Team Per-Johan Jakobsson
We aim to explore targets and pathways in rheumatic and related diseases driven by inflammation using a pharmacological approach.
Translational inflammation research
We focus on the arachidonic acid cascade and the development of mPGES-1 inhibitors. We also investigate biomarkers in rheumatoid arthritis and systemic autoimmune inflammatory diseases and investigate e.g. the pathophysiological role of associated antigens and autoantibodies. Analytically, we e.g. perform proteomics, lipid metabolomics and cytokine profiling.
Ongoing collaboration with Guangdong Provincial Hospital of Chinese Medicine
There is growing interest in society and in the scientific community to decipher the mechanisms of action of plant-based traditional Chinese medicine using evidence-
based research methods. For this, we have established a research project called Joint Research Base for Chinese Medicine (JRBCM) at KI. The overall aim of JRBCM is to explore Chinese traditional herbal-based medicine as a source for evidence based drug discovery and development. The JRBCM will assess the large amount of existing clinical data and explore the vast and unique resource of Chinese traditional medicine, with the ultimate aim of drug discovery and drug development for clinical use. The research is focused on isolation of bioactive compounds, exploration of their modes of action alone or in combinations, and ultimately development of novel medication for the treatment of and possibly prevention of rheumatoid arthritis.
Team
Per-Johan Jakobsson
Professor/forskargruppsledare.- Erdem Aybay, PhD student
- Louise Berg, Senior lab manager
- Emma Birgersson Wettersand, PhD student
- Sanjaykumar Boddul, Laboratory manager
- Louisa Brieskorn, Laboratory technician
- Iro Chaitoglou, Affiliated to research
- Aikaterini Chatzidionysiou, Affiliated to research
- Charlotte Edenius, Affiliated to research
- Anna Ulrika Hofling, Affiliated to research
- Helena Idborg, Laboratory coordinator
- Jinjing Jia, Affiliated to research
- Marina Korotkova, Researcher
- Karin Larsson, Senior research specialist
- Matina Liapi, PhD student
- Jianyang Liu, PhD student
- Malena Loberg-Haarhaus, affiliated to research
- Liyan Mei, Affiliated to research
- Stina Nordman, Coordinator
- Julia Norkko, Biomedical scientist
- Lucymary Okechukwu, Biomedical scientist
- Hamed Rezaei, Affiliated to research
- Sabreen S.H. Alabbasi, Labaratory technician
- Julia Steinmetz Späh, PhD student
- Ronald van Vollenhoven, Affiliated to research
- Mirjam de Vries, Affiliated to research
- Janika Welzel, PhD student
- Franziska Wrobel, Affiliated to research
- Ahlem Zaghmi, Postdoc
PhD theses from the group
- Julia Steinmetz-Späh, 2023 https://openarchive.ki.se/xmlui/handle/10616/48324
- Charlotta Preger, 2022 https://openarchive.ki.se/xmlui/handle/10616/48069
- Filip Bergqvist, 2019 https://openarchive.ki.se/xmlui/handle/10616/46768
- Joan Raouf, 2017 https://openarchive.ki.se/xmlui/handle/10616/45508
- Cátia Cerqueira, 2016 https://openarchive.ki.se/xmlui/handle/10616/44960
- Patrick Leclerc, 2012 https://openarchive.ki.se/xmlui/handle/10616/41554
- Hanna Eriksson, 2011 https://openarchive.ki.se/xmlui/handle/10616/40473
- Karina Gheorghe, 2010 https://openarchive.ki.se/xmlui/handle/10616/40276
- Sven-Christian Pawelzik, 2010 https://openarchive.ki.se/xmlui/handle/10616/40357
- Sipra Saha, 2006 https://openarchive.ki.se/xmlui/handle/10616/38943
- Marie Westman, 2005 https://openarchive.ki.se/xmlui/handle/10616/43487
- Staffan Thorén, 2003 https://openarchive.ki.se/xmlui/handle/10616/38540