Hassan Abolhassani

Hassan Abolhassani

Assistant Professor
Visiting address: Solnavägen 9, 17165 Solna
Postal address: C2 Medicinsk biokemi och biofysik, C2 Immunologi Hammarström, 171 77 Stockholm

About me

  • He obtained his degree of Medical Doctor (MD) at the Tehran University of Medical Sciences in 2012. He started his training in Pediatrics primary immunodeficiency (PID) at Children Medical Center Hospital for 8 years and became a Master of Public Health (MPH) in the same period. In parallel, he had an internship for immune disorders at the Research Center for Immunodeficiencies and in the group of Prof. Aghamohammadi. During the following years, he was the adjunct clinical head and became the clinical head of the national PID registry in 2013. He is an active consultant for in- and outpatient pediatric PID clinics at the national PID network. In 2012, he was awarded the Razi Festival Award in Medical Sciences as the best young MD researcher in the country.

    Regarding scientific mobility and proving his capacity for re-establishment in a new lab, in 2014 he traveled to Sweden and joined a new group at Karolinska Institutet (KI, Prof. Hammarström) to obtain his PhD in clinical immunology and immunogenetics of chronic infectious and inflammatory disease. During his Post-doc he started an independent line of research on single-cell multi-omics evaluation of novel PID genetic defects after he obtained the Jonas Söderquist award for the best PhD thesis at KI in the field of immunology.

    He is currently an assistant professor and team leader of PID research in Prof. Pan-Hammarström's lab (KI, QPH). Hassan Abolhassani is the president of the Middle East and North Africa Registry on Inborn Errors of Immunity (MENA-IEI), one of the largest PID cohorts worldwide (>17000 patients) performing translational research on immune defects and specific PID with B cell defects and immune dysregulation. He is a steering member of the J Project experts (professional network on PID and related diseases in East-European countries) and a distinguished clinical immunologist collaborator of Global Burden of Disease (GBD).

    Additionally, he was a previous leading member (2019-2021) and currently is the communication focus group leader (2022-now) of the junior faculty at KI. Within a long-term collaboration with the Center for Vaccine Equity, and Task Force for Global Health, he is coordinating the guidelines for diagnosis, treatment, transplantation and vaccinations in PID patients. Fortunately, he is honored as top 1% of highly cited scientific researchers in the field of Immunology, Essential Science Indicators (ESI, Web of Science) and the World's Top 2% widely cited scientists based on Stanford University ranking (Scopus/Elsevier database, since 1788 until now)

Research

  • The goal of our clinical research is to investigate the pathogenesis of primary antibody deficiency and the immune pathways involved that may help physicians and immunologists to understand genes with currently unknown functions aiding in deciding the therapeutic approach for the patients. Molecular diagnosis will also help all family members of the patient by using carrier detection, and pre-implantation testing in conjunction with in vitro fertilization. Moreover, genetic analysis is required to confirm the diagnosis and establish the inheritance pattern. This information is not only a guide for an abortion decision, but it could be used for long-term planning and individualized medicine, such as bone marrow transplantation, targeted therapy, and gene therapy of the infant at birth. The result of this genetic testing could include screening for newborns in selected families or ethnic groups.

Teaching

  • SUBJECT AREA COMPETENCE AND CURRENT TEACHING ACTIVITY
    Basic immunology and clinical immunology
    Philosophy of sciences
    Management of disease and health care organizations
    Biostatistics and Bioinformatics
    Methods of research, epidemiology, advanced statistic
    National registry handling

    TEACHING IN NURSING AND MEDICINE AND FOR HEALTHCARE PRACTITIONERS
    Approach to recurrent infections
    Pediatric and adult primary immunodeficiency disorders
    Intravenous and subcutaneous immunoglobulin replacement therapy
    Family communication and genetic counseling

Selected publications

  • Article: CLINICAL IMMUNOLOGY. 2022;244:109131
    Jamee M; Azizi G; Baris S; Karakoc-Aydiner E; Ozen A; Kiliç SŞ; Kose H; Chavoshzadeh Z; Mahdaviani SA; Momen T; Shamsian BS; Fallahi M; Sharafian S; Gülez N; Aygun A; Karaca NE; Kutukculer N; Al Sukait N; Al Farsi T; Al-Tamemi S; Khalifa N; Shereen R; El-Ghoneimy D; El-Owaidy R; Radwan N; Alzyoud R; Barbouche M-R; Ben-Mustapha I; Mekki N; Rais A; Boukari R; Belbouab R; Djenouhat K; Tahiat A; Touri S; Elghazali G; Al-Hammadi S; Shendi HM; Alkuwaiti A; Belaid B; Djidjik R; Artac H; Adeli M; Sobh A; Elnagdy MH; Bahgat SA; Nasrullayeva G; Chou J; Rezaei N; Al-Herz W; Geha RS; Abolhassani H; MENA-I. E. I. Study Group
  • Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2022;150(5):1059-1073
    Abolhassani H; Delavari S; Landegren N; Shokri S; Bastard P; Du L; Zuo F; Hajebi R; Abolnezhadian F; Iranparast S; Modaresi M; Vosughimotlagh A; Salami F; Aranda-Guillén M; Cobat A; Marcotte H; Zhang S-Y; Zhang Q; Rezaei N; Casanova J-L; Kämpe O; Hammarström L; Pan-Hammarström Q
  • Article: NATURE COMMUNICATIONS. 2022;13(1):2670
    Zuo F; Abolhassani H; Du L; Piralla A; Bertoglio F; de Campos-Mata L; Wan H; Schubert M; Cassaniti I; Wang Y; Sammartino JC; Sun R; Vlachiotis S; Bergami F; Kumagai-Braesch M; Andréll J; Zhang Z; Xue Y; Wenzel EV; Calzolai L; Varani L; Rezaei N; Chavoshzadeh Z; Baldanti F; Hust M; Hammarström L; Marcotte H; Pan-Hammarström Q
  • Article: SCIENCE IMMUNOLOGY. 2021;6(62):eabl4348
    Asano T; Boisson B; Onodi F; Matuozzo D; Moncada-Velez M; Maglorius Renkilaraj MRL; Zhang P; Meertens L; Bolze A; Materna M; Korniotis S; Gervais A; Talouarn E; Bigio B; Seeleuthner Y; Bilguvar K; Zhang Y; Neehus A-L; Ogishi M; Pelham SJ; Le Voyer T; Rosain J; Philippot Q; Soler-Palacín P; Colobran R; Martin-Nalda A; Rivière JG; Tandjaoui-Lambiotte Y; Chaïbi K; Shahrooei M; Darazam IA; Olyaei NA; Mansouri D; Hatipoğlu N; Palabiyik F; Ozcelik T; Novelli G; Novelli A; Casari G; Aiuti A; Carrera P; Bondesan S; Barzaghi F; Rovere-Querini P; Tresoldi C; Franco JL; Rojas J; Reyes LF; Bustos IG; Arias AA; Morelle G; Christèle K; Troya J; Planas-Serra L; Schlüter A; Gut M; Pujol A; Allende LM; Rodriguez-Gallego C; Flores C; Cabrera-Marante O; Pleguezuelo DE; de Diego RP; Keles S; Aytekin G; Akcan OM; Bryceson YT; Bergman P; Brodin P; Smole D; Smith CIE; Norlin A-C; Campbell TM; Covill LE; Hammarström L; Pan-Hammarström Q; Abolhassani H; Mane S; Marr N; Ata M; Al Ali F; Khan T; Spaan AN; Dalgard CL; Bonfanti P; Biondi A; Tubiana S; Burdet C; Nussbaum R; Kahn-Kirby A; Snow AL; COVID Human Genetic Effort; COVID-STORM Clinicians; COVID Clinicians; Imagine COVID Group; French COVID Cohort Study Group; CoV-Contact Cohort; Amsterdam UMC Covid-; Biobank; NIAID-USUHS COVID Study Group; Bustamante J; Puel A; Boisson-Dupuis S; Zhang S-Y; Béziat V; Lifton RP; Bastard P; Notarangelo LD; Abel L; Su HC; Jouanguy E; Amara A; Soumelis V; Cobat A; Zhang Q; Casanova J-L
  • Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2021;41(6):1339-1351
    Aghamohammadi A; Rezaei N; Yazdani R; Delavari S; Kutukculer N; Topyildiz E; Ozen A; Baris S; Karakoc-Aydiner E; Kilic SS; Kose H; Gulez N; Genel F; Reisli I; Djenouhat K; Tahiat A; Boukari R; Ladj S; Belbouab R; Ferhani Y; Belaid B; Djidjik R; Kechout N; Attal N; Saidani K; Barbouche R; Bousfiha A; Sobh A; Rizk R; Elnagdy MH; Al-Ahmed M; Al-Tamemi S; Nasrullayeva G; Adeli M; Al-Nesf M; Hassen A; Mehawej C; Irani C; Megarbane A; Quinn J; MENA-I. E. I. Study Group; Maródi L; Modell V; Modell F; Al-Herz W; Geha RS; Abolhassani H
  • Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2020;145(5):1452-1463
    Tesch VK; Abolhassani H; Shadur B; Zobel J; Mareika Y; Sharapova S; Karakoc-Aydiner E; Rivière JG; Garcia-Prat M; Moes N; Haerynck F; Gonzales-Granado LI; Santos Pérez JL; Mukhina A; Shcherbina A; Aghamohammadi A; Hammarström L; Dogu F; Haskologlu S; İkincioğulları AI; Köstel Bal S; Baris S; Kilic SS; Karaca NE; Kutukculer N; Girschick H; Kolios A; Keles S; Uygun V; Stepensky P; Worth A; van Montfrans JM; Peters AMJ; Meyts I; Adeli M; Marzollo A; Padem N; Khojah AM; Chavoshzadeh Z; Avbelj Stefanija M; Bakhtiar S; Florkin B; Meeths M; Gamez L; Grimbacher B; Seppänen MRJ; Lankester A; Gennery AR; Seidel MG; Inborn Errors, Clinical, and Registry Working Part
  • Review: BLOOD. 2020;135(9):656-667
    Abolhassani H; Hammarström L; Cunningham-Rundles C
  • Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2018;141(4):1450-1458
    Abolhassani H; Chou J; Bainter W; Platt CD; Tavassoli M; Momen T; Tavakol M; Eslamian MH; Gharagozlou M; Movahedi M; Ghadami M; Hamidieh AA; Azizi G; Yazdani R; Afarideh M; Ghajar A; Havaei A; Chavoshzadeh Z; Mahdaviani SA; Cheraghi T; Behniafard N; Amin R; Aleyasin S; Faridhosseini R; Jabbari-Azad F; Nabavi M; Bemanian MH; Arshi S; Molatefi R; Sherkat R; Mansouri M; Mesdaghi M; Babaie D; Mohammadzadeh I; Ghaffari J; Shafiei A; Kalantari N; Ahanchian H; Khoshkhui M; Soheili H; Dabbaghzadeh A; Shirkani A; Nasiri Kalmarzi R; Mortazavi SH; Tafaroji J; Khalili A; Mohammadi J; Negahdari B; Joghataei M-T; Al-Ramadi BK; Picard C; Parvaneh N; Rezaei N; Chatila TA; Massaad MJ; Keles S; Hammarström L; Geha RS; Aghamohammadi A
  • Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2017;214(1):91-106
    Abolhassani H; Edwards ESJ; Ikinciogullari A; Jing H; Borte S; Buggert M; Du L; Matsuda-Lennikov M; Romano R; Caridha R; Bade S; Zhang Y; Frederiksen J; Fang M; Bal SK; Haskologlu S; Dogu F; Tacyildiz N; Matthews HF; McElwee JJ; Gostick E; Price DA; Palendira U; Aghamohammadi A; Boisson B; Rezaei N; Karlsson AC; Lenardo MJ; Casanova J-L; Hammarström L; Tangye SG; Su HC; Pan-Hammarström Q
  • Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2014;134(6):1375-1380
    Abolhassani H; Wang N; Aghamohammadi A; Rezaei N; Lee YN; Frugoni F; Notarangelo LD; Pan-Hammarström Q; Hammarström L

Articles

All other publications

Grants

Employments

  • Assistant Professor, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2023-2025

Degrees and Education

  • Degree Of Doctor Of Philosophy, Department of Laboratory Medicine, Karolinska Institutet, 2018
  • Master of Philosophy (MPhil), Master of Philosophy (MPhil), Research accessory of Tehran University of Medical Sciences, Tehran University of Medical Sciences, 2013
  • Doctor of Medicine (MD), Medicine (MD), Health Policy for Common Variable Immunodeficiency: Burden of the Disease, School of Medicine, Tehran University of Medical Sciences, 2012
  • Master of Public Health (MPH), Master of Public Health (MPH), Health Policy for Common Variable Immunodeficiency: Burden of the Disease, School of Health, Tehran University of Medical Sciences, 2012
  • Biology &Experimental Science Diploma, Sama High School, 2004
  • Mathematic Diploma, Mofid High School, 2003

Leadership and responsibility assignments

  • Research team leader, Team leader of immunogenetics and immunotherapy, Division of Clinical Immunology at the Department of Laboratory Medicine, Karolinska Institute, 2020-

Distinction and awards

  • 2024-now: First decentile of both Karolinska lnstitutet (Kl) and Stockholms lans landsting (SLL) regarding "world's most highly cited publications (share top 5%)" based on bibliometrics.ki.se analysis, https://kib.ki.se/en/publish-analyse/bibliometrics-verification, 2024
  • Prof. Isil Berat Barlan Award, In Primary Immunodeficiency Diseases., Turkish Society of Immunology, https://twitter.com/TurkImmunoloji/status/1585301036264136706, 2022
  • Designation as a Distinguished Visiting Professor, In the field of Clinical Immunology., Shahid Beheshti University of Medical Sciences, https://app.box.com/s/jnei7i5fr5ikhfk474w0cmzbibdverth, 2022
  • USERN LAUREATES 2021 in Medical Sciences, Selected by Nobel laureates and 1% top scientists., USERN, https://usern.tums.ac.ir/News/New?title=USERN%20Prize%20Festival%202021, 2021
  • Anna-Greta Crafoords prize for reumatologisk forskning, , Royal Swedish Academy of Sciences, https://crafoord.se/en/, 2021
  • 2020-now: First decentile of both Karolinska lnstitutet (Kl) and Stockholms lans landsting (SLL) regarding "average journal impact for top publications" based on bibliometrics.ki.se analysis, https://kib.ki.se/en/publish-analyse/bibliometrics-verification, 2020
  • 2020-now: First decentile of both Karolinska lnstitutet (Kl) and Stockholms lans landsting (SLL) regarding "citation average for top publications" based on bibliometrics.ki.se analysis, https://kib.ki.se/en/publish-analyse/bibliometrics-verification, 2020
  • 2022-now: First decentile of both Karolinska lnstitutet (Kl) and Stockholms lans landsting (SLL) regarding "Field Normalized Citation Score" based on bibliometrics.ki.se analysis, https://kib.ki.se/en/publish-analyse/bibliometrics-verification, 2020
  • 2020-now: Ranked among the top World Experts in the following medical topics based on Expertscape: Primary: Immunodeficiency Diseases, Common Variable Immunodeficiency: Dysgammaglobulinemia, Gammaglobulinemia, Hyper-lgM Immunodeficiency, IgA Deficiency, Severe Combined Immunodeficiency, DNA Repair­Deficiency, Immunologic Syndromes , Lumphoproliferative Disorders, Intravenous lmmunoglobulins, Inborn Genetic Diseases, Ataxia Telangiectasia, Hypeer lgE Syndrome, Immune System Diseases, Genetic diseases, COVID-19, https://expertscape.com/, 2020
  • Designation as a Distinguished Visiting Professor, In the field of Primary Immunodeficiency., Tehran University of Medical Sciences, https://gsia.tums.ac.ir/dira/page/19751/Hassan-Abolhassani, 2019
  • Top three clinical immunologists of Sweden, Essential Science Indicators (ESI), https://clarivate.com/, 2019
  • Top 10 PhD thesis in the history of Karolinska Institutet, Stockholm, Sweden, Karolinska Institute, 2018
  • 2016-now: First decentile of both Karolinska lnstitutet (Kl) and Stockholms lans landsting (SLL) regarding "world's most highly cited publications (count top 5%)" based on bibliometrics.ki.se analysis, https://kib.ki.se/en/publish-analyse/bibliometrics-verification, 2016
  • 2015-now: First decentile of both Karolinska lnstitutet (Kl) and Stockholms lans landsting (SLL) regarding "number of citations", based on bibliometrics.ki.se analysis, https://kib.ki.se/en/publish-analyse/bibliometrics-verification, 2015
  • 2015-now: First decentile of both Karolinska lnstitutet (Kl) and Stockholms lans landsting (SLL) regarding "aggregated journal impact factors" based on bibliometrics.ki.se analysis, https://kib.ki.se/en/publish-analyse/bibliometrics-verification, 2015
  • 2015-now: First decentile of both Karolinska lnstitutet (Kl) and Stockholms lans landsting (SLL) regarding "number of publications" based on bibliometrics.ki.se analysis, https://kib.ki.se/en/publish-analyse/bibliometrics-verification, 2015
  • Distinctive Elite PhD doctoral student of Iran, Tehran, Iran, 2015
  • The 1st Rank of the Best Researcher and Best comprehensive student in the first student Avicenna festival, Tehran, Iran, 2014
  • The 1st Rank of the National Best Young Researcher in the Razi Research Festival, Tehran, Iran, 2014
  • Distinctive Elite Medical Doctoral Student (MD) of Iran, Tehran, Iran, 2013
  • Paramount Young Scientists of the country in Medical Sciences, Tehran, Iran, 2013
  • Distinctive Research for MD-MPH thesis in the 13th Avicenna Festivals, Tehran University of Medical Sciences, 2012
  • The 3rd Rank of the Best Article in Basic Sciences in the Festival of National Academy of Medical Sciences, Tehran, Iran, 2012
  • Distinctive Young Researcher, Tehran University of Medical Sciences, 2009

Supervisor

  • Bobak Moazzemi, MD thesis: Respiratory Complications in Patients with Hyper IgM Syndrome., 2017
  • Mahmoud Tavassoli, Clinical Immunologist subspecialist thesis: The first cohort of Iranian patients with hyper immunoglobulin E syndrome: A long-term follow-up and genetic analysis, 2017
  • Saeed Bazregari, Clinical Immunologist subspecialist thesis: Evaluation of infectious and non-infectious complications in patients with primary immunodeficiency., 2016
  • Ghazal Sadri, MD thesis: Pulmonary evaluation of patients with common variable immunodeficeincy, 2016
  • Mohsen Afarideh, MD thesis: Clinical, immunologic, and genetic spectrum of 696 patients with combined immunodeficiency., 2016
  • Na Lu, PhD project: Development of advance pipeline for analysis of whole exome sequencing for patients with primary immunodeficiencies, 2015
  • Parisa Amirifar, PhD thesis:Ataxia-telangiectasia: A review of clinical features and molecular pathology, 2015
  • Farzaneh Tofighi, PhD thesis:Immunophenotypic and functional analysis of lymphocyte subsets in common variable immunodeficiency patients without monogenic defects, 2014
  • Bamdad Sadeqi, MD thesis: Economic burden of common variable immunodeficiency: annual cost of disease, 2014
  • Shervin Shahinpour, MD thesis: Report on the First Survey of Iranian Patients with Hereditary Angioedema., 2014
  • Babak Mirminachi, MD thesis: Cohort oflranian Patients with Congenital Agammaglobulinemia: Mutation Analysis and Novel Gene Defects., 2014
  • Mohammadreza Shaghaghi, MD thesis: Vaccine-Derived Polioviruses in Children with Primary Immunodeficiency, 2014
  • Behzad Gharib, Paediatric specialist thesis: Autoimmunity in patients with selective IgA deficiency, 2014
  • Gholamreza Azizi, PhD thesis: Clinical, immunologic, molecular analyses and outcomes of iranian patients with LRBA deficiency: A longitudinal study., 2013
  • Fatemeh Akbari, MD thesis: Morbidity and mortality oflranian patients with hyper IgM syndrome: a clinical analysis, 2013
  • Yaser Bagheri, PhD thesis:B cells and T cells abnormalities in patients with selective IgA deficiency., 2013
  • Reza Yazdani, PhD thesis: Role of apoptosis in common variable immunodeficiency and selective immunoglobulin A deficiency, 2012
  • Alireza Ghajar, MD thesis: Otological findings in pediatric patients with hypogammaglobulinemia., 2012
  • Alireza Allahverdi, Paediatric specialist thesis: Comparison of pulmonary diseases in common variable immunodeficiency and X-linked agammaglobulinaemia, 2012
  • Davud Amirkasahani, Paediatric specialist thesis: Autoimmune phenotype in patients with common variable immunodeficiency, 2012
  • Najmoddin Kalantari, Clinical Immunologist subspecialist thesis:Cutaneous granulomas in common variable immunodeficiency, 2012
  • Habib Soheili, Clinical Immunologist subspecialist thesis: Evaluation of natural regulatory T cells in subjects with selective IgA deficiency: from senior idea to novel opportunities., 2012
  • Nasrin Behniafard, Clinical Immunologist subspecialist thesis:Autoimmunity in X-Iinked agammaglobulinemia: Kawasaki disease and review of the literature., 2012
  • Mahmoud Tavassoli, Paediatric specialist thesis: Infectious and Non-Infectious Complications among Undiagnosed Patients with Common Variable Immunodeficiency, 2011
  • Daan van Beek, MSc thesis: Clinical genetics and common variable immunodeficiency
  • Shifan Ding, MSc thesis: Assessing the Influence of Permeabilization on BD Rhapsody TM Single-Cell Analysis Svstem
  • Stylianos Vlachiotis, MSc project: Singel cell multiomics assesment of monogenic inborn errors of immunity
  • Nilahazra Khoirunnisa, MSc thesis: Association of Epstein-Barr virus EBV reactivation and COVID-19 complications
  • Jelena Tolic, BSc project:Identifiering av mutationer i samband med svara virusinfektioner hos patienter med immunbrist
  • Sude Tınaz, BSc project: Confirmation of known mutation in patients with antibody deficiencies
  • Lindström Henrik, BSc project:Determining sensitivity of Next Generation Sequencing result of definite diagnosis of patients with primarv immunodeficiency
  • Jason Krogh-Pedersen, BSc project: Gastrointestinal Dysfunction and Liver Complications in Common Variable Immunodeficiency
  • Fereshteh Salami, MSc thesis: The Effects of Stimulation with PMA/Ionomycin on CD4+ T Cell Proliferation and Surface CD4 Molecule Modulation of Patients with LRBA Deficiency and CVID with the Unsolved Genetic Defect.
  • Salar Pashangzadeh, MSc thesis: Non-Infectious Complications in B-Lymphopenic Common Variable Immunodeficiency.
  • Fathemeh Babaha, MSc thesis: Congenital ficolin-3 deficiency with primary immunodeficiency
  • Farzad Nazari, MSc thesis: Agammaglobulinemia: Epidemiology, Pathogenesis, Clinical Phenotype, Diagnosis, Prognosis and Management.
  • Tannaz Moeinishad, MSc thesis: Variable Abnormalities in T and B Cell Subsets in Ataxia Telangiectasia.
  • Zahra Hamidi, MSc thesis: PIK3R1 Mutation Associated with Hyper IgM APDS2 Syndrome
  • Mohammad Biglari, PhD thesis: Analysis of switched memory B cells in patients with IgA deficiency.
  • Agnes Vyöni, BSc project: Validation of mutations found in patients with Primary immunodeficiencies

Committee work

  • Member, The working group for developing postdoc program for clinical researchers : the research council KI-Region Stockholm, 2023
  • Chair, Leader of Communication Focus Group at KI Junior Faculty, https://staff.ki.se/jf-steering-group, 2022
  • Member, Leadership of Junior Faculty at Karolinska Institute, 2020-2022
  • Member, Junior Faculty at Karolinska Institute, Karolinska Institute, 2019

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