Qiang Pan-Hammarström

Qiang Pan-Hammarström

Professor
Telephone: +46852486568
Visiting address: Solnavägen 9, 17165 Solna
Postal address: C2 Medicinsk biokemi och biofysik, C2 Immunologi Hammarström, 171 77 Stockholm
Part of:

About me

  • I am Professor of Clinical Immunology and Head of the Division of Immunology at the Department of Medical Biochemistry and Biophysics, Karolinska Institutet.

    I trained as a medical doctor at Sun Yat-sen Medical University, and worked as a physician at Guangzhou Respiratory Disease Research Institute (1993–1994). I received my PhD in Clinical Immunology/Immunology from Karolinska Institutet in 1999 and completed postdoctoral training at Harvard Medical School (2000) and Karolinska Institutet (2001–2003). I then became associate professor and group leader in 2004 and was appointed professor in 2011.

    I was a guest professor at Peking University and Sun Yat-sen University Cancer Center, and a visiting scientist/professor at Harvard Medical School (sabbatical), Rockefeller University (short sabbaticals), and Institute of Human Biology, Roche (short sabbaticals). I am currently a guest professor at Tianjin Medical University Cancer Institute and a visiting scientist at Broad Institute (short sabbaticals).

    I have supervised 14 PhD students and trained 24 postdoctoral fellows, and have published 240 papers on immunoglobulin gene diversification, primary immunodeficiencies, genome instability, infectious diseases, B-cell malignancies, and cancer genetics.


    Education
    - Bachelor degree in Medicine, Sun Yat-Sen Medical University, China, 1988-1993
    - PhD degree in Clinical Immunology/Immunology, Department of Laboratory Medicine, Karolinska Institutet, Sweden, 1994-1999
    - Executive education program of leadership development, Harvard Business School, USA, 2017-2019

    Academic honours, awards and prizes
    - Scholarship for postdoctoral medical research, Swedish Society for Medical Research, 2003
    - Assistant Professor position, 4 years, Swedish Research Council, 2003
    - Young investigator prize, Swedish Society of Medicine, 2007
    - ERC Starting Grant, European Research Council, 2009
    - Senior researcher position, 6 years, Swedish Research Council, 2010
    - Distinguished Alumni, Faculty of Medical Sciences, Sun Yat-Sen University, 2011
    - Senior investigator award, 5 years, Center for Innovation Medicine, 2016
    - Elected member of the Nobel Assembly at the Karolinska Institutet, 2019
    - Adjunct member of the Nobel Committee for Physiology or Medicine, 2023, 2025, 2026
    - Elected member of the Royal Swedish Academy of Sciences,  2023

    - Wallenberg Scholar award, 5 years, the Knut and Alice Wallenberg Foundation, 2024

Research

  • Current projects

    Regulation of immunoglobulin class switch recombination in human B cells
    This project aims to understand the complex molecular mechanisms involved in DNA editing, repair, and recombination during immunoglobulin class switch recombination (CSR) and somatic hypermutation (SHM), as well as their roles in the pathophysiological processes leading to immunodeficiency, genomic instability, and cancer development in humans.

    Induced pluripotent stems cells a platform for personalized diagnosis and therapy in patients with primary immunodeficiency
    This project aims to reprogram fibroblasts or peripheral blood B cells derived from IgA-deficient (IgAD) patients into induced pluripotent stem (iPS) cells and to redifferentiate these iPS cells into antibody-producing B cells. If successful, this approach may provide a potentially curative treatment for patients with IgA deficiency. It may also serve as a methodological platform for studies aimed at cell replacement therapies in patients with a variety of other primary immunodeficiency diseases, as well as autoimmune and neurological disorders associated with these conditions.

    Discovery of therapeutic targets in B cell lymphoma by next generation sequencing
    This project aims to identify potentially treatable molecular targets in mature B-cell lymphomas, with a focus on diffuse large B-cell lymphoma, follicular lymphoma, and mantle cell lymphoma, using high-throughput next-generation sequencing omics technologies such as whole-genome and whole-exome sequencing, bulk RNA-seq, single-cell RNA-seq (scRNA-seq), and spatial RNA-seq. In parallel, we are developing in vitro models for lymphoma.

    Antibody therapy against COVID-19
    This project aims to establish a passive immunotherapy approach for COVID-19, with a current focus on the development of a mucosally delivered IgA-based therapy. This strategy is also being extended to target other respiratory and gastrointestinal infections.

    Our research is funded by the Swedish Research Council (VR), Swedish Cancer Society (Cancerfonden), Stockholm Cancer Society (Radiumhemmets), Vinnova, Knut and Alice Wallenberg Foundation and Mayo Clinic Cancer Research Center and Cancer Research KI (Cancer Research Award).

Selected publications

  • Article: CELL. 2023;186(10):2193-2207.e19
    Wang Y; Zhang S; Yang X; Hwang JK; Zhan C; Lian C; Wang C; Gui T; Wang B; Xie X; Dai P; Zhang L; Tian Y; Zhang H; Han C; Cai Y; Hao Q; Ye X; Liu X; Liu J; Cao Z; Huang S; Song J; Pan-Hammarstrom Q; Zhao Y; Alt FW; Zheng X; Da L-T; Yeap L-S; Meng F-L
  • Letter: LANCET REGIONAL HEALTH-WESTERN PACIFIC. 2023;33:100762
    Zuo F; Sun R; Abolhassani H; Du L; Wang Y; Vlachiotis S; Bertoglio F; Schubert M; Rezaei N; Chavoshzadeh Z; Guerra C; Cavalli A; Andrell J; Kumagai-Braesch M; Xue Y; Cao Y; Hust M; Robbiani DF; Xie XS; Hammarstrom L; Marcotte H; Pan-Hammarstrom Q
  • Article: SCIENCE IMMUNOLOGY. 2023;8(81):eade1167
    Hao Q; Zhan C; Lian C; Luo S; Cao W; Wang B; Xie X; Ye X; Gui T; Voena C; Pighi C; Wang Y; Tian Y; Wang X; Dai P; Cai Y; Liu X; Ouyang S; Sun S; Hu Q; Liu J; Ye Y; Zhao J; Lu A; Wang J-Y; Huang C; Su B; Meng F-L; Chiarle R; Pan-Hammarstrom Q; Yeap L-S
  • Article: SCIENCE IMMUNOLOGY. 2023;8(81):eade0958
    Bianchini F; Crivelli V; Abernathy ME; Guerra C; Palus M; Muri J; Marcotte H; Piralla A; Pedotti M; De Gasparo R; Simonelli L; Matkovic M; Toscano C; Biggiogero M; Calvaruso V; Svoboda P; Rincon TC; Fava T; Podesvova L; Shanbhag AA; Celoria A; Sgrignani J; Stefanik M; Honig V; Pranclova V; Michalcikova T; Prochazka J; Guerrini G; Mehn D; Clabbattini A; Abolhassani H; Jarrossay D; Uguccioni M; Medaglini D; Pan-Hammarstroem Q; Calzolai L; Fernandez D; Baldanti F; Franzetti-Pellanda A; Garzoni C; Sedlacek R; Ruzek D; Varani L; Cavalli A; Barnes CO; Robbiani DF
  • Article: CLINICAL AND TRANSLATIONAL MEDICINE. 2022;12(12):e1118
    Nie M; Ren W; Ye X; Berglund M; Wang X; Fjorden K; Du L; Giannoula Y; Lei D; Su W; Li W; Liu D; Linderoth J; Jiang C; Bao H; Jiang W; Huang H; Hou Y; Zhu S; Enblad G; Jerkeman M; Wu K; Zhang H; Amini R-M; Li Z-M; Pan-Hammarstrom Q
  • Letter: NEW ENGLAND JOURNAL OF MEDICINE. 2022;387(21):e55
    Zuo F; Marcotte H; Hammarstrom L; Pan-Hammarstrom Q
  • Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2022;150(5):1059-1073
    Abolhassani H; Delavari S; Landegren N; Shokri S; Bastard P; Du L; Zuo F; Hajebi R; Abolnezhadian F; Iranparast S; Modaresi M; Vosughimotlagh A; Salami F; Aranda-Guillen M; Cobat A; Marcotte H; Zhang S-Y; Zhang Q; Rezaei N; Casanova J-L; Kampe O; Hammarstrom L; Pan-Hammarstrom Q
  • Editorial: SIGNAL TRANSDUCTION AND TARGETED THERAPY. 2022;7(1):294
    Marcotte H; Hammarstrom L; Pan-Hammarstrom Q
  • Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2022;219(8):e20220131
    Zhang Q; Matuozzo D; Le Pen J; Lee D; Moens L; Asano T; Bohlen J; Liu Z; Moncada-Velez M; Kendir-Demirkol Y; Jing H; Bizien L; Marchal A; Abolhassani H; Delafontaine S; Bucciol G; Bayhan GI; Keles S; Kiykim A; Hancerli S; Haerynck F; Florkin B; Hatipoglu N; Ozcelik T; Morelle G; Zatz M; Ng LFP; Lye DC; Young BE; Leo Y-S; Dalgard CL; Lifton RP; Renia L; Meyts I; Jouanguy E; Hammarstrom L; Pan-Hammarstrom Q; Boisson B; Bastard P; Su HC; Boisson-Dupuis S; Abel L; Rice CM; Zhang S-Y; Cobat A; Casanova J-L
  • Article: SCIENCE IMMUNOLOGY. 2022;7(73):eabq3277
    Yang R; Avery DT; Jackson KJL; Ogishi M; Benhsaien I; Du L; Ye X; Han J; Rosain J; Peel JN; Alyanakian M-A; Neven B; Winter S; Puel A; Boisson B; Payne KJ; Wong M; Russell AJ; Mizoguchi Y; Okada S; Uzel G; Goodnow CC; Latour S; El Bakkouri J; Bousfiha A; Preece K; Gray PE; Keller B; Warnatz K; Boisson-Dupuis S; Abel L; Pan-Hammarstrom Q; Bustamante J; Ma CS; Casanova J-L; Tangye SG
  • Article: NATURE COMMUNICATIONS. 2022;13(1):2670
    Zuo F; Abolhassani H; Du L; Piralla A; Bertoglio F; de Campos-Mata L; Wan H; Schubert M; Cassaniti I; Wang Y; Sammartino JC; Sun R; Vlachiotis S; Bergami F; Kumagai-Braesch M; Andrell J; Zhang Z; Xue Y; Wenzel EV; Calzolai L; Varani L; Rezaei N; Chavoshzadeh Z; Baldanti F; Hust M; Hammarstrom L; Marcotte H; Pan-Hammarstrom Q
  • Article: CELL REPORTS. 2022;39(3):110713
    Ye X; Wang L; Nie M; Wang Y; Dong S; Ren W; Li G; Li Z-M; Wu K; Pan-Hammarstrom Q
  • Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2022;42(3):471-483
    Abolhassani H; Landegren N; Bastard P; Materna M; Modaresi M; Du L; Aranda-Guillen M; Sardh F; Zuo F; Zhang P; Marcotte H; Marr N; Khan T; Ata M; Al-Ali F; Pescarmona R; Belot A; Beziat V; Zhang Q; Casanova J-L; Kampe O; Zhang S-Y; Hammarstrom L; Pan-Hammarstrom Q
  • Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2022;42(1):1-9
    Abolhassani H; Vosughimotlagh A; Asano T; Landegren N; Boisson B; Delavari S; Bastard P; Aranda-Guillen M; Wang Y; Zuo F; Sardh F; Marcotte H; Du L; Zhang S-Y; Zhang Q; Rezaei N; Kampe O; Casanova J-L; Hammarstrom L; Pan-Hammarstrom Q
  • Review: CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY. 2021;21(6):553-558
    Hammarstrom L; Marcotte H; Piralla A; Baldanti F; Pan-Hammarstrom Q
  • Article: SCIENCE IMMUNOLOGY. 2021;6(62):eabl4348
    Asano T; Boisson B; Onodi F; Matuozzo D; Moncada-Velez M; Renkilaraj MRLM; Zhang P; Meertens L; Bolze A; Materna M; Korniotis S; Gervais A; Talouarn E; Bigio B; Seeleuthner Y; Bilguvar K; Zhang Y; Neehus A-L; Ogishi M; Pelham SJ; Le Voyer T; Rosain J; Philippot Q; Soler-Palacin P; Colobran R; Martin-Nalda A; Riviere JG; Tandjaoui-Lambiotte Y; Chaibi K; Shahrooei M; Darazam IA; Olyaei NA; Mansouri D; Palabiyik F; Ozcelik T; Novelli G; Novelli A; Casari G; Aiuti A; Carrera P; Bondesan S; Barzaghi F; Rovere-Querini P; Tresoldi C; Franco JL; Rojas J; Reyes LF; Bustos IG; Arias AA; Morelle G; Kyheng C; Troya J; Planas-Serra L; Schluter A; Gut M; Pujol A; Allende LM; Rodriguez-Gallego C; Flores C; Cabrera-Marante O; Pleguezuelo DE; de Diego RP; Keles S; Aytekin G; Akcan OM; Bryceson YT; Bergman P; Brodin P; Smole D; Smith CIE; Norlin A-C; Campbell TM; Covill LE; Hammarstrom L; Pan-Hammarstrom Q; Abolhassani H; Mane S; Marr N; Ata M; Al Ali F; Khan T; Spaan AN; Dalgard CL; Bonfanti P; Biondi A; Tubiana S; Burdet C; Nussbaum R; Kahn-Kirby A; Snow AL; Bustamante J; Puel A; Boisson-Dupuis S; Zhang S-Y; Beziat V; Lifton RP; Bastard P; Notarangelo LD; Abel L; Su HC; Jouanguy E; Amara A; Soumelis V; Cobat A; Zhang Q; Casanova J-L
  • Article: SCIENCE IMMUNOLOGY. 2021;6(62):eabl4340
    Bastard P; Gervais A; Le Voyer T; Rosain J; Philippot Q; Manry J; Michailidis E; Hoffmann H-H; Eto S; Garcia-Prat M; Bizien L; Parra-Martinez A; Yang R; Haljasmagi L; Migaud M; Sarekannu K; Maslovskaja J; de Prost N; Tandjaoui-Lambiotte Y; Luyt C-E; Amador-Borrero B; Gaudet A; Poissy J; Morel P; Richard P; Cognasse F; Troya J; Trouillet-Assant S; Belot A; Saker K; Garcon P; Riviere JG; Lagier J-C; Gentile S; Rosen LB; Shaw E; Morio T; Tanaka J; Dalmau D; Tharaux P-L; Sene D; Stepanian A; Megarbane B; Triantafyllia V; Fekkar A; Heath JR; Franco JL; Anaya J-M; Sole-Violan J; Imberti L; Biondi A; Bonfanti P; Castagnoli R; Delmonte OM; Zhang Y; Snow AL; Holland SM; Biggs CM; Moncada-Velez M; Arias AA; Lorenzo L; Boucherit S; Coulibaly B; Anglicheau D; Planas AM; Haerynck F; Duvlis S; Nussbaum RL; Ozcelik T; Keles S; Bousfiha AA; El Bakkouri J; Ramirez-Santana C; Paul S; Pan-Hammarstrom Q; Hammarstrom L; Dupont A; Kurolap A; Metz CN; Aiuti A; Casari G; Lampasona V; Ciceri F; Barreiros LA; Dominguez-Garrido E; Vidigal M; Zatz M; van de Beek D; Sahanic S; Tancevski I; Stepanovskyy Y; Boyarchuk O; Nukui Y; Tsumura M; Vidaur L; Tangye SG; Burrel S; Duffy D; Quintana-Murci L; Klocperk A; Kann NY; Shcherbina A; Lau Y-L; Leung D; Coulongeat M; Marlet J; Koning R; Reyes LF; Chauvineau-Grenier A; Venet F; Monneret G; Nussenzweig MC; Arrestier R; Boudhabhay I; Baris-Feldman H; Hagin D; Wauters J; Meyts I; Dyer AH; Kennelly SP; Bourke NM; Halwani R; Sharif-Askari NS; Dorgham K; Sallette J; Sedkaoui SM; AlKhater S; Rigo-Bonnin R; Morandeira F; Roussel L; Vinh DC; Ostrowski SR; Condino-Neto A; Prando C; Bondarenko A; Spaan AN; Gilardin L; Fellay J; Lyonnet S; Bilguvar K; Lifton RP; Mane S; Anderson MS; Boisson B; Beziat V; Zhang S-Y; Andreakos E; Hermine O; Pujol A; Peterson P; Mogensen TH; Rowen L; Mond J; Debette S; de Lamballerie X; Duval X; Mentre F; Zins M; Soler-Palacin P; Colobran R; Gorochov G; Solanich X; Susen S; Martinez-Picado J; Raoult D; Vasse M; Gregersen PK; Piemonti L; Rodriguez-Gallego C; Notarangelo LD; Su HC; Kisand K; Okada S; Puel A; Jouanguy E; Rice CM; Tiberghien P; Zhang Q; Cobat A; Abel L; Casanova J-L
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(22):e2104504118
    Fangazio M; Ladewig E; Gomez K; Garcia-Ibanez L; Kumar R; Teruya-Feldstein J; Rossi D; Filip I; Pan-Hammarstrom Q; Inghirami G; Boldorini R; Ott G; Staiger AM; Chapuy B; Gaidano G; Bhagat G; Basso K; Rabadan R; Pasqualucci L; Dalla-Favera R
  • Article: NATURE. 2021;593(7859):424-428
    De Gasparo R; Pedotti M; Simonelli L; Nickl P; Muecksch F; Cassaniti I; Percivalle E; Lorenzi JCC; Mazzola F; Magri D; Michalcikova T; Haviernik J; Honig V; Mrazkova B; Polakova N; Fortova A; Tureckova J; Iatsiuk V; Di Girolamo S; Palus M; Zudova D; Bednar P; Bukova I; Bianchini F; Mehn D; Nencka R; Strakova P; Pavlis O; Rozman J; Gioria S; Sammartino JC; Giardina F; Gaiarsa S; Pan-Hammarstrom Q; Barnes CO; Bjorkman PJ; Calzolai L; Piralla A; Baldanti F; Nussenzweig MC; Bieniasz PD; Hatziioannou T; Prochazka J; Sedlacek R; Robbiani DF; Ruzek D; Varani L
  • Article: MED. 2021;2(3):281-295.e4
    Sherina N; Piralla A; Du L; Wan H; Kumagai-Braesch M; Andrell J; Braesch-Andersen S; Cassaniti I; Percivalle E; Sarasini A; Bergami F; Di Martino R; Colaneri M; Vecchia M; Sambo M; Zuccaro V; Bruno R; Sachs M; Oggionni T; Meloni F; Abolhassani H; Bertoglio F; Schubert M; Byrne-Steele M; Han J; Hust M; Xue Y; Hammarstrom L; Baldanti F; Marcotte H; Pan-Hammarstrom Q
  • Show more

Articles

All other publications

  • Preprint: MEDRXIV. 2026;MEDRXIV
    Gervais A; Marchal A; Maillard A; Le Voyer T; Rosain J; Philipot Q; Bizien L; Peel J; Cederholm A; Migaud M; Pons S; Saker K; Laforet P; Aubart M; Gitiaux C; Biggs C; Leon Lopez R; Souvannanorath S; Tard C; Nadaj Pakleza A; Grapperon A-M; Heming N; Annane D; Verschueren A; Attarian S; Bigaut K; Hankiewicz K; Kouton L; Villar-Quiles R-N; Cauquil C; Fleury M-C; Rocher E; Nicolas G; de Paula Estephan E; da Penha Ananias Morita M; Zanoteli E; Saied Z; Rachdi A; Rim A; Belal S; Ben Sassi S; Hübers A; Faure E; Desguerre I; Basse C; Girard N; Béziat V; Pan-Hammarström Q; Hammarström L; Bodansky A; Parent AV; Anderson MS; DeRisi JL; Demeret S; Truffault F; Fort R; Ader F; Wallet F; Abel L; Molina T; Alyanakian M-A; Le Panse R; Solé G; Cobat A; Landegren N; Casanova J-L; Puel A; Bastard P; Jouanguy E
  • Preprint: BIORXIV. 2026
    Hong L; Liu M; Sridhar S; Ong ZYC; Tay SCN; Lai WXC; Tipgomut C; Jaynes P; Peng Y; Tan CL; Hue SS-S; Ng S-B; De Mel S; Poon L; Batumalai Y; Jayalakshmi; Brooks J; Hamberger F; Lane BJ; Jimenez-Sanchez D; Braubach O; Pan-Hammarstrom Q; Sudharshan R; Tsang A; Rao A; Keller ET; Hawula Z; Burgess M; Tuczko N; Keane C; Ponzoni M; Tripodo C; Jeyasekharan AD
  • Preprint: MEDRXIV. 2026
    Bendes A; Björkander S; Kere M; Merid SK; Kumar A; Dahl L; Yu Z; Vogt A; Kim C; Pan-Hammarström Q; Bergström A; Kull I; Merritt A-S; Ekström S; Lövquist A; Murrell B; Roxhed N; Melén E; Schwenk J
  • Letter: JOURNAL OF THORACIC ONCOLOGY. 2025;20(12):e134-e137
    Carbone M; Minaai M; Kittaneh M; Krausz T; Miettinen MM; Hammarstrom QP; Hammarstrom L; Abolhassani H; Pagano I; Xu R; Novelli F; Gaudino G; Pastorino S; Sarin KY; Ripley RT; Pass HI; Schrump DS; Yang H
  • Dataset: KI DATA REPOSITORY. 2025
    Wan H; Pan-Hammarström Q
  • Preprint: BIORXIV. 2025
    Li Q; Daumiller D; Zuo F; Marcotte H; Pan-Hammarström Q; Bryant P
  • Preprint: BIORXIV. 2025;BIORXIV
    Arribas AJ; Guidetti F; Cannas E; Cascione L; Napoli S; Sartori G; Fuzio F; Pesenti E; Tarantelli C; Spriano F; Zucchetto A; Rossi FM; Bruscaggin A; Rinaldi A; Castro de Moura M; Jovic S; Raimondi A; Pittau RB; Terzi di Bergamo L; Ye X; Stathis A; Ben-David Y; Pan-Hammarström Q; Simonetta F; Stussi G; Zucca E; Gattei V; Brown JR; Esteller M; Rossi D; Bertoni F
  • Editorial: TRENDS IN IMMUNOLOGY. 2025;46(3):186-188
    Hammarstrom L; Pan-Hammarstrom Q
  • Letter: JOURNAL OF VIROLOGY. 2025;99(1):e0174024-e01724
    Zuo F; Cao Y; Sun R; Wang Q; Simonelli L; Du L; Bertoglio F; Schubert M; Guerra C; Cavalli A; Hust M; Robbiani DF; Varani L; Abolhassani H; Xie XS; Hammarstrom L; Marcotte H; Pan-Hammarstrom Q
  • Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2024;32:1549-1550
    Claes K; Backers L; Beyls E; Duthoo E; Parton B; Debacker V; De Leeneer K; De Bruyne M; Hoste L; Baeyens A; Vral A; Huang P; Gudjonsson T; Kerre T; Pan-Hammarstrom Q; Sorensen CS; Haerynck F; Tavernier SJ
  • Conference publication: 2024;:a1550-a1552
    Liu M; Bertolazzi G; Sridhar S; Hong L; Korfi K; Jiang Z; Lee RX; Jaynes P; Mulder K; Syn N; Hoppe MM; Fan S; Peng Y; Thng J; Chua R; Jayalakshmi; Batumalai Y; Mel SD; Poon L; Chan EHL; Lee J; Hue SS-S; Chang S-T; Chuang S-S; George Chandy K; Ye X; Pan-Hammarström Q; Ginhoux F; Chee YL; Ng S-B; Tipgomut C; Tripodo C; Jeyasekharan AD
  • Preprint: MEDRXIV. 2024
    Duthoo E; Beyls E; Backers L; Gudjónsson T; Huang P; Jonckheere L; Riemann S; Parton B; Du L; Debacker V; De Bruyne M; Hoste L; Baeyens A; Vral A; Van Braeckel E; Staal J; Mortier G; Kerre T; Pan-Hammarström Q; Sørensen CS; Haerynck F; Claes KBM; Tavernier S
  • Editorial: LANCET INFECTIOUS DISEASES. 2024;24(1):e7-e9
    Zuo F; Cao Y; Sun R; Yisimayi A; Du L; Bertoglio F; Schubert M; Guerra C; Cavalli A; Hust M; Robbiani DF; Abolhassani H; Xie XS; Hammarstroem L; Marcotte H; Pan-Hammarstroem Q
  • Preprint: MEDRXIV. 2023;MEDRXIV
    Marchal A; Cirulli ET; Neveux I; Bellos E; Thwaites RS; Schiabor Barrett KM; Zhang Y; Nemes-Bokun I; Kalinova M; Catchpole A; Tangye SG; Spaan AN; Lack JB; Ghosn J; Burdet C; Gorochov G; Tubach F; Hausfater P; COVID Human Genetic Effort; COVIDeF Study Group; French COVID Cohort Study Group; CoV-Contact Cohort; COVID-STORM Clinicians; COVID Clinicians; Orchestra Working Group; Amsterdam UMC Covid-19 Biobank; NIAID-USUHS COVID Study Group; Dalgard CL; Zhang S-Y; Zhang Q; Chiu C; Fellay J; Grzymski JJ; Sancho-Shimizu V; Abel L; Casanova J-L; Cobat A; Bolze A
  • Corrigendum: LEUKEMIA. 2023;37(9):1944-1951
    Alaggio R; Amador C; Anagnostopoulos I; Attygalle AD; de Oliveira Araujo IB; Berti E; Bhagat G; Borges AM; Boyer D; Calaminici M; Chadburn A; Chan JKC; Cheuk W; Chng W-J; Choi JK; Chuang S-S; Coupland SE; Czader M; Dave SS; de Jong D; Di Napoli A; Du M-Q; Elenitoba-Johnson KS; Ferry J; Geyer J; Gratzinger D; Guitart J; Gujral S; Harris M; Harrison CJ; Hartmann S; Hochhaus A; Jansen PM; Karube K; Kempf W; Khoury J; Kimura H; Klapper W; Kovach AE; Kumar S; Lazar AJ; Lazzi S; Leoncini L; Leung N; Leventaki V; Li X-Q; Lim MS; Liu W-P; Louissaint AJ; Marcogliese A; Medeiros LJ; Michal M; Miranda RN; Mitteldorf C; Montes-Moreno S; Morice W; Nardi V; Naresh KN; Natkunam Y; Ng S-B; Oschlies I; Ott G; Parrens M; Pulitzer M; Rajkumar SV; Rawstron AC; Rech K; Rosenwald A; Said J; Sarkozy C; Sayed S; Saygin C; Schuh A; Sewell W; Siebert R; Sohani AR; Suzuki R; Tooze R; Traverse-Glehen A; Vega F; Vergier B; Wechalekar AD; Wood B; Xerri L; Xiao W; Akinola NO; Akkari Y; Allende LM; Aozasa K; Araujo I; Arcaini L; Ardeshna KM; Asano N; Attarbaschi A; Bacon CM; Barrans SL; Batchelor T; Battistella M; Baughn LB; Behdad A; Berentsen S; Bianchi G; Bledsoe J; Borchmann P; Bower M; Buldini B; Burger JA; Burkhardt B; Cassaday RD; Cazzaniga G; Cerf-Bensussan N; Cesarman E; Chandy M; Chapman JR; Chapuy B; Chen X; Cheng CL; Chiattone C; Chiorazzi N; Cook LB; Cooper WA; Corboy GP; Cowan AJ; Cozzolino I; Cree IA; d'Amore ESG; Davies AJ; Deckert M; Delabie J; Demicco EG; Deshpande V; Diepstra A; Dierickx D; Dunleavy K; Eichhorst B; Ennishi D; Fajgenbaum DC; Farinha P; Fernandez de Larrea C; Fisher KE; Fitzgibbon J; Flanagan M; Fromm J; Garcia JF; Geddie WR; Gertz M; Gopal A; Gopal S; Greipp PT; Gru A; Gupta R; Hansmann M-L; Hebeda KM; Herfarth K; Herling M; Hermine O; Khe H-X; Hodge J; Hu S; Huang Y; Hung YP; Hunger S; Inaba H; Inagaki H; Iqbal J; Ishitsuka K; Iwaki N; Iwatsuki K; Jain N; Jeon YK; Kadin M; Kaji S; Kakkar A; Karadimitris A; Kataoka K; Kato S; Kersten MJ; Ketterling RP; Kim JE; Kratz CP; Kridel R; Kristinsson S; Kuppers R; Kuzu I; Yok-Lam; Lacasce A; Lamant-Rochaix L; Lamy T; Landgren O; Laskar S; Laskin WB; Lenz G; Li S; Di Li G; Lin P; Locatelli F; Lorsbach RB; Lossos I; Loughran TPJ; Macon WR; Maleszewski JJ; Malhotra P; Marafioti T; Maruyama D; Marx A; Mbulaiteye SM; Meignin V; Mejstrikova E; Michelow P; Miettinen M; Miles RR; Miyoshi H; Molina TJ; Mollejo M; Momose S; Mori T; Morice WG; Nadel B; Nagai H; Nagane M; Nair R; Nakamura N; Nakazawa A; Nasr S; Nicholson AG; Nicolae A; Ohgami RS; Oishi N; Olson TS; Ortonne N; Paiva B; Pan-Hammarstrom Q; Parihar M; Paulli M; Petersen A; Picarsic J; Pileri A; Pimpinelli N; Plaza JA; Rabin KR; Raderer M; Rai K; Randen U; Rao H; Robson A; Rochford R; Rosenquist R; Rossi D; Rossi ED; Rule S; Rymkiewicz G; Sabattini E; Saha V; Sakata-Yanagimoto M; Sander CA; Sangueza JM; Sangueza OP; Santucci M; Sato Y; Satou A; Schafernak KT; Schmitt F; Semenzato G; Sengar M; Shanafelt T; Shimada K; Slack GW; Slager S; Soffietti R; Solomon DA; Stamatopoulos K; Steidl C; Stilgenbauer S; Sukswai N; Takeuchi K; Tallini G; Tamaru J; Tan S-Y; Tembhare P; Tiacci E; Tokura Y; Tournilhac O; Treon S; Truemper L; Tsukasaki K; van Rhee F; Varghese A; Vermeer MH; Vielh P; Walker B; Wang M; Wang H-Y; Wang Z; Watanabe T; Weigert O; Wein-Stock D; Whittaker SJ; Willemze R; Woessmann W; Wu CJ; Yamaguchi M; Yamamoto H; Yamashita D; Yang S; Yang DT; Yasuda T; Yin W-H; Zen Y; Zhao S; Zhao W-L
  • Review: JOURNAL OF INTERNAL MEDICINE. 2023;294(2):127-144
    Pan-Hammarstrom Q; Casanova J-L
  • Preprint: BIORXIV. 2023;BIORXIV
    Bugaytsova JA; Moonens K; Piddubnyi A; Schmidt A; Edlund JO; Lisiutin G; Brännström K; Chernov YA; Thorel K; Tkachenko I; Sharova O; Vikhrova I; Butsyk A; Shubin P; Chyzhma R; Johansson DX; Marcotte H; Sjöström R; Shevtsova A; Bylund G; Rakhimova L; Lundquist A; Berhilevych O; Kasianchuk V; Loboda A; Ivanytsia V; Hultenby K; Persson MAA; Gomes J; Matos R; Gartner F; Reis CA; Whitmire JM; Merrell DS; Pan-Hammarström Q; Landström M; Oscarson S; D'Elios MM; Agreus L; Ronkainen J; Aro P; Engstrand L; Graham DY; Kachkovska V; Mukhopadhyay A; Chaudhuri S; Karmakar BC; Paul S; Kravets O; Camorlinga M; Torres J; Berg DE; Moskalenko R; Haas R; Remaut H; Hammarström L; Borén T
  • Review: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2023;151(4):818-831
    Tangye SG
  • Corrigendum: NATURE BIOTECHNOLOGY. 2023;41(4):578
    Yakneen S; Waszak SM; PCAWG Technical Working Group; Gertz M; Korbel JO; PCAWG Consortium
  • Editorial: JOURNAL OF CLINICAL IMMUNOLOGY. 2022;42(7):1354-1359
    Bolze A; Mogensen TH; Zhang S-Y; Abel L; Andreakos E; Arkin LM; Borghesi A; Brodin P; Hagin D; Novelli G; Okada S; Peter J; Renia L; Severe K; Tiberghien P; Vinh DC; Cirulli ET; Casanova J-L; Hsieh EWY
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Grants

  • Mechanistic insights into germinal center associated B-cell lymphoma and experimental modeling using immune organoids
    Swedish Research Council
    1 January 2026 - 1 January 2029
  • Development of IgA antibody therapy for COVID-19 and beyond
    Swedish Research Council
    1 January 2025 - 1 January 2026
  • Swedish Research Council
    1 December 2024 - 30 November 2026
    Most approved antibodies against SARS-CoV-2 are ineffective against Omicron subvariants, highlighting the urgent need for alternative therapies. Secretory IgA (sIgA) is the predominant immunoglobulin type in secretions and plays a crucial role in mucosal defenses. Results from our previous VR project, "Mucosal Immunity Against SARS-CoV-2 - A Neglected Field", suggested that both dimeric and sIgA1 antibodies were superior to IgG in neutralizing SARS-CoV-2, providing protection in a mouse model through intranasal delivery. In this project, we plan to further advance the development of a broadly neutralizing IgA antibody lead candidate by generating a stable cell line with the antibody genes integrated into the genome and optimizing the production and purification processes under standard laboratory conditions. All relevant data and protocols used during cell line development and characterization will ensure compliance with regulatory standards and facilitate transfer to GMP facilities. This proof of principal proposal will help us to achieve the next goal, i.e., to further develop and commercialize the lead IgA antibody candidates as a nasal spray to block viral entry and enhance mucosal immunity against future SARS-CoV-2 variants. If successful, this approach could be extended to develop a cocktail of broadly neutralizing IgA antibodies against SARS-CoV-2 for use in a nasal spray. This will help us achieve our long-term goal of preparing for the next pandemic.
  • Regulation of immunoglobulin gene diversification: with relevance for immunodeficiency
    Swedish Cancer Society
    1 January 2024 - 1 January 2026
  • The interplay between Inborn Error of Immunity and blood disorders: unravelling immune defects behind common haematological diseases
    VINNOVA
    1 January 2024 - 1 January 2026
  • Human B cells in health and disease, from immunodeficiency to cancer
    Knut and Alice Wallenberg Foundation
    1 January 2024 - 1 January 2029
  • Swedish Research Council
    1 January 2024 - 31 December 2026
  • Swedish Research Council
    1 January 2023 - 31 December 2025
  • Swedish Research Council
    1 January 2021 - 31 December 2023
  • Knut and Alice Wallenberg Foundation
    1 January 2020 - 1 January 2025
  • Swedish Research Council
    1 January 2020 - 31 December 2024
  • European Research Council
    1 December 2009 - 30 November 2014

Employments

  • Professor, Clinical Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2023-
  • Professor, Clinical Immunology, Department of Biosciences and Nutrition, Karolinska Institutet, 2018-2023
  • Professor, Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet, 2011-2018

Degrees and Education

  • Docent, Karolinska Institutet, 2004
  • Doctor Of Philosophy, Department of Laboratory Medicine, Karolinska Institutet, 1999
  • Bachelor degree in Medicine, Sun Yat-sen University, 1993

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