are at increased risk for a wide range of adverse outcomes. Nevertheless, despite the importance of reducing this form of inequality, research on the intergenerational transmission of mental health problems is plagued by three important limitations. These include an overreliance on small samples and retrospective (biased) reportsa failure to address psychiatric comorbidityand inadequate control of unmeasured confounding. The aim of this project is to answer three research questions: 1) What are the associations between psychiatric diagnoses in parents and adverse outcomes in their children? 2) Can these be attributed to broad comorbidity? 3) Does treatment of the parents’ psychiatric disorders reduce the risk of adverse outcomes in children?Data and method: We will include all individuals born in Sweden between 1970 and 2000 (N = 2 797 086). The exposures are 6 psychiatric diagnoses in their parents, and the outcomes are 34 adverse events in the offspring recorded until the end of 2019 (e.g., psychiatric disorders, psychotropic medications, criminality, school and employment problems, etc.). We will estimate associations between the exposures and outcomesadjust for comorbidity using multiple regression and a general factor modeland apply causal inference techniques to control for unmeasured confounding.Plan for project realisation: We will hire a PhD student and a postdoc to complete the project. The PI, along with experts in epidemiology and psychiatry, will provide support.Relevance: Our project will contribute to the study of intergenerational transmission of mental health problems in three important ways. First, because psychiatric treatment resources are becoming increasingly scarce as more individuals seek help, parental psychiatric history can help guide treatment allocation by identifying those at higher risk and by screening out low risk persons. Second, we will highlight the importance of focusing on parental comorbidity, which will guide clinicians to additionally focus on the number of parental diagnoses (rather than only type) when predicting patient prognosis. Third, if a parental psychiatric diagnosis appears causally related to an outcome, then it would be beneficial to develop a policy for child and adolescent mental health providers to recommend that the parent also seek treatment.
- Swedish Research Council1 January 2024 - 31 December 2026RESEARCH PROBLEMAbout 1-2% of the Swedish population suffer from celiac disease. My earlier research has mainly focused on severe complications of celiac disease (e.g. death and cancer). In this project I will use laboratory data and primary care data to study early comorbidity in celiac disease, especially kidney-liver disease and neuro-cognitive/psychiatric disorders, such as stress-related illness, depression and dementia. DATA AND METHODProject 1: Through Swedish pathology departments, we have identified some 50,000 individuals with celiac disease. We expect that approx. 12-13,000 of these live in the Stockholm area and can therefore be linked to the laboratory database “SCREAM”. For these patients, we will identify all kidney and liver blood samples to follow kidney and liver function longitudinally.Project 2: Via a primary care dataset (covering 20 of 21 Swedish regions), we will examine celiac disease and the risk of neuro-cognitive disorders. WORK PLANProject 1: Using the personal identity number, data on celiac disease are linked to laboratory data in the SCREAM study. Using linear regression, we will study the development of early kidney and liver disease using laboratory data.Project 2: Data have already been linked. We will use Cox regression to calculate hazard ratios for our outcomes. RELEVANCEAn increased understanding of early comorbidity in celiac disease can improve the care of patients. In the long term, our goal is to prevent comorbidity in celiac disease.
- Nordforsk1 July 2023 - 30 June 2027Project aiming to improve the well-being of young people by increasing our understanding of vulnerabilities and resilience in determining post-pandemic outcomes. SISU unites a strong, multidisciplinary team of 4 Nordic partners, including renewed researchers with expertise in child and adolescent well-being, developmental psychology, child psychiatry, educational outcomes, and pandemic consequence. SISU builds on exceptional opportunities for Nordic countries with the availability of large longitudinal data sets, including school and municipality surveys, prospective cohort studies with genetic data, and population-based registries. We are aware that pandemics happen to societies as a wholethus, our bioecological approach addresses this by integrating societal, contextual, developmental, and biological layers of inference. Through our intersection of individual dispositions, and school and societal environments, we can provide explanations relevant to municipal and national stakeholders forming schools and health services. Furthermore, by evaluating both negative and positive aspects of the pandemic environment's interaction with individual susceptibility, we aim to lay a foundation for resilient recovery from the pandemic.
- Swedish Research Council for Health Working Life and Welfare1 January 2023 - 31 December 2025Research problem and specific questions: Intellectual disability (ID) affects 2% of children worldwide. The disability is present throughout the lifespan, leading to significant morbidity and premature deaths. Early-life risk factors and low socioeconomic status (SES) are associated with ID. But the absence of genetically-informative studies prevented researchers from distinguishing between potential causal environmental influences and genetic confounding. In the proposed project, we will study the effect of early-life environmental factors for ID and identify risk groups in need of clinical follow-up.The aim of this project is to answer the following research questions:What is the causal mechanism by which early-life risk factors are associated with risk of ID?What is the mechanism underlying the association between SES and ID? Which early-life risk factors mediate this associations?Which risk groups are mostly likely to benefit from targeted pediatric surveillance and early health interventions?Data and method: We will use large-scale longitudinal linkages of administrative and health registers along with the Swedish Twin and Multi-Generation Registers. We will examine association between exposures to 1) early-life risk factors and 2) low SES with the outcome of ID. The association will be investigated in the overall population (between-family analyses) and, to address potential causality by adjusting for familial confounding in siblings (i) full-siblings, half-siblings, cousins and (ii) twins (within-family analyses). We will apply causal inference methods for mediation and interactions. 3) We will develop a Clinical Risk Score for prediction of ID based on early-life risk factors, SES and familial risk score.Plan for project realization: The project will be carried out over three years in close collaboration with reference group involving representatives from self-advocacy group “Grunden and Inre Ringen” and relevant stakeholders such as Young People and Adults with Intellectual Disability (FUB), the National Board of Health and Welfare, the Swedish Agency for Participation and the Swedish Municipalities and Regions (SKR).Relevance: The project will increase our knowledge on modifiable risk factors for ID, crucial for informing prevention in the population. If we can identify children atrisk of disabilities, we will be able to plan follow-ups and provide the best opportunities for timely diagnosis and early interventions in children and their families.
- Swedish Research Council1 January 2023 - 31 December 2025What is important? Evidence points to substantial comorbidity between adult ADHD and cardiometabolic disease, i.e., obesity, type-2 Diabetes (T2DM), and cardiovascular disease (CVD). Guidelines for care of cardiometabolic disease stress the importance of co-occurring psychiatric disorders, yet ADHD is rarely mentioned. This is problematic as ADHD is a common psychiatric disorder (2–5%) and behaviours and cognitive challenges associated with ADHD may lead to poor outcomes due to poor adherence and risky behaviours. Also, stimulant medications used to treat ADHD may increase risk for adverse outcomes for those with underlying CVD or in interaction with other pharmacological treatments.What is to be done? First, determine how ADHD associates with outcomes (i.e., cardiometabolic risk profiles, adherence to treatments for cardiometabolic disease, and severe post-surgery/diagnosis outcomes) after bariatric surgery, T2DM and CVD diagnosis. Second, explore real-world effectiveness and safety of ADHD medication in relation to cardiometabolic outcomes/treatments. Third, develop prediction tool that allow identification of patients with ADHD at high-risk for poor cardiometabolic outcomes and treatment adherence.How the research will be carried out? An interdisciplinary team of experts will apply state-of-the art statistical approaches and beyond on data from a comprehensive linkage of national registers, including three unique quality registers of bariatric surgery, T2DM and CVD.
- Swedish Research Council for Health Working Life and Welfare1 April 2019 - 31 March 2022
- Swedish Research Council1 January 2018 - 31 December 2021
- Psychiatric disorders in monogenic diabetes and type 1 diabetesMinistry of Science and Higher Education8 July 2013 - 7 July 2015
- Hypospadias as a factor deteriorating social functioning and mental patientsMinistry of Science and Higher Education1 January 2013 - 31 July 2013
Employments
- Principal Researcher, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2024-
Degrees and Education
- Docent, Karolinska Institutet, 2022