Harold Marcotte
About me
I am currently a researcher and a docent in the Division of Immunology within the Department of Medical Biochemistry and Biophysics (MBB). My primary research focus is to establish passive immunotherapy against mucosal infectious diseases and studying host-microbe interactions. My work includes the development and engineering of human monoclonal and camelid antibodies against coronaviruses, Helicobacter pylori, and noroviruses. I am also investigating the use of recombinant Lactobacillus as a delivery system for antibodies at mucosal surfaces. More recently, I have been conducting research on the systemic and mucosal immune response to SARS-CoV-2 in vaccinated and infected individuals.
Research
Mucosal immunology, infectious diseases, SARS-CoV-2, and antibody engineering,
Teaching
- I am teaching immunology for the Biomedicine Laboratory Science program (Biomedicinska analytikerprogrammet).
Articles
- Journal article: JOURNAL OF VIROLOGY. 2025;99(1):e0174024-e01724Zuo F; Cao Y; Sun R; Wang Q; Simonelli L; Du L; Bertoglio F; Schubert M; Guerra C; Cavalli A; Hust M; Robbiani DF; Varani L; Abolhassani H; Xie XS; Hammarstrom L; Marcotte H; Pan-Hammarstrom Q
- Article: GENES AND IMMUNITY. 2024;25(2):158-167Garcia-Vega M; Wan H; Resendiz-Sandoval M; Hinojosa-Trujillo D; Valenzuela O; Mata-Haro V; Dehesa-Canseco F; Solis-Hernandez M; Marcotte H; Pan-Hammarstrom Q; Hernandez J
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2024;121(3):e2315354120Marcotte H; Cao Y; Zuo F; Simonelli L; Sammartino JC; Pedotti M; Sun R; Cassaniti I; Hagbom M; Piralla A; Yang J; Du L; Percivalle E; Bertoglio F; Schubert M; Abolhassani H; Sherina N; Guerra C; Borte S; Rezaei N; Kumagai-Braesch M; Xue Y; Su C; Yan Q; He P; Groenwall C; Klareskog L; Calzolai L; Cavalli A; Wang Q; Robbiani DF; Hust M; Shi Z; Feng L; Svensson L; Chen L; Bao L; Baldanti F; Xiao J; Qin C; Hammarstrom L; Yang X; Varani L; Xie XS; Pan-Hammarstrom Q
- Journal article: LANCET INFECTIOUS DISEASES. 2024;24(1):e7-e9Zuo F; Cao Y; Sun R; Yisimayi A; Du L; Bertoglio F; Schubert M; Guerra C; Cavalli A; Hust M; Robbiani DF; Abolhassani H; Xie XS; Hammarstroem L; Marcotte H; Pan-Hammarstroem Q
- Article: NATURE COMMUNICATIONS. 2023;14(1):6527Hueting D; Schriever K; Sun R; Vlachiotis S; Zuo F; Du L; Persson H; Hofstrom C; Ohlin M; Wallden K; Buggert M; Hammarstrom L; Marcotte H; Pan-Hammarstroem Q; Andrell J; Syren P-O
- Article: ISCIENCE. 2023;26(4):106562Garcia-Vega M; Melgoza-Gonzalez EA; Hernandez-Valenzuela S; Hinojosa-Trujillo D; Resendiz-Sandoval M; Llamas-Covarrubias MA; Loza-Lopez M; Valenzuela O; Soto-Gaxiola A; Hernandez-Onate MA; Mata-Haro V; Cassaniti I; Sammartino JC; Ferrari A; Simonelli L; Pedotti M; Sun R; Zuo F; Baldanti F; Varani L; Marcotte H; Pan-Hammarstrom Q; Hernandez J
- Journal article: LANCET REGIONAL HEALTH-WESTERN PACIFIC. 2023;33:100762Zuo F; Sun R; Abolhassani H; Du L; Wang Y; Vlachiotis S; Bertoglio F; Schubert M; Rezaei N; Chavoshzadeh Z; Guerra C; Cavalli A; Andrell J; Kumagai-Braesch M; Xue Y; Cao Y; Hust M; Robbiani DF; Xie XS; Hammarstrom L; Marcotte H; Pan-Hammarstrom Q
- Article: SCIENCE IMMUNOLOGY. 2023;8(81):eade0958Bianchini F; Crivelli V; Abernathy ME; Guerra C; Palus M; Muri J; Marcotte H; Piralla A; Pedotti M; De Gasparo R; Simonelli L; Matkovic M; Toscano C; Biggiogero M; Calvaruso V; Svoboda P; Rincon TC; Fava T; Podesvova L; Shanbhag AA; Celoria A; Sgrignani J; Stefanik M; Honig V; Pranclova V; Michalcikova T; Prochazka J; Guerrini G; Mehn D; Clabbattini A; Abolhassani H; Jarrossay D; Uguccioni M; Medaglini D; Pan-Hammarstroem Q; Calzolai L; Fernandez D; Baldanti F; Franzetti-Pellanda A; Garzoni C; Sedlacek R; Ruzek D; Varani L; Cavalli A; Barnes CO; Robbiani DF
- Article: PHARMACEUTICS. 2022;15(1):63Yuki Y; Zuo F; Kurokawa S; Uchida Y; Sato S; Sakon N; Hammarstroem L; Kiyono H; Marcotte H
- Journal article: NEW ENGLAND JOURNAL OF MEDICINE. 2022;387(21):e55Zuo F; Marcotte H; Hammarstrom L; Pan-Hammarstrom Q
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2022;150(5):1059-1073Abolhassani H; Delavari S; Landegren N; Shokri S; Bastard P; Du L; Zuo F; Hajebi R; Abolnezhadian F; Iranparast S; Modaresi M; Vosughimotlagh A; Salami F; Aranda-Guillen M; Cobat A; Marcotte H; Zhang S-Y; Zhang Q; Rezaei N; Casanova J-L; Kampe O; Hammarstrom L; Pan-Hammarstrom Q
- Journal article: SIGNAL TRANSDUCTION AND TARGETED THERAPY. 2022;7(1):294Marcotte H; Hammarstrom L; Pan-Hammarstrom Q
- Article: NATURE COMMUNICATIONS. 2022;13(1):2670Zuo F; Abolhassani H; Du L; Piralla A; Bertoglio F; de Campos-Mata L; Wan H; Schubert M; Cassaniti I; Wang Y; Sammartino JC; Sun R; Vlachiotis S; Bergami F; Kumagai-Braesch M; Andrell J; Zhang Z; Xue Y; Wenzel EV; Calzolai L; Varani L; Rezaei N; Chavoshzadeh Z; Baldanti F; Hust M; Hammarstrom L; Marcotte H; Pan-Hammarstrom Q
- Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2022;42(3):471-483Abolhassani H; Landegren N; Bastard P; Materna M; Modaresi M; Du L; Aranda-Guillen M; Sardh F; Zuo F; Zhang P; Marcotte H; Marr N; Khan T; Ata M; Al-Ali F; Pescarmona R; Belot A; Beziat V; Zhang Q; Casanova J-L; Kampe O; Zhang S-Y; Hammarstrom L; Pan-Hammarstrom Q
- Article: BMC MEDICINE. 2022;20(1):102Schubert M; Bertoglio F; Steinke S; Heine PA; Ynga-Durand MA; Maass H; Sammartino JC; Cassaniti I; Zuo F; Du L; Korn J; Milosevic M; Wenzel EV; Krstanovic F; Polten S; Pribanic-Matesic M; Brizic I; Baldanti F; Hammarstrom L; Duebel S; Sustic A; Marcotte H; Strengert M; Protic A; Piralla A; Pan-Hammarstroem Q; Cicin-Sain L; Hust M
- Article: ISCIENCE. 2022;25(2):103743Marcotte H; Piralla A; Zuo F; Du L; Cassaniti I; Wan H; Kumagai-Braesh M; Andrell J; Percivalle E; Sammartino JC; Wang Y; Vlachiotis S; Attevall J; Bergami F; Ferrari A; Colaneri M; Vecchia M; Sambo M; Zuccaro V; Asperges E; Bruno R; Oggionni T; Meloni F; Abolhassani H; Bertoglio F; Schubert M; Calzolai L; Varani L; Hust M; Xue Y; Hammarstrom L; Baldanti F; Pan-Hammarstrom Q
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2022;149(1):65-75.e8Bjorkander S; Du L; Zuo F; Ekstrom S; Wang Y; Wan H; Sherina N; Schoutens L; Andrell J; Andersson N; Georgelis A; Bergstrom A; Marcotte H; Kull I; Hammarstrom L; Melen E; Pan-Hammarstrom Q
- Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2022;42(1):1-9Abolhassani H; Vosughimotlagh A; Asano T; Landegren N; Boisson B; Delavari S; Bastard P; Aranda-Guillen M; Wang Y; Zuo F; Sardh F; Marcotte H; Du L; Zhang S-Y; Zhang Q; Rezaei N; Kampe O; Casanova J-L; Hammarstrom L; Pan-Hammarstrom Q
- Article: MED. 2021;2(3):281-295.e4Sherina N; Piralla A; Du L; Wan H; Kumagai-Braesch M; Andrell J; Braesch-Andersen S; Cassaniti I; Percivalle E; Sarasini A; Bergami F; Di Martino R; Colaneri M; Vecchia M; Sambo M; Zuccaro V; Bruno R; Sachs M; Oggionni T; Meloni F; Abolhassani H; Bertoglio F; Schubert M; Byrne-Steele M; Han J; Hust M; Xue Y; Hammarstrom L; Baldanti F; Marcotte H; Pan-Hammarstrom Q
- Article: VACCINES. 2020;8(4):E758-758Kalusche S; Vanshylla K; Kleipass F; Gruell H; Muller B; Zeng Z; Koch K; Stein S; Marcotte H; Klein F; Dietrich U
- Article: JOURNAL OF INFECTIOUS DISEASES. 2020;222(3):470-478Yuki Y; Kurokawa S; Sato S; Sasou A; Matsumoto N; Suzuki A; Sakon N; Goda Y; Takeyama N; Miyoshi T; Marcotte H; Tanaka T; Hammarstrom L; Kiyono H
- Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2020;146(1):58-60Hammarstrom L; Abolhassani H; Baldanti F; Marcotte H; Pan-Hammarstrom Q
- Article: CLINICAL GENETICS. 2020;97(6):844-856Abolhassani H; Marcotte H; Fang M; Hammarstrom L
- Article: APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 2019;85(19):e00800-e00819Zeng Z; Zu F; Marcotte H
- Article: BMC INFECTIOUS DISEASES. 2019;19(1):824Marcotte H; Larsson PG; Andersen KK; Zuo F; Mikkelsen LS; Brandsborg E; Gray G; Laher F; Otwombe K
- Article: ACS SYNTHETIC BIOLOGY. 2019;8(8):1723-1729Zuo F; Zeng Z; Hammarstrom L; Marcotte H
- Article: MICROBIOLOGICAL RESEARCH. 2017;205:88-98Marcotte H; Andersen KK; Lin Y; Zuo F; Zeng Z; Larsson PG; Brandsborg E; Bronstad G; Hammarstrom L
- Article: MICROBIAL CELL FACTORIES. 2017;16(1):148Lin Y; Krogh-Andersen K; Hammarstrom L; Marcotte H
- Article: PLOS ONE. 2016;11(9):e0162733Lin Y; Krogh-Andersen K; Pelletier J; Marcotte H; Ostenson C-G; Hammarstrom L
- Article: SCIENTIFIC REPORTS. 2016;6:30171Gunaydin G; Yu S; Graslund T; Hammarstrom L; Marcotte H
- Article: INFECTION AND IMMUNITY. 2016;84(2):395-406Andersen KK; Strokappe NM; Hultberg A; Truusalu K; Smidt I; Mikelsaar R-H; Mikelsaar M; Verrips T; Hammarstrom L; Marcotte H
- Article: APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 2015;81(17):5784-5793Alvarez B; Krogh-Andersen K; Tellgren-Roth C; Martinez N; Guenaydin G; Lin Y; Cruz Martin M; Alvarez MA; Hammarstroem L; Marcotte H
- Article: BMC INFECTIOUS DISEASES. 2015;15:255Pendharkar S; Brandsborg E; Hammarstrom L; Marcotte H; Larsson P-G
- Article: PLOS ONE. 2014;9(4):e96409Gunaydin G; Alvarez B; Lin Y; Hammarstroem L; Marcotte H
- Article: VACCINE. 2014;32(4):470-477Gunaydin G; Zhang R; Hammarstroem L; Marcotte H
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2013;123(9):3829-3838Tokuhara D; Alvarez B; Mejima M; Hiroiwa T; Takahashi Y; Kurokawa S; Kuroda M; Oyama M; Kozuka-Hata H; Nochi T; Sagara H; Aladin F; Marcotte H; Frenken LGJ; Iturriza-Gomara M; Kiyono H; Hammarstrom L; Yuki Y
- Article: BMC INFECTIOUS DISEASES. 2013;13:43Pendharkar S; Magopane T; Larsson P-G; de Bruyn G; Gray GE; Hammarstrom L; Marcotte H
- Article: BMC BIOTECHNOLOGY. 2011;11:126Andersen KK; Marcotte H; Alvarez B; Boyaka PN; Hammarstrom L
- Article: BMC INFECTIOUS DISEASES. 2011;11:223Larsson P-G; Brandsborg E; Forsum U; Pendharkar S; Andersen KK; Nasic S; Hammarstrom L; Marcotte H
- Article: FUTURE MICROBIOLOGY. 2011;6(5):583-593Pant N; Marcotte H; Hermans P; Bezemer S; Frenken L; Johansen K; Hammarstrom L
- Article: APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 2011;77(6):2174-2179Cruz Martin M; Pant N; Ladero V; Gunaydin G; Andersen KK; Alvarez B; Martinez N; Alvarez MA; Hammarstrom L; Marcotte H
- Article: CURRENT MICROBIOLOGY. 2010;61(6):560-566Koll P; Maendar R; Smidt I; Huett P; Truusalu K; Mikelsaar R-H; Shchepetova J; Krogh-Andersen K; Marcotte H; Hammarstrom L; Mikelsaar M
- Article: FUTURE VIROLOGY. 2008;3(4):327-341Marcotte H; Pant N; Hammarstrom L
- Article: MOLECULAR ORAL MICROBIOLOGY. 2008;23(2):139-147Koll P; Maendar R; Marcotte H; Leibur E; Mikelsaar M; Hammarstro L
- Article: BMC MICROBIOLOGY. 2007;7:86Pant N; Marcotte H; Bruessow H; Svensson L; Hammarstrom L
- Article: BMC BIOTECHNOLOGY. 2007;7:58Hultberg A; Tremblay DM; de Haard H; Verrips T; Moineau S; Hammarstoem L; Marcotte H
- Article: JOURNAL OF INFECTIOUS DISEASES. 2006;194(11):1580-1588Pant N; Hultberg A; Zhao Y; Svensson L; Pan-Hammarstrom Q; Johansen K; Pouwels PH; Ruggeri FM; Hermans P; Frenken L; Boren T; Marcotte H; Hammarstrom L
- Article: APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 2006;72(4):732-737Kruger C; Hultberg A; Marcotte H; Hermans P; Bezemer S; Frenken LGJ; Hammarstrom L
- Article: JOURNAL OF APPLIED MICROBIOLOGY. 2006;100(2):256-263Marcotte H; Koll-Klais P; Hultberg A; Zhao Y; Gmür R; Mändar R; Mikelsaar M; Hammarström L
- Article: MOLECULAR ORAL MICROBIOLOGY. 2005;20(6):354-361Koll-Klais P; Mändar R; Leibur E; Marcotte H; Hammarström L; Mikelsaar M
- Article: MOLECULAR BIOTECHNOLOGY. 2005;31(3):221-231Passive immunization by lactobacilli expressing single-chain antibodies against Streptococcus mutansKrüger C; Hultberg A; van Dollenweerd C; Marcotte H; Hammarström L
- Article: INFECTION AND IMMUNITY. 2004;72(5):2753-2761Robinson K; Chamberlain LM; Lopez MC; Rush CM; Marcotte H; Le Page RWF; Wells JM
- Article: JOURNAL OF APPLIED MICROBIOLOGY. 2004;97(4):749-756Marcotte H; Ferrari S; Cesena C; Hammarström L; Morelli L; Pozzi G; Oggioni MR
- Article: NATURE BIOTECHNOLOGY. 2002;20(7):702-706Krüger C; Hu YZ; Pan Q; Marcotte H; Hultberg A; Delwar D; van Dalen PJ; Pouwels PH; Leer RJ; Kelly CG; van Dollenweerd C; Ma JK; Hammarström L
- Article: MICROBIAL PATHOGENESIS. 2001;30(4):229-235Ricci S; Medaglini D; Marcotte H; Olsén A; Pozzi G; Björck L
- Article: VACCINE. 2001;19(15-16):1931-1939Medaglini D; Ciabattini A; Spinosa MR; Maggi T; Marcotte H; Oggioni MR; Pozzi G
- Article: MOLECULAR ORAL MICROBIOLOGY. 1997;12(3):141-147Marcotte H; Lavoie MC
- Article: INFECTION AND IMMUNITY. 1996;64(11):4694-4699Marcotte H; Lavoie MC
- Article: JOURNAL OF INFECTIOUS DISEASES. 1996;173(4):1034-1037Marcotte H; Levesque D; Delanay K; Bourgeault A; delaDurantaye R; Brochu S; Lavoie MC
- Article: MOLECULAR ORAL MICROBIOLOGY. 1995;10(3):168-174MARCOTTE H; RODRIGUE L; COULOMBE C; GOYETTE N; LAVOIE MC
- Article: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1995;371B:1173-1176Marcotte H; Rodrigue L; Gamache M; Lavoie MC
- Journal article: MICROBIAL ECOLOGY. 1993;26(3):267-275RODRIGUE L; BARRAS MJ; MARCOTTE H; LAVOIE MC
- Journal article: JOURNAL OF IMMUNOASSAY. 1993;14(1-2):63-81MARCOTTE H; LAVOIE MC
- Journal article: MICROBIAL ECOLOGY IN HEALTH AND DISEASE. 1993;6(5):245-251GADBOIS T; MARCOTTE H; RODRIGUE L; COULOMBE C; GOYETTE N; LAVOIE MC
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All other publications
- Preprint: BIORXIV. 2025Li Q; Daumiller D; Zuo F; Marcotte H; Pan-Hammarström Q; Bryant P
- Preprint: BIORXIV. 2022;BIORXIVBianchini F; Crivelli V; Abernathy ME; Guerra C; Palus M; Muri J; Marcotte H; Piralla A; Pedotti M; De Gasparo R; Simonelli L; Matkovic M; Toscano C; Biggiogero M; Calvaruso V; Svoboda P; Rincón TC; Fava T; Podešvová L; Shanbhag AA; Celoria A; Sgrignani J; Stefanik M; Hönig V; Pranclova V; Michalcikova T; Prochazka J; Guerrini G; Mehn D; Ciabattini A; Abolhassani H; Jarrossay D; Uguccioni M; Medaglini D; Pan-Hammarström Q; Calzolai L; Fernandez D; Baldanti F; Franzetti-Pellanda A; Garzoni C; Sedlacek R; Ruzek D; Varani L; Cavalli A; Barnes CO; Robbiani DF
- Preprint: RESEARCH SQUARE. 2022Syren P-O; Hueting D; Schriever K; Zuo F; Du L; Persson H; Hofström C; Ohlin M; Wallden K; Hammarstrom L; Marcotte H; Pan-Hammarstrom Q; Andrell J
- Preprint: MEDRXIV. 2021Schubert M; Bertoglio F; Steinke S; Heine PA; Ynga-Durand MA; Zuo F; Du L; Korn J; Milošević M; Wenzel EV; Maass H; Krstanović F; Polten S; Pribanić-Matešić M; Brizić I; Piralla A; Baldanti F; Hammarström L; Dübel S; Šustić A; Marcotte H; Strengert M; Protić A; Pan-Hammarström Q; Čičin-Šain L; Hust M
- Review: CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY. 2021;21(6):553-558Hammarstrom L; Marcotte H; Piralla A; Baldanti F; Pan-Hammarstrom Q
- Review: CURRENT OPINION IN BIOTECHNOLOGY. 2021;70:75-82Zuo F; Marcotte H
- Review: BIOTECHNOLOGY ADVANCES. 2020;45:107654Zuo F; Chen S; Marcotte H
- Review: CURRENT MICROBIOLOGY. 2019;76(6):774-782Dicks LMT; Mikkelsen LS; Brandsborg E; Marcotte H
- Review: BENEFICIAL MICROBES. 2018;9(1):3-20Dicks LMT; Geldenhuys J; Mikkelsen LS; Brandsborg E; Marcotte H
- Book chapter: VIRAL GASTROENTERITIS. 2016;p. 47-71Marcotte H; Hammarström L
- Book chapter: MUCOSAL IMMUNOLOGY. 2015;p. 1403-1434Marcotte H; Hammarström L
- Published conference paper: BENEFICIAL MICROBES. 2011;2(1):79-90Huett P; Koll P; Stsepetova J; Alvarez B; Maendar R; Krogh-Andersen K; Marcotte H; Hammarstroem L; Mikelsaar M
- Review: MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS. 1998;62(1):71-109Marcotte H; Lavoie MC
Grants
- Swedish Research Council1 December 2024 - 30 November 2026Most approved antibodies against SARS-CoV-2 are ineffective against Omicron subvariants, highlighting the urgent need for alternative therapies. Secretory IgA (sIgA) is the predominant immunoglobulin type in secretions and plays a crucial role in mucosal defenses. Results from our previous VR project, "Mucosal Immunity Against SARS-CoV-2 - A Neglected Field", suggested that both dimeric and sIgA1 antibodies were superior to IgG in neutralizing SARS-CoV-2, providing protection in a mouse model through intranasal delivery. In this project, we plan to further advance the development of a broadly neutralizing IgA antibody lead candidate by generating a stable cell line with the antibody genes integrated into the genome and optimizing the production and purification processes under standard laboratory conditions. All relevant data and protocols used during cell line development and characterization will ensure compliance with regulatory standards and facilitate transfer to GMP facilities. This proof of principal proposal will help us to achieve the next goal, i.e., to further develop and commercialize the lead IgA antibody candidates as a nasal spray to block viral entry and enhance mucosal immunity against future SARS-CoV-2 variants. If successful, this approach could be extended to develop a cocktail of broadly neutralizing IgA antibodies against SARS-CoV-2 for use in a nasal spray. This will help us achieve our long-term goal of preparing for the next pandemic.
Employments
- Researcher, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2023-
Degrees and Education
- Docent, Karolinska Institutet, 2018