Christian Göritz's Group
We are studying homeostasis and tissue repair mechanisms in the mammalian system with a focus on pericytes, perivascular cells of the microvasculature.
Commonly, tissue damage triggers a wound closure reaction that can lead to pathological tissue formation, causing functional impairment and blocking regeneration.
We discovered that a specific subpopulation of pericytes participate in the wound closure reaction and following scar formation after spinal cord injury.
Pericytes are abundant throughout the body and have a great potential to be a general source for scar formation and fibrosis in different injuries and diseases. We are aiming to understand the nature of these cells, their heterogeneity, stem cell potential and functions.
|Daniel Holl||Doktorand, Forskarstuderande|
|Yildiz Kelahmetoglu||Doktorand, Forskarstuderande|
A pericyte origin of spinal cord scar tissue.
Science 2011 Jul;333(6039):238-42
EphB signaling controls lineage plasticity of adult neural stem cell niche cells.
Cell Stem Cell 2010 Dec;7(6):730-43
RBPJkappa-dependent signaling is essential for long-term maintenance of neural stem cells in the adult hippocampus.
J. Neurosci. 2010 Oct;30(41):13794-807
Origin of new glial cells in intact and injured adult spinal cord.
Cell Stem Cell 2010 Oct;7(4):470-82
Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke.
Nat. Neurosci. 2009 Mar;12(3):259-67