Leire de Campos Mata

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About me

I am a postdoctoral researcher at Karolinska Institutet. My main research of
interest is creating a single-cell atlas of the B cell compartment across
human tissues using state-of-the-art technologies
I am a postdoctoral researcher at Karolinska Institutet. I did my PhD in
Biomedicine at the UPF in Spain. During my PhD I uncovered an unanticipated
role of the exonuclease Xrn1 in translational control under physiological
conditions and in cell adaptation and survival under osmotic stress
conditions. During 2020, I focused my career on the profiling of immune cell
and antibody responses in a cohort of moderate to severe COVID-19 patients.
Additionally, I generated monoclonal antibodies isolated from convalescent
individuals that neutralize SARS-CoV-2 variants of concern as a putative
therapy to treat COVID-19. Nowadays, my main research of interest is creating
a single-cell atlas of the B cell compartment and surrounding
microenvironment across different tissues in deceased healthy individuals
using state-of-the-art technologies such as single cell RNA sequencing.
2021: Postdoctoral researcher at Karolinska Institutet
2019: PhD in biomedicine at Universitat Pompeu Fabra "The exonuclease Xrn1: a
key regulator of gene expression under physiological and perturbed
conditions"
2014: Master in Molecular Biology and Biomedicine at Basque Country
University
2013: Bachelor in Biology at Basque Country University

Articles

Article: YEAST. 2024;41(7):458-472

Comparison of Xrn1 and Rat1 5' → 3' exoribonucleases in budding yeast supports the specific role of Xrn1 in cotranslational mRNA decay.

Pérez-Ortín JE; Jordán-Pla A; Zhang Y; Moreno-García J; Bassot C; Barba-Aliaga M; de Campos-Mata L; Choder M; Díez J; Piazza I; Pelechano V; García-Martínez J
Article: NATURE COMMUNICATIONS. 2024;15(1):1051

A monoclonal antibody targeting a large surface of the receptor binding motif shows pan-neutralizing SARS-CoV-2 activity.

de Campos-Mata L; Trinité B; Modrego A; Tejedor Vaquero S; Pradenas E; Pons-Grífols A; Rodrigo Melero N; Carlero D; Marfil S; Santiago C; Raïch-Regué D; Bueno-Carrasco MT; Tarrés-Freixas F; Abancó F; Urrea V; Izquierdo-Useros N; Riveira-Muñoz E; Ballana E; Pérez M; Vergara-Alert J; Segalés J; Carolis C; Arranz R; Blanco J; Magri G
Article: NATURE COMMUNICATIONS. 2022;13(1):2670

Heterologous immunization with inactivated vaccine followed by mRNA-booster elicits strong immunity against SARS-CoV-2 Omicron variant.

Zuo F; Abolhassani H; Du L; Piralla A; Bertoglio F; de Campos-Mata L; Wan H; Schubert M; Cassaniti I; Wang Y; Sammartino JC; Sun R; Vlachiotis S; Bergami F; Kumagai-Braesch M; Andréll J; Zhang Z; Xue Y; Wenzel EV; Calzolai L; Varani L; Rezaei N; Chavoshzadeh Z; Baldanti F; Hust M; Hammarström L; Marcotte H; Pan-Hammarström Q
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(9):e1339

SARS-CoV-2 sculpts the immune system to induce sustained virus-specific naïve-like and memory B-cell responses.

de Campos-Mata L; Tejedor Vaquero S; Tachó-Piñot R; Piñero J; Grasset EK; Arrieta Aldea I; Rodrigo Melero N; Carolis C; Horcajada JP; Cerutti A; Villar-García J; Magri G
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:737083

The mRNA-1273 Vaccine Induces Cross-Variant Antibody Responses to SARS-CoV-2 With Distinct Profiles in Individuals With or Without Pre-Existing Immunity.

Tejedor Vaquero S; de Campos-Mata L; Ramada JM; Díaz P; Navarro-Barriuso J; Ribas-Llaurado C; Rodrigo Melero N; Carolis C; Cerutti A; Gimeno R; Magri G
Article: NATURE COMMUNICATIONS. 2019;10(1):1298

The exonuclease Xrn1 activates transcription and translation of mRNAs encoding membrane proteins.

Blasco-Moreno B; de Campos-Mata L; Böttcher R; García-Martínez J; Jungfleisch J; Nedialkova DD; Chattopadhyay S; Gas M-E; Oliva B; Pérez-Ortín JE; Leidel SA; Choder M; Díez J

All other publications

Preprint: BIORXIV. 2023

Atypical memory B cells form a pre-plasmacellular reservoir for steady-state IgD responses to common nasopharyngeal antigens

Tachó-Piñot R; Bashour H; Filipska M; Tejedor-Vaquero S; de Campos-Mata L; Sáez-Gordón A; Perera-Bel J; Guzman M; Marcos-Fa X; Canales-Herrerias P; Domínguez-Barragán J; Arcós-Ribas B; Slabodkin A; Chernigovskaya M; de la Concepción MLR; Gutierrez-Marcos J; García-García A; Nascimento-Osorio A; Pascal M; Alsina L; Aróstegui J; Mehandru S; Cunningham-Rundles C; Carrillo J; Magri G; Greiff V; Cerutti A
Preprint: BIORXIV. 2023

A Novel Monoclonal Antibody Targeting a Large Surface of the Receptor Binding Motif Shows Pan-neutralizing SARS-CoV-2 Activity Including BQ.1.1 Variant

de Campos-Mata L; Trinité B; Modrego A; Vaquero ST; Pradenas E; Melero NR; Carlero D; Marfil S; Pons-Grífols A; Bueno-Carrasco MT; Santiago C; Tarrés-Freixas F; Urrea V; Izquierdo N; Riveira-Muñoz E; Ballana E; Pérez M; Vergara-Alert J; Segalés J; Carolis C; Arranz R; Blanco J; Magri G
Preprint: MEDRXIV. 2020

SARS-CoV-2-Specific Antibody Profiles Distinguish Patients with Moderate from Severe COVID-19

de Campos Mata L; Piñero J; Vaquero ST; Tachó-Piñot R; Kuksin M; Aldea IA; Melero NR; Carolis C; Furlong L; Cerutti A; Villar-García J; Magri G

Grants

Investigating the impact of air pollution on B cell-mediated immunity in human tissues

Tore Nilson Foundation

1 January 2024 - 30 September 2024
Uncovering the role of the cellular exonuclease Xrn1 in infectious and non-infectious cellular perturbations

Agència de Gestió d’Ajuts Universitaris i de Recerca

1 March 2016 - 28 February 2019
Collaboration scholarship

Ministerio de Educación, Cultura y Deporte

1 September 2012 - 30 June 2013

Employments

Postdoctoral Researcher, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2023-2024
Postdoctoral Researcher, Department of Biosciences and Nutrition, Karolinska Institutet, 2021-2023
Postdoctoral researcher, Immune responses to SARS-CoV-2 infection and immunization, Institut Hospital del Mar d'Investigacions Mèdiques, 2020-2021
PhD researcher, The exonuclease Xrn1: a key regulator of gene expression under physiological and perturbed conditions, Pompeu Fabra University, 2015-2019

Degrees and Education

Master in Molecular Biology and Biomedicine, University of the Basque Country, 2014
Bachelor in Biology, University of the Basque Country, 2013

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