Konstantinos Meletis

About me
Publications
Grants
CV
Public outreach and news

About me

Konstantinos Meletis is Professor of Systems Neuroscience in the Department of Neuroscience.

Selected academic honours, awards and prizes
- 2024 – The Arvid Carlsson Foundation Prize
- 2015 – William K. Bowes Jr. Foundation Associate Professor Award
- 2013 – Framtidens Forskningsledare, FFL5, Stiftelsen för Strategisk Forskning
- 2011 – William K. Bowes Jr. Foundation Assistant Professor Award
- 2010 – Marie Curie Reintegration Grant FP7 (EU)
- 2010 – NARSAD Young Investigator Award (USA)

Research

Investigation of the organization and function of brain circuits and neuron types that regulate motivated behaviors and decision-making, including the circuit and cellular mechanisms underlying dysfunction in mouse models of stress or mood disorders.

Selected publications

Review: ANNUAL REVIEW OF NEUROSCIENCE. 2021;44:547-562
Spatial Transcriptomics: Molecular Maps of the Mammalian Brain
Ortiz C; Carlen M; Meletis K
Article: SCIENCE ADVANCES. 2020;6(26):eabb3446
Molecular atlas of the adult mouse brain
Ortiz C; Navarro JF; Jurek A; Martin A; Lundeberg J; Meletis K
Article: CELL REPORTS. 2019;29(13):4320-4333.e5
A Spatiomolecular Map of the Striatum
Martin A; Calvigioni D; Tzortzi O; Fuzik J; Warnberg E; Meletis K
Article: MOLECULAR PSYCHIATRY. 2019;24(9):1351-1368
A hypothalamus-habenula circuit controls aversion
Lazaridis I; Tzortzi O; Weglage M; Martin A; Xuan Y; Parent M; Johansson Y; Fuzik J; Furth D; Fenno LE; Ramakrishnan C; Silberberg G; Deisseroth K; Carlen M; Meletis K
Article: NATURE NEUROSCIENCE. 2018;21(1):139-149
An interactive framework for whole-brain maps at cellular resolution
Furth D; Vaissiere T; Tzortzi O; Xuan Y; Martin A; Lazaridis I; Spigolon G; Fisone G; Tomer R; Deisseroth K; Carlen M; Miller CA; Rumbaugh G; Meletis K
Article: NEURON. 2014;83(3):663-678
A Whole-Brain Atlas of Inputs to Serotonergic Neurons of the Dorsal and Median Raphe Nuclei
Dorocic IP; Furth D; Xuan Y; Johansson Y; Pozzi L; Silberberg G; Carlen M; Meletis K
Article: PLOS ONE. 2014;9(1):e83879
Mice Lacking NMDA Receptors in Parvalbumin Neurons Display Normal Depression-Related Behavior and Response to Antidepressant Action of NMDAR Antagonists
Pozzi L; Dorocic IP; Wang X; Carlen M; Meletis K
Article: JOURNAL OF NEUROSCIENCE. 2013;33(4):1678-1683
Target Selectivity of Feedforward Inhibition by Striatal Fast-Spiking Interneurons
Szydlowski SN; Dorocic IP; Planert H; Carlen M; Meletis K; Silberberg G

Articles

Article: BIORXIV. 2024;:2023.09.27.559787
Syngap1 Promotes Cognitive Function through Regulation of Cortical Sensorimotor Dynamics.
Vaissiere T; Michaelson SD; Creson T; Goins J; Fürth D; Balazsfi D; Rojas C; Golovin R; Meletis K; Miller CA; O'Connor D; Fontolan L; Rumbaugh G
Article: ISCIENCE. 2024;27(5):109743
Cell-type-specific representation of spatial context in the rat prefrontal cortex
Brunner H; Kim H; Ahrlund-Richter S; van Lunteren JA; Crestani AP; Meletis K; Carlen M
Article: ENEURO. 2023;10(7):1-20
A Selective Projection from the Subthalamic Nucleus to Parvalbumin-Expressing Interneurons of the Striatum
Kondabolu K; Doig NM; Ayeko O; Khan B; Torres A; Calvigioni D; Meletis K; Koos T; Magil PJ
Article: NATURE NEUROSCIENCE. 2023;26(7):1245-1255
Esr1⁺ hypothalamic-habenula neurons shape aversive states
Calvigioni D; Fuzik J; Le Merre P; Slashcheva M; Jung F; Ortiz C; Lentini A; Csillag V; Graziano M; Nikolakopoulou I; Weglage M; Lazaridis I; Kim H; Lenzi I; Park H; Reinius B; Carlen M; Meletis K
Article: NUCLEIC ACIDS RESEARCH (NAR). 2023;51(8):e47
The spatial landscape of gene expression isoforms in tissue sections
Lebrigand K; Bergenstrahle J; Thrane K; Mollbrink A; Meletis K; Barbry P; Waldmann R; Lundeberg J
Article: CELL REPORTS. 2021;36(4):109437
Complete representation of action space and value in all dorsal striatal pathways
Weglage M; Warnberg E; Lazaridis I; Calvigioni D; Tzortzi O; Meletis K
Article: PLOS BIOLOGY. 2021;19(7):e3001341
Assessing the replicability of spatial gene expression using atlas data from the adult mouse brain
Lu S; Ortiz C; Furth D; Fischer S; Meletis K; Zador A; Gillis J
Article: JOURNAL OF NEUROSCIENCE. 2021;41(14):3120-3141
Adult trkB Signaling in Parvalbumin Interneurons is Essential to Prefrontal Network Dynamics.
Guyon N; Zacharias LR; van Lunteren JA; Immenschuh J; Fuzik J; Märtin A; Xuan Y; Zilberter M; Kim H; Meletis K; Lopes-Aguiar C; Carlén M
Article: NATURE COMMUNICATIONS. 2021;12(1):1026
Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice
Wu H; Petitpre C; Fontanet P; Sharma A; Bellardita C; Quadros RM; Jannig PR; Wang Y; Heimel JA; Cheung KKY; Wanderoy S; Xuan Y; Meletis K; Ruas J; Gurumurthy CB; Kiehn O; Hadjab S; Lallemend F
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(51):25958-25967
Brain-wide genetic mapping identifies the indusium griseum as a prenatal target of pharmacologically unrelated psychostimulants
Fuzik J; Rehman S; Girach F; Miklosi AG; Korchynska S; Arque G; Romanov RA; Hanics J; Wagner L; Meletis K; Yanagawa Y; Kovacs GG; Alpar A; Hokfelt TGM; Harkany T
Article: NATURE NEUROSCIENCE. 2019;22(4):657-668
A whole-brain atlas of monosynaptic input targeting four different cell types in the medial prefrontal cortex of the mouse
Ahrlund-Richter S; Xuan Y; van Lunteren JA; Kim H; Ortiz C; Dorocic IP; Meletis K; Carlen M
Article: JOURNAL OF COMPARATIVE NEUROLOGY. 2017;525(15):3227-3250
Monosynaptic retrograde tracing of neurons expressing the G-protein coupled receptor Gpr151 in the mouse brain
Broms J; Grahm M; Haugegaard L; Blom T; Meletis K; Tingstrom A
Article: CELL RESEARCH. 2016;26(9):1033-1047
Cortical neurons gradually attain a post-mitotic state
de Anda FC; Madabhushi R; Rei D; Meng J; Graeff J; Durak O; Meletis K; Richter M; Schwanke B; Mungenast A; Tsai L-H
Article: NATURE. 2012;489(7414):150-154
Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision
Song J; Zhong C; Bonaguidi MA; Sun GJ; Hsu D; Gu Y; Meletis K; Huang ZJ; Ge S; Enikolopov G; Deisseroth K; Luscher B; Christian KM; Ming G-L; Song H
Article: NATURE NEUROSCIENCE. 2012;15(7):1022-1031
Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex
de Anda FC; Rosario AL; Durak O; Tran T; Graeff J; Meletis K; Rei D; Soda T; Madabhushi R; Ginty DD; Kolodkin AL; Tsai L-H
Article: MOLECULAR PSYCHIATRY. 2012;17(5):537-548
A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior
Carlen M; Meletis K; Siegle JH; Cardin JA; Futai K; Vierling-Claassen D; Ruehlmann C; Jones SR; Deisseroth K; Sheng M; Moore CI; Tsai L-H
Article: ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY. IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY. ANNUAL INTERNATIONAL CONFERENCE. 2011;2011:7529-7532
Chronically implanted hyperdrive for cortical recording and optogenetic control in behaving mice.
Siegle JH; Carlen M; Meletis K; Tsai L-H; Moore CI; Ritt J
Article: CELL STEM CELL. 2010;7(4):470-482
Origin of New Glial Cells in Intact and Injured Adult Spinal Cord
Barnabe-Heider F; Goritz C; Sabelstrom H; Takebayashi H; Pfrieger FW; Meletis K; Frisen J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(33):14657-14661
Efficient reprogramming of adult neural stem cells to monocytes by ectopic expression of a single gene
Forsberg M; Carlen M; Meletis K; Yeung MSY; Barnabe-Heider F; Persson MAA; Aarum J; Frisen J
Article: JOURNAL OF NEUROSCIENCE. 2010;30(31):10391-10406
Centrosome Motility Is Essential for Initial Axon Formation in the Neocortex
de Anda FC; Meletis K; Ge X; Rei D; Tsai L-H
Article: NEURON. 2010;67(1):33-48
Dixdc1 Is a Critical Regulator of DISC1 and Embryonic Cortical Development
Singh KK; Ge X; Mao Y; Drane L; Meletis K; Samuels BA; Tsai L-H
Article: BRAIN. 2010;133(Pt 4):983-995
A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2α
Seidel S; Garvalov BK; Wirta V; von Stechow L; Schaenzer A; Meletis K; Wolter M; Sommerlad D; Henze A-T; Nister M; Reifenberger G; Lundeberg J; Frisen J; Acker T
Article: NATURE PROTOCOLS. 2010;5(2):247-254
Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2
Cardin JA; Carlen M; Meletis K; Knoblich U; Zhang F; Deisseroth K; Tsai L-H; Moore CI
Article: NATURE. 2009;459(7247):663-667
Driving fast-spiking cells induces gamma rhythm and controls sensory responses
Cardin JA; Carlen M; Meletis K; Knoblich U; Zhang F; Deisseroth K; Tsai L-H; Moore CI
Article: NATURE NEUROSCIENCE. 2009;12(3):259-267
Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke
Carlen M; Meletis K; Goritz C; Darsalia V; Evergren E; Tanigaki K; Amendola M; Barnabe-Heider F; Yeung MSY; Naldini L; Honjo T; Kokaia Z; Shupliakov O; Cassidy RM; Lindvall O; Frisen J
Article: PLOS BIOLOGY. 2008;6(7):1494-1507
Spinal cord injury reveals multilineage differentiation of ependymal cells
Meletis K; Barnabe-Heider F; Carlen M; Evergren E; Tomilin N; Shupliakov O; Frisen J
Article: NATURE METHODS. 2008;5(2):189-196
Genetic manipulation of adult mouse neurogenic niches by in vivo electroporation
Barnabe-Heider F; Meletis K; Eriksson M; Bergmann O; Sabelstrom H; Harvey MA; Mikkers H; Frisen J
Article: DEVELOPMENTAL DYNAMICS. 2007;236(6):1663-1676
Ablation of de novo DNA methyltransferase dnmt3a in the nervous system leads to neuromuscular defects and shortened lifespan
Nguyen' S; Meletis K; Fu D; Jhaveri S; Jaenisch R
Article: EXPERIMENTAL CELL RESEARCH. 2006;312(15):2851-2859
Genetic visualization of neurogenesis
Carlen M; Meletis K; Barnabe-Heider F; Frisen J
Article: EXPERIMENTAL CELL RESEARCH. 2006;312(10):1798-1812
Catalog of gene expression in adult neural stem cells and their in vivo microenvironment
Williams C; Wirta V; Meletis K; Wikstrom L; Carlsson L; Frisen J; Lundeberg J
Article: MOLECULAR AND CELLULAR BIOLOGY. 2006;26(8):2976-2983
Suppression of intestinal neoplasia by deletion of Dnmt3b
Lin HJ; Yamada Y; Nguyen S; Linhart H; Jackson-Grusby L; Meissner A; Meletis K; Lo G; Jaenisch R
Article: DEVELOPMENT. 2006;133(2):363-369
P53 suppresses the self-renewal of adult neural stem cells
Meletis K; Wirta V; Hede SM; Nistér M; Lundeberg J; Frisén J
Article: DEVELOPMENTAL NEUROSCIENCE. 2006;28(1-2):118-127
Recording Notch signaling in real time
Hansson EM; Teixeira AI; Gustafsson MV; Dohda T; Chapman G; Meletis K; Muhr J; Lendahl U
Article: BMC NEUROSCIENCE. 2005;6:28
Transcriptome analysis in primary neural stem cells using a tag cDNA amplification method -: art. no. 28
Sievertzon M; Wirta V; Mercer A; Meletis K; Erlandsson R; Wikström L; Frisén J; Lundeberg J
Show more

All other publications

Preprint: BIORXIV. 2023
Cell type-specific representation of spatial context in the rat prefrontal cortex
Brünner H; Kim H; Ährlund-Richter S; van Lunteren J; Crestani AP; Meletis K; Carlén M
Preprint: BIORXIV. 2023
Recurrent circuits encode visual center-surround computations in the mouse superior colliculus
Cui P; Song K; Mariatos-Metaxas D; Isla A; Femenia T; Lazaridis I; Meletis K; Kumar A; Kardamakis A
Preprint: BIORXIV. 2022
Esr1+ hypothalamic-habenula neurons shape aversive states
Calvigioni D; Fuzik J; Le Merre P; Slashcheva M; Jung F; Ortiz C; Lentini A; Csillag V; Graziano M; Nikolakopoulou I; Weglage M; Lazaridis I; Kim H; Lenzi I; Park H; Reinius B; Carlén M; Meletis K
Preprint: BIORXIV. 2022
Sst+ GPi output neurons provide direct feedback to key nodes of the basal ganglia and drive behavioral flexibility
Weglage M; Ährlund-Richter S; Fuzik J; Skara V; Lazaridis I; Meletis K
Preprint: BIORXIV. 2020
A selective projection from the subthalamic nucleus to parvalbumin-expressing interneurons of the striatum
Kondabolu K; Doig N; Ayeko O; Khan B; Torres A; Calvigioni D; Meletis K; Magill P; Koós T
Preprint: BIORXIV. 2020
Replicability of spatial gene expression atlas data from the adult mouse brain
Lu S; Ortiz C; Fürth D; Fischer S; Meletis K; Zador A; Gillis J
Preprint: BIORXIV. 2020
The spatial landscape of gene expression isoforms in tissue sections
Lebrigand K; Bergenstråhle J; Thrane K; Mollbrink A; Meletis K; Meletis K; Barbry P; Waldmann R; Lundeberg J
Preprint: BIORXIV. 2020
A critical role for trkB signaling in the adult function of parvalbumin interneurons and prefrontal network dynamics
Guyon N; Zacharias LR; van Lunteren JA; Immenschuh J; Fuzik J; Märtin A; Xuan Y; Zilberter M; Kim H; Meletis K; Lopes-Aguiar C; Carlén M
Preprint: BIORXIV. 2020
Complete representation of action space and value in all striatal pathways
Weglage M; Wärnberg E; Lazaridis I; Tzortzi O; Meletis K
Preprint: BIORXIV. 2019
Molecular Atlas of the Adult Mouse Brain
Ortiz C; Navarro JF; Jurek A; Märtin A; Lundeberg J; Meletis K
Preprint: BIORXIV. 2019
Brain-wide genetic mapping identifies the indusium griseum as a prenatal and shared target of pharmacologically-unrelated psychostimulants
Fuzik J; Rehman S; Girach F; Miklosi A; Korchynska S; Arque G; Romanov R; Hanics J; Wagner L; Meletis K; Yanagawa Y; Kovacs G; Alpár A; Hökfelt TGM; Harkany T
Corrigendum: NATURE NEUROSCIENCE. 2019;22(6):1037
A whole-brain atlas of monosynaptic input targeting four different cell types in the medial prefrontal cortex of the mouse (vol 22, pg 657, 2019)
Ahrlund-Richter S; Xuan Y; van Lunteren JA; Kim H; Ortiz C; Dorocic IP; Meletis K; Carlen M
Preprint: BIORXIV. 2019
A Spatiomolecular Map of the Striatum
Märtin A; Calvigioni D; Tzortzi O; Fuzik J; Wärnberg E; Meletis K
Corrigendum: NATURE NEUROSCIENCE. 2018;21(6):895
An interactive framework for whole-brain maps at cellular resolution (vol 21, pg 139, 2018)
Furth D; Vaissiere T; Tzortzi O; Xuan Y; Martin A; Lazaridis I; Spigolon G; Fisone G; Tomer R; Deisseroth K; Carlen M; Miller CA; Rumbaugh G; Meletis K
Corrigendum: NATURE NEUROSCIENCE. 2014;17(12):1840
Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex (vol 15, pg 1022, 2012)
de Anda FC; Rosario AL; Durak O; Tran T; Graeff J; Meletis K; Rei D; Soda T; Madabhushi R; Ginty DD; Kolodkin AL; Tsai L-H
Corrigendum: PLOS ONE. 2014;9(2):e91486
Mice Lacking NMDA Receptors in Parvalbumin Neurons Display Normal Depression-Related Behavior and Response to Antidepressant Action of NMDAR Antagonists (vol 9, e83879, 2014)
Pozzi L; Dorocic PI; Wang X; Carlen M; Meletis K
Thesis / dissertation: 2006
Studies on adult stem cells
Meletis, Konstantinos
Editorial comment: TRENDS IN NEUROSCIENCES. 2003;26(6):292-296
Blood on the tracks:: a simple twist of fate?
Meletis K; Frisén J
Editorial comment: JOURNAL OF CELL BIOLOGY. 2001;155(5):699-702
Have the bloody cells gone to our heads?
Meletis K; Frisén J

Grants

Brain circuits in decision-making
Knut and Alice Wallenberg Foundation
1 January 2020 - 1 January 2025
The organization and function of striatal circuits.
Swedish Research Council
1 January 2019 - 31 December 2024
Brain circuits regulating reward, anhedonia and addiction.
Swedish Research Council
1 January 2018 - 31 December 2021
Development of a whole-brain cellular mapping approach in a genetic model of autism and intellectual disability
National Institute of Mental Health
15 April 2016 - 31 March 2018
Optogenetic dissection of limbic circuits
Swedish Foundation for Strategic Research
1 January 2014 - 31 December 2018
ERA-NET NEURON Mental Disorders RDmaria aDBS
Swedish Research Council
1 January 2014 - 31 December 2016
Optogenetic characterization of limbic circuits for reward and addiction.
Swedish Research Council
1 January 2013 - 31 December 2017

Employments

Professor, Department of Neuroscience, Karolinska Institutet, 2021-2025

Degrees and Education

Docent, Karolinska Institutet, 2015
Doctor Of Philosophy, Department of Cell and Molecular Biology, Karolinska Institutet, 2006
Master Of Medical Science, Karolinska Institutet, 2000

About me

Research

Selected publications

Articles

All other publications

Grants

Employments

Degrees and Education

News from KI

Events from KI