Projects
Research covers different aspects of coronary heart disease and include (1) the assessment of the risk-benefit relationship between bleeding and ischemia in patients with myocardial infarction, (2) studies on the effects of family history and social determinants of health from preclinical to recurrent cardiovascular disease, (3) the effects of incretin treatments on coronary healing and restenosis after PCI, (4) the value of beta-blockers after myocardial infarction with preserved ejection fraction, (5) diagnostic algorithms in the emergency room for patients with chest-pain and/or hypertension, (6) diagnostic assessments and prognosis of patients with myocardial infarction with normal coronary arteries (MINOCA). The studies are both observational and interventional.
HELP-SWEDEHEART
The nationwide cluster-randomized trial HELP-SWEDEHEART is evaluating whether Helicobacter Pylori screening can prevent upper gastrointestinal bleeding in patients with acute myocardial infarction. Robin Hofmann is the coordinating investigator and is leading this project together with a SWEDEHEART steering group. Other aspects of Helicobacter Pylori are studied in the related projects HELP-FIA3, HELP-TAMI3, HELP-KKT and HELP-SCAPIS.
Phd Students: Jonatan Wärme and Martin Sundqvist
Family history, socioeconomics and cardiovascular disease
The effects of family history and social determinants of health from preclinical to recurrent cardiovascular disease are studied in the population-based SCAPIS and TwinGene-studies, national quality registers and health data together with linked national registers. The project aims to advance the understanding on how family history and socioeconomics interact and cause cardiovascular disease and identify targets for treatment to reduce health inequity.
Phd Students: Agnes Wahrenberg and Sebastian Herlitz
Diabetes and coronary heart disease
The effect of diabetes, glycemic control and treatment with incretins on restenosis after coronary stenting is studied in both interventional and observational studies.
Phd Student: Irene Santos Pardo
Betablockers and myocardial infarction
Different aspects of beta-blocker therapy after myocardial infarction with preserved ejection fraction are studied in observational and interventional studies such asthe REDUCE -study.
Phd Student: Katarina Mars
Diagnostic algorithms in the emergency department
Diagnostic algorithms and risk factors for patients with suspected acute coronary syndrome in the emergency department (ED) are studied in observational studies based on regional health data and national quality registers. We participate in FAST-CCTA, a randomized study that evaluates a diagnostic strategy with early coronary computed tomography angiography (CCTA) in patients with chest pain and intermediate risk. We also study prognosis and algorithms for patients with elevated blood pressure in the ED.
Phd Students Ruslan Alam and Pontus Oras
Myocardial infarction with non obstructive coronary arteries
The diagnostic performance of early invasive coronary angiogram (ICA) and coronary computed tomography (CCTA) is studied in patients with myocardial infarction with non obstructive coronary arteries (MINOCA).
Phd Student Oscar Winnberg
Collaborations
Collaborators include other departments at Karolinska Institutet, Uppsala University, Umeå University.
Research support
The Swedish Research Council
Swedish Heart and Lung Foundation
The Swedish Heart and Lung Association