Osama Saher

About me
Publications
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Public outreach and news

About me

•A passionate lecturer and post-doc researcher with over 10 years of experience in the field of pharmaceutics and drug delivery.
•Eager to establish useful connections between the worlds of pharmaceutical science and molecular biology.
•Experienced in teaching undergraduate and postgraduate students in different universities around the world.

Research

Research area/interest: Gene Therapy, Pharmaceutical Sciences, Drug Delivery.

Teaching

Invited lecturer at Research School for Clinicians in Molecular Biology (2021 &
2023)- Lecture titled "Oligonucleotide therapies and formulations”.

Articles

Article: INTERNATIONAL IMMUNOPHARMACOLOGY. 2024;129:111584
Tumor cell derived osteopontin and prostaglandin E2 synergistically promote the expansion of myeloid derived suppressor cells during the tumor immune escape phase
Mamand DR; Bazaz S; Mohammad DK; Saher O; Wiklander OPB; Sadeghi B; Hassan M; EL-Andaloussi S; Abedi-Valugerdi M
Article: SCIENCE ADVANCES. 2023;9(35):eadh1168
The cellular response to extracellular vesicles is dependent on their cell source and dose
Hagey DW; Ojansivu M; Bostancioglu BR; Saher O; Bost JP; Gustafsson MO; Gramignoli R; Svahn M; Gupta D; Stevens MM; Goergens A; EL Andaloussi S
Article: NUCLEIC ACID THERAPEUTICS. 2023;33(2):117-131
Chemical Modifications and Design Influence the Potency of Huntingtin Antigene Oligonucleotides
Saher O; Zaghloul EMM; Umek T; Hagey DWW; Mozafari N; Danielsen MBB; Gouda ASS; Lundin KEE; Jorgensen PTT; Wengel J; Smith CIE; Zain R
Article: ADVANCED HEALTHCARE MATERIALS. 2022;11(5):e2101658
Growth Media Conditions Influence the Secretion Route and Release Levels of Engineered Extracellular Vesicles
Bost JP; Saher O; Hagey D; Mamand DR; Liang X; Zheng W; Corso G; Gustafsson O; Gorgens A; Smith CIE; Zain R; El Andaloussi S; Gupta D
Article: COMMUNICATIONS BIOLOGY. 2022;5(1):185
Novel endosomolytic compounds enable highly potent delivery of antisense oligonucleotides
Bost JP; Ojansivu M; Munson MJ; Wesen E; Gallud A; Gupta D; Gustafsson O; Saher O; Radler J; Higgins SG; Lehto T; Holme MN; Dahlen A; Engkvist O; Stromstedt P-E; Andersson S; Smith CIE; Stevens MM; Esbjorner EK; Collen A; El Andaloussi S
Article: NUCLEIC ACID THERAPEUTICS. 2021;31(6):443-456
Oligonucleotides Targeting DNA Repeats Downregulate Huntingtin Gene Expression in Huntington's Patient-Derived Neural Model System
Umek T; Olsson T; Gissberg O; Saher O; Zaghloul EM; Lundin KE; Wengel J; Hanse E; Zetterberg H; Vizlin-Hodzic D; Smith CIE; Zain R
Article: BIOMEDICINES. 2021;9(8):1046
Novel Orthogonally Hydrocarbon-Modified Cell-Penetrating Peptide Nanoparticles Mediate Efficient Delivery of Splice-Switching Antisense Oligonucleotides In Vitro and In Vivo
Bazaz S; Lehto T; Tops R; Gissberg O; Gupta D; Bestas B; Bost J; Wiklander OPB; Sork H; Zaghloul EM; Mamand DR; Hallbrink M; Sillard R; Saher O; Ezzat K; Smith CIE; El Andaloussi S; Lehto T
Article: PHARMACEUTICS. 2021;13(1):116
Lipophilic Peptide Dendrimers for Delivery of Splice-Switching Oligonucleotides
Daralnakhla H; Saher O; Zamolo S; Bazaz S; P. Bost J; Heitz M; Lundin KE; El Andaloussi S; Darbre T; Reymond J-L; Zain R; Smith CIE
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2020;9(1):1800222
Quantification of extracellular vesicles in vitro and in vivo using sensitive bioluminescence imaging
Gupta D; Liang X; Pavlova S; Wiklander OPB; Corso G; Zhao Y; Saher O; Bost J; Zickler AM; Piffko A; Maire CL; Ricklefs FL; Gustafsson O; Llorente VC; Gustafsson MO; Bostancioglu RB; Mamand DR; Hagey DW; Goergens A; Nordin JZ; EL Andaloussi S
Article: BLOOD ADVANCES. 2020;4(11):2439-2450
Novel mouse model resistant to irreversible BTK inhibitors: a tool identifying new therapeutic targets and side effects
Estupinan HY; Bouderlique T; He C; Berglof A; Gupta D; Saher O; Daza Cruz MA; Pena-Perez L; Yu L; Zain R; Karlsson MCI; Mansson R; Smith CIE
Article: PHARMACEUTICS. 2019;11(12):E666-666
Sugar and Polymer Excipients Enhance Uptake and Splice-Switching Activity of Peptide-Dendrimer/Lipid/Oligonucleotide Formulations
Saher O; Lehto T; Gissberg O; Gupta D; Gustafsson O; EL Andaloussi S; Darbre T; Lundin KE; Smith CIE; Zain R
Article: NATURE COMMUNICATIONS. 2019;10(1):2331
The viral protein corona directs viral pathogenesis and amyloid aggregation
Ezzat K; Pernemalm M; Palsson S; Roberts TC; Jarver P; Dondalska A; Bestas B; Sobkowiak MJ; Levanen B; Skold M; Thompson EA; Saher O; Kari OK; Lajunen T; Ekstrom ES; Nilsson C; Ishchenko Y; Malm T; Wood MJA; Power UF; Masich S; Linden A; Sandberg JK; Lehtio J; Spetz A-L; EL Andaloussi S
Article: MOLECULES. 2019;24(6):E1180-1180
Oligonucleotide-Palladacycle Conjugates as Splice-Correcting Agents
Hande M; Saher O; Lundin KE; Smith CIE; Zain R; Lonnberg T
Article: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 2018;132:29-40
Novel peptide-dendrimer/lipid/oligonucleotide ternary complexes for efficient cellular uptake and improved splice-switching activity
Saher O; Rocha CSJ; Zaghioul EM; Wiklander OPB; Zamolo S; Heitz M; Ezzat K; Gupta D; Reymond J-L; Zain R; Hollfelder F; Darbre T; Lundin KE; El Andaloussi S; Smith CIE

All other publications

Thesis / dissertation: 2021
Pharmaceutical insights into improving oligonucleotide delivery and efficacy
Saher, Osama

Employments

Postdoctoral Researcher, Department of Laboratory Medicine, Karolinska Institutet, 2022-2025

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Laboratory Medicine, Karolinska Institutet, 2021

About me

Research

Teaching

Articles

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Employments

Degrees and Education

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