Research group - Qiang Pan-Hammarström
We focus on two main areas of research: Immunogenetics and Cancer Genetics.
Regulation of immunoglobulin class switch recombination in human B cells
The project is aimed at understanding the complex molecular mechanisms involved in DNA editing, repair and recombination during immunoglobulin class switch recombination (CSR) and somatic hypermutation (SHM) and their involvement in the pathophysiological processes leading to immunodeficiency, genome instability and cancer development in humans.
Induced pluripotent stems cells a platform for personalized diagnosis and therapy in patients with primary immunodeficiency
The project is aimed at reprogramming the fibroblasts or peripheral blood B cells derived from IgA deficient (IgAD) patients into pluripotent stem (iPS) cells and to re-differentiate these iPS cells into antibody-producing B cells. If successful, this study may provide a potentially curative treatment in patients with IgA deficiency. They will also provide a methodological platform for studies aimed at replacing cells in patients with a variety of other primary immunodeficiency diseases as well as autoimmune and neurological disorders associated with these diseases.
Discovery of therapeutic targets in B cell lymphoma by next generation sequencing
The project is aimed at identifying potentially treatable molecular targets in mature B cell lymphomas (with focus on diffuse large B cell lymphomas and mantle cell lymphomas) by high-throughput, next generation-sequencing omic- technologies such as whole genome and exome sequencing and RNA-seq.
Our research is supported by the Swedish Research Council (VR), the Swedish Cancer Society (Cancerfonden) and the European Research Council (ERC).
Research group leader Qiang Pan-Hammarström
|Likun Du||Laboratory coordinator|
|Marco Mandolesi||Graduate Student|
|Qiang Pan Hammarström||Professor|
|Xiaofei Ye||PhD student|
DNA sequencing, including whole exome and whole genome sequencing
Gene expression analysis including realtime PCR and RNAseq/transcriptome analysis
B and T cell functional assays
Gene editing using the CRISPR/Cas9 system
The Swedish Research Council, Cancerfonden, European Research Council (ERC), Barncancerfonden (Swedish Children Cancer Fund), The Swedish Foundation for International Cooperation in Research and Higher Education (STINT), Stockholm County Council (ALF), Center for Innovative Medicine (CIMED) and Radiumhemmets research fund.
Postdoctoral fellowship available
Postdoc scholarship position on Immunology/Immunogenetics available. For details contact Prof. Pan-Hammarström
Reduced immunoglobulin gene diversity in patients with Cornelia de Lange syndrome.
J. Allergy Clin. Immunol. 2018 Jan;141(1):408-411.e8
Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency.
J. Exp. Med. 2017 Jan;214(1):91-106
Common variants at PVT1, ATG13-AMBRA1, AHI1 and CLEC16A are associated with selective IgA deficiency.
Nat. Genet. 2016 Nov;48(11):1425-1429
Genetic basis of PD-L1 overexpression in diffuse large B-cell lymphomas.
Blood 2016 06;127(24):3026-34
Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas.
Nat Commun 2015 Dec;6():10131
Aberrant recombination and repair during immunoglobulin class switching in BRCA1-deficient human B cells.
Proc. Natl. Acad. Sci. U.S.A. 2015 Feb;112(7):2157-62
B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.
Cell 2014 Dec;159(7):1524-37
Exome sequencing reveals novel mutation targets in diffuse large B-cell lymphomas derived from Chinese patients.
Blood 2014 Oct;124(16):2544-53
A regulatory role for the cohesin loader NIPBL in nonhomologous end joining during immunoglobulin class switch recombination.
J. Exp. Med. 2013 Nov;210(12):2503-13
New facets of antibody deficiencies.
Curr. Opin. Immunol. 2013 Oct;25(5):629-38
DNA repair genes are selectively mutated in diffuse large B cell lymphomas.
J. Exp. Med. 2013 Aug;210(9):1729-42
Nurture your scientific curiosity early in your research career.
Nat. Genet. 2013 Feb;45(2):116-8
Cernunnos influences human immunoglobulin class switch recombination and may be associated with B cell lymphomagenesis.
J. Exp. Med. 2012 Feb;209(2):291-305