Christian Göritz

About me
Publications
Public outreach and news

About me

Principal Investigator
Fibrosis and Tissue Repair of the Central Nervous System
Fibroblast functions in blood flow regulation

Previous ERC Starting Grant (https://erc.europa.eu/)
Wallenberg Academy Fellow
(https://kaw.wallenberg.org/en/research/research-scarring-paving-way-new-treatments-spinal-cord-injuries)
Ming Wai Lau Centre for Reparative Medicine Fellow
(https://ki.se/en/research/ming-wai-lau-centre-for-reparative-medicine)

Director of StratRegen (https://ki.se/en/research/about-stratregen)

CV
Diploma in Biochemistry (FU Berlin)
PhD in Neuroscience (Max Planck / CNRS)
Postdoc on CNS Regeneration (Karolinska Institutet)

Research

Christian Göritz's group. [1]
[1] http://ki.se/en/cmb/christian-goritzs-group

Articles

Journal article: BONE RESEARCH. 2024;12(1):56
Multimodal analyses of immune cells during bone repair identify macrophages as a therapeutic target in musculoskeletal trauma
Hachemi Y; Perrin S; Ethel M; Julien A; Vettese J; Geisler B; Goritz C; Colnot C
Article: NATURE NEUROSCIENCE. 2024;27(7):1285-1298
Distinct origin and region-dependent contribution of stromal fibroblasts to fibrosis following traumatic injury in mice
Holl D; Hau WF; Julien A; Banitalebi S; Kalkitsas J; Savant S; Llorens-Bobadilla E; Herault Y; Pavlovic G; Amiry-Moghaddam M; Dias DO; Goritz C
Journal article: NATURE CARDIOVASCULAR RESEARCH. 2024;3(6):685-700
Macrophages upregulate mural cell-like markers and support healing of ischemic injury by adopting functions important for vascular support
Amoedo-Leite C; Parv K; Testini C; Herrera-Hidalgo C; Xu F; Giraud A; Malaquias M; Fasterius E; Holl D; Seignez C; Goeritz C; Christoffersson G; Phillipson M
Article: SCIENCE. 2024;383(6683):eade8064
Corpora cavernosa fibroblasts mediate penile erection
Guimaraes EL; Dias DO; Hau WF; Julien A; Holl D; Garcia-Collado M; Savant S; Vagesjo E; Phillipson M; Jakobsson L; Goritz C
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2024;221(2):e20230675
CD163⁺ macrophages monitor enhanced permeability at the blood-dorsal root ganglion barrier
Lund H; Hunt MA; Kurtovic Z; Sandor K; Kagy PB; Fereydouni N; Julien A; Goritz C; Vazquez-Liebanas E; Andaloussi Mae M; Jurczak A; Han J; Zhu K; Harris RA; Lampa J; Graversen JH; Etzerodt A; Haglund L; Yaksh TL; Svensson CI
Article: CELL REPORTS. 2022;38(9):110440
Identification of a discrete subpopulation of spinal cord ependymal cells with neural stem cell properties
Stenudd M; Sabelstrom H; Llorens-Bobadilla E; Zamboni M; Blom H; Brismar H; Zhang S; Basak O; Clevers H; Goritz C; Barnabe-Heider F; Frisen J
Article: NATURE COMMUNICATIONS. 2021;12(1):5501
Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions
Dias DO; Kalkitsas J; Kelahmetoglu Y; Estrada CP; Tatarishvili J; Holl D; Jansson L; Banitalebi S; Amiry-Moghaddam M; Ernst A; Huttner HB; Kokaia Z; Lindvall O; Brundin L; Frisen J; Goritz C
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(33):e2104119118
Astrocyte-derived neurons provide excitatory input to the adult striatal circuitry
Dorst MC; Diaz-Moreno M; Dias DO; Guimaraes EL; Holl D; Kalkitsas J; Silberberg G; Goritz C
Article: THE FASEB JOURNAL. 2020;34(10):13978-13992
Circadian vulnerability of cisplatin-induced ototoxicity in the cochlea
Tserga E; Moreno-Paublete R; Sarlus H; Bjorn E; Guimaraes E; Goritz C; Cederroth CR; Canlon B
Article: EMBO JOURNAL. 2018;37(9):embj201798280
Glutamate transporter Slc1a3 mediates inter-niche stem cell activation during skin growth
Reichenbach B; Classon J; Aida T; Tanaka K; Genander M; Goeritz C
Article: CELL. 2018;173(1):153-165.e22
Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury
Dias DO; Kim H; Holl D; Solnestam BW; Lundeberg J; Carlen M; Goritz C; Frisen J
Article: SCIENCE. 2014;346(6206):237-241
A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse
Magnusson JP; Goritz C; Tatarishvili J; Dias DO; Smith EMK; Lindvall O; Kokaia Z; Frisen J
Article: NEURON. 2014;83(5):1085-1097
A Transcriptional Mechanism Integrating Inputs from Extracellular Signals to Activate Hippocampal Stem Cells
Andersen J; Urban N; Achimastou A; Ito A; Simic M; Ullom K; Martynoga B; Lebel M; Goritz C; Frisen J; Nakafuku M; Guillemot F
Article: SCIENCE. 2013;342(6158):637-640
Resident Neural Stem Cells Restrict Tissue Damage and Neuronal Loss After Spinal Cord Injury in Mice
Sabelstrom H; Stenudd M; Reu P; Dias DO; Elfineh M; Zdunek S; Damberg P; Goritz C; Frisen J
Article: SCIENCE. 2011;333(6039):238-242
A Pericyte Origin of Spinal Cord Scar Tissue
Goritz C; Dias DO; Tomilin N; Barbacid M; Shupliakov O; Frisen J
Article: MOLECULAR BIOLOGY OF THE CELL. 2011;22(11):1864-1877
In neurons, activity-dependent association of dendritically transported mRNA transcripts with the transacting factor CBF-A is mediated by A2RE/RTS elements
Raju CS; Fukuda N; Lopez-Iglesias C; Goritz C; Visa N; Percipalle P
Article: CELL STEM CELL. 2010;7(6):730-743
EphB Signaling Controls Lineage Plasticity of Adult Neural Stem Cell Niche Cells
Nomura T; Goritz C; Catchpole T; Henkemeyer M; Frisen J
Article: JOURNAL OF NEUROSCIENCE. 2010;30(41):13794-13807
RBPJκ-Dependent Signaling Is Essential for Long-Term Maintenance of Neural Stem Cells in the Adult Hippocampus
Ehm O; Goritz C; Covic M; Schaeffner I; Schwarz TJ; Karaca E; Kempkes B; Kremmer E; Pfrieger FW; Espinosa L; Bigas A; Giachino C; Taylor V; Frisen J; Lie DC
Article: CELL STEM CELL. 2010;7(4):470-482
Origin of New Glial Cells in Intact and Injured Adult Spinal Cord
Barnabe-Heider F; Goritz C; Sabelstrom H; Takebayashi H; Pfrieger FW; Meletis K; Frisen J
Article: NATURE NEUROSCIENCE. 2009;12(3):259-267
Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke
Carlen M; Meletis K; Goritz C; Darsalia V; Evergren E; Tanigaki K; Amendola M; Barnabe-Heider F; Yeung MSY; Naldini L; Honjo T; Kokaia Z; Shupliakov O; Cassidy RM; Lindvall O; Frisen J
Article: MOLECULAR BIOLOGY OF THE CELL. 2008;19(7):3008-3019
In cultured Oligodendrocytes the A/B-type hnRNP CBF-A accompanies MBP mRNA bound to mRNA trafficking sequences
Raju CS; Goritz C; Nord Y; Hermanson O; Lopez-Iglesias C; Visa N; Castelo-Branco G; Percipalle P
Article: GLIA. 2007;55(15):1565-1576
Transgenic mice for conditional gene manipulation in astroglial cells
Slezak M; Goritz C; Niemiec A; Frisen J; Chambon P; Metzger D; Pfrieger FW
Article: GLIA. 2007;55(11):1108-1122
Glia-induced neuronal differentiation by transcriptional regulation
Goritz C; Thiebaut R; Tessier L-H; Nieweg K; Moehle C; Buard I; Dupont J-L; Schurgers LJ; Schmitz G; Pfrieger FW
Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2005;29(2):190-201
Multiple mechanisms mediate cholesterol-induced synaptogenesis in a CNS neuron
Goritz C; Mauch DH; Pfrieger FW
Article: JOURNAL OF PHYSIOLOGY PARIS. 2002;96(3-4):257-263
Role of glia-derived cholesterol in synaptogenesis:: new revelations in the synapse-glia affair
Göritz C; Mauch DH; Nägler K; Pfrieger FW
Article: SCIENCE. 2001;294(5545):1354-1357
CNS synaptogenesis promoted by glia-derived cholesterol
Mauch DH; Nägler K; Schumacher S; Göritz C; Müller EC; Otto A; Pfrieger FW
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All other publications

Review: AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY. 2023;325(6):c1415-c1420
Decoding fibrosis in the human central nervous system
Holl D; Goeritz C
Preprint: BIORXIV. 2023
A network of CD163⁺macrophages monitors enhanced permeability at the blood-dorsal root ganglion barrier
Lund H; Hunt M; Kurtovic Z; Sandor K; Fereydouni N; Julien A; Göritz C; Han J; Zhu K; Harris R; Lampa J; Haglund L; Yaksh T; Svensson C
Preprint: RESEARCH SQUARE. 2022
Macrophages support healing of ischemic injury by transdifferentiating towards mural cells and adopting functions important for vascular support
Parv K; Hidalgo CH; Xu F; Amoedo-Leite C; Giraud A; Holl D; Seignez C; Goeritz C; Christoffersson G; Phillipson M
Preprint: BIORXIV. 2020
Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions
Dias DO; Kalkitsas J; Kelahmetoglu Y; Estrada CP; Tatarishvili J; Ernst A; Huttner HB; Kokaia Z; Lindvall O; Brundin L; Frisén J; Göritz C
Conference publication: GLIA. 2019;67:E38
Mechanisms of fibrotic scarring and axon regeneration
Goritz C
Review: MATRIX BIOLOGY. 2018;68-69:561-570
Fibrotic scarring following lesions to the central nervous system
Dias DO; Goritz C
Conference publication: GLIA. 2017;65:E53-E54
Attenuation of pericyte-derived fibrosis promotes axonal regeneration and functional recovery following CNS injury
Goritz C
Conference publication: GLIA. 2017;65:E534-E535
Attenuation of pericyte-derived scarring promotes axonal regeneration and functional recovery following spinal cord injury
Dias DO; Kim H; Holl D; Solnestam BW; Lundeberg J; Carlen M; Frisen J; Goritz C
Editorial comment: CELL STEM CELL. 2012;10(6):657-659
Neural Stem Cells and Neurogenesis in the Adult
Goritz C; Frisen J
Conference publication: CHEMISTRY AND PHYSICS OF LIPIDS. 2005;136(2):134
Cholesterol biosynthesis and its regulation in neurons and glial cells
Nieweg K; Goritz C; Pfrieger FW
Conference publication: MOLECULAR BIOLOGY OF THE CELL. 2001;12:378A
Identification of a glia-derived factor promoting synaptogenesis
Mauch D; Nagler K; Schumacher S; Goritz C; Muller EC; Otto A; Pfrieger FW

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