Per-Johan Jakobsson

Publications
CV
Public outreach and news

Articles

Article: NATURE NEUROSCIENCE. 2024;27(8):1534-1544
NG2 glia protect against prion neurotoxicity by inhibiting microglia-to-neuron prostaglandin E2 signaling
Liu Y; Guo J; Matoga M; Korotkova M; Jakobsson P-J; Aguzzi A
Article: ARTHRITIS RESEARCH & THERAPY. 2024;26(1):61
Urinary prostanoids are elevated by anti-TNF and anti-IL6 receptor disease-modifying antirheumatic drugs but are not predictive of response to treatment in early rheumatoid arthritis
Liu J; Idborg H; Korotkova M; Lend K; van Vollenhoven R; Lampa J; Rudin A; Nordstrom D; Gudbjornsson B; Grondal G; Uhlig T; Horslev-Petersen K; Merete HL; Ostergaard M; Nurmohamed M; Jakobsson P-J
Article: ANNALS OF THE RHEUMATIC DISEASES. 2024;83(3):277-287
In early rheumatoid arthritis, anticitrullinated peptide antibodies associate with low number of affected joints and rheumatoid factor associates with systemic inflammation
Pertsinidou E; Saevarsdottir S; Manivel VA; Klareskog L; Alfredsson L; Mathsson-Alm L; Hansson M; Cornillet M; Serre G; Holmdahl R; Skriner K; Jakobsson P-J; Westerlind H; Askling J; Roennelid J
Article: MOLECULAR ONCOLOGY. 2024;18(2):317-335
High-content screening of drug combinations of an mPGES-1 inhibitor in multicellular tumor spheroids leads to mechanistic insights into neuroblastoma chemoresistance
Zaghmi A; Aybay E; Jiang L; Shang M; Steinmetz-Spah J; Wermeling F; Kogner P; Korotkova M; Ostling P; Jakobsson P-J; Seashore-Ludlow B; Larsson K
Article: FRONTIERS IN IMMUNOLOGY. 2024;15:1372927
High-mannose glycans from Schistosoma mansoni eggs are important for priming of Th2 responses via Dectin-2 and prostaglandin E2
Almeida L; van Roey R; Patente TA; Otto F; Veldhuizen T; Ghorasaini M; van Diepen A; Schramm G; Liu J; Idborg H; Korotkova M; Jakobsson P-J; Giera M; Hokke CH; Everts B
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2023;180(15):1981-1998
Microsomal prostaglandin E synthase-1 inhibition prevents adverse cardiac remodelling after myocardial infarction in mice
Zhang Y; Steinmetz-Spah J; Idborg H; Zhu L; Li H; Rao H; Chen Z; Guo Z; Hu L; Xu C; Chen H; Korotkova M; Jakobsson P-J; Wang M
Article: PROSTAGLANDINS AND OTHER LIPID MEDIATORS. 2023;167:106738
Microsomal prostaglandin E synthase-1 inhibition promotes shunting in arachidonic acid metabolism during inflammatory responses in vitro
Liu J; Peng B; Steinmetz-Spah J; Idborg H; Korotkova M; Jakobsson P-J
Article: JOURNAL OF AUTOIMMUNITY. 2023;134:102951
Autoantigenic properties of the aminoacyl tRNA synthetase family in idiopathic inflammatory myopathies
Preger C; Notarnicola A; Hellstrom C; Wigren E; Fernandes-Cerqueira C; Kvarnstrom M; Wahren-Herlenius M; Idborg H; Lundberg IE; Persson H; Graslund S; Jakobsson P-J
Article: JOURNAL OF LIPID RESEARCH. 2022;63(12):100310
Biosynthesis of prostaglandin 15dPGJ₂ -glutathione and 15dPGJ₂-cysteine conjugates in macrophages and mast cells via MGST3
Steinmetz-Spah J; Liu J; Singh R; Ekoff M; Boddul S; Tang X; Bergqvist F; Idborg H; Heitel P; Ronnberg E; Merk D; Wermeling F; Haeggstrom JZ; Nilsson G; Steinhilber D; Larsson K; Korotkova M; Jakobsson P-J
Article: JOURNAL OF AUTOIMMUNITY. 2022;133:102903
Autoantibodies targeting malondialdehyde-modifications in rheumatoid arthritis regulate osteoclasts via inducing glycolysis and lipid biosynthesis
Sakuraba K; Krishnamurthy A; Sun J; Zheng X; Xu C; Peng B; Engstrom M; Jakobsson P-J; Wermeling F; Catrina S; Gronwall C; Catrina AI; Rethi B
Article: EMBO REPORTS. 2022;23(5):e54096
Helminthic dehydrogenase drives PGE₂ and IL-10 production in monocytes to potentiate Treg induction
Prodjinotho UF; Gres V; Henkel F; Lacorcia M; Dandl R; Haslbeck M; Schmidt V; Winkler AS; Sikasunge C; Jakobsson P-J; Henneke P; Bieren JE-V; da Costa CP
Article: LIFE SCIENCES. 2022;295:120394
Omega-3 fatty acids decrease CRYAB, production of oncogenic prostaglandin E₂ and suppress tumor growth in medulloblastoma
Ljungblad L; Bergqvist F; Tummler C; Madawala S; Olsen TK; Andonova T; Jakobsson P-J; Johnsen JI; Pickova J; Strandvik B; Kogner P; Gleissman H; Wickstrom M
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2022;179(7):1433-1449
Effects of microsomal prostaglandin E synthase-1 inhibition on resistance artery tone in patients with end stage kidney disease
Steinmetz-Spah J; Arefin S; Larsson K; Jahan J; Mudrovcic N; Wennberg L; Stenvinkel P; Korotkova M; Kublickiene K; Jakobsson P-J
Article: ARTHRITIS RESEARCH & THERAPY. 2022;24(1):62
Longitudinal assessment of reactivity and affinity profile of anti-Jo1 autoantibodies to distinct HisRS domains and a splice variant in a cohort of patients with myositis and anti-synthetase syndrome
Notarnicola A; Preger C; Lundstrom SL; Renard N; Wigren E; Van Gompel E; Galindo-Feria AS; Persson H; Fathi M; Grunewald J; Jakobsson P-J; Graslund S; Lundberg IE; Fernandes-Cerqueira C
Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2021;50(6):479-484
Temperature response to cold challenge and mobile phone thermography as outcome measures for systemic sclerosis-related Raynaud's phenomenon
Herrick AL; Heal C; Wilkinson J; Dinsdale G; Manning J; Gunnarsson K; Jakobsson P-J; Murray A
Article: CELLULAR AND MOLECULAR IMMUNOLOGY. 2021;18(6):1463-1475
Serum-circulating His-tRNA synthetase inhibits organ-targeted immune responses
Adams RA; Fernandes-Cerqueira C; Notarnicola A; Mertsching E; Xu Z; Lo W-S; Ogilvie K; Chiang KP; Ampudia J; Rosengren S; Cubitt A; King DJ; Mendlein JD; Yang X-L; Nangle LA; Lundberg IE; Jakobsson P-J; Schimmel P
Article: EMBO REPORTS. 2021;22(3):e51329
Phosphodiesterase 4A confers resistance to PGE2-mediated suppression in CD25⁺/CD54⁺ NK cells
Chen Z; Yang Y; Neo SY; Shi H; Chen Y; Wagner AK; Larsson K; Tong L; Jakobsson P-J; Alici E; Wu J; Cao Y; Wang K; Liu LL; Mao Y; Sarhan D; Lundqvist A
Article: TRANSLATIONAL RESEARCH. 2021;229:69-82
Identifying novel B-cell targets for chronic inflammatory autoimmune disease by screening of chemical probes in a patient-derived cell assay
Sundstrom Y; Shang M-M; Panda SK; Gronwall C; Wermeling F; Gunnarsson I; Lundberg IE; Sundstrom M; Jakobsson P-J; Berg L
Article: CELL DEATH AND DISEASE. 2021;12(2):135
Inhibition of mPGES-1 attenuates efficient resolution of acute inflammation by enhancing CX3CL1 expression
Rappl P; Roesser S; Maul P; Bauer R; Huard A; Schreiber Y; Thomas D; Geisslinger G; Jakobsson P-J; Weigert A; Bruene B; Schmid T
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2020;295(41):13981-13993
Generation and validation of recombinant antibodies to study human aminoacyl-tRNA synthetases
Preger C; Wigren E; Ossipova E; Marks C; Lengqvist J; Hofstrom C; Andersson O; Jakobsson P-J; Graslund S; Persson H
Article: ARTHRITIS & RHEUMATOLOGY. 2020;72(10):1658-1667
Anti-Citrullinated Protein Antibody Specificities, Rheumatoid Factor Isotypes, and Incident Cardiovascular Events in Patients With Rheumatoid Arthritis
Westerlind H; Ronnelid J; Hansson M; Alfredsson L; Mathsson-Alm L; Serre G; Cornillet M; Holmdahl R; Jakobsson P-J; Skriner K; Klareskog L; Saevarsdottir S; Askling J
Article: CARDIOVASCULAR RESEARCH (CVR). 2020;116(12):1972-1980
Mechanistic definition of the cardiovascular mPGES-1/COX-2/ADMA axis
Kirkby NS; Raouf J; Ahmetaj-Shala B; Liu B; Mazi SI; Edin ML; Chambers MG; Korotkova M; Wang X; Wahli W; Zeldin DC; Nusing R; Zhou Y; Jakobsson P-J; Mitchell JA
Article: PHYTOCHEMISTRY LETTERS. 2020;38:6-11
Bisabolane sesquiterpenes from the leaves of Lindera benzoin reduce prostaglandin E2 formation in A549 cells
Ryen AH; Goels T; Steinmetz J; Tahir A; Jakobsson P-J; Backlund A; Urban E; Glasl S
Article: THE FASEB JOURNAL. 2020;34(8):11101-11114
Establishment of an in vitro 3D model for neuroblastoma enables preclinical investigation of combined tumor-stroma drug targeting
Kock A; Bergqvist F; Steinmetz J; Elfman LHM; Korotkova M; Johnsen JI; Jakobsson P-J; Kogner P; Larsson K
Article: ACS OMEGA. 2020;5(28):17242-17254
Descriptive Proteome Analysis to Investigate Context-Dependent Treatment Responses to OXPHOS Inhibition in Colon Carcinoma Cells Grown as Monolayer and Multicellular Tumor Spheroids
Steinmetz J; Senkowski W; Lengqvist J; Rubin J; Ossipova E; Herman S; Larsson R; Jakobsson P-J; Fryknas M; Kultima K
Article: ARTHRITIS RESEARCH & THERAPY. 2020;22(1):170
Presence of autoantibodies in "seronegative" rheumatoid arthritis associates with classical risk factors and high disease activity
Reed E; Hedstrom AK; Hansson M; Mathsson-Alm L; Brynedal B; Saevarsdottir S; Cornillet M; Jakobsson P-J; Holmdahl R; Skriner K; Serre G; Alfredsson L; Ronnelid J; Lundberg K
Article: SCIENCE TRANSLATIONAL MEDICINE. 2020;12(540):eaay0605
An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products
Jimenez MDLR; Lechner A; Alessandrini F; Bohnacker S; Schindela S; Trompette A; Haimerl P; Thomas D; Henkel F; Mourao A; Geerlof A; da Costa CP; Chaker AM; Bruene B; Nuesing R; Jakobsson P-J; Nockher WA; Feige MJ; Haslbeck M; Ohnmacht C; Marsland BJ; Voehringer D; Harris NL; Schmidt-Weber CB; Esser-von Bieren J
Article: FRONTIERS IN MEDICINE. 2020;7:484
Chinese Herbal Formula Huayu-Qiangshen-Tongbi Decoction Compared With Leflunomide in Combination With Methotrexate in Patients With Active Rheumatoid Arthritis: An Open-Label, Randomized, Controlled, Pilot Study
Wu J; Chen X; Lv Y; Gao K; Liu Z; Zhao Y; Chen X; He X; Chu Y; Wu X; Ou A; Wen Z; Zhang J; Peng J; Huang Z; Jakobsson P-J; Huang Q; Huang R
Article: FRONTIERS IN PHARMACOLOGY. 2020;11:613
Anti-Inflammatory Properties of Chemical Probes in Human Whole Blood: Focus on Prostaglandin E₂ Production
Bergqvist F; Sundstrom Y; Shang M-M; Gunnarsson I; Lundberg IE; Sundstrom M; Jakobsson P-J; Berg L
Article: FRONTIERS IN IMMUNOLOGY. 2020;11:585282
Extracellular miR-574-5p Induces Osteoclast Differentiation via TLR 7/8 in Rheumatoid Arthritis
Hegewald AB; Breitwieser K; Ottinger SM; Mobarrez F; Korotkova M; Rethi B; Jakobsson P-J; Catrina AI; Wahamaa H; Saul MJ
Article: ARTHRITIS & RHEUMATOLOGY. 2020;72(1):179-191
Proinflammatory Histidyl-Transfer RNA Synthetase-Specific CD4+T Cells in the Blood and Lungs of Patients With Idiopathic Inflammatory Myopathies
Galindo-Feria AS; Albrecht I; Fernandes-Cerqueira C; Notarnicola A; James EA; Herrath J; Dastmalchi M; Sandalova T; Ronnblom L; Jakobsson P-J; Fathi M; Achour A; Grunewald J; Malmstrom V; Lundberg IE
Article: BIOMEDICINE & PHARMACOTHERAPY. 2020;121:109581
Microsomal prostaglandin E synthase-1 promotes lung metastasis via SDF-1/CXCR4-mediated recruitment of CD11b⁺Gr1⁺MDSCs from bone marrow
Takahashi R; Amano H; Ito Y; Eshima K; Satoh T; Iwamura M; Nakamura M; Kitasato H; Uematsu S; Raouf J; Jakobsson P-J; Akira S; Majima M
Article: FRONTIERS IN PHARMACOLOGY. 2020;11:196
Proteomics-Based Characterization of miR-574-5p Decoy to CUGBP1 Suggests Specificity for mPGES-1 Regulation in Human Lung Cancer Cells
Emmerich AC; Wellstein J; Ossipova E; Baumann I; Lengqvists J; Kultima K; Jakobsson P-J; Steinhilber D; Saul MJ
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2019;176(24):4625-4638
Biological characterization of new inhibitors of microsomal PGE synthase-1 in preclinical models of inflammation and vascular tone
Larsson K; Steinmetz J; Bergqvist F; Arefin S; Spahiu L; Wannberg J; Pawelzik S-C; Morgenstern R; Stenberg P; Kublickiene K; Korotkova M; Jakobsson P-J
Article: PROSTAGLANDINS AND OTHER LIPID MEDIATORS. 2019;145:106361
Urinary prostaglandin D₂ and E₂ metabolites associate with abdominal obesity, glucose metabolism, and triglycerides in obese subjects
Pawelzik S-C; Avignon A; Idborg H; Boegner C; Stanke-Labesque F; Jakobsson P-J; Sultan A; Back M
Article: ACTA PAEDIATRICA, INTERNATIONAL JOURNAL OF PAEDIATRICS. 2019;108(10):1879-1886
Urinary PGE₂ metabolite levels in hospitalised infants with infections compared to age-matched controls
Hamrin J; Perez-Manzo M; Idborg H; Jakobsson P-J; Bjork L; Eriksson M; Nilsson A; Herlenius E
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2019;105(3):616-624
Distinct HLA Associations with Rheumatoid Arthritis Subsets Defined by Serological Subphenotype
Terao C; Brynedal B; Chen Z; Jiang X; Westerlind H; Hansson M; Jakobsson P-J; Lundberg K; Skriner K; Serre G; Ronnelid J; Mathsson-Alm L; Brink M; Dahlqvist SR; Padyukov L; Gregersen PK; Barton A; Alfredsson L; Klareskog L; Raychaudhuri S
Article: INTERNATIONAL JOURNAL OF OBESITY. 2019;43(9):1724-1734
Inflammation increases MMP levels via PGE₂ in human vascular wall and plasma of obese women
Ozen G; Boumiza S; Deschildre C; Topal G; Longrois D; Jakobsson PJ; Michel JB; Jacob MP; Chahed K; Norel X
Article: NATURE GENETICS. 2019;51(7):1082-1091
A genetics-led approach defines the drug target landscape of 30 immune-related traits
Fang H; Beckmann G; Bountra C; Bowness P; Burgess-Brown N; Carpenter L; Chen L; Damerell D; Egner U; Fujii R; Howe T; Jakobsson P-J; Katopodis A; Knight JC; Marsden BD; De Martino J; Matthias G; McVean G; Mueller-Fahrnow A; Malarstig A; O'Callaghan CA; Ostermann N; Paez-cortez JR; Peeters PJ; Prinz F; Soulard P; Sundstrom M; Yabuki C; Vlach J; De Wolf H; Knezevic B; Burnham KL; Osgood J; Sanniti A; Lara AL; Kasela S; De Cesco S; Wegner JK; Handunnetthi L; McCann FE; Sekine T; Brennan PE; Sundstrom Y; Milani L; Berg L; Gohlmann HW; Fairfax BP
Article: THE FASEB JOURNAL. 2019;33(6):6933-6947
miR-574-5p as RNA decoy for CUGBP1 stimulates human lung tumor growth by mPGES-1 induction
Saul MJ; Baumann I; Bruno A; Emmerich AC; Wellstein J; Ottinger SM; Contursi A; Dovizio M; Donnini S; Tacconelli S; Raouf J; Idborg H; Stein S; Korotkova M; Savai R; Terzuoli E; Sala G; Seeger W; Jakobsson P-J; Patrignani P; Suess B; Steinhilber D
Article: ARTHRITIS RESEARCH & THERAPY. 2019;21(1):74
Divergent roles of prostacyclin and PGE₂ in human tendinopathy
Bergqvist F; Carr AJ; Wheway K; Watkins B; Oppermann U; Jakobsson P-J; Dakin SG
Article: JOURNAL OF PROTEOME RESEARCH. 2019;18(3):1208-1217
Cytokine Profiles in Autoantibody Defined Subgroups of Systemic Lupus Erythematosus
Torell F; Eketjall S; Idborg H; Jakobsson P-J; Gunnarsson I; Svenungsson E; Trygg J
Article: ARTHRITIS RESEARCH & THERAPY. 2019;21(1):62
Two subgroups in systemic lupus erythematosus with features of antiphospholipid or Sjogren's syndrome differ in molecular signatures and treatment perspectives
Idborg H; Zandian A; Sandberg A-S; Nilsson B; Elvin K; Truedsson L; Sohrabian A; Ronnelid J; Mo J; Grosso G; Kvarnstrom M; Gunnarsson I; Lehtio J; Nilsson P; Svenungsson E; Jakobsson P-J
Article: ARTHRITIS RESEARCH & THERAPY. 2019;21(1):60
Mass spectrometry-based analysis of cerebrospinal fluid from arthritis patients-immune-related candidate proteins affected by TNF blocking treatment
Estelius J; Lengqvist J; Ossipova E; Idborg H; Le Maitre E; Andersson MLA; Brundin L; Khademi M; Svenungsson E; Jakobsson P-J; Lampa J
Article: JOURNAL OF PROTEOMICS. 2019;190:67-76
The human CSF pain proteome
Khoonsari PE; Ossipova E; Lengqvist J; Svensson CI; Kosek E; Kadetoff D; Jakobsson P-J; Kultima K; Lampa J
Article: FRONTIERS IN PHARMACOLOGY. 2019;10:640
Mass Spectrometry-Based Proteomics Approach Characterizes the Dual Functionality of miR-328 in Monocytes
Saul MJ; Hegewald AB; Emmerich AC; Ossipova E; Vogel M; Baumann I; Kultima K; Lengqivst J; Steinhilber D; Jakobsson PJ
Article: FRONTIERS IN PHARMACOLOGY. 2019;10:636
Inhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells
Bergqvist F; Ossipova E; Idborg H; Raouf J; Checa A; Englund K; Englund P; Khoonsari PE; Kultima K; Wheelock CE; Larsson K; Korotkova M; Jakobsson P-J
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1029
Circulating Levels of Interferon Regulatory Factor-5 Associates With Subgroups of Systemic Lupus Erythematosus Patients
Idborg H; Zandian A; Ossipova E; Wigren E; Preger C; Mobarrez F; Checa A; Sohrabian A; Pucholt P; Sandling JK; Fernandes-Cerqueira C; Ronnelid J; Oke V; Grosso G; Kvarnstrom M; Larsson A; Wheelock CE; Syvanen A-C; Ronnblom L; Kultima K; Persson H; Graslund S; Gunnarsson I; Nilsson P; Svenungsson E; Jakobsson P-J
Article: FRONTIERS IN MICROBIOLOGY. 2019;10:3121
sRNA scr5239 Involved in Feedback Loop Regulation of Streptomyces coelicolor Central Metabolism
Engel F; Ossipova E; Jakobsson P-J; Vockenhuber M-P; Suess B
Article: JOURNAL OF HEPATOLOGY. 2018;69(1):110-120
Inhibition of microsomal prostaglandin E synthase-1 facilitates liver repair after hepatic injury in mice
Nishizawa N; Ito Y; Eshima K; Ohkubo H; Kojo K; Inoue T; Raouf J; Jakobsson P-J; Uematsu S; Akira S; Narumiya S; Watanabe M; Majima M
Article: ACS CHEMICAL BIOLOGY. 2018;13(6):1525-1535
Stabilized Cyclic Peptides as Scavengers of Autoantibodies: Neutralization of Anticitrullinated Protein/Peptide Antibodies in Rheumatoid Arthritis
Gunasekera S; Fernandes-Cerqueira C; Wennmalm S; Wahamaa H; Sommarin Y; Catrina AI; Jakobsson P-J; Goransson U
Article: EBIOMEDICINE. 2018;32:84-92
Inhibition of Microsomal Prostaglandin E Synthase-1 in Cancer-Associated Fibroblasts Suppresses Neuroblastoma Tumor Growth
Kock A; Larsson K; Bergqvist F; Eissler N; Elfman LHM; Raouf J; Korotkova M; Johnsen JI; Jakobsson P-J; Kogner P
Article: ARTHRITIS RESEARCH & THERAPY. 2018;20(1):83
Targeted lipidomics analysis identified altered serum lipid profiles in patients with polymyositis and dermatomyositis
Raouf J; Idborg H; Englund P; Alexanderson H; Dastmalchi M; Jakobsson P-J; Lundberg IE; Korotkova M
Article: ANNALS OF THE RHEUMATIC DISEASES. 2018;77(2):203-211
Anticitrullinated protein/peptide antibody multiplexing defines an extended group of ACPA-positive rheumatoid arthritis patients with distinct genetic and environmental determinants
Ronnelid J; Hansson M; Mathsson-Alm L; Cornillet M; Reed E; Jakobsson P-J; Alfredsson L; Holmdahl R; Skriner K; Serre G; Lundberg K; Klareskog L
Article: PLOS ONE. 2018;13(2):e0193210
Microsomal prostaglandin E synthase-1 gene deletion impairs neuro-immune circuitry of the cholinergic anti-inflammatory pathway in endotoxaemic mouse spleen
Revathikumar P; Estelius J; Karmakar U; Le Maitre E; Korotkova M; Jakobsson P-J; Lampa J
Article: THERANOSTICS. 2018;8(16):4477-4490
Integration of magnetic resonance imaging and protein and metabolite CSF measurements to enable early diagnosis of secondary progressive multiple sclerosis
Herman S; Khoonsari PE; Tolf A; Steinmetz J; Zetterberg H; Akerfeldt T; Jakobsson P-J; Larsson A; Spjuth O; Burman J; Kultima K
Article: LUPUS SCIENCE AND MEDICINE. 2018;5(1):e000260
TNF-α and plasma albumin as biomarkers of disease activity in systemic lupus erythematosus
Idborg H; Eketjall S; Pettersson S; Gustafsson JT; Zickert A; Kvarnstrom M; Oke V; Jakobsson P-J; Gunnarsson I; Svenungsson E
Article: LUPUS SCIENCE AND MEDICINE. 2018;5(1):e000254
Kynurenine pathway is altered in patients with SLE and associated with severe fatigue
Akesson K; Pettersson S; Stahl S; Surowiec IM; Hedenstrom M; Eketjall S; Trygg J; Jakobsson P-J; Gunnarsson I; Svenungsson E; Idborg H
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2017;174(22):4087-4098
Inhibition of microsomal PGE synthase-1 reduces human vascular tone by increasing PGI₂: a safer alternative to COX-2 inhibition
Ozen G; Gomez I; Daci A; Deschildre C; Boubaya L; Teskin O; Uydes-Dogan BS; Jakobsson P-J; Longrois D; Topal G; Norel X
Article: LUPUS. 2017;26(10):1023-1033
Dysregulations in circulating sphingolipids associate with disease activity indices in female patients with systemic lupus erythematosus: a cross-sectional study
Checa A; Idborg H; Zandian A; Sar DG; Surowiec I; Trygg J; Svenungsson E; Jakobsson P-J; Nilsson P; Gunnarsson I; Wheelock CE
Article: METABOLOMICS. 2017;13(10):114
Multivariate strategy for the sample selection and integration of multi-batch data in metabolomics
Surowiec I; Johansson E; Torell F; Idborg H; Gunnarsson I; Svenungsson E; Jakobsson P-J; Trygg J
Article: ARTHRITIS & RHEUMATOLOGY. 2017;69(1):58-69
Differences in the Spectrum of Anti-Citrullinated Protein Antibody Fine Specificities Between Malaysian and Swedish Patients With Rheumatoid Arthritis: Implications for Disease Pathogenesis
Too CL; Murad S; Hansson M; Alm LM; Dhaliwal JS; Holmdahl R; Jakobsson P-J; Alfredsson L; Klareskog L; Ronnelid J; Padyukov L
Article: CLINICAL SCIENCE. 2016;130(24):2295-2303
Deletion of mPGES-1 affects platelet functions in mice
Raouf J; Mobarrez F; Larsson K; Jakobsson P-J; Korotkova M
Article: JOURNAL OF NEUROINFLAMMATION. 2016;13(1):256
Immunomodulatory effects of nicotine on interleukin 1β activated human astrocytes and the role of cyclooxygenase 2 in the underlying mechanism
Revathikumar P; Bergqvist F; Gopalakrishnan S; Korotkova M; Jakobsson P-J; Lampa J; Le Maitre E
Article: SCIENTIFIC REPORTS. 2016;6:31995
UPF1 regulates myeloid cell functions and S100A9 expression by the hnRNP E2/miRNA-328 balance
Saul MJ; Stein S; Grez M; Jakobsson P-J; Steinhilber D; Suess B
Article: ARTHRITIS & RHEUMATOLOGY. 2016;68(7):1738-1750
Endurance Exercise Improves Molecular Pathways of Aerobic Metabolism in Patients With Myositis
Munters LA; Loell I; Ossipova E; Raouf J; Dastmalchi M; Lindroos E; Chen Y-W; Esbjornsson M; Korotkova M; Alexanderson H; Nagaraju K; Crofford LJ; Jakobsson P-J; Lundberg IE
Article: ANNALS OF THE RHEUMATIC DISEASES. 2016;75(4):730-738
Autoantibodies to citrullinated proteins induce joint pain independent of inflammation via a chemokine-dependent mechanism
Wigerblad G; Bas DB; Fernades-Cerqueira C; Krishnamurthy A; Nandakumar KS; Rogoz K; Kato J; Sandor K; Su J; Miguel Jimenez-Andrade J; Finn A; Farinotti AB; Amara K; Lundberg K; Holmdahl R; Jakobsson P-J; Malmstrom V; Catrina AI; Klareskog L; Svensson CI
Article: ANNALS OF THE RHEUMATIC DISEASES. 2016;75(4):721-729
Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss
Krishnamurthy A; Joshua V; Hensvold AH; Jin T; Sun M; Vivar N; Ytterberg AJ; Engstrom M; Fernandes-Cerqueira C; Amara K; Magnusson M; Wigerblad G; Kato J; Jimenez-Andrade JM; Tyson K; Rapecki S; Lundberg K; Catrina S-B; Jakobsson P-J; Svensson C; Malmstrom V; Klareskog L; Wahamaa H; Catrina AI
Article: SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES. 2016;33(1):17-28
ALTERATIONS IN THE MEMBRANE-ASSOCIATED PROTEOME FRACTION OF ALVEOLAR MACROPHAGES IN SARCOIDOSIS
Kjellin H; Silva E; Branca RM; Eklund A; Jakobsson P-J; Grunewald J; Lehtio J; Wheelock AM
Article: PLOS ONE. 2016;11(9):e0163600
Arg126 and Asp49 Are Essential for the Catalytic Function of Microsomal Prostaglandin E₂ Synthase 1 and Ser127 Is Not
Raouf J; Rafique N; Goodman MC; Idborg H; Bergqvist F; Armstrong RN; Jakobsson P-J; Morgenstern R; Spahiu L
Article: PLOS ONE. 2016;11(4):e0153751
Prostaglandin E₂ Exerts Multiple Regulatory Actions on Human Obese Adipose Tissue Remodeling, Inflammation, Adaptive Thermogenesis and Lipolysis
Garcia-Alonso V; Titos E; Alcaraz-Quiles J; Rius B; Lopategi A; Lopez-Vicario C; Jakobsson P-J; Delgado S; Lozano J; Claria J
Article: PLOS ONE. 2016;11(3):e0152116
Structural and Functional Analysis of Calcium Ion Mediated Binding of 5-Lipoxygenase to Nanodiscs
Kumar RB; Zhu L; Idborg H; Radmark O; Jakobsson P-J; Rinaldo-Matthis A; Hebert H; Jegerschold C
Article: ANNALS OF THE RHEUMATIC DISEASES. 2015;74(9):1772-1777
Shared immunological targets in the lungs and joints of patients with rheumatoid arthritis: identification and validation
Ytterberg AJ; Joshua V; Reynisdottir G; Tarasova NK; Rutishauser D; Ossipova E; Hensvold AH; Eklund A; Skold CM; Grunewald J; Malmstrom V; Jakobsson PJ; Ronnelid J; Padyukov L; Zubarev RA; Klareskog L; Catrina AI
Article: PROSTAGLANDINS AND OTHER LIPID MEDIATORS. 2015;121(Pt B):155-162
Impaired vagus-mediated immunosuppression in microsomal prostaglandin E synthase-1 deficient mice
Le Maitre E; Revathikumar P; Idborg H; Raouf J; Korotkova M; Jakobsson P-J; Lampa J
Article: PROSTAGLANDINS AND OTHER LIPID MEDIATORS. 2015;120:161-165
Inhibition of microsomal prostaglandin E synthase-1 as targeted therapy in cancer treatment
Larsson K; Jakobsson P-J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(26):8070-8075
COX/mPGES-1/PGE₂ pathway depicts an inflammatory-dependent high-risk neuroblastoma subset
Larsson K; Kock A; Idborg H; Henriksson MA; Martinsson T; Johnsen JI; Korotkova M; Kogner P; Jakobsson P-J
Article: ARTHRITIS RESEARCH & THERAPY. 2015;17(1):155
Targeting of anti-citrullinated protein/peptide antibodies in rheumatoid arthritis using peptides mimicking endogenously citrullinated fibrinogen antigens
Fernandes-Cerqueira C; Ossipova E; Gunasekera S; Hansson M; Mathsson L; Catrina AI; Sommarin Y; Klareskog L; Lundberg K; Ronnelid J; Goransson U; Jakobsson P-J
Article: ONCOTARGET. 2015;6(12):10284-10296
MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer
Olesch C; Sha W; Angioni C; Sha LK; Acaf E; Patrignani P; Jakobsson P-J; Radeke HH; Groesch S; Geisslinger G; von Knethen A; Weigert A; Bruene B
Article: ANNALS OF THE RHEUMATIC DISEASES. 2015;74(2):375-380
Environmental and genetic factors in the development of anticitrullinated protein antibodies (ACPAs) and ACPA-positive rheumatoid arthritis: an epidemiological investigation in twins
Hensvold AH; Magnusson PKE; Joshua V; Hansson M; Israelsson L; Ferreira R; Jakobsson P-J; Holmdahl R; Hammarstrom L; Malmstrom V; Askling J; Klareskog L; Catrina AI
Article: PLOS ONE. 2015;10(7):e0133669
Expression of Prostaglandin E₂ Enzymes in the Synovium of Arthralgia Patients at Risk of Developing Rheumatoid Arthritis and in Early Arthritis Patients
de Hair MJH; Leclerc P; Newsum EC; Maijer KI; van de Sande MGH; Ramwadhdoebe TH; van Schaardenburg D; van Baarsen LGM; Korotkova M; Gerlag DM; Tak P-P; Jakobsson P-J
Article: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS. 2014;91(6):269-275
Evaluation of urinary prostaglandin E₂ metabolite as a biomarker in infants with fever due to viral infection
Idborg H; Pawelzik S-C; Perez-Manso M; Bjork L; Hamrin J; Herlenius E; Jakobsson P-J
Article: ARTHRITIS RESEARCH & THERAPY. 2014;16(4):R167
Affinity purified anti-citrullinated protein/peptide antibodies target antigens expressed in the rheumatoid joint
Ossipova E; Cerqueira CF; Reed E; Kharlamova N; Israelsson L; Holmdahl R; Nandakumar KS; Engstrom M; Harre U; Schett G; Catrina AI; Malmstrom V; Sommarin Y; Klareskog L; Jakobsson P-J; Lundberg K
Article: PLOS ONE. 2014;9(2):e87951
Differentially Expressed Proteins in Malignant and Benign Adrenocortical Tumors
Kjellin H; Johansson H; Hoog A; Lehtio J; Jakobsson P-J; Kjellman M
Article: PLOS ONE. 2014;9(11):e113924
IgG Antibodies to Cyclic Citrullinated Peptides Exhibit Profiles Specific in Terms of IgG Subclasses, Fc-Glycans and a Fab-Peptide Sequence
Lundstrom SL; Fernandes-Cerqueira C; Ytterberg AJ; Ossipova E; Hensvold AH; Jakobsson P-J; Malmstrom V; Catrina AI; Klareskog L; Lundberg K; Zubarev RA
Article: PROSTAGLANDINS AND OTHER LIPID MEDIATORS. 2013;107:26-34
Characterization of a human and murine mPGES-1 inhibitor and comparison to mPGES-1 genetic deletion in mouse models of inflammation
Leclerc P; Idborg H; Spahiu L; Larsson C; Nekhotiaeva N; Wannberg J; Stenberg P; Korotkova M; Jakobsson P-J
Article: PROSTAGLANDINS AND OTHER LIPID MEDIATORS. 2013;107:18-25
Effects of mPGES-1 deletion on eicosanoid and fatty acid profiles in mice
Idborg H; Olsson P; Leclerc P; Raouf J; Jakobsson P-J; Korotkova M
Article: PROSTAGLANDINS AND OTHER LIPID MEDIATORS. 2013;106:99-105
Genetic deletion of microsomal prostaglandin E synthase-1 suppresses mouse mammary tumor growth and angiogenesis
Howe LR; Subbaramaiah K; Kent CV; Zhou XK; Chang S-H; Hla T; Jakobsson P-J; Hudis CA; Dannenberg AJ
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2013;33(9):2193-2201
NOD2-Mediated Innate Immune Signaling Regulates the Eicosanoids in Atherosclerosis
Liu H-Q; Zhang X-Y; Edfeldt K; Nijhuis MO; Idborg H; Back M; Roy J; Hedin U; Jakobsson P-J; Laman JD; de Kleijn DP; Pasterkamp G; Hansson GK; Yan Z-Q
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(25):10258-10263
MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells
Zirath H; Frenzel A; Oliynyk G; Segerstrom L; Westermark UK; Larsson K; Persson MM; Hultenby K; Lehtio J; Einvik C; Pahlman S; Kogner P; Jakobsson P-J; Henriksson MA
Article: JOURNAL OF PROTEOME RESEARCH. 2013;12(6):2622-2629
Mass Spectrometry-Based Proteomics Identifies UPF1 as a Critical Gene Expression Regulator in MonoMac 6 Cells
Ochs MJ; Ossipova E; Oliynyk G; Steinhilber D; Suess B; Jakobsson P-J
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2013;77(5):350-360
IL-1 β/HMGB1 Complexes Promote The PGE₂ Biosynthesis Pathway in Synovial Fibroblasts
Leclerc P; Wahamaa H; Idborg H; Jakobsson PJ; Harris HE; Korotkova M
Article: CARCINOGENESIS. 2013;34(5):1081-1088
Low-dose aspirin delays an inflammatory tumor progression in vivo in a transgenic mouse model of neuroblastoma
Carlson L-M; Rasmuson A; Idborg H; Segerstrom L; Jakobsson P-J; Sveinbjornsson B; Kogner P
Article: ARTHRITIS & RHEUMATOLOGY. 2013;65(4):899-910
Multiplex Analyses of Antibodies Against Citrullinated Peptides in Individuals Prior to Development of Rheumatoid Arthritis
Brink M; Hansson M; Mathsson L; Jakobsson P-J; Holmdahl R; Hallmans G; Stenlund H; Ronnelid J; Klareskog L; Rantapaa-Dahlqvist S
Article: PROSTAGLANDINS AND OTHER LIPID MEDIATORS. 2013;102:1-12
Characterization of a new mPGES-1 inhibitor in rat models of inflammation
Leclerc P; Pawelzik S-C; Idborg H; Spahiu L; Larsson C; Stenberg P; Korotkova M; Jakobsson P-J
Article: ANNALS OF THE RHEUMATIC DISEASES. 2013;72(2):293-299
Activated LTB4 pathway in muscle tissue of patients with polymyositis or dermatomyositis
Loell I; Munters LA; Pandya J; Zong M; Alexanderson H; Fasth AE; Hallengren CS; Radmark O; Lundberg IE; Jakobsson P-J; Korotkova M
Article: PEDIATRIC RESEARCH. 2012;72(5):460-467
mPGES-1 and prostaglandin E₂: vital role in inflammation, hypoxic response, and survival
Siljehav V; Hofstetter AO; Jakobsson P-J; Herlenius E
Article: ARTHRITIS RESEARCH & THERAPY. 2012;14(5):R201
Validation of a multiplex chip-based assay for the detection of autoantibodies against citrullinated peptides
Hansson M; Mathsson L; Schlederer T; Israelsson L; Matsson P; Nogueira L; Jakobsson P-J; Lundberg K; Malmstrom V; Serre G; Holmdahl R; Nystrand M; Klareskog L; Ronnelid J
Article: CIRCULATION. 2012;125(23):2904-2913
Lack of Microsomal Prostaglandin E₂ Synthase-1 in Bone Marrow-Derived Myeloid Cells Impairs Left Ventricular Function and Increases Mortality After Acute Myocardial Infarction
Degousee N; Simpson J; Fazel S; Scholich K; Angoulvant D; Angioni C; Schmidt H; Korotkova M; Stefanski E; Wang X-H; Lindsay TF; Ofek E; Pierre S; Butany J; Jakobsson P-J; Keating A; Li R-K; Nahrendorf M; Geisslinger G; Backx PH; Rubin BB
Article: ARTHRITIS RESEARCH & THERAPY. 2012;14(3):R121
Limited effect of anti-rheumatic treatment on 15-prostaglandin dehydrogenase in rheumatoid arthritis synovial tissue
Gheorghe KR; Sadique S; Leclerc P; Idborg H; Wobst I; Catrina AI; Jakobsson P-J; Korotkova M
Article: JOURNAL OF CLINICAL INVESTIGATION. 2012;122(5):1791-1802
Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin
Harre U; Georgess D; Bang H; Bozec A; Axmann R; Ossipova E; Jakobsson P-J; Baum W; Nimmerjahn F; Szarka E; Sarmay G; Krumbholz G; Neumann E; Toes R; Scherer H-U; Catrina AI; Klareskog L; Jurdic P; Schett G
Article: BIOCHEMISTRY. 2012;51(11):2348-2356
Observation of Two Modes of Inhibition of Human Microsomal Prostaglandin E Synthase 1 by the Cyclopentenone 15-Deoxy-Δ^12,14-prostaglandin J₂
Prage EB; Morgenstern R; Jakobsson P-J; Stec DF; Voehler MW; Armstrong RN
Article: BIOCHEMISTRY. 2011;50(35):7684-7693
Location of Inhibitor Binding Sites in the Human Inducible Prostaglandin E Synthase, MPGES1
Prage EB; Pawelzik S-C; Busenlehner LS; Kim K; Morgenstern R; Jakobsson P-J; Armstrong RN
Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2011;19(8):908-914
Variants of gene for microsomal prostaglandin E2 synthase show association with disease and severe inflammation in rheumatoid arthritis
Korotkova M; Daha NA; Seddighzadeh M; Ding B; Catrina AI; Lindblad S; Huizinga TWJ; Toes REM; Alfredsson L; Klareskog L; Jakobsson P-J; Padyukov L
Article: AMERICAN JOURNAL OF PATHOLOGY. 2011;178(4):1676-1688
Expression of Prostaglandin E Synthases in Periodontitis Immunolocalization and Cellular Regulation
Bage T; Kats A; Lopez BS; Morgan G; Nilsson G; Burt I; Korotkova M; Corbett L; Knox AJ; Pino L; Jakobsson P-J; Modeer T; Yucel-Lindberg T
Article: AMINO ACIDS. 2011;40(2):697-711
Observed peptide pI and retention time shifts as a result of post-translational modifications in multidimensional separations using narrow-range IPG-IEF
Lengqvist J; Eriksson H; Gry M; Uhlen K; Bjorklund C; Bjellqvist B; Jakobsson P-J; Lehtio J
Article: PLOS ONE. 2011;6(1):e16378
Prostaglandin E₂ Synthesizing Enzymes in Rheumatoid Arthritis B Cells and the Effects of B Cell Depleting Therapy on Enzyme Expression
Gheorghe KR; Thurlings RM; Westman M; Boumans MJ; Malmstrom V; Trollmo C; Korotkova M; Jakobsson P-J; Tak P-P
Article: EUROPEAN JOURNAL OF OBSTETRICS AND GYNECOLOGY AND REPRODUCTIVE BIOLOGY. 2010;152(2):205-209
C. albicans activates cyclooxygenase but not its product prostaglandin E₂ in HPV 16-stabilized cells
Deva R; Sczepanski M; Saha S; Zafiriou M-P; Kerstin N; Jakobsson P-J; Inoue Y; Nigam S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(38):29254-29261
Identification of Key Residues Determining Species Differences in Inhibitor Binding of Microsomal Prostaglandin E Synthase-1
Pawelzik S-C; Uda NR; Spahiu L; Jegerschold C; Stenberg P; Hebert H; Morgenstern R; Jakobsson P-J
Article: PROTEOMICS - CLINICAL APPLICATIONS. 2010;4(5):511-518
MS analysis of rheumatoid arthritic synovial tissue identifies specific citrullination sites on fibrinogen
Hermansson M; Artemenko K; Ossipova E; Eriksson H; Lengqvist J; Makrygiannakis D; Catrina AI; Nicholas AP; Klareskog L; Savitski M; Zubarev RA; Jakobsson P-J
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2010;1801(4):462-472
Hyperforin induces Ca²⁺-Andependent arachidonic acid release in human platelets by facilitating cytosolic phospholipase A₂ activation through select phospholipid interactions
Hoffmann M; Lopez JJ; Pergola C; Feisst C; Pawelczik S; Jakobsson P-J; Sorg BL; Glaubitz C; Steinhilber D; Werz O
Article: NEUROSCIENCE LETTERS. 2010;470(1):10-12
Cyclooxygenase-1 mediates the immediate corticosterone response to peripheral immune challenge induced by lipopolysaccharide
Elander L; Ruud J; Korotkova M; Jakobsson P-J; Blomqvist A
Article: FRONTIERS IN PHARMACOLOGY. 2010;1:146
Microsomal prostaglandin E synthase-1 in rheumatic diseases
Korotkova M; Jakobsson P-J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(44):18757-18762
Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells
Hanaka H; Pawelzik S-C; Johnsen JI; Rakonjac M; Terawaki K; Rasmuson A; Sveinbjornsson B; Schumacher MC; Hamberg M; Samuelsson B; Jakobsson P-J; Kogner P; Radmark O
Article: LEUKEMIA AND LYMPHOMA. 2009;50(7):1198-1203
Lymphoblastic T-cell lymphoma in mice is unaffected by Celecoxib as single agent or in combination with cyclophosphamide
Johansson A-S; Pawelzik S-C; Larefalk A; Jakobsson P-J; Holmberg D; Lindskog M
Article: JOURNAL OF NEUROSCIENCE. 2009;29(5):1404-1413
Inducible Prostaglandin E₂ Synthesis Interacts in a Temporally Supplementary Sequence with Constitutive Prostaglandin-Synthesizing Enzymes in Creating the Hypothalamic-Pituitary-Adrenal Axis Response to Immune Challenge
Elander L; Engstrom L; Ruud J; Mackerlova L; Jakobsson P-J; Engblom D; Nilsberth C; Blomqvist A
Article: ARTHRITIS RESEARCH & THERAPY. 2009;11(3):R83
Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids
Gheorghe KR; Korotkova M; Catrina AI; Backman L; Af Klint E; Claesson H-E; Radmark O; Jakobsson P-J
Article: ANNALS OF THE RHEUMATIC DISEASES. 2008;67(11):1596-1602
Effects of immunosuppressive treatment on microsomal prostaglandin E synthase 1 and cyclooxygenases expression in muscle tissue of patients with polymyositis or dermatomyositis
Korotkova M; Helmers SB; Loell I; Alexanderson H; Grundtman C; Dorph C; Lundberg IE; Jakobsson P-J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(32):11110-11115
Structural basis for induced formation of the inflammatory mediator prostaglandin E₂
Jegerschold C; Paweizik S-C; Purhonen P; Bhakat P; Gheorghe KR; Gyobu N; Mitsuoka K; Morgenstern R; Jakobsson P-J; Hebert H
Article: PROTEOMICS. 2008;8(15):3008-3018
Quantitative membrane proteomics applying narrow range peptide isoelectric focusing for studies of small cell lung cancer resistance mechanisms
Eriksson H; Lengqvist J; Hedlund J; Uhlen K; Orre LM; Bjellqvist B; Persson B; Lehtio J; Jakobsson P-J
Article: CIRCULATION. 2008;117(13):1701-1710
Microsomal prostaglandin E₂ synthase-1 deletion leads to adverse left ventricular remodeling after myocardial infarction
Degousee N; Fazel S; Angoulvant D; Stefanski E; Pawelzik S-C; Korotkova M; Arab S; Liu P; Lindsay TF; Zhuo S; Butany J; Li R-K; Audoly L; Schmidt R; Angioni C; Geisslinger G; Jakobsson P-J; Rubin BB
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(23):9894-9899
The induced prostaglandin E₂ pathway is a key regulator of the respiratory response to infection and hypoxia in neonates
Hofstetter AO; Saha S; Siljehav V; Jakobsson P-J; Herlenius E
Article: THE FASEB JOURNAL. 2006;20(9):1352-1360
Inhibition of prostaglandin E₂ synthesis by SC-560 is independent of cyclooxygenase 1 inhibition
Brenneis C; Maier TJ; Schmidt R; Hofacker A; Zulauf L; Jakobsson P-J; Scholich K; Geisslinger G
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(24):16443-16452
c-Jun N-terminal kinase-mediated stabilization of microsomal prostaglandin E₂ synthase-1 mRNA regulates delayed microsomal prostaglandin E₂ synthase-1 expression and prostaglandin E₂ biosynthesis by cardiomyocytes
Degousee N; Angoulvant D; Fazel S; Stefanski E; Saha S; Iliescu K; Lindsay TF; Fish JE; Marsden PA; Li R-K; Audoly LP; Jakobsson P-J; Rubin BB
Article: ARTHRITIS & RHEUMATOLOGY. 2005;52(11):3439-3447
Effects of antirheumatic treatments on the prostaglandin E₂ Biosynthetic pathway
Korotkova M; Westman M; Gheorghe KR; af Klint E; Trollmo C; Ulfgren AK; Klareskog L; Jakobsson PJ
Article: AMERICAN JOURNAL OF PHYSIOLOGY. REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2005;288(5):R1100-R1107
Impaired febrile responses to immune challenge in mice deficient in microsomal prostaglandin E synthase-1
Saha S; Engstrom L; Mackerlova L; Jakobsson PJ; Blomqvist A
Article: THE FEBS JOURNAL. 2005;272(7):1688-1703
Bioinformatic and enzymatic characterization of the MAPEG superfamily
Bresell A; Weinander R; Lundqvist G; Raza H; Shimoji M; Sun TH; Balk L; Wiklund R; Eriksson J; Jansson C; Persson B; Jakobsson PJ; Morgenstern R
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2005;62(1):87-94
Microsomal glutathione S-transferases:: selective up-regulation of leukotriene C₄ synthase during lipopolysaccharide-induced pyresis
Schröder O; Sjöström M; Qiu H; Jakobsson PJ; Haeggström JZ
Article: ARTHRITIS & RHEUMATOLOGY. 2004;50(6):1774-1780
Expression of microsomal prostaglandin E synthase 1 in rheumatoid arthritis synovium
Westman M; Korotkova M; af Klint E; Stark A; Audoly LP; Klareskog L; Ulfgren AK; Jakobsson P
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2003;312(2):271-276
Molecular and catalytic properties of three rat leukotriene C₄ synthase homologs
Schröder O; Sjöström M; Qiu H; Stein J; Jakobsson PJ; Haeggström JZ
Article: INTERNATIONAL JOURNAL OF CANCER. 2003;107(4):551-556
Expression of microsomal prostaglandin E synthase-1 in intestinal type gastric adenocarcinoma and in gastric cancer cell lines
van Rees BP; Sivula A; Thorén S; Yokozaki H; Jakobsson PJ; Offerhaus GJA; Ristimäki A
Article: NATURE NEUROSCIENCE. 2003;6(11):1137-1138
Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis
Engblom D; Saha S; Engström L; Westman M; Audoly LP; Jakobsson PJ; Blomqvist A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(15):9044-9049
Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase
Trebino CE; Stock JL; Gibbons CP; Naiman BM; Wachtmann TS; Umland JP; Pandher K; Lapointe JM; Saha S; Roach ML; Carter D; Thomas NA; Durtschi BA; McNeish JD; Hambor JE; Jakobsson PJ; Carty TJ; Perez JR; Audoly LP
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(25):22199-22209
Human microsomal prostaglandin E synthase-1 -: Purification, functional characterization, and projection structure determination
Thorén S; Weinander R; Saha S; Jegerschöld C; Pettersson PL; Samuelsson B; Hebert H; Hamberg M; Morgenstern R; Jakobsson PJ
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2003;1627(2-3):79-84
Basal expression of the human MAPEG members microsomal glutathione transferase 1 and prostaglandin E synthase genes is mediated by Sp1 and Sp3
Ekström L; Lyrenäs L; Jakobsson PJ; Morgenstern R; Kelner MJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(47):44877-44885
Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides
Kozak KR; Crews BC; Morrow JD; Wang LH; Ma YH; Weinander R; Jakobsson PJ; Marnett LJ
Article: JOURNAL OF COMPARATIVE NEUROLOGY. 2002;452(3):205-214
Induction of microsomal prostaglandin E synthase in the rat brain endothelium and parenchyma in adjuvant-induced arthritis
Engblom D; Ek M; Andersson IM; Saha S; Dahlström M; Jakobsson PJ; Ericsson-Dahlstrand A; Blomqvist A
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2002;1583(1):53-62
Human mast cells express two leukotriene C₄ synthase isoenzymes and the CysLT₁ receptor
Sjöström M; Jakobsson PJ; Juremalm M; Ahmed A; Nilsson G; Macchia L; Haeggström JZ
Article: NEUROSCIENCE. 2002;115(3):891-897
Expression of microsomal glutathione S-transferase type 3 mRNA in the rat nervous system
Fetissov SO; Schröder O; Jakobsson PJ; Samuelsson B; Haeggström JZ; Hökfelt T
Article: CLINICAL CANCER RESEARCH. 2001;7(12):3971-3976
Inducible microsomal prostaglandin E synthase is overexpressed in colorectal adenomas and cancer
Yoshimatsu K; Golijanin D; Paty PB; Soslow RA; Jakobsson PJ; DeLellis RA; Subbaramaiah K; Dannenberg AJ
Article: CLINICAL CANCER RESEARCH. 2001;7(9):2669-2674
Inducible prostaglandin E synthase is overexpressed in non-small cell lung cancer
Yoshimatsu K; Altorki NK; Golijanin D; Zhang F; Jakobsson PJ; Dannenberg AJ; Subbaramaiah K
Article: JOURNAL OF IMMUNOLOGY. 2001;167(1):469-474
Microsomal prostaglandin E synthase is regulated by proinflammatory cytokines and glucocorticoids in primary rheumatoid synovial cells
Stichtenoth DO; Thorén S; Bian HM; Peters-Golden M; Jakobsson PJ; Crofford LJ
Article: THE FEBS JOURNAL. 2001;268(9):2578-2586
Human umbilical vein endothelial cells generate leukotriene C₄ via microsomal glutathione S-transferase type 2 and express the CysLT₁ receptor
Sjöström M; Jakobsson PJ; Heimburger M; Palmblad J; Haeggström JZ
Article: NATURE. 2001;410(6827):430-431
Inflammatory response - Pathway across the blood-brain barrier
Ek M; Engblom D; Saha S; Blomqvist A; Jakobsson PJ; Ericsson-Dahlstrand A
Article: THE FEBS JOURNAL. 2000;267(21):6428-6434
Coordinate up- and down-regulation of glutathione-dependent prostaglandin E synthase and cyclooxygenase-2 in A549 cells -: Inhibition by NS-398 and leukotriene C₄
Thorén S; Jakobsson PJ
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2000;276(2):488-492
Functional coupling of cyclooxygenase 1 and 2 to discrete prostanoid synthases in liver macrophages
Dieter P; Scheibe R; Jakobsson PJ; Watanabe K; Kolada A; Kamionka S
Article: FEBS LETTERS. 2000;471(1):78-82
Human glutathione dependent prostaglandin E synthase:: gene structure and regulation
Forsberg L; Leeb L; Thorén S; Morgenstern R; Jakobsson PJ
Article: BLOOD. 2000;95(4):1456-1464
Aberrant expression of active leukotriene C₄ synthase in CD16⁺ neutrophils from patients with chronic myeloid leukemia
Sjölinder M; Stenke L; Näsman-Glaser B; Widell S; Doucet J; Jakobsson PJ; Lindgren J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(13):7220-7225
Identification of human prostaglandin E synthase:: A microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target
Jakobsson PJ; Thorén S; Morgenstern R; Samuelsson B
Article: PROTEIN SCIENCE. 1999;8(3):689-692
Common structural features of MAPEG -: A widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism
Jakobsson PJ; Morgenstern R; Mancini J; Ford-Hutchinson A; Persson B
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(36):22934-22939
Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities.
Jakobsson PJ; Mancini JA; Riendeau D; Ford-Hutchinson AW
Article: JOURNAL OF LIPID MEDIATORS AND CELL SIGNALLING. 1997;17(1):15-19
Characterization of microsomal GST-II by western blot and identification of a novel LTC4 isomer.
Jakobsson PJ; Scoggan KA; Yergey J; Mancini JA; Ford-Hutchinson AW
Article: CELL DEATH AND DIFFERENTIATION. 1997;4(6):479-486
Inhibitors of arachidonic acid metabolism reduce DNA and nuclear fragmentation induced by TNF plus cycloheximide in U937 cells
Vanags DM; Larsson P; Feltenmark S; Jakobsson PJ; Orrenius S; Claesson HE; AguilarSantelises M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(15):10182-10187
Production of leukotriene C4 in different human tissues is attributable to distinct membrane bound biosynthetic enzymes.
Scoggan KA; Jakobsson PJ; Ford-Hutchinson AW
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(36):22203-22210
Identification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5-lipoxygenase-activating protein and leukotriene C4 synthase.
Jakobsson PJ; Mancini JA; Ford-Hutchinson AW
Article: THE FEBS JOURNAL. 1995;232(1):37-46
STUDIES ON THE REGULATION AND LOCALIZATION OF 5-LIPOXYGENASE IN HUMAN B-LYMPHOCYTES
JAKOBSSON PJ; SHASKIN P; LARSSON P; FELTENMARK S; ODLANDER B; AGUILARSANTELISES M; JONDAL M; BIBERFELD P; CLAESSON HE
Article: BRITISH JOURNAL OF HAEMATOLOGY. 1995;90(3):585-594
DIVERSE EXPRESSION OF CYTOSOLIC PHOSPHOLIPASE-A(2), 5-LIPOXYGENASE AND PROSTAGLANDIN-H SYNTHASE-2 IN ACUTE PRE-B-LYMPHOCYTIC LEUKEMIA-CELLS
FELTENMARK S; RUNARSSON G; LARSSON P; JAKOBSSON PJ; BJORKHOLM M; CLAESSON HE
Show more

All other publications

Letter: NATURE COMMUNICATIONS. 2023;14(1):7172
Failure to apply standard limit-of-detection or limit-of-quantitation criteria to specialized pro-resolving mediator analysis incorrectly characterizes their presence in biological samples
O'Donnell VB; Schebb NH; Milne GL; Murphy MP; Thomas CP; Steinhilber D; Gelhaus SL; Kuehn H; Gelb MH; Jakobsson P-J; Blair IA; Murphy RC; Freeman BA; Brash AR; Fitzgerald GA
Review: EXPERT OPINION ON THERAPEUTIC TARGETS. 2023;27(11):1115-1123
The anti-inflammatory and vasoprotective properties of mPGES-1 inhibition offer promising therapeutic potential
Steinmetz-Spah J; Jakobsson P-J
Editorial comment: FRONTIERS IN PHARMACOLOGY. 2023;14:1135803
Editorial: Disease-modifying antirheumatic drugs: Approaches and lessons learned from traditional medicine
Mei L; Gao K; He X; Jakobsson P-J; Huang R
Editorial comment: FRONTIERS IN PHARMACOLOGY. 2023;14:1223761
Editorial: Insights in inflammation pharmacology: 2022
Patrignani P; Ballerini P; Jakobsson P-J; Steinhilber D
Review: JOURNAL OF INTERNAL MEDICINE. 2022;292(5):745-763
Where traditional Chinese medicine meets Western medicine in the prevention of rheumatoid arthritis
Jakobsson P-J; Robertson L; Welzel J; Zhang M; Yang Z; Gao K; Huang R; Wen Z; Korotkova M; Goransson U
Review: FRONTIERS IN PHARMACOLOGY. 2022;13:838782
Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators-What is the Evidence so far?
Schebb NH; Kuehn H; Kahnt AS; Rund KM; O'Donnell VB; Flamand N; Peters-Golden M; Jakobsson P-J; Weylandt KH; Rohwer N; Murphy RC; Geisslinger G; FitzGerald GA; Hanson J; Dahlgren C; Alnouri MW; Offermanns S; Steinhilber D
Other: EUROPEAN JOURNAL OF IMMUNOLOGY. 2021;51(6):1309
Anca Catrina 1971-2021 Obituary
Klareskog L; Rethi B; Hensvold A; Wahamaa H; Jakobsson P-J
Editorial comment: FRONTIERS IN PHARMACOLOGY. 2021;12:707811
Editorial: Traditional Medicine and Rheumatology
Yang Z; Tang X; Liang H; Gao K; Wang M; He X; Jakobsson P-J; Huang R
Review: PROSTAGLANDINS AND OTHER LIPID MEDIATORS. 2020;147:106383
A review on mPGES-1 inhibitors: From preclinical studies to clinical applications
Bergqvist F; Morgenstern R; Jakobsson P-J
Corrigendum: AMERICAN JOURNAL OF HUMAN GENETICS. 2019;105(4):880
Distinct HLA Associations with Rheumatoid Arthritis Subsets Defined by Serological Subphenotype (vol 105, pg 616, 2019)
Terao C; Brynedal B; Chen Z; Jiang X; Westerlind H; Hansson M; Jakobsson P-J; Lundberg K; Skriner K; Serre G; Ronnelid J; Mathsson-Alm L; Brink M; Dahlqvist SR; Padyukov L; Gregersen PK; Barton A; Alfredsson L; Klareskog L; Raychaudhuri S
Editorial comment: FRONTIERS IN PHARMACOLOGY. 2019;10:1604
Editorial: New Therapies in the Field of Rheumatology
Chighizola CB; Jakobsson P-J; Gerosa M
Published conference paper: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 2019;1161:89-100
Targeting the COX/mPGES-1/PGE2 Pathway in Neuroblastoma
Larsson K; Kock A; Kogner P; Jakobsson P-J
Review: FRONTIERS IN PHARMACOLOGY. 2018;9:356
The Effectiveness and Safety of Tripterygium wilfordii Hook. F Extracts in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis
Zhou Y-Y; Xia X; Peng W-K; Wang Q-H; Peng J-H; Li Y-L; Wu J-X; Zhang J-Y; Zhao Y; Chen X-M; Huang R-Y; Jakobsson P-J; Wen Z-H; Huang Q-C
Review: FRONTIERS IN PHARMACOLOGY. 2018;9:914
The Bone-Protecting Efficiency of Chinese Medicines Compared With Western Medicines in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis of Comparative Studies
Cai X; Chen X-M; Xia X; Bao K; Wang R-R; Peng J-H; Liu H-J; Yang Q-W; Yan J-Y; Wang M-J; Yu H; Lu J-J; Hu Y-J; Jakobsson P-J; Wen Z-H; Huang R-Y; Huang Q-C
Editorial comment: PROSTAGLANDINS AND OTHER LIPID MEDIATORS. 2015;121(Pt A):1-3
Special Issue 5th European Workshop on Lipid Mediators
Topal G; Claria J; Norel X; Steinhilber D; Jakobsson P-J; Dogan SU; Bannenberg G
Editorial comment: NATURE REVIEWS DRUG DISCOVERY. 2015;14(3):149-150
Preclinical target validation using patient-derived cells
Edwards AM; Arrowsmith CH; Bountra C; Bunnage ME; Feldmann M; Knight JC; Patel DD; Prinos P; Taylor MD; Sundstrom M
Review: NATURE REVIEWS. RHEUMATOLOGY. 2014;10(4):229-241
Persisting eicosanoid pathways in rheumatic diseases
Korotkova M; Jakobsson P-J
Review: BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. 2014;114(1):13-17
Neutralization of AntiCitrullinated Protein Antibodies in Rheumatoid Arthritis - A Way to Go?
Cerqueira CF; Klareskog L; Jakobsson P-J
Review: BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. 2014;114(1):64-69
Characterization of Microsomal Prostaglandin E Synthase 1 Inhibitors
Korotkova M; Jakobsson P-J
Review: CHEMICAL REVIEWS. 2011;111(10):5821-5865
Enzymes of the Cyclooxygenase Pathways of Prostanoid Biosynthesis
Smith WL; Urade Y; Jakobsson P-J
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2011;70:A75
LIMITED EFFECTS OF METHOTREXATE ON ENZYMES OF THE PGE₂ PATHWAY IN RHEUMATOID ARTHRITIS SYNOVIAL TISSUE
Gheorghe KR; Sadique S; Idborg H; Wobst Y; Catrina AI; Jakobsson P-J; Korotkova M
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2011;70:a23-A24
PROTEOME ANALYSIS REVEALS AN UPREGULATION OF HEAT-SHOCK PROTEINS IN LPS-INDUCED PERITONEAL MACROPHAGES FROM MPGES-1 KNOCK-OUT MICE
Korotkova M; Ossipova E; Idborg H; Ghorghe K; Leclerc P; Jakobsson P-J
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2011;70:A3
HUMORAL IMMUNE RESPONSE AGAINST FIBRINOGEN EPITOPES CITRULLINATED IN VIVO IN RHEUMATOID ARTHRITIS SYNOVIAL TISSUE DETECTED BY AUTOANTIBODY MULTIPLEXING
Ronnelid J; Ossipova E; Mathsson L; Catrina A; Matsson P; Israelsson L; Malmstrom V; Klareskog L; Jakobsson P-J
Editorial comment: NATURE REVIEWS. RHEUMATOLOGY. 2010;6(12):679-681
PAIN How macrophages mediate inflammatory pain via ATP signaling
Jakobsson P-J
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2010;69:a4-A5
IDENTIFICATION OF SPECIFIC CITRULLINATION SITES ON FIBRINOGEN IN RA
Ossipova E; Malmstrom V; Catrina AI; Klareskog L; Zubarev R; Jakobsson P-J
Review: PHARMACOLOGICAL REVIEWS. 2007;59(3):207-224
Membrane prostaglandin E synthase-1: A novel therapeutic target
Samuelsson B; Morgenstern R; Jakobsson P-J
Meeting abstract: ARTHRITIS RESEARCH & THERAPY. 2005;7:S35
Expression of microsomal prostaglandin E synthase-1 in muscle tissue of patients with idiopathic inflammatory myopathies
Korotkova I; Barbasso S; Jakobsson P-J; Lundberg I
Review: METHODS IN ENZYMOLOGY. 2005;401:147-161
Human microsomal prostaglandin E synthase 1:: A member of the MAPEG protein superfamily
Pettersson PL; Thorén S; Jakobsson PJ
Meeting abstract: ARTHRITIS RESEARCH & THERAPY. 2005;7:S34
Effects of anti-rheumatic treatments on the prostaglandin E₂ biosynthetic pathway in synovial tissue and synovial fluid cells from patients with rheumatoid arthritis
Korotkova M; Westman M; Gheorghe KR; af Klint E; Trollmo C; Ulfgren A-K; Klareskog L; Jakobsson P-J
Meeting abstract: PEDIATRIC RESEARCH. 2004;56(3):482
Reduced expression of microsomal prostaglandin synthase 1 attenuates ventilatory effects of interleukin-1A in neonatal DBA/1LacJ mice
Hofstetter AO; Saha S; Lagercrantz H; Jakobsson PJ; Herlenius E
Meeting abstract: ARTHRITIS RESEARCH & THERAPY. 2004;6:S32-S33
Effects of anti-rheumatic treatments on expression of microsomal prostaglandin E synthase-1 in rheumatoid arthritis synovium
Korotkova M; Westman M; af Klint E; Ulfgren AK; Klareskog L; Jakobsson PJ
Published conference paper: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 2002;507:287-291
Characterization of microsomal, glutathione dependent prostaglandin E synthase
Jakobsson PJ; Thorén S; Morgenstern R; Samuelsson B
Review: JOURNAL OF MOLECULAR MEDICINE. 2002;80(1):5-15
Prostaglandins as inflammatory messengers across the blood-brain barrier
Engblom D; Ek M; Saha S; Ericsson-Dahlstrand A; Jakobsson PJ; Blomqvist A
Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2001;133(1-3):153-154
Prostaglandin E synthase:: a microsomal, glutathione dependent, inducible member of the MAPEG superfamily
Jakobsson PJ; Thorén S; Morgenstern R; Samuelsson B
Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2001;133(1-3):301-303
Structure and transcriptional regulation of the human microsomal glutathione transferase 1 (MGST1) and prostaglandin E synthase (PGES) genes
Forsberg L; Persson L; Kelner MJ; Jakobsson PJ; Morgenstern R
Published conference paper: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2000;161(2):S20-S24
Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG) - A widespread protein superfamily
Jakobsson PJ; Morgenstern R; Mancini J; Ford-Hutchinson A; Persson B
Review: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1995;23:293-298
THE 5-LIPOXYGENASE PATHWAY IN NORMAL AND MALIGNANT HUMAN B-LYMPHOCYTES
JAKOBSSON PJ; LARSSON P; FELTENMARK S; ODLANDER B; RUNARSSON G; BJORKHOLM M; CLAESSON HE
Show more

Employments

Professor/Specialist Physician, Department of Medicine, Karolinska Institutet, 2014-

Degrees and Education

University Medical Degree, Karolinska Institutet, 2003
Docent, Karolinska Institutet, 2000
Bachelor Of Medical Science, Karolinska Institutet, 1996

Articles

All other publications

Employments

Degrees and Education

News from KI

Events from KI