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Research group - Samir EL Andaloussi

Our research efforts focus on one of the greatest challenges facing modern therapeutics; delivery. Despite the unprecedented knowledge of diseases and their mechanisms due to advances in biomedical sciences; many promising therapeutic approaches are still clinically unavailable. This is simply because there is no efficient means of delivering these therapeutics to the right organ with the right dose.

Such therapeutics include proteins for replacement therapy or antibodies for anti-inflammatory treatment as well as nucleic acids for gene therapy of diseases including muscular dystrophies and neurodegenerative disorders. We develop innovative drug delivery technologies that are able to carry protein and/or gene therapies to the target tissues safely and efficiently. We have developed a promising technology based on reprogramming exosomes, which are vesicles that are naturally used by cells to communicate, to carry therapeutic proteins and nucleic acids. We engineer exosomes with enhanced delivery and targeting capacities and screen our wide array of exosome designs in disease-relevant cellular and animal models. We are also developing methods for large-scale production and purification of such exosome therapeutics. Additionally, our lab develops methods for gene therapy based on modified cell-penetrating peptides that are efficient carriers of nucleic acids and proteins across biological barriers. We test our different technologies in models of inflammatory diseases as well as neurodegenerative and neuromuscular disorders. Our main aim is to one day unlock the potential of protein and gene therapy of such diseases by the development of novel and efficient delivery technologies.

Research group leader - Samir EL Andaloussi


Samir El-Andaloussi

Telefon: 08-585 838 73
Enhet: Kliniskt forskningscentrum

Group members

Osama AhmedForskarstuderande
Safa Safin Hayder Bazaz HidushForskarstuderande
Beklem BostanciogluPostdoc
Giulia CorsoForskarstuderande, Teknisk assistent
Samir El-AndaloussiDocent
Dhanu GuptaDoktorand
Oskar GustafssonFOU-praktikant
Manuela GustafssonPostdoc
André GörgensAnknuten, Postdoc
Daniel HageyPostdoc
Rim JawadPostdoc
Xiuming LiangPostdoc
Doste Rashid MamandForskarstuderande
Dara MohammadPostdoc
Joel NordinAnknuten
Oscar WiklanderForskarstuderande
Antje ZicklerPostdoc

External funding

Swedish Medical Research Council, EuroNanoMed (EraNet), Swedish Society of Medical Research (SSMF), KID funding, Vinnova, Moderna Therapeutics, Åke Wiberg stiftelse, SSF IRC funding, Evox Therapeutics, KI Senior Researcher central funding

Selected publications