Nicholas Mitsios

Publications
Public outreach and news

Articles

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(33):e2123146119
The neuropeptide landscape of human prefrontal cortex
Zhong W; Barde S; Mitsios N; Adori C; Oksvold P; von Feilitzen K; O'Learyd L; Csiba L; Hortobagyi T; Szocsics P; Mechawar N; Magloczky Z; Renner E; Palkovits M; Uhlen M; Mulder J; Hokfelt T
Article: NPJ PRECISION ONCOLOGY. 2021;5(1):97
FOXP3+ T cells in uterine sarcomas are associated with favorable prognosis, low extracellular matrix expression and reduced YAP activation
Gultekin O; Gonzalez-Molina J; Hardell E; Moyano-Galceran L; Mitsios N; Mulder J; Kokaraki G; Isaksson A; Sarhan D; Lehti K; Carlson JW
Article: KNEE SURGERY, SPORTS TRAUMATOLOGY, ARTHROSCOPY. 2021;29(7):2228-2236
Increased levels of inflammatory markers in the subscapularis tendon and joint capsule in patients with subacromial impingement
Farfaras S; Roshani L; Mulder J; Mitsios N; Hallstrom EK; Kartus J-T
Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2021;41(3):617-629
The cellular basis of increased PET hypoxia tracer uptake in focal cerebral ischemia with comparison between [¹⁸F]FMISO and [⁶⁴Cu]CuATSM
Little PV; Arnberg F; Jussing E; Lu L; Jensen AI; Mitsios N; Mulder J; Tran TA; Holmin S
Article: CANCERS. 2020;13(1):E114-114
TGFBR3L-An Uncharacterised Pituitary Specific Membrane Protein Detected in the Gonadotroph Cells in Non-Neoplastic and Tumour Tissue
Sjostedt E; Kolnes AJ; Olarescu NC; Mitsios N; Hikmet F; Sivertsson A; Lindskog C; Oystese KAB; Jorgensen AP; Bollerslev J; Casar-Borota O
Article: TRANSLATIONAL PSYCHIATRY. 2020;10(1):401
Exploring autoantibody signatures in brain tissue from patients with severe mental illness
Just D; Manberg A; Mitsios N; Stockmeier CA; Rajkowska G; Uhlen M; Mulder J; Feuk L; Cunningham JL; Nilsson P; Carlstrom EL
Article: SCIENCE. 2020;367(6482):eaay5947
An atlas of the protein-coding genes in the human, pig, and mouse brain
Sjostedt E; Zhong W; Fagerberg L; Karlsson M; Mitsios N; Adori C; Oksvold P; Edfors F; Limiszewska A; Hikmet F; Huang J; Du Y; Lin L; Dong Z; Yang L; Liu X; Jiang H; Xu X; Wang J; Yang H; Bolund L; Mardinoglu A; Zhang C; von Feilitzen K; Lindskog C; Ponten F; Luo Y; Hokfelt T; Uhlen M; Mulder J
Journal article: IBRO REPORTS. 2019;6:s526
Introducing the HPA Brain Atlas, a brain-centric sub atlas with regional expression maps of the human, mouse and pig brain
Sjöstedt E; Zhong W; Mitsios N; Oksvold P; Norradin FH; Lindskog C; Pontén F; Fagerberg L; Hökfelt T; Luo Y; Ulhén M; Mulder J
Article: JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2019;111(9):983-995
Impact of Epithelial-Stromal Interactions on Peritumoral Fibroblasts in Ductal Carcinoma in Situ
Strell C; Paulsson J; Jin S-B; Tobin NP; Mezheyeuski A; Roswall P; Mutgan C; Mitsios N; Johansson H; Wickberg SM; Svedlund J; Nilsson M; Hall P; Mulder J; Radisky DC; Pietras K; Bergh J; Lendahl U; Warnberg F; Ostman A
Article: BRAIN RESEARCH. 2019;1711:140-145
In vitro phosphodiesterase 10A (PDE10A) binding in whole hemisphere human brain using the PET radioligand [¹⁸F]MNI-659
Svedberg MM; Varnas K; Varrone A; Mitsios N; Mulder J; Gulyas B; Beaumont V; Munoz-Sanjuan I; Zaleska MM; Schmidt CJ; Halldin C; Mrzljak L
Article: JOURNAL OF CLINICAL INVESTIGATION. 2018;128(9):3757-3768
Ca²⁺- binding protein NECAB2 facilitates inflammatory pain hypersensitivity
Zhang M-D; Su J; Adori C; Cinquina V; Malenczyk K; Girach F; Peng C; Ernfors P; Low P; Borgius L; Kiehn O; Watanabe M; Uhlen M; Mitsios N; Mulder J; Harkany T; Hokfelt T
Article: EPILEPSIA. 2018;59(8):1507-1517
The expression of inflammatory markers and their potential influence on efflux transporters in drug-resistant mesial temporal lobe epilepsy tissue
Weidner LD; Kannan P; Mitsios N; Kang SJ; Hall MD; Theodore WH; Innis RB; Mulder J
Article: CEREBRAL CORTEX. 2017;27(6):3360-3377
Injury Leads to the Appearance of Cells with Characteristics of Both Microglia and Astrocytes in Mouse and Human Brain
Wilhelmsson U; Andersson D; De Pablo Y; Pekny R; Stahlberg A; Mulder J; Mitsios N; Hortobagyi T; Pekny M; Pekna M
Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2017;37(6):2062-2075
An automated method measures variability in P-glycoprotein and ABCG2 densities across brain regions and brain matter
Kannan P; Schain M; Kretzschmar WW; Weidner L; Mitsios N; Gulyas B; Blom H; Gottesman MM; Innis RB; Hall MD; Mulder J
Article: NUCLEAR MEDICINE AND BIOLOGY. 2017;46:50-53
Development of [¹¹C]/[³H-1]THK-5351-A potential novel carbon-11 tau imaging PET radioligand
Stepanov V; Svedberg M; Jia Z; Krasikova R; Lemoine L; Okamura N; Furumoto S; Mitsios N; Mulder J; Langstrom B; Nordberg A; Halldin C
Article: PROTEOMICS - CLINICAL APPLICATIONS. 2016;10(12):1242-1253
CSF profiling of the human brain enriched proteome reveals associations of neuromodulin and neurogranin to Alzheimer's disease
Remnestal J; Just D; Mitsios N; Fredolini C; Mulder J; Schwenk JM; Uhlen M; Kultima K; Ingelsson M; Kilander L; Lannfelt L; Svenningsson P; Nellgard B; Zetterberg H; Blennow K; Nilsson P; Haggmark-Manberg A
Article: BRAIN STRUCTURE AND FUNCTION. 2016;221(7):3803-3823
Comparative anatomical distribution of neuronal calcium-binding protein (NECAB) 1 and-2 in rodent and human spinal cord
Zhang M-D; Barde S; Szodorai E; Josephson A; Mitsios N; Watanabe M; Attems J; Lubec G; Kovacs GG; Uhlen M; Mulder J; Harkany T; Hokfelt T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(8):2188-2193
Anoctamin 2 identified as an autoimmune target in multiple sclerosis
Ayoglu B; Mitsios N; Kockum I; Khademi M; Zandian A; Sjoberg R; Forsstrom B; Bredenberg J; Bomfim IL; Holmgren E; Gronlund H; Guerreiro-Cacais AO; Abdelmagid N; Uhlen M; Waterboer T; Alfredsson L; Mulder J; Schwenk JM; Olsson T; Nilsson P
Article: FRONTIERS IN NEUROLOGY. 2016;7:23
Lesion Size Is Exacerbated in Hypoxic Rats Whereas Hypoxia-Inducible Factor-1 Alpha and Vascular Endothelial Growth Factor Increase in Injured Normoxic Rats: A Prospective Cohort Study of Secondary Hypoxia in Focal Traumatic Brain Injury
Thelin EP; Frostell A; Mulder J; Mitsios N; Damberg P; Aski SN; Risling M; Svensson M; Morganti-Kossmann MC; Bellander B-M
Article: ACTA NEUROPATHOLOGICA. 2015;129(4):541-563
Critical role of somatostatin receptor 2 in the vulnerability of the central noradrenergic system: new aspects on Alzheimer's disease
Adori C; Glueck L; Barde S; Yoshitake T; Kovacs GG; Mulder J; Magloczky Z; Havas L; Boelcskei K; Mitsios N; Uhlen M; Szolcsanyi J; Kehr J; Ronnback A; Schwartz T; Rehfeld JF; Harkany T; Palkovits M; Schulz S; Hokfelt T
Article: STROKE. 2015;46(3):835-842
Imaging of a Clinically Relevant Stroke Model Glucose Hypermetabolism Revisited
Arnberg F; Grafstrom J; Lundberg J; Nikkhou-Aski S; Little P; Damberg P; Mitsios N; Mulder J; Lu L; Soderman M; Stone-Elander S; Holmin S
Article: PLOS ONE. 2015;10(6):e0130028
Defining the Human Brain Proteome Using Transcriptomics and Antibody-Based Profiling with a Focus on the Cerebral Cortex
Sjostedt E; Fagerberg L; Hallstrom BM; Haggmark A; Mitsios N; Nilsson P; Ponten F; Hokfelt T; Uhlen M; Mulder J
Article: EJNMMI RESEARCH. 2014;4(1):34
Evaluation of efficacy of a new MEK inhibitor, RO4987655, in human tumor xenografts by [¹⁸F] FDG-PET imaging combined with proteomic approaches
Tegnebratt T; Ruge E; Bader S; Ishii N; Aida S; Yoshimura Y; Ooi C-H; Lu L; Mitsios N; Meresse V; Mulder J; Pawlak M; Venturi M; Tessier J; Stone-Elander S
Article: JOURNAL OF PROTEOME RESEARCH. 2014;13(11):4607-4619
Affinity Proteomic Profiling of Plasma, Cerebrospinal Fluid, and Brain Tissue within Multiple Sclerosis
Bystrom S; Ayoglu B; Haggmark A; Mitsios N; Hong M-G; Drobin K; Forsstrom B; Fredolini C; Khademi M; Amor S; Uhlen M; Olsson T; Mulder J; Nilsson P; Schwenk JM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(12):E1149-E1158
Neuronal calcium-binding proteins 1/2 localize to dorsal root ganglia and excitatory spinal neurons and are regulated by nerve injury
Zhang M-D; Tortoriello G; Hsueh B; Tomer R; Ye L; Mitsios N; Borgius L; Grant G; Kiehn O; Watanabe M; Uhlen M; Mulder J; Deisseroth K; Harkany T; Hokfelt TGM
Article: EUROPEAN JOURNAL OF NEUROLOGY. 2008;15(1):25-33
Leukaemia inhibitory factor is over-expressed by ischaemic brain tissue concomitant with reduced plasma expression following acute stroke
Slevin M; Krupinski J; Mitsios N; Perikleous C; Cuadrado E; Montaner J; Sanfeliu C; Luque A; Kumar S; Kumar P; Gaffney J
Article: BMC NEUROSCIENCE. 2007;8:93
A microarray study of gene and protein regulation in human and rat brain following middle cerebral artery occlusion
Mitsios N; Saka M; Krupinski J; Pennucci R; Sanfeliu C; Wang Q; Rubio F; Gaffney J; Kumar P; Kumar S; Sullivan M; Slevin M
Article: INTERNATIONAL JOURNAL OF CANCER. 2007;120(6):1223-1231
Investigation of downstream target genes of PAX3c, PAX3e and PAX3g isoforms in melanocytes by microarray analysis
Wang Q; Kumar S; Mitsios N; Slevin M; Kumar P
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2007;85(3):602-611
Cellular prion protein is increased in the plasma and peri-infarcted brain tissue after acute stroke
Mitsios N; Saka M; Krupinski J; Pennucci R; Sanfeliu C; Turu MM; Gaffney J; Kumar P; Kumar S; Sullivan M; Slevin M
Article: BRAIN PATHOLOGY. 2007;17(1):11-23
Expression of cyclin-dependent kinase 5 mRNA and protein in the human brain following acute ischemic stroke
Mitsios N; Pennucci R; Krupinski J; Sanfeliu C; Gaffney J; Kumar P; Kumar S; Juan-Babot O; Slevin M
Article: BRAIN. 2006;129(Pt 8):2158-2176
Changes in hyaluronan production and metabolism following ischaemic stroke in man
Al'Qteishat A; Gaffney J; Krupinski J; Rubio F; West D; Kumar S; Kumar P; Mitsios N; Slevin M
Journal article: THE FASEB JOURNAL. 2006;20(4):a460
Expression of cyclin‐dependent kinase 5 mRNA and protein in the human brain following acute ischemic stroke
Mitsios N; Pennucci R; Krupinski J; Sanfeliu C; Gaffney J; Kumar P; Kumar S; Slevin M
Article: ANGIOGENESIS. 2005;8(1):53-62
Expression of basic fibroblast growth factor mRNA and protein in the human brain following ischaemic stroke.
Issa R; AlQteishat A; Mitsios N; Saka M; Krupinski J; Tarkowski E; Gaffney J; Slevin M; Kumar S; Kumar P
Journal article: BIOCHEMICAL SOCIETY TRANSACTIONS. 2002;30(3):a84
An investigation in changes in gene regulation and subsequent signal transduction activation after ischemic stroke
Mitsios N; Gaffney J; Kumar P; Kumar S; Slevin M
Journal article: BIOCHEMICAL SOCIETY TRANSACTIONS. 2002;30(3):a71
An investigation in changes in gene regulation and subsequent signal transduction activation after ischemic stroke
Mitsios N; Gaffney J; Kumar P; Kumar S; Slevin M
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Conference publication: JOURNAL OF NEUROTRAUMA. 2022;39(15-16):A8-A9
CYTOTOXIC BRAIN EDEMA IS ASSOCIATED WITH NEUROINFLAMMATION AND RETRACTION OF PERIVASCULAR AQUAPORIN-4 FOLLOWING EXPERIMENTAL SEVERE TRAUMATIC BRAIN INJURY - A MULTI-MODAL IMAGING STUDY
Lindblad C; Mitsios N; Falk-Delgado A; Mattsson P; Morganti-Kossmann MC; Frostell A; Mulder J; Risling M; Damberg P; Bellander BM; Thelin E; Svensson M
Preprint: BIORXIV. 2021
Regulatory FOXP3+ T cells in uterine sarcomas are associated with favorable prognosis, low extracellular matrix expression and reduced YAP activation
Gultekin O; Gonzalez-Molina J; Hardell E; Moyano-Galceran L; Mitsios N; Mulder J; Kokaraki G; Isaksson A; Sarhan D; Lehti K; Carlson J
Conference publication: MOLECULAR BIOLOGY OF THE CELL. 2018;29(26)
Deep immunological profiling of the murine brain and spleen after high fat diet by CODEX multiplexed imaging.
Gnann C; Casals AM; Xu H; Kheder S; Archer A; Mulder J; Mitsios N; Williams C; Lundberg E; Ayoglu B
Corrigendum: BRAIN STRUCTURE AND FUNCTION. 2016;221(7):3843
Comparative anatomical distribution of neuronal calcium-binding protein (NECAB) 1 and -2 in rodent and human spinal cord (vol 221, pg 3803, 2016)
Zhang M-D; Barde S; Szodorai E; Josephson A; Mitsios N; Watanabe M; Attems J; Lubec G; Kovacs GG; Uhlen M; Mulder J; Harkany T; Hokfelt T
Conference publication: JOURNAL OF NEUROTRAUMA. 2016;33(3):A7
HYPOXIA FOLLOWING TRAUMATIC BRAIN INJURY EXACERBATES LESION SIZE WHEREAS HYPOXIA-INDUCIBLE FACTOR 1 ALPHA AND VASCULAR ENDOTHELIAL GROWTH FACTOR INCREASE IN NORMOXIC RATS
Thelin EP; Frostell A; Mulder J; Mitsios N; Damberg P; Nikkhou-Aski S; Risling M; Svensson M; Morganti-Kossmann MC; Bellander BM
Conference publication: EUROPEAN JOURNAL OF NEUROLOGY. 2016;23:57
Anoctamin 2 identified as an autoimmune target in multiple sclerosis
Ayoglu B; Mitsios N; Kockum I; Olsson T; Nilsson P
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2014;20:49-50
Anoctamin 2, a novel autoimmune target candidate in multiple sclerosis
Ayoglu B; Mitsios N; Khademi M; Alfredsson L; Uhlen M; Mulder J; Olsson T; Schwenk JM; Nilsson P
Published conference paper: CELL BIOCHEMISTRY AND BIOPHYSICS. 2007;47(1):73-85
Expression of signaling molecules associated with apoptosis in human ischemic stroke tissue
Mitsios N; Gaffney J; Krupinski J; Mathias R; Wang Q; Hayward S; Rubio F; Kumar P; Kumar S; Slevin M
Review: PATHOBIOLOGY. 2006;73(4):159-175
Pathophysiology of acute ischaemic stroke: An analysis of common signalling mechanisms and identification of new molecular targets
Mitsios N; Gaffney J; Kumar P; Krupinski J; Kumar S; Slevin M

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