Leire de Campos Mata
Postdoctoral Researcher
E-mail: leire.de.campos.mata@ki.se
Visiting address: Solnavägen 9, 17165 Solna
Postal address: C2 Medicinsk biokemi och biofysik, C2 Immunologi Hammarström, 171 77 Stockholm
About me
- I am a postdoctoral researcher at Karolinska Institutet. My main research of
interest is creating a single-cell atlas of the B cell compartment across
human tissues using state-of-the-art technologies
I am a postdoctoral researcher at Karolinska Institutet. I did my PhD in
Biomedicine at the UPF in Spain. During my PhD I uncovered an unanticipated
role of the exonuclease Xrn1 in translational control under physiological
conditions and in cell adaptation and survival under osmotic stress
conditions. During 2020, I focused my career on the profiling of immune cell
and antibody responses in a cohort of moderate to severe COVID-19 patients.
Additionally, I generated monoclonal antibodies isolated from convalescent
individuals that neutralize SARS-CoV-2 variants of concern as a putative
therapy to treat COVID-19. Nowadays, my main research of interest is creating
a single-cell atlas of the B cell compartment and surrounding
microenvironment across different tissues in deceased healthy individuals
using state-of-the-art technologies such as single cell RNA sequencing.
2021: Postdoctoral researcher at Karolinska Institutet
2019: PhD in biomedicine at Universitat Pompeu Fabra "The exonuclease Xrn1: a
key regulator of gene expression under physiological and perturbed
conditions"
2014: Master in Molecular Biology and Biomedicine at Basque Country
University
2013: Bachelor in Biology at Basque Country University
Articles
- Article: YEAST. 2024;41(7):458-472Perez-Ortin JE; Jordan-Pla A; Zhang Y; Moreno-Garcia J; Bassot C; Barba-Aliaga M; de Campos-Mata L; Choder M; Diez J; Piazza I; Pelechano V; Garcia-Martinez J
- Article: NATURE COMMUNICATIONS. 2024;15(1):1051de Campos-Mata L; Trinite B; Modrego A; Tejedor Vaquero S; Pradenas E; Pons-Grifols A; Rodrigo Melero N; Carlero D; Marfil S; Santiago C; Raich-Regue D; Bueno-Carrasco MT; Tarres-Freixas F; Abanco F; Urrea V; Izquierdo-Useros N; Riveira-Munoz E; Ballana E; Perez M; Vergara-Alert J; Segales J; Carolis C; Arranz R; Blanco J; Magri G
- Article: NATURE COMMUNICATIONS. 2022;13(1):2670Zuo F; Abolhassani H; Du L; Piralla A; Bertoglio F; de Campos-Mata L; Wan H; Schubert M; Cassaniti I; Wang Y; Sammartino JC; Sun R; Vlachiotis S; Bergami F; Kumagai-Braesch M; Andrell J; Zhang Z; Xue Y; Wenzel EV; Calzolai L; Varani L; Rezaei N; Chavoshzadeh Z; Baldanti F; Hust M; Hammarstrom L; Marcotte H; Pan-Hammarstrom Q
- Article: FRONTIERS IN IMMUNOLOGY. 2021;12:737083Tejedor Vaquero S; de Campos-Mata L; Maria Ramada J; Diaz P; Navarro-Barriuso J; Ribas-Llaurado C; Rodrigo Melero N; Carolis C; Cerutti A; Gimeno R; Magri G
- Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(9):e1339de Campos-Mata L; Tejedor Vaquero S; Tacho-Pinot R; Pinero J; Grasset EK; Arrieta Aldea I; Rodrigo Melero N; Carolis C; Horcajada JP; Cerutti A; Villar-Garcia J; Magri G
- Article: NATURE COMMUNICATIONS. 2019;10(1):1298Blasco-Moreno B; de Campos-Mata L; Bottcher R; Garcia-Martinez J; Jungfleisch J; Nedialkova DD; Chattopadhyay S; Gas M-E; Oliva B; Perez-Ortin JE; Leidel SA; Choder M; Diez J
All other publications
- Preprint: BIORXIV. 2023Tachó-Piñot R; Bashour H; Filipska M; Tejedor-Vaquero S; de Campos-Mata L; Sáez-Gordón A; Perera-Bel J; Guzman M; Marcos-Fa X; Canales-Herrerias P; Domínguez-Barragán J; Arcós-Ribas B; Slabodkin A; Chernigovskaya M; de la Concepción MLR; Gutierrez-Marcos J; García-García A; Nascimento-Osorio A; Pascal M; Alsina L; Aróstegui J; Mehandru S; Cunningham-Rundles C; Carrillo J; Magri G; Greiff V; Cerutti A
- Preprint: BIORXIV. 2023de Campos-Mata L; Trinité B; Modrego A; Vaquero ST; Pradenas E; Melero NR; Carlero D; Marfil S; Pons-Grífols A; Bueno-Carrasco MT; Santiago C; Tarrés-Freixas F; Urrea V; Izquierdo N; Riveira-Muñoz E; Ballana E; Pérez M; Vergara-Alert J; Segalés J; Carolis C; Arranz R; Blanco J; Magri G
- Preprint: MEDRXIV. 2020de Campos Mata L; Piñero J; Vaquero ST; Tachó-Piñot R; Kuksin M; Aldea IA; Melero NR; Carolis C; Furlong L; Cerutti A; Villar-García J; Magri G
Grants
- Swedish Research Council for Environment Agricultural Sciences and Spatial Planning1 January 2025 - 31 December 2028Air pollutants, particularly particulate matter (PM), pose a major health risk by infiltrating the body and accumulating in peripheral organs, including immune organs. Our research detected PM in organs relevant to immune B cell function. However, the link between PM exposure and B cell-mediated immunity is limited to epidemiological observations. The purpose of this project is to study the effects of PM on human B cell responses through evaluation of postmortem lung-associated tissues with signs of PM exposure. Specifically, we will examine whether lifelong exposure to PM correlates with changes in lymphoid tissue integrity and B cell profiles by immunophenotyping and spatial transcriptomics. Additionally, we will study how PM influences B cell responses to antigens in vitro, unraveling potential links to immune-related disorders. Last, we aim to identify B cell activation pathways affected by PM using molecular techniques. This study contributes to Sustainable Development Goal 3 (Good Health and Well-being), by aiming to characterize the polarization of B cells in the pathologic response to PM and by identifying potential drug targets that modulate immune responses in regions affected by air pollution (Target 3.9). By advancing our understanding of environmental immunology and its clinical significance, this project aims to inform public health strategies to mitigate the health risks associated with air pollution.
- Investigating the impact of air pollution on B cell-mediated immunity in human tissuesTore Nilson Foundation1 January 2024 - 30 September 2024
- Uncovering the role of the cellular exonuclease Xrn1 in infectious and non-infectious cellular perturbationsAgència de Gestió d’Ajuts Universitaris i de Recerca1 March 2016 - 28 February 2019
- Collaboration scholarshipMinisterio de Educación, Cultura y Deporte1 September 2012 - 30 June 2013
Employments
- Postdoctoral Researcher, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2023-2026
- Postdoctoral Researcher, Department of Biosciences and Nutrition, Karolinska Institutet, 2021-2023
- Postdoctoral researcher, Immune responses to SARS-CoV-2 infection and immunization, Institut Hospital del Mar d'Investigacions Mèdiques, 2020-2021
- PhD researcher, The exonuclease Xrn1: a key regulator of gene expression under physiological and perturbed conditions, Pompeu Fabra University, 2015-2019
Degrees and Education
- Master in Molecular Biology and Biomedicine, University of the Basque Country, 2014
- Bachelor in Biology, University of the Basque Country, 2013