Lina Marcela Diaz-Gallo
Research Specialist
E-mail: lina.diaz@ki.se
Visiting address: D2:01, Karolinska Universitetssjukhuset, 17177 Stockholm
Postal address: K2 Medicin, Solna, K2 Reuma Klareskog L Padyukov L, 171 77 Stockholm
About me
- My research aims to uncover homogenous subgroups of patients with autoimmune
diseases by integrating relevant data domains to contribute to developing
prevention-precision medicine in this field.
I'm specialized in genetics and genomics in the context of autoimmune
diseases. I have experience in applied bioinformatics, designing, leading,
and executing analyses of different data domains to contribute to
translational research. I have mostly used R and Python programming
languages and implemented diverse bioinformatic tools.
I really enjoy interacting with people in different settings, such as our
international and diverse workplace, the Division of Rheumatology [1], where
I have met excellent human beings and scientists. Through teaching, I
contribute to empowering people, which is part of my professional role. I'm
constantly improving and broadening my research and teaching skills. I
organize and teach the basic bioinformatic course [2].
[1] https://ki.se/en/meds/rheumatology
[2] https://kiwas.ki.se/katalog/kursplan/show/4477
Research
- My research line aims to identify and characterize homogenous subgroups of
patients with rheumatic and musculoskeletal diseases (/RMDs/) by integrating
relevant disease data domains, such as genetics, genomics, clinical
variables, and immunological profiles. To achieve that my research is woven
into other study areas such as immunology and epidemiology. I have been
studying rheumatoid arthritis (RA), systemic lupus erythematosus (SLE),
systemic scleroderma (SSc), and idiopathic inflammatory myopathies (IIM).
During my postdoc, I contributed to understanding how gene-gene interactions
are important for the genetic susceptibility and heritability of RA
(pubmed:29967194 [1]). I, together with my collaborators, have demonstrated
that autoantibodies can be used to identify more homogeneous subgroups of
patients with SLE (pubmed: 34658170 [2] pubmed:35315244
[3] pubmed:35642868 [4]) or IIM (pubmed:35315244 [5] preprint [6]), which
differ in genetic risk factors and probably in pathogenic mechanisms.
In collaboration with Associate Professor Karine Chemin [7], we are exploring
the role of T-cells at the site of inflammation of RMDs and aim to integrate
the results from those projects into the subsetting of patients suffering
from RMDs.
[1] https://www.ncbi.nlm.nih.gov/pubmed/?term=Systematic+approach+demonstrates+enrichment+of+multiple+interactions+between+non-HLA+risk+variants+and+HLA-DRB1+risk+alleles+in+rheumatoid+arthritis
[2] https://pubmed.ncbi.nlm.nih.gov/34658170/
[3] https://pubmed.ncbi.nlm.nih.gov/35315244/
[4] https://pubmed.ncbi.nlm.nih.gov/35642868/
[5] https://pubmed.ncbi.nlm.nih.gov/35315244/
[6] https://t.co/bcIwYEhljl
[7] https://staff.ki.se/people/karine-chemin
Teaching
- I am the director of the annual doctoral course in basic bioinformatics [1].
[1] https://kiwas.ki.se/katalog/kursplan/show/4477
Articles
- Article: RHEUMATOLOGY. 2024;63(5):1221-1229
- Article: JOURNAL OF AUTOIMMUNITY. 2024;143:103166
- Article: EMBO MOLECULAR MEDICINE. 2023;15(10):e17240
- Article: EBIOMEDICINE. 2023;96:104804
- Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY (EJE). 2023;38(7):809-819
- Article: JOURNAL OF AUTOIMMUNITY. 2023;136:103022
- Article: RHEUMATOLOGY. 2023;62(2):924-933
- Article: ARTHRITIS & RHEUMATOLOGY. 2022;74(8):1440-1450
- Article: ACR OPEN RHEUMATOLOGY. 2022;4(1):27-39
- Article: ARTHRITIS RESEARCH & THERAPY. 2021;23(1):46
- Article: PLOS ONE. 2021;16(4):e0250282
- Article: SCIENTIFIC REPORTS. 2019;9(1):18633
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2018;77(10):1454-1462
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2018;48(4):655-669
- Article: ARTHRITIS RESEARCH & THERAPY. 2017;19(1):19
- Article: MOLECULAR MEDICINE. 2016;22:322-328
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2015;125(12):4612-4624
- Article: CLINICAL IMMUNOLOGY. 2015;158(1):19-28
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2013;72(12):2032-2038
- Article: HUMAN MOLECULAR GENETICS. 2013;22(19):4021-4029
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2013;72(7):1233-1238
- Article: PLOS ONE. 2013;8(4):e60646
- Article: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2012;30(4):520-524
- Article: INFLAMMATORY BOWEL DISEASES. 2012;18(2):305-311
- Article: GENES AND IMMUNITY. 2011;12(8):635-642
- Article: INFLAMMATORY BOWEL DISEASES. 2011;17(11):2287-2294
- Article: HUMAN IMMUNOLOGY. 2011;72(10):969-972
- Article: PLOS GENETICS. 2011;7(7):e1002178
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2011;70(3):454-462
- Journal article: JOURNAL OF TRANSLATIONAL MEDICINE. 2010;8(Suppl 1):p2
- Article: REUMATOLOGIA CLINICA. 2010;6 Suppl 2:12-15
- Article: PLOS ONE. 2010;5(7):e11520
- Article: JOURNAL OF RHEUMATOLOGY. 2010;37(5):1016-1019
- Article: HUMAN IMMUNOLOGY. 2010;71(5):515-519
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2010;69(2):462-465
- Journal article: JOURNAL OF TRANSLATIONAL MEDICINE. 2010;8(Suppl 1):o1
- Article: AUTOIMMUNITY REVIEWS. 2008;7(4):322-330
- Show more
All other publications
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2023;31:311-312
- Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2022;81:658-659
- Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2022;81:178
- Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2022;81:104-105
- Conference publication: ARTHRITIS & RHEUMATOLOGY. 2015;67
- Editorial comment: GENOME MEDICINE. 2012;4(2):13
- Letter: ANNALS OF THE RHEUMATIC DISEASES. 2012;71(2):314-316
- Editorial comment: EXPERT REVIEW OF CLINICAL IMMUNOLOGY. 2012;8(2):107-109
- Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2009;1173:589-599