Taavi Lehto

Publications
Public outreach and news

Articles

Article: NATURE COMMUNICATIONS. 2023;14(1):4734

Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles

Zheng W; Raedler J; Sork H; Niu Z; Roudi S; Bost JPP; Goergens A; Zhao Y; Mamand DRR; Liang X; Wiklander OPB; Lehto T; Gupta D; Nordin JZZ; EL Andaloussi S
Article: MOLECULAR THERAPY. 2022;30(9):3078-3094

mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cells

Bevers S; Kooijmans SAA; Van de Velde E; Evers MJW; Seghers S; Gitz-Francois JJJM; van Kronenburg NCH; Fens MHAM; Mastrobattista E; Hassler L; Sork H; Lehto T; Ahmed KE; El Andaloussi S; Fiedler K; Breckpot K; Maes M; Van Hoorick D; Bastogne T; Schiffelers RM; De Koker S
Article: COMMUNICATIONS BIOLOGY. 2022;5(1):185

Novel endosomolytic compounds enable highly potent delivery of antisense oligonucleotides

Bost JP; Ojansivu M; Munson MJ; Wesen E; Gallud A; Gupta D; Gustafsson O; Saher O; Radler J; Higgins SG; Lehto T; Holme MN; Dahlen A; Engkvist O; Stromstedt P-E; Andersson S; Smith CIE; Stevens MM; Esbjorner EK; Collen A; El Andaloussi S
Article: BIOMEDICINES. 2021;9(8):1046

Novel Orthogonally Hydrocarbon-Modified Cell-Penetrating Peptide Nanoparticles Mediate Efficient Delivery of Splice-Switching Antisense Oligonucleotides In Vitro and In Vivo

Bazaz S; Lehto T; Tops R; Gissberg O; Gupta D; Bestas B; Bost J; Wiklander OPB; Sork H; Zaghloul EM; Mamand DR; Hallbrink M; Sillard R; Saher O; Ezzat K; Smith CIE; El Andaloussi S; Lehto T
Article: PHARMACEUTICS. 2021;13(6):878

Efficient Peptide-Mediated In Vitro Delivery of Cas9 RNP

Gustafsson O; Radler J; Roudi S; Lehto T; Hallbrink M; Lehto T; Gupta D; EL Andaloussi S; Nordin JZ
Article: FRONTIERS IN PHYSIOLOGY. 2021;12:689179

Fine Tuning of Phosphorothioate Inclusion in 2′-O-Methyl Oligonucleotides Contributes to Specific Cell Targeting for Splice-Switching Modulation

Aoki Y; Rocha CSJ; Lehto T; Miyatake S; Johansson H; Hashimoto Y; Nordin JZ; Mager I; Aoki M; Graham M; Sathyaprakash C; Roberts TC; Wood MJA; Behlke MA; El Andaloussi S
Article: MOLECULAR MEDICINE REPORTS. 2020;22(6):4589-4600

Smad-binding decoy reduces extracellular matrix expression in human hypertrophic scar fibroblasts

Fan C; El Andaloussi S; Lehto T; Kong KW; Seow Y
Article: PHARMACEUTICS. 2019;11(12):E666-666

Sugar and Polymer Excipients Enhance Uptake and Splice-Switching Activity of Peptide-Dendrimer/Lipid/Oligonucleotide Formulations

Saher O; Lehto T; Gissberg O; Gupta D; Gustafsson O; EL Andaloussi S; Darbre T; Lundin KE; Smith CIE; Zain R
Article: ADVANCED FUNCTIONAL MATERIALS. 2019;29(48)

Supramolecular Assembly of Aminoethylene-Lipopeptide PMO Conjugates into RNA Splice-Switching Nanomicelles

Kuhn J; Klein PM; Al Danaf N; Nordin JZ; Reinhard S; Loy DM; Hoehn M; El Andaloussi S; Lamb DC; Wagner E; Aoki Y; Lehto T; Laechelt U
Article: BIOCONJUGATE CHEMISTRY. 2017;28(9):2393-2409

Systemic Delivery of Folate-PEG siRNA Lipopolyplexes with Enhanced Intracellular Stability for In Vivo Gene Silencing in Leukemia

Lee D-J; Kessel E; Lehto T; Liu X; Yoshinaga N; Padari K; Chen Y-C; Kempter S; Uchida S; Raedler JO; Pooga M; Sheu M-T; Kataoka K; Wagner E
Article: BIOMATERIALS. 2016;77:98-110

Dual antitumoral potency of EG5 siRNA nanoplexes armed with cytotoxic bifunctional glutamyl-methotrexate targeting ligand.

Lee D-J; Kessel E; Edinger D; He D; Klein PM; Voith von Voithenberg L; Lamb DC; Lächelt U; Lehto T; Wagner E
Article: NANO LETTERS. 2015;15(7):4364-4373

Self-Assembly into Nanoparticles Is Essential for Receptor Mediated Uptake of Therapeutic Antisense Oligonucleotides

Ezzat K; Aoki Y; Koo T; McClorey G; Benner L; Coenen-Stass A; O'Donovan L; Lehto T; Garcia-Guerra A; Nordin J; Saleh AF; Behlke M; Morris J; Goyenvalle A; Dugovic B; Leumann C; Gordon S; Gait MJ; El-Andaloussi S; Wood MJA
Article: METHODS IN MOLECULAR BIOLOGY. 2015;1206:15-27

Sequence-defined oligoaminoamides for the delivery of siRNAs.

Lee D-J; Wagner E; Lehto T
Article: NUCLEIC ACIDS RESEARCH. 2014;42(5):3207-3217

Cellular trafficking determines the exon skipping activity of Pip6a-PMO in mdx skeletal and cardiac muscle cells.

Lehto T; Castillo Alvarez A; Gauck S; Gait MJ; Coursindel T; Wood MJA; Lebleu B; Boisguerin P
Article: JOURNAL OF MOLECULAR DIAGNOSTICS. 2014;16(1):127-135

Sensitive and rapid detection of Chlamydia trachomatis by recombinase polymerase amplification directly from urine samples.

Krõlov K; Frolova J; Tudoran O; Suhorutsenko J; Lehto T; Sibul H; Mäger I; Laanpere M; Tulp I; Langel Ü
Article: MOLECULAR PHARMACEUTICS. 2013;10(1):199-210

PepFect14 Peptide Vector for Efficient Gene Delivery in Cell Cultures

Veiman K-L; Maeger I; Ezzat K; Margus H; Lehto T; Langel K; Kurrikoff K; Arukuusk P; Suhorutsenko J; Padari K; Pooga M; Lehto T; Langel U
Article: PLOS ONE. 2013;8(7):e69659

Transfection of infectious RNA and DNA/RNA layered vectors of semliki forest virus by the cell-penetrating peptide based reagent PepFect6.

Pärn K; Viru L; Lehto T; Oskolkov N; Langel Ü; Merits A
Article: JOURNAL OF CONTROLLED RELEASE. 2012;162(1):1-8

Solid formulation of cell-penetrating peptide nanocomplexes with siRNA and their stability in simulated gastric conditions

Ezzat K; Zaghloul EM; Andaloussi SEL; Lehto T; El-Sayed R; Magdy T; Smith CIE; Langel U
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2012;1818(3):502-511

The role of endocytosis on the uptake kinetics of luciferin-conjugated cell-penetrating peptides.

Mäger I; Langel K; Lehto T; Eiríksdóttir E; Langel U
Article: MOLECULAR THERAPY. 2011;19(8):1457-1467

A Peptide-based Vector for Efficient Gene Transfer In Vitro and In Vivo

Lehto T; Simonson OE; Mager I; Ezzat K; Sork H; Copolovici D-M; Viola JR; Zaghloul EM; Lundin P; Moreno PMD; Mae M; Oskolkov N; Suhorutsenko J; Smith CIE; Andaloussi SEL
Article: JOURNAL OF CONTROLLED RELEASE. 2011;153(2):163-172

Insights into the cellular trafficking of splice redirecting oligonucleotides complexed with chemically modified cell-penetrating peptides.

Hassane FS; Abes R; El Andaloussi S; Lehto T; Sillard R; Langel U; Lebleu B
Article: NUCLEIC ACIDS RESEARCH. 2011;39(12):5284-5298

PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation

Ezzat K; EL Andaloussi S; Zaghloul EM; Lehto T; Lindberg S; Moreno PMD; Viola JR; Magdy T; Abdo R; Guterstam P; Sillard R; Hammond SM; Wood MJA; Arzumanov AA; Gait MJ; Smith CIE; Hallbrink M; Langel U
Article: VIROLOGY JOURNAL. 2011;8:243

Novel viral vectors utilizing intron splice-switching to activate genome rescue, expression and replication in targeted cells

Viru L; Heller G; Lehto T; Paern K; El Andaloussi S; Langel U; Merits A
Article: NUCLEIC ACIDS RESEARCH. 2011;39(9):3972-3987

Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo

Andaloussi SEL; Lehto T; Maeger I; Rosenthal-Aizman K; Oprea II; Simonson OE; Sork H; Ezzat K; Copolovici DM; Kurrikoff K; Viola JR; Zaghloul EM; Sillard R; Johansson HJ; Hassane FS; Guterstam P; Suhorutsenko J; Moreno PMD; Oskolkov N; Haelldin J; Tedebark U; Metspalu A; Lebleu B; Lehtioe J; Smith CIE; Langel U
Article: METHODS IN MOLECULAR BIOLOGY. 2011;683:361-373

Application of PepFect peptides for the delivery of splice-correcting oligonucleotides.

Andaloussi SEL; Lehto T; Lundin P; Langel U
Article: BIOCONJUGATE CHEMISTRY. 2010;21(9):1662-1672

Cellular internalization kinetics of (luciferin-)cell-penetrating peptide conjugates.

Eiríksdóttir E; Mäger I; Lehto T; El Andaloussi S; Langel U
Article: JOURNAL OF CONTROLLED RELEASE. 2010;141(1):42-51

Delivery of nucleic acids with a stearylated (RxR)₄ peptide using a non-covalent co-incubation strategy

Lehto T; Abes R; Oskolkov N; Suhorutsenko J; Copolovici D-M; Mager I; Viola JR; Simonson OE; Ezzat K; Guterstam P; Eriste E; Smith CIE; Lebleu B; El Andaloussi S; Langel U
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Corrigendum: ACS NANO. 2021;15(11):18590-18591

Delivery of Oligonucleotide Therapeutics: Chemical Modifications, Lipid Nanoparticles, and Extracellular Vesicles (vol 15, pg 13993, 2021)

Bost JP; Barriga H; Holme MN; Gallud A; Maugeri M; Gupta D; Lehto T; Valadi H; Esbjorner EK; Stevens MM; El-Andaloussi S
Review: ACS NANO. 2021;15(9):13993-14021

Delivery of Oligonucleotide Therapeutics: Chemical Modifications, Lipid Nanoparticles, and Extracellular Vesicles

Bost JP; Barriga H; Holme MN; Gallud A; Maugeri M; Gupta D; Lehto T; Valadi H; Esbjorner EK; Stevens MM; El-Andaloussi S
Review: EMBO MOLECULAR MEDICINE. 2021;13(4):e13243

Delivery of oligonucleotide-based therapeutics: challenges and opportunities

Hammond SM; Aartsma-Rus A; Alves S; Borgos SE; Buijsen RAM; Collin RWJ; Covello G; Denti MA; Desviat LR; Echevarria L; Foged C; Gaina G; Garanto A; Goyenvalle AT; Guzowska M; Holodnuka I; Jones DR; Krause S; Lehto T; Montolio M; Van Roon-Mom W; Arechavala-Gomeza V
Review: EMBO MOLECULAR MEDICINE. 2017;9(5):545-557

Delivery is key: lessons learnt from developing splice-switching antisense therapies

Godfrey C; Desviat LR; Smedsrod B; Pietri-Rouxel F; Denti MA; Disterer P; Lorain S; Nogales-Gadea G; Sardone V; Anwar R; El Andaloussi S; Lehto T; Khoo B; Brolin C; van Roon-Mom WMC; Goyenvalle A; Aartsma-Rus A; Arechavala-Gomeza V
Review: ADVANCED DRUG DELIVERY REVIEWS. 2016;106(Pt A):172-182

Peptides for nucleic acid delivery

Lehto T; Ezzat K; Wood MJA; EL Andaloussi S
Review: NANOMEDICINE. 2014;9(18):2843-2859

Sequence-defined polymers for the delivery of oligonucleotides.

Lehto T; Wagner E
Review: EXPERT OPINION ON DRUG DELIVERY. 2012;9(7):823-836

Cell-penetrating peptides for the delivery of nucleic acids.

Lehto T; Kurrikoff K; Langel Ü
Review: PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY. 2011;104:397-426

Peptide Nanoparticles for Oligonucleotide Delivery

Lehto T; Ezzat K; Langel U
Review: EXPERT OPINION ON DRUG DELIVERY. 2009;6(11):1195-1205

Chemically modified cell-penetrating peptides for the delivery of nucleic acids

Mae M; El Andaloussi S; Lehto T; Langel U

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