Taavi Lehto

Publications
Public outreach and news

Articles

Article: NATURE COMMUNICATIONS. 2023;14(1):4734
Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles
Zheng W; Raedler J; Sork H; Niu Z; Roudi S; Bost JPP; Goergens A; Zhao Y; Mamand DRR; Liang X; Wiklander OPB; Lehto T; Gupta D; Nordin JZZ; EL Andaloussi S
Article: MOLECULAR THERAPY. 2022;30(9):3078-3094
mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cells
Bevers S; Kooijmans SAA; Van de Velde E; Evers MJW; Seghers S; Gitz-Francois JJJM; van Kronenburg NCH; Fens MHAM; Mastrobattista E; Hassler L; Sork H; Lehto T; Ahmed KE; El Andaloussi S; Fiedler K; Breckpot K; Maes M; Van Hoorick D; Bastogne T; Schiffelers RM; De Koker S
Article: COMMUNICATIONS BIOLOGY. 2022;5(1):185
Novel endosomolytic compounds enable highly potent delivery of antisense oligonucleotides
Bost JP; Ojansivu M; Munson MJ; Wesen E; Gallud A; Gupta D; Gustafsson O; Saher O; Radler J; Higgins SG; Lehto T; Holme MN; Dahlen A; Engkvist O; Stromstedt P-E; Andersson S; Smith CIE; Stevens MM; Esbjorner EK; Collen A; El Andaloussi S
Article: BIOMEDICINES. 2021;9(8):1046
Novel Orthogonally Hydrocarbon-Modified Cell-Penetrating Peptide Nanoparticles Mediate Efficient Delivery of Splice-Switching Antisense Oligonucleotides In Vitro and In Vivo
Bazaz S; Lehto T; Tops R; Gissberg O; Gupta D; Bestas B; Bost J; Wiklander OPB; Sork H; Zaghloul EM; Mamand DR; Hallbrink M; Sillard R; Saher O; Ezzat K; Smith CIE; El Andaloussi S; Lehto T
Article: PHARMACEUTICS. 2021;13(6):878
Efficient Peptide-Mediated In Vitro Delivery of Cas9 RNP
Gustafsson O; Radler J; Roudi S; Lehto T; Hallbrink M; Lehto T; Gupta D; EL Andaloussi S; Nordin JZ
Article: FRONTIERS IN PHYSIOLOGY. 2021;12:689179
Fine Tuning of Phosphorothioate Inclusion in 2′-O-Methyl Oligonucleotides Contributes to Specific Cell Targeting for Splice-Switching Modulation
Aoki Y; Rocha CSJ; Lehto T; Miyatake S; Johansson H; Hashimoto Y; Nordin JZ; Mager I; Aoki M; Graham M; Sathyaprakash C; Roberts TC; Wood MJA; Behlke MA; El Andaloussi S
Article: MOLECULAR MEDICINE REPORTS. 2020;22(6):4589-4600
Smad-binding decoy reduces extracellular matrix expression in human hypertrophic scar fibroblasts
Fan C; El Andaloussi S; Lehto T; Kong KW; Seow Y
Article: PHARMACEUTICS. 2019;11(12):E666-666
Sugar and Polymer Excipients Enhance Uptake and Splice-Switching Activity of Peptide-Dendrimer/Lipid/Oligonucleotide Formulations
Saher O; Lehto T; Gissberg O; Gupta D; Gustafsson O; EL Andaloussi S; Darbre T; Lundin KE; Smith CIE; Zain R
Article: ADVANCED FUNCTIONAL MATERIALS. 2019;29(48)
Supramolecular Assembly of Aminoethylene-Lipopeptide PMO Conjugates into RNA Splice-Switching Nanomicelles
Kuhn J; Klein PM; Al Danaf N; Nordin JZ; Reinhard S; Loy DM; Hoehn M; El Andaloussi S; Lamb DC; Wagner E; Aoki Y; Lehto T; Laechelt U
Article: BIOCONJUGATE CHEMISTRY. 2017;28(9):2393-2409
Systemic Delivery of Folate-PEG siRNA Lipopolyplexes with Enhanced Intracellular Stability for In Vivo Gene Silencing in Leukemia
Lee D-J; Kessel E; Lehto T; Liu X; Yoshinaga N; Padari K; Chen Y-C; Kempter S; Uchida S; Raedler JO; Pooga M; Sheu M-T; Kataoka K; Wagner E
Article: BIOMATERIALS. 2016;77:98-110
Dual antitumoral potency of EG5 siRNA nanoplexes armed with cytotoxic bifunctional glutamyl-methotrexate targeting ligand.
Lee D-J; Kessel E; Edinger D; He D; Klein PM; Voith von Voithenberg L; Lamb DC; Lächelt U; Lehto T; Wagner E
Article: NANO LETTERS. 2015;15(7):4364-4373
Self-Assembly into Nanoparticles Is Essential for Receptor Mediated Uptake of Therapeutic Antisense Oligonucleotides
Ezzat K; Aoki Y; Koo T; McClorey G; Benner L; Coenen-Stass A; O'Donovan L; Lehto T; Garcia-Guerra A; Nordin J; Saleh AF; Behlke M; Morris J; Goyenvalle A; Dugovic B; Leumann C; Gordon S; Gait MJ; El-Andaloussi S; Wood MJA
Article: METHODS IN MOLECULAR BIOLOGY. 2015;1206:15-27
Sequence-defined oligoaminoamides for the delivery of siRNAs.
Lee D-J; Wagner E; Lehto T
Article: NUCLEIC ACIDS RESEARCH. 2014;42(5):3207-3217
Cellular trafficking determines the exon skipping activity of Pip6a-PMO in mdx skeletal and cardiac muscle cells.
Lehto T; Castillo Alvarez A; Gauck S; Gait MJ; Coursindel T; Wood MJA; Lebleu B; Boisguerin P
Article: JOURNAL OF MOLECULAR DIAGNOSTICS. 2014;16(1):127-135
Sensitive and rapid detection of Chlamydia trachomatis by recombinase polymerase amplification directly from urine samples.
Krõlov K; Frolova J; Tudoran O; Suhorutsenko J; Lehto T; Sibul H; Mäger I; Laanpere M; Tulp I; Langel Ü
Article: MOLECULAR PHARMACEUTICS. 2013;10(1):199-210
PepFect14 Peptide Vector for Efficient Gene Delivery in Cell Cultures
Veiman K-L; Maeger I; Ezzat K; Margus H; Lehto T; Langel K; Kurrikoff K; Arukuusk P; Suhorutsenko J; Padari K; Pooga M; Lehto T; Langel U
Article: PLOS ONE. 2013;8(7):e69659
Transfection of infectious RNA and DNA/RNA layered vectors of semliki forest virus by the cell-penetrating peptide based reagent PepFect6.
Pärn K; Viru L; Lehto T; Oskolkov N; Langel Ü; Merits A
Article: JOURNAL OF CONTROLLED RELEASE. 2012;162(1):1-8
Solid formulation of cell-penetrating peptide nanocomplexes with siRNA and their stability in simulated gastric conditions
Ezzat K; Zaghloul EM; Andaloussi SEL; Lehto T; El-Sayed R; Magdy T; Smith CIE; Langel U
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2012;1818(3):502-511
The role of endocytosis on the uptake kinetics of luciferin-conjugated cell-penetrating peptides.
Mäger I; Langel K; Lehto T; Eiríksdóttir E; Langel U
Article: MOLECULAR THERAPY. 2011;19(8):1457-1467
A Peptide-based Vector for Efficient Gene Transfer In Vitro and In Vivo
Lehto T; Simonson OE; Mager I; Ezzat K; Sork H; Copolovici D-M; Viola JR; Zaghloul EM; Lundin P; Moreno PMD; Mae M; Oskolkov N; Suhorutsenko J; Smith CIE; Andaloussi SEL
Article: JOURNAL OF CONTROLLED RELEASE. 2011;153(2):163-172
Insights into the cellular trafficking of splice redirecting oligonucleotides complexed with chemically modified cell-penetrating peptides.
Hassane FS; Abes R; El Andaloussi S; Lehto T; Sillard R; Langel U; Lebleu B
Article: NUCLEIC ACIDS RESEARCH. 2011;39(12):5284-5298
PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation
Ezzat K; EL Andaloussi S; Zaghloul EM; Lehto T; Lindberg S; Moreno PMD; Viola JR; Magdy T; Abdo R; Guterstam P; Sillard R; Hammond SM; Wood MJA; Arzumanov AA; Gait MJ; Smith CIE; Hallbrink M; Langel U
Article: VIROLOGY JOURNAL. 2011;8:243
Novel viral vectors utilizing intron splice-switching to activate genome rescue, expression and replication in targeted cells
Viru L; Heller G; Lehto T; Paern K; El Andaloussi S; Langel U; Merits A
Article: NUCLEIC ACIDS RESEARCH. 2011;39(9):3972-3987
Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo
Andaloussi SEL; Lehto T; Maeger I; Rosenthal-Aizman K; Oprea II; Simonson OE; Sork H; Ezzat K; Copolovici DM; Kurrikoff K; Viola JR; Zaghloul EM; Sillard R; Johansson HJ; Hassane FS; Guterstam P; Suhorutsenko J; Moreno PMD; Oskolkov N; Haelldin J; Tedebark U; Metspalu A; Lebleu B; Lehtioe J; Smith CIE; Langel U
Article: METHODS IN MOLECULAR BIOLOGY. 2011;683:361-373
Application of PepFect peptides for the delivery of splice-correcting oligonucleotides.
Andaloussi SEL; Lehto T; Lundin P; Langel U
Article: BIOCONJUGATE CHEMISTRY. 2010;21(9):1662-1672
Cellular internalization kinetics of (luciferin-)cell-penetrating peptide conjugates.
Eiríksdóttir E; Mäger I; Lehto T; El Andaloussi S; Langel U
Article: JOURNAL OF CONTROLLED RELEASE. 2010;141(1):42-51
Delivery of nucleic acids with a stearylated (RxR)₄ peptide using a non-covalent co-incubation strategy
Lehto T; Abes R; Oskolkov N; Suhorutsenko J; Copolovici D-M; Mager I; Viola JR; Simonson OE; Ezzat K; Guterstam P; Eriste E; Smith CIE; Lebleu B; El Andaloussi S; Langel U
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Corrigendum: ACS NANO. 2021;15(11):18590-18591
Delivery of Oligonucleotide Therapeutics: Chemical Modifications, Lipid Nanoparticles, and Extracellular Vesicles (vol 15, pg 13993, 2021)
Bost JP; Barriga H; Holme MN; Gallud A; Maugeri M; Gupta D; Lehto T; Valadi H; Esbjorner EK; Stevens MM; El-Andaloussi S
Review: ACS NANO. 2021;15(9):13993-14021
Delivery of Oligonucleotide Therapeutics: Chemical Modifications, Lipid Nanoparticles, and Extracellular Vesicles
Bost JP; Barriga H; Holme MN; Gallud A; Maugeri M; Gupta D; Lehto T; Valadi H; Esbjorner EK; Stevens MM; El-Andaloussi S
Review: EMBO MOLECULAR MEDICINE. 2021;13(4):e13243
Delivery of oligonucleotide-based therapeutics: challenges and opportunities
Hammond SM; Aartsma-Rus A; Alves S; Borgos SE; Buijsen RAM; Collin RWJ; Covello G; Denti MA; Desviat LR; Echevarria L; Foged C; Gaina G; Garanto A; Goyenvalle AT; Guzowska M; Holodnuka I; Jones DR; Krause S; Lehto T; Montolio M; Van Roon-Mom W; Arechavala-Gomeza V
Review: EMBO MOLECULAR MEDICINE. 2017;9(5):545-557
Delivery is key: lessons learnt from developing splice-switching antisense therapies
Godfrey C; Desviat LR; Smedsrod B; Pietri-Rouxel F; Denti MA; Disterer P; Lorain S; Nogales-Gadea G; Sardone V; Anwar R; El Andaloussi S; Lehto T; Khoo B; Brolin C; van Roon-Mom WMC; Goyenvalle A; Aartsma-Rus A; Arechavala-Gomeza V
Review: ADVANCED DRUG DELIVERY REVIEWS. 2016;106(Pt A):172-182
Peptides for nucleic acid delivery
Lehto T; Ezzat K; Wood MJA; EL Andaloussi S
Review: NANOMEDICINE. 2014;9(18):2843-2859
Sequence-defined polymers for the delivery of oligonucleotides.
Lehto T; Wagner E
Review: EXPERT OPINION ON DRUG DELIVERY. 2012;9(7):823-836
Cell-penetrating peptides for the delivery of nucleic acids.
Lehto T; Kurrikoff K; Langel Ü
Review: PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY. 2011;104:397-426
Peptide Nanoparticles for Oligonucleotide Delivery
Lehto T; Ezzat K; Langel U
Review: EXPERT OPINION ON DRUG DELIVERY. 2009;6(11):1195-1205
Chemically modified cell-penetrating peptides for the delivery of nucleic acids
Mae M; El Andaloussi S; Lehto T; Langel U

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