Meletis group

The Meletis laboratory is investigating the circuit mechanisms that shape motivated behaviors and the circuit imbalance that underlies core phenotypes of mood disorders.

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Research focus

Meletis laboratory research focus
Image: Dinos Meletis

A key to this investigation is the development and use of advanced technologies to probe the organization and function of candidate circuits, focusing on the basal ganglia, hypothalamus, habenula, and the serotonin system. The investigation of neurons and circuit is based on genetic access to neuron types in combination with technologies to record or manipulate neuronal activity with high temporal and spatial precision during behavioral tasks. 

The Meletis laboratory has developed and applied a number of methods to map circuit organization and function, ranging from advanced molecular methods to determine gene expression patterns in cells and tissue – to in vivo approaches to define the role of neurons in aversion and motivation. Functional circuit mapping as well as molecular definitions of cell types and brain regions are central to establish a comprehensive understanding of how neurons and circuits generate motivated behaviors.

  1. Optogenetic control of a Parvalbumin-expressing GABAergic interneuron.
  2. Circuit and behavior control through electronic interface board with LED and gyroscope.
  3. Corticostriatal circuit dissection with genetically modified viruses.

Publications

Selected publications

Staff and contact

Group leader

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Contact us

Postal address

Department of Neuroscience
Attn: Konstantinos Meletis group
Karolinska Institutet, SE-171 77 Stockholm

Visiting address (visitors, couriers, etc.)

Karolinska Institutet, Biomedicum, Quarter B4
Solnavägen 9, SE-171 65 Solna

Delivery address (goods, parcels, etc.)

Tomtebodavägen 16, SE-171 65 Solna

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Karolinska Institutet, Biomedicum, Solnavägen 9