Qiang Pan Hammarström

Qiang Pan Hammarström

Professor | Docent
Visiting address: Solnavägen 9, 17165 Solna
Postal address: C2 Medicinsk biokemi och biofysik, C2 Immunologi Hammarström, 171 77 Stockholm
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About me

  • I am a professor of clinical immunology at the Division of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet. 



  • I was trained as a medical doctor and graduated from Sun Yat-Sen Medical University in China in 1993. During 1993 and 1994, I worked as a physician at the Guangzhou Respiratory Disease Research Institute. I obtained my PhD degree in Clinical Immunology / Immunology at the Karolinska Institutet in 1999 and carried out postdoc training at Harvard Medical School in 2000. In 2001 I came back to the Karolinska Institutet where I became an associate professor and group leader in 2004. I was appointed professor of clinical immunology at the Karolinska Institutet in 2011.

    I was a guest professor at Beijing University (2005-2009), Sun Yat-Sen University Cancer Centre (2012-2021) and Tianjin Medical University Cancer Institute (2015-2023). I was also a visiting scientist/professor in Harvard Medical School (2012), Rockefeller University (2013-2015, short sabbatical visits) and the Broad Institute at Harvard and MIT (2015-2019, 2022, short sabbatical visits).

    I have supervised 12 PhD students and trained 24 postdocs and have published altogether 215 papers in areas of immunoglobulin gene diversifications, primary immunodeficiencies, genome instability, infectious diseases, B cell malignancies and cancer genetics.

    Education
    - Bachelor degree in Medicine, Sun Yat-Sen Medical University, China, 1988-1993
    - PhD degree in Clinical Immunology/Immunology, Department of Laboratory Medicine, Karolinska Institutet, Sweden, 1994-1999
    - Executive education program of leadership development, Harvard Business School, USA, 2017-2019

    Academic honours, awards and prizes
    - Scholarship for postdoctoral medical research, Swedish Society for Medical Research, 2003
    - Assistant Professor position, 4 years, awarded by the Swedish Research Council, 2003
    - Young investigator prize, awarded by the Swedish Society of Medicine, 2007
    - ERC Starting Grant, awarded by the European Research Council, 2009
    - Senior researcher position, 6 years, awarded by the Swedish Research Council, 2010
    - Distinguished Alumni, Faculty of Medical Sciences, Sun Yat-Sen University, 2011
    - Senior investigator award, 5 years, Center for Innovation Medicine, 2016
    - Elected member of the Nobel Assembly at the Karolinska Institutet, 2019
    - Adjunct member of the Nobel Committee for Physiology or Medicine, 2023
    - Elected member of the Royal Swedish Academy of Sciences,  
  • 2023

Research

  • Current projects

    Regulation of immunoglobulin class switch recombination in human B cells
    The project is aimed at understanding the complex molecular mechanisms involved in DNA editing, repair and recombination during immunoglobulin class switch recombination (CSR) and somatic hypermutation (SHM) and their involvement in the pathophysiological processes leading to immunodeficiency, genome instability and cancer development in humans.

    Induced pluripotent stems cells a platform for personalized diagnosis and therapy in patients with primary immunodeficiency
    The project is aimed at reprogramming the fibroblasts or peripheral blood B cells derived from IgA deficient (IgAD) patients into pluripotent stem (iPS) cells and to re-differentiate these iPS cells into antibody-producing B cells. If successful, this study may provide a potentially curative treatment in patients with IgA deficiency. They will also provide a methodological platform for studies aimed at replacing cells in patients with a variety of other primary immunodeficiency diseases as well as autoimmune and neurological disorders associated with these diseases.

    Discovery of therapeutic targets in B cell lymphoma by next generation sequencing
    The project is aimed at identifying potentially treatable molecular targets in mature B cell lymphomas (with focus on diffuse large B cell lymphomas and mantle cell lymphomas) by high-throughput, next generation-sequencing omic- technologies such as whole genome and exome sequencing and RNA-seq.

    Antibody therapy against CVID-19
    The project is aimed at establishing a passive immunotherapy against coronavirus COVID19. To reach this overall goal, we will obtain blood samples from convalescent donors, i.e. people who have recovered from the infection, to isolate antibodies that can be used to prevent and to treat the disease.

    Our research is funded by the Swedish Research Council (VR), Swedish Cancer Society (Cancerfonden), Stockholm Cancer Society (Radiumhemmets), Vinnova, Knut and Alice Wallenberg Foundation and Mayo Clinic Cancer Research Center and Cancer Research KI (Cancer Research Award).

Selected publications

  • Article: CELL. 2023;186(10):2193-2207.e19
    Wang Y; Zhang S; Yang X; Hwang JK; Zhan C; Lian C; Wang C; Gui T; Wang B; Xie X; Dai P; Zhang L; Tian Y; Zhang H; Han C; Cai Y; Hao Q; Ye X; Liu X; Liu J; Cao Z; Huang S; Song J; Pan-Hammarstrom Q; Zhao Y; Alt FW; Zheng X; Da L-T; Yeap L-S; Meng F-L
  • Letter: THE LANCET REGIONAL HEALTH. WESTERN PACIFIC. 2023;33:100762
    Zuo F; Sun R; Abolhassani H; Du L; Wang Y; Vlachiotis S; Bertoglio F; Schubert M; Rezaei N; Chavoshzadeh Z; Guerra C; Cavalli A; Andrell J; Kumagai-Braesch M; Xue Y; Cao Y; Hust M; Robbiani DF; Xie XS; Hammarstrom L; Marcotte H; Pan-Hammarstrom Q
  • Article: SCIENCE IMMUNOLOGY. 2023;8(81):eade1167
    Hao Q; Zhan C; Lian C; Luo S; Cao W; Wang B; Xie X; Ye X; Gui T; Voena C; Pighi C; Wang Y; Tian Y; Wang X; Dai P; Cai Y; Liu X; Ouyang S; Sun S; Hu Q; Liu J; Ye Y; Zhao J; Lu A; Wang J-Y; Huang C; Su B; Meng F-L; Chiarle R; Pan-Hammarstrom Q; Yeap L-S
  • Article: SCIENCE IMMUNOLOGY. 2023;8(81):eade0958
    Bianchini F; Crivelli V; Abernathy ME; Guerra C; Palus M; Muri J; Marcotte H; Piralla A; Pedotti M; De Gasparo R; Simonelli L; Matkovic M; Toscano C; Biggiogero M; Calvaruso V; Svoboda P; Rincon TC; Fava T; Podesvova L; Shanbhag AA; Celoria A; Sgrignani J; Stefanik M; Honig V; Pranclova V; Michalcikova T; Prochazka J; Guerrini G; Mehn D; Clabbattini A; Abolhassani H; Jarrossay D; Uguccioni M; Medaglini D; Pan-Hammarstroem Q; Calzolai L; Fernandez D; Baldanti F; Franzetti-Pellanda A; Garzoni C; Sedlacek R; Ruzek D; Varani L; Cavalli A; Barnes CO; Robbiani DF
  • Article: CLINICAL AND TRANSLATIONAL MEDICINE. 2022;12(12):e1118
    Nie M; Ren W; Ye X; Berglund M; Wang X; Fjorden K; Du L; Giannoula Y; Lei D; Su W; Li W; Liu D; Linderoth J; Jiang C; Bao H; Jiang W; Huang H; Hou Y; Zhu S; Enblad G; Jerkeman M; Wu K; Zhang H; Amini R-M; Li Z-M; Pan-Hammarstrom Q
  • Letter: NEW ENGLAND JOURNAL OF MEDICINE. 2022;387(21):e55
    Zuo F; Marcotte H; Hammarstrom L; Pan-Hammarstrom Q
  • Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2022;150(5):1059-1073
    Abolhassani H; Delavari S; Landegren N; Shokri S; Bastard P; Du L; Zuo F; Hajebi R; Abolnezhadian F; Iranparast S; Modaresi M; Vosughimotlagh A; Salami F; Aranda-Guillen M; Cobat A; Marcotte H; Zhang S-Y; Zhang Q; Rezaei N; Casanova J-L; Kampe O; Hammarstrom L; Pan-Hammarstrom Q
  • Editorial comment: SIGNAL TRANSDUCTION AND TARGETED THERAPY. 2022;7(1):294
    Marcotte H; Hammarstrom L; Pan-Hammarstrom Q
  • Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2022;219(8):e20220131
    Zhang Q; Matuozzo D; Le Pen J; Lee D; Moens L; Asano T; Bohlen J; Liu Z; Moncada-Velez M; Kendir-Demirkol Y; Jing H; Bizien L; Marchal A; Abolhassani H; Delafontaine S; Bucciol G; Bayhan GI; Keles S; Kiykim A; Hancerli S; Haerynck F; Florkin B; Hatipoglu N; Ozcelik T; Morelle G; Zatz M; Ng LFP; Lye DC; Young BE; Leo Y-S; Dalgard CL; Lifton RP; Renia L; Meyts I; Jouanguy E; Hammarstrom L; Pan-Hammarstrom Q; Boisson B; Bastard P; Su HC; Boisson-Dupuis S; Abel L; Rice CM; Zhang S-Y; Cobat A; Casanova J-L
  • Article: SCIENCE IMMUNOLOGY. 2022;7(73):eabq3277
    Yang R; Avery DT; Jackson KJL; Ogishi M; Benhsaien I; Du L; Ye X; Han J; Rosain J; Peel JN; Alyanakian M-A; Neven B; Winter S; Puel A; Boisson B; Payne KJ; Wong M; Russell AJ; Mizoguchi Y; Okada S; Uzel G; Goodnow CC; Latour S; El Bakkouri J; Bousfiha A; Preece K; Gray PE; Keller B; Warnatz K; Boisson-Dupuis S; Abel L; Pan-Hammarstrom Q; Bustamante J; Ma CS; Casanova J-L; Tangye SG
  • Article: NATURE COMMUNICATIONS. 2022;13(1):2670
    Zuo F; Abolhassani H; Du L; Piralla A; Bertoglio F; de Campos-Mata L; Wan H; Schubert M; Cassaniti I; Wang Y; Sammartino JC; Sun R; Vlachiotis S; Bergami F; Kumagai-Braesch M; Andrell J; Zhang Z; Xue Y; Wenzel EV; Calzolai L; Varani L; Rezaei N; Chavoshzadeh Z; Baldanti F; Hust M; Hammarstrom L; Marcotte H; Pan-Hammarstrom Q
  • Article: CELL REPORTS. 2022;39(3):110713
    Ye X; Wang L; Nie M; Wang Y; Dong S; Ren W; Li G; Li Z-M; Wu K; Pan-Hammarstrom Q
  • Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2022;42(3):471-483
    Abolhassani H; Landegren N; Bastard P; Materna M; Modaresi M; Du L; Aranda-Guillen M; Sardh F; Zuo F; Zhang P; Marcotte H; Marr N; Khan T; Ata M; Al-Ali F; Pescarmona R; Belot A; Beziat V; Zhang Q; Casanova J-L; Kampe O; Zhang S-Y; Hammarstrom L; Pan-Hammarstrom Q
  • Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2022;42(1):1-9
    Abolhassani H; Vosughimotlagh A; Asano T; Landegren N; Boisson B; Delavari S; Bastard P; Aranda-Guillen M; Wang Y; Zuo F; Sardh F; Marcotte H; Du L; Zhang S-Y; Zhang Q; Rezaei N; Kampe O; Casanova J-L; Hammarstrom L; Pan-Hammarstrom Q
  • Review: CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY. 2021;21(6):553-558
    Hammarstrom L; Marcotte H; Piralla A; Baldanti F; Pan-Hammarstrom Q
  • Article: SCIENCE IMMUNOLOGY. 2021;6(62):eabl4348
    Asano T; Boisson B; Onodi F; Matuozzo D; Moncada-Velez M; Renkilaraj MRLM; Zhang P; Meertens L; Bolze A; Materna M; Korniotis S; Gervais A; Talouarn E; Bigio B; Seeleuthner Y; Bilguvar K; Zhang Y; Neehus A-L; Ogishi M; Pelham SJ; Le Voyer T; Rosain J; Philippot Q; Soler-Palacin P; Colobran R; Martin-Nalda A; Riviere JG; Tandjaoui-Lambiotte Y; Chaibi K; Shahrooei M; Darazam IA; Olyaei NA; Mansouri D; Palabiyik F; Ozcelik T; Novelli G; Novelli A; Casari G; Aiuti A; Carrera P; Bondesan S; Barzaghi F; Rovere-Querini P; Tresoldi C; Franco JL; Rojas J; Reyes LF; Bustos IG; Arias AA; Morelle G; Kyheng C; Troya J; Planas-Serra L; Schluter A; Gut M; Pujol A; Allende LM; Rodriguez-Gallego C; Flores C; Cabrera-Marante O; Pleguezuelo DE; de Diego RP; Keles S; Aytekin G; Akcan OM; Bryceson YT; Bergman P; Brodin P; Smole D; Smith CIE; Norlin A-C; Campbell TM; Covill LE; Hammarstrom L; Pan-Hammarstrom Q; Abolhassani H; Mane S; Marr N; Ata M; Al Ali F; Khan T; Spaan AN; Dalgard CL; Bonfanti P; Biondi A; Tubiana S; Burdet C; Nussbaum R; Kahn-Kirby A; Snow AL; Bustamante J; Puel A; Boisson-Dupuis S; Zhang S-Y; Beziat V; Lifton RP; Bastard P; Notarangelo LD; Abel L; Su HC; Jouanguy E; Amara A; Soumelis V; Cobat A; Zhang Q; Casanova J-L
  • Article: SCIENCE IMMUNOLOGY. 2021;6(62):eabl4340
    Bastard P; Gervais A; Le Voyer T; Rosain J; Philippot Q; Manry J; Michailidis E; Hoffmann H-H; Eto S; Garcia-Prat M; Bizien L; Parra-Martinez A; Yang R; Haljasmagi L; Migaud M; Sarekannu K; Maslovskaja J; de Prost N; Tandjaoui-Lambiotte Y; Luyt C-E; Amador-Borrero B; Gaudet A; Poissy J; Morel P; Richard P; Cognasse F; Troya J; Trouillet-Assant S; Belot A; Saker K; Garcon P; Riviere JG; Lagier J-C; Gentile S; Rosen LB; Shaw E; Morio T; Tanaka J; Dalmau D; Tharaux P-L; Sene D; Stepanian A; Megarbane B; Triantafyllia V; Fekkar A; Heath JR; Franco JL; Anaya J-M; Sole-Violan J; Imberti L; Biondi A; Bonfanti P; Castagnoli R; Delmonte OM; Zhang Y; Snow AL; Holland SM; Biggs CM; Moncada-Velez M; Arias AA; Lorenzo L; Boucherit S; Coulibaly B; Anglicheau D; Planas AM; Haerynck F; Duvlis S; Nussbaum RL; Ozcelik T; Keles S; Bousfiha AA; El Bakkouri J; Ramirez-Santana C; Paul S; Pan-Hammarstrom Q; Hammarstrom L; Dupont A; Kurolap A; Metz CN; Aiuti A; Casari G; Lampasona V; Ciceri F; Barreiros LA; Dominguez-Garrido E; Vidigal M; Zatz M; van de Beek D; Sahanic S; Tancevski I; Stepanovskyy Y; Boyarchuk O; Nukui Y; Tsumura M; Vidaur L; Tangye SG; Burrel S; Duffy D; Quintana-Murci L; Klocperk A; Kann NY; Shcherbina A; Lau Y-L; Leung D; Coulongeat M; Marlet J; Koning R; Reyes LF; Chauvineau-Grenier A; Venet F; Monneret G; Nussenzweig MC; Arrestier R; Boudhabhay I; Baris-Feldman H; Hagin D; Wauters J; Meyts I; Dyer AH; Kennelly SP; Bourke NM; Halwani R; Sharif-Askari NS; Dorgham K; Sallette J; Sedkaoui SM; AlKhater S; Rigo-Bonnin R; Morandeira F; Roussel L; Vinh DC; Ostrowski SR; Condino-Neto A; Prando C; Bondarenko A; Spaan AN; Gilardin L; Fellay J; Lyonnet S; Bilguvar K; Lifton RP; Mane S; Anderson MS; Boisson B; Beziat V; Zhang S-Y; Andreakos E; Hermine O; Pujol A; Peterson P; Mogensen TH; Rowen L; Mond J; Debette S; de Lamballerie X; Duval X; Mentre F; Zins M; Soler-Palacin P; Colobran R; Gorochov G; Solanich X; Susen S; Martinez-Picado J; Raoult D; Vasse M; Gregersen PK; Piemonti L; Rodriguez-Gallego C; Notarangelo LD; Su HC; Kisand K; Okada S; Puel A; Jouanguy E; Rice CM; Tiberghien P; Zhang Q; Cobat A; Abel L; Casanova J-L
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(22):e2104504118
    Fangazio M; Ladewig E; Gomez K; Garcia-Ibanez L; Kumar R; Teruya-Feldstein J; Rossi D; Filip I; Pan-Hammarstrom Q; Inghirami G; Boldorini R; Ott G; Staiger AM; Chapuy B; Gaidano G; Bhagat G; Basso K; Rabadan R; Pasqualucci L; Dalla-Favera R
  • Article: NATURE. 2021;593(7859):424-428
    De Gasparo R; Pedotti M; Simonelli L; Nickl P; Muecksch F; Cassaniti I; Percivalle E; Lorenzi JCC; Mazzola F; Magri D; Michalcikova T; Haviernik J; Honig V; Mrazkova B; Polakova N; Fortova A; Tureckova J; Iatsiuk V; Di Girolamo S; Palus M; Zudova D; Bednar P; Bukova I; Bianchini F; Mehn D; Nencka R; Strakova P; Pavlis O; Rozman J; Gioria S; Sammartino JC; Giardina F; Gaiarsa S; Pan-Hammarstrom Q; Barnes CO; Bjorkman PJ; Calzolai L; Piralla A; Baldanti F; Nussenzweig MC; Bieniasz PD; Hatziioannou T; Prochazka J; Sedlacek R; Robbiani DF; Ruzek D; Varani L
  • Article: MED. 2021;2(3):281-295.e4
    Sherina N; Piralla A; Du L; Wan H; Kumagai-Braesch M; Andrell J; Braesch-Andersen S; Cassaniti I; Percivalle E; Sarasini A; Bergami F; Di Martino R; Colaneri M; Vecchia M; Sambo M; Zuccaro V; Bruno R; Sachs M; Oggionni T; Meloni F; Abolhassani H; Bertoglio F; Schubert M; Byrne-Steele M; Han J; Hust M; Xue Y; Hammarstrom L; Baldanti F; Marcotte H; Pan-Hammarstrom Q
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Employments

  • Professor, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2023-

Degrees and Education

  • Docent, Karolinska Institutet, 2004
  • Doctor Of Philosophy, Department of Laboratory Medicine, Karolinska Institutet, 1999
  • Bachelor degree in Medicine, Sun Yat-sen University, 1993

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