Dionysis Nikolopoulos

Publications
Public outreach and news

Articles

Article: ANNALS OF THE RHEUMATIC DISEASES. 2024;83(9):1132-1143

Disentangling the riddle of systemic lupus erythematosus with antiphospholipid syndrome: blood transcriptome analysis reveals a less-pronounced IFN-signature and distinct molecular profiles in venous versus arterial events

Nikolopoulos D; Loukogiannaki C; Sentis G; Garantziotis P; Manolakou T; Kapsala N; Nikoloudaki M; Pieta A; Flouda S; Parodis I; Bertsias G; Fanouriakis A; Filia A; Boumpas DT
Journal article: RHEUMATOLOGY INTERNATIONAL. 2024;44(9):1679-1689

Neuropsychiatric involvement in systemic lupus erythematosus contributes to organ damage beyond the nervous system: a post-hoc analysis of 5 phase III randomized clinical trials

Nikolopoulos D; Cetrez N; Lindblom J; Parodis I
Journal article: KIDNEY INTERNATIONAL REPORTS. 2024;9(6):1817-1835

Interferon and B-cell Signatures Inform Precision Medicine in Lupus Nephritis

Parodis I; Lindblom J; Toro-Dominguez D; Beretta L; Borghi MO; Castillo J; Carnero-Montoro E; Enman Y; Mohan C; Alarcon-Riquelme ME; Barturen G; Nikolopoulos D; PRECISESADS Clinical Consortium OBOPREC
Journal article: RHEUMATOLOGY. 2024;:keae278

Can we predict kidney involvement in patients with systemic lupus erythematosus? A retrospective cohort study with independent validation

Katechis S; Nikolopoulos D; Flouda S; Adamichou C; Chavatza K; Kapsala N; Katsimbri P; Bertsias G; Boumpas DT; Fanouriakis A
Article: RHEUMATOLOGY. 2024;:keae216

Patients with NPSLE experience poorer HRQoL and more fatigue than SLE patients with no neuropsychiatric involvement, irrespective of neuropsychiatric activity

Nikolopoulos D; Cetrez N; Lindblom J; Palazzo L; Enman Y; Parodis I
Article: LUPUS. 2024;33(2):166-171

Impaired serotonin synthesis in hippocampus of murine lupus represents an early neuropsychiatric event

Nikolopoulos D; Nakos-Bimpos M; Manolakou T; Polissidis A; Boumpas DT
Article: ANNALS OF THE RHEUMATIC DISEASES. 2023;82(5):646-657

Microglia activation in the presence of intact blood-brain barrier and disruption of hippocampal neurogenesis via IL-6 and IL-18 mediate early diffuse neuropsychiatric lupus

Nikolopoulos D; Manolakou T; Polissidis A; Filia A; Bertsias G; Koutmani Y; Boumpas DT
Journal article: BMC GENOMICS. 2023;24(1):207

Restoration of aberrant gene expression of monocytes in systemic lupus erythematosus via a combined transcriptome-reversal and network-based drug repurposing strategy

Nikolakis D; Garantziotis P; Sentis G; Fanouriakis A; Bertsias G; Frangou E; Nikolopoulos D; Banos A; Boumpas DT
Journal article: LUPUS. 2023;32(2):225-230

Relapses are common in severe hematologic systemic lupus erythematosus and may be prevented by early institution of immunosuppressive agents: Α real-life single-center study

Moysidou G-S; Garantziotis P; Nikolopoulos D; Katsimbri P; Fanouriakis A; Boumpas DT
Journal article: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2023;41(1):74-81

From first symptoms to diagnosis of systemic lupus erythematosus: mapping the journey of patients in an observational study

Kapsala NN; Nikolopoulos DS; Flouda SP; Chavatza AP; Tseronis DD; Aggelakos MD; Katsimbri PP; Bertsias GK; Fanouriakis AC; Boumpas DT
Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1203848

A network-based approach reveals long non-coding RNAs associated with disease activity in lupus nephritis: key pathways for flare and potential biomarkers to be used as liquid biopsies

Sentis G; Loukogiannaki C; Malissovas N; Nikolopoulos D; Manolakou T; Flouda S; Grigoriou M; Banos A; Boumpas DTT; Filia A
Article: SCIENCE ADVANCES. 2022;8(43):eabo5840

ATR-mediated DNA damage responses underlie aberrant B cell activity in systemic lupus erythematosus

Manolakou T; Nikolopoulos D; Gkikas D; Filia A; Samiotaki M; Stamatakis G; Fanouriakis A; Politis P; Banos A; Alissafi T; Verginis P; Boumpas DT
Article: ANNALS OF THE RHEUMATIC DISEASES. 2022;81(10):1409-1419

Cross-species transcriptome analysis for early detection and specific therapeutic targeting of human lupus nephritis

Frangou E; Garantziotis P; Grigoriou M; Banos A; Nikolopoulos D; Pieta A; Doumas SA; Fanouriakis A; Hatzioannou A; Manolakou T; Alissafi T; Verginis P; Athanasiadis E; Dermitzakis E; Bertsias G; Filia A; Boumpas DT
Journal article: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2022;40(9):1769-1778

Remission or low disease activity at pregnancy onset are linked to improved foetal outcomes in women with systemic lupus erythematosus: results from a prospective observational study

Ntali S; Nikolopoulos D; Pantazi L; Emmanouilidou E; Papagoras C; Fanouriakis A; Dimopoulou D; Kallitsakis I; Boki K; Dania V; Sidiropoulos PI; Boumpas DT; Bertsias G
Journal article: RHEUMATOLOGY INTERNATIONAL. 2022;42(8):1307-1319

Tailored treatment strategies and future directions in systemic lupus erythematosus

Nikolopoulos D; Fotis L; Gioti O; Fanouriakis A
Journal article: AMERICAN JOURNAL OF MEDICINE. 2022;135(2):244-253.e3

First Diagnosis of Systemic Lupus Erythematosus in Hospitalized Patients: Clinical Phenotypes and Pitfalls for the Non-Specialist

Kapsala N; Nikolopoulos D; Flouda S; Chavatza A; Tseronis D; Aggelakos M; Katsimbri P; Bertsias G; Fanouriakis A; Boumpas DT
Journal article: FRONTIERS IN IMMUNOLOGY. 2022;13:1074044

Clinical response trajectories and drug persistence in systemic lupus erythematosus patients on belimumab treatment: A real-life, multicentre observational study

Nikoloudaki M; Nikolopoulos D; Koutsoviti S; Flouri I; Kapsala N; Repa A; Katsimbri P; Theotikos E; Pitsigavdaki S; Pateromichelaki K; Bertsias A; Elezoglou A; Sidiropoulos P; Fanouriakis A; Boumpas D; Bertsias G
Journal article: FRONTIERS IN NEUROLOGY. 2022;13:889613

Demyelinating Syndromes in Systemic Lupus Erythematosus: Data From the "Attikon" Lupus Cohort

Nikolopoulos D; Kitsos D; Papathanasiou M; Kapsala N; Garantziotis P; Pieta A; Gioti O; Grivas A; Voumvourakis K; Boumpas D; Fanouriakis A
Article: ANNALS OF THE RHEUMATIC DISEASES. 2021;80(9):1175-1182

Quality indicators for systemic lupus erythematosus based on the 2019 EULAR recommendations: development and initial validation in a cohort of 220 patients

Chavatza K; Kostopoulou M; Nikolopoulos D; Gioti O; Togia K; Andreoli L; Aringer M; Boletis J; Doria A; Houssiau FA; Jayne D; Mosca M; Svenungsson E; Tincani A; Bertsias G; Fanouriakis A; Boumpas DT
Journal article: RHEUMATOLOGY. 2021;60(9):4166-4174

Demyelination with autoimmune features: a distinct clinical entity? Results from a longitudinal cohort

Nikolopoulos D; Kitsos D; Papathanasiou M; Chondrogianni M; Theodorou A; Garantziotis P; Pieta A; Doskas T; Bertsias G; Voumvourakis K; Boumpas DT; Fanouriakis A
Journal article: ANNALS OF THE RHEUMATIC DISEASES. 2021;80(6):758-766

Lupus or not? SLE Risk Probability Index (SLERPI): a simple, clinician-friendly machine learning-based model to assist the diagnosis of systemic lupus erythematosus

Adamichou C; Genitsaridi I; Nikolopoulos D; Nikoloudaki M; Repa A; Bortoluzzi A; Fanouriakis A; Sidiropoulos P; Boumpas DT; Bertsias GK
Journal article: EXPERT REVIEW OF CLINICAL IMMUNOLOGY. 2021;17(4):317-329

Treatment of neuropsychiatric systemic lupus erythematosus: clinical challenges and future perspectives

Nikolopoulos D; Fanouriakis A; Bertsias G
Journal article: CLINICAL RHEUMATOLOGY. 2021;40(4):1447-1456

The role of plasma exchange in antineutrophil cytoplasmic antibody-associated vasculitis: a meta-analysis

Bellos I; Michelakis I; Nikolopoulos D
Article: SEMINARS IN ARTHRITIS AND RHEUMATISM. 2020;50(6):1387-1393

Lymphopenia as a risk factor for neurologic involvement and organ damage accrual in patients with systemic lupus erythematosus: A multi-center observational study

Yavuz S; Cansu DU; Nikolopoulos D; Crisafulli F; Antunes AM; Adamichou C; Reid S; Stagnaro C; Andreoli L; Tincani A; Moraes-Fontes MF; Mosca M; Leonard D; Jonsen A; Bengtsson A; Svenungsson E; Gunnarsson I; Dahlqvist SR; Sjowall C; Bertsias G; Fanouriakis A; Ronnblom L
Journal article: MEDITERRANEAN JOURNAL OF RHEUMATOLOGY. 2020;31(3):330

Interstitial Pneumonia with Autoimmune Features (IPAF): A Single-Centre, Prospective Study.

Karampeli M; Thomas K; Flouda S; Chavatza A; Nikolopoulos D; Pieta A; Tseronis D; Aggelakos M; Kassara D; Tzavara V; Katsimbri P; Boumpas D; Karageorgas T
Journal article: MEDITERRANEAN JOURNAL OF RHEUMATOLOGY. 2020;31(3):366

Mitophagy Balance in Various Cell Subsets in Patients with ANCA-Associated Vasculitis and Correlation with the Presence of Anti-Neutrophil Cytoplasmic Antibodies.

Banos A; Thomas K; Garantziotis P; Malissovas N; Filia A; Pieta A; Nikolopoulos D; Moustafa S; Panagiotopoulos A; Boumpas DT; Vassilopoulos D
Journal article: LUPUS SCIENCE & MEDICINE. 2020;7(1):e000394

Transition to severe phenotype in systemic lupus erythematosus initially presenting with non-severe disease: implications for the management of early disease

Nikolopoulos DS; Kostopoulou M; Pieta A; Flouda S; Chavatza K; Banos A; Boletis J; Katsimbri P; Boumpas DT; Fanouriakis A
Journal article: LUPUS. 2020;29(5):514-522

Evolving phenotype of systemic lupus erythematosus in Caucasians: low incidence of lupus nephritis, high burden of neuropsychiatric disease and increased rates of late-onset lupus in the 'Attikon' cohort

Nikolopoulos D; Kostopoulou M; Pieta A; Karageorgas T; Tseronis D; Chavatza K; Flouda S; Rapsomaniki P; Banos A; Kremasmenou E; Tzavara V; Katsimbri P; Fanouriakis A; Boumpas DT
Article: MEDITERRANEAN JOURNAL OF RHEUMATOLOGY. 2020;31(1):87-91

Development and Implementation of a Pilot Registry for Monitoring the Efficacy and Safety of Novel Therapies in Patients with Systemic Lupus Erythematosus.

Adamichou C; Flouri I; Fanouriakis A; Nikoloudaki M; Nikolopoulos D; Repa A; Boki K; Chatzidionysiou K; Garyfallos A; Boumpas D; Sidiropoulos P; Bertsias G
Journal article: ANNALS OF THE RHEUMATIC DISEASES. 2020;79(2):232-241

In an early SLE cohort the ACR-1997, SLICC-2012 and EULAR/ACR-2019 criteria classify non-overlapping groups of patients: use of all three criteria ensures optimal capture for clinical studies while their modification earlier classification and treatment

Adamichou C; Nikolopoulos D; Genitsaridi I; Bortoluzzi A; Fanouriakis A; Papastefanakis E; Kalogiannaki E; Gergianaki I; Sidiropoulos P; Boumpas DT; Bertsias GK
Journal article: ANNALS OF THE RHEUMATIC DISEASES. 2020;79(2):242-253

Transcriptome reprogramming and myeloid skewing in haematopoietic stem and progenitor cells in systemic lupus erythematosus

Grigoriou M; Banos A; Filia A; Pavlidis P; Giannouli S; Karali V; Nikolopoulos D; Pieta A; Bertsias G; Verginis P; Mitroulis I; Boumpas DT
Journal article: CURRENT OPINION IN RHEUMATOLOGY. 2019;31(6):669-677

Update on the pathogenesis of central nervous system lupus

Nikolopoulos D; Fanouriakis A; Boumpas DT
Journal article: BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY. 2019;33(4):101425

Suspected systemic rheumatic diseases in patients presenting with cytopenias

Nikolopoulos D; Adamichou C; Bertsias G
Journal article: MEDITERRANEAN JOURNAL OF RHEUMATOLOGY. 2019;30(1):7-15

Cerebrovascular Events in Systemic Lupus Erythematosus: Diagnosis and Management.

Nikolopoulos D; Fanouriakis A; Boumpas DT
Journal article: MEDITERRANEAN JOURNAL OF RHEUMATOLOGY. 2018;29(4):228-231

Birth Registry of Women With Systematic Lupus Erythematosus: The Greek Experience.

Ntali S; Pantazi L; Mpoki K; Nikolopoulos D; Fanouriakis A; Kallitsakis I; Papagoras C; Dimopoulou D; Kteniadaki E; Emmanouilidou E; Chania V; Bertsias G
Journal article: MEDITERRANEAN JOURNAL OF RHEUMATOLOGY. 2018;29(4):232-235

Comparative analysis of the sensitivity and specificity of the classification criteria and correlation with prognosis of disease in patients with Systemic Lupus Erythematosus.

Adamichou C; Nikolopoulos D; Papastefanakis E; Kalogiannaki E; Gergianaki I; Kountouri A; Repa A; Avgoustidis N; Kougkas N; Sidiropoulos P; Fanouriakis A; Bertsias G
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Review: EXPERT OPINION ON PHARMACOTHERAPY. 2024;25(6):705-716

Advances in the pharmacological management of systemic lupus erythematosus

Tsoi A; Nikolopoulos D; Parodis I
Conference publication: 2024;:a14-a15

O11 Unsupervised machine-learning identifies distinct clusters based on B cell phenotyping and autoantibody profiles in patients with systemic lupus erythematosus

Gatto M; Depascale R; Cetrez N; Lindblom J; Nikolopoulos D; Doria A; Parodis I
Conference publication: 2024;:a86.1-a8a86

P62 Machine learning approaches for prediction of renal flares in systemic lupus erythematosus: knowledge-driven models outperformed data-driven models

Cetrez N; Lindblom J; Mutten RD; Nikolopoulos D; Parodis I
Review: BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY. 2023;37(4):101894

Reframing health disparities in SLE: A critical reassessment of racial and ethnic differences in lupus disease outcomes.

Parodis I; Lanata C; Nikolopoulos D; Blazer A; Yazdany J
Review: FRONTIERS IN MEDICINE. 2023;10:1217147

Janus kinase inhibitors in systemic lupus erythematosus: implications for tyrosine kinase 2 inhibition

Nikolopoulos D; Parodis I
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2022;81:484.1-48484

DISRUPTED HIPPOCAMPAL NEUROGENESIS MEDIATED BY IL-6 AND IL-18 INDUCE NEUROPSYCHIATRIC CHANGES IN MURINE LUPUS

Nikolopoulos D; Manolakou T; Polissidis A; Filia A; Koutmani Y; Boumpas D
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2021;80:635-636

EULAR RECOMMENDATION-BASED QUALITY INDICATORS (QIS) FOR SYSTEMIC LUPUS ERYTHEMATOSUS (SLE): ELABORATION, FINAL SET, PERFORMANCE AND INITIAL VALIDATION

Chavatza K; Kostopoulou M; Nikolopoulos D; Gioti O; Togia K; Flouda S; Kapsala N; Kosmetatou M; Moysidou GS; Grivas A; Pieta A; Ntourou A; Rapsomaniki P; Gerogianni T; Tseronis D; Aggelakos M; Karageorgas T; Katsimpri P; Andreoli L; Aringer M; Boletis N; Doria A; Houssiau F; Jayne D; Mosca M; Svenungsson E; Tincani A; Bertsias G; Fanouriakis A; Boumpas D
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2021;80:439.2-43440

COMBINED ANALYSIS OF METABOLIC AND TRANSCRIPTOMIC KIDNEY PROFILES OF NZW/B-F1 MURINE LUPUS UNCOVERS BIOLOGICAL MECHANISMS PRECEDING THE ONSET OF NEPHRITIS

Manolakou T; Tsiara I; Nikolopoulos D; Garantziotis P; Benaki D; Gikas E; Frangou E; Mikroa E; Boumpas D
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2021;80:21.1-2122

HIPPOCAMPAL IMMUNE CELL TRAFFICKING AND A MYELOID PREDOMINANT INFLAMMATORY RESPONSE WITH ENHANCED ANTIGEN PRESENTATION AND DECREASED LEVELS OF NEUROTRANSMITTERS UNDERLY THE NEUROPSYCHIATRIC PHENOTYPE OF THE NZW/NZB MURINE LUPUS MODEL

Nikolopoulos D; Manolakou T; Filia A; Nakos-Bimpos M; Polissidis A; Boumpas D
Review: CURRENT VASCULAR PHARMACOLOGY. 2020;18(6):549-565

Cardiovascular Disease in Systemic Lupus Erythematosus: Recent Data on Epidemiology, Risk Factors and Prevention

Kostopoulou M; Nikolopoulos D; Parodis I; Bertsias G

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