André Görgens

Publications
Public outreach and news

Articles

Journal article: ADVANCED SCIENCE. 2024;11(42):e2407619
Novel Endogenous Engineering Platform for Robust Loading and Delivery of Functional mRNA by Extracellular Vesicles
Zickler AM; Liang X; Gupta D; Mamand DR; De Luca M; Corso G; Errichelli L; Hean J; Sen T; Elsharkasy OM; Kamei N; Niu Z; Zhou G; Zhou H; Roudi S; Wiklander OPB; Gorgens A; Nordin JZ; Castilla-Llorente V; EL Andaloussi S
Article: NATURE BIOMEDICAL ENGINEERING. 2024;8(11):1453-1468
Antibody-displaying extracellular vesicles for targeted cancer therapy
Wiklander OPB; Mamand DR; Mohammad DK; Zheng W; Jawad Wiklander R; Sych T; Zickler AM; Liang X; Sharma H; Lavado A; Bost J; Roudi S; Corso G; Lennaard AJ; Abedi-Valugerdi M; Maeger I; Alici E; Sezgin E; Nordin JZ; Gupta D; Goergens A; EL Andaloussi S
Journal article: JOURNAL OF PROTEOME RESEARCH. 2024;23(9):4114-4127
Defining the Soluble and Extracellular Vesicle Protein Compartments of Plasma Using In-Depth Mass Spectrometry-Based Proteomics
Sharma N; Angori S; Sandberg A; Mermelekas G; Lehtio J; Wiklander OPB; Gorgens A; El Andaloussi S; Eriksson H; Pernemalm M
Journal article: HUMAN REPRODUCTION. 2024;39(Supplement_1):deae108.313
O-266 Multi-omics landscape of uterine fluid-derived extracellular vesicles across the menstrual cycle
Apostolov A; Mladenovic D; Baev V; Yahubyan G; Tilk K; Görgens A; Bergamelli M; Kalinina A; Saare M; Lõhmus A; Milov A; Nikolova M; Milova N; Salumets A; Aleksejeva E
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2024;13(6):e12463
Inter-laboratory multiplex bead-based surface protein profiling of MSC-derived EV preparations identifies MSC-EV surface marker signatures
Nguyen VVT; Welsh JA; Tertel T; Choo A; van de Wakker SI; Defourny KAY; Giebel B; Vader P; Padmanabhan J; Lim SK; Nolte-'t Hoen ENM; Verhaar MC; Bostancioglu RB; Zickler AM; Hong JM; Jones JC; EL Andaloussi S; van Balkom BWM; Goergens A
Article: STEM CELL RESEARCH AND THERAPY. 2024;15(1):77
Transcriptomic and proteomic profiles of fetal versus adult mesenchymal stromal cells and mesenchymal stromal cell-derived extracellular vesicles
Gencer EB; Lor YK; Abomaray F; El Andaloussi S; Pernemalm M; Sharma N; Hagey DW; Gorgens A; Gustafsson MO; Le Blanc K; Toonsi MA; Walther-Jallow L; Goetherstrom C
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2024;13(2):e12404
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
Welsh JA; Goberdhan DCI; O'Driscoll L; Buzas EI; Blenkiron C; Bussolati B; Cai H; Di Vizio D; Driedonks TAP; Erdbrugger U; Falcon-Perez JM; Fu Q-L; Hill AF; Lenassi M; Lim SK; Mahoney MG; Mohanty S; Moller A; Nieuwland R; Ochiya T; Sahoo S; Torrecilhas AC; Zheng L; Zijlstra A; Abuelreich S; Bagabas R; Bergese P; Bridges EM; Brucale M; Burger D; Carney RP; Cocucci E; Colombo F; Crescitelli R; Hanser E; Harris AL; Haughey NJ; Hendrix A; Ivanov AR; Jovanovic-Talisman T; Kruh-Garcia NA; Faustino VK-L; Kyburz D; Lasser C; Lennon KM; Lotvall J; Maddox AL; Martens-Uzunova ES; Mizenko RR; Newman LA; Ridolfi A; Rohde E; Rojalin T; Rowland A; Saftics A; Sandau US; Saugstad JA; Shekari F; Swift S; Ter-Ovanesyan D; Tosar JP; Useckaite Z; Valle F; Varga Z; van der Pol E; van Herwijnen MJC; Wauben MHM; Wehman AM; Williams S; Zendrini A; Zimmerman AJ; Thery C; Witwer KW
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2024;13(1):e12396
Size matters: Functional differences of small extracellular vesicle subpopulations in cardiac repair responses
van de Wakker SI; Bauza-Martinez J; Rios Arceo C; Manjikian H; Snijders Blok CJB; Roefs MT; Willms E; Maas RGC; Pronker MF; de Jong OG; Wu W; Goergens A; El Andaloussi S; Sluijter JPG; Vader P
Article: CELL REPORTS MEDICINE. 2023;4(9):101171
Targeting nucleic acid sensors in tumor cells to reprogram biogenesis and RNA cargo of extracellular vesicles for T cell-mediated cancer immunotherapy
Heidegger S; Stritzke F; Dahl S; Dassler-Plenker J; Joachim L; Buschmann D; Fan K; Sauer CM; Ludwig N; Winter C; Enssle S; Li S; Perl M; Goergens A; Haas T; Orberg ET; Goettert S; Woelfel C; Engleitner T; Cortes-Ciriano I; Rad R; Herr W; Giebel B; Ruland J; Bassermann F; Coch C; Hartmann G; Poeck H
Article: SCIENCE ADVANCES. 2023;9(35):eadh1168
The cellular response to extracellular vesicles is dependent on their cell source and dose
Hagey DW; Ojansivu M; Bostancioglu BR; Saher O; Bost JP; Gustafsson MO; Gramignoli R; Svahn M; Gupta D; Stevens MM; Goergens A; EL Andaloussi S
Article: HAEMATOLOGICA. 2023;108(9):2422-2434
Myeloid cells from Langerhans cell histiocytosis patients exhibit increased vesicle trafficking and an altered secretome capable of activating NK cells
Hagey DW; Kvedaraite E; Akber M; Goergens A; Javadi J; Greenwood TVB; Bjorklund C; Akefeldt SO; Hannegard-Hamrin T; Arnell H; Dobra K; Herold N; Svensson M; El Andaloussi S; Henter J-I; Lourda M
Article: NATURE COMMUNICATIONS. 2023;14(1):4734
Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles
Zheng W; Raedler J; Sork H; Niu Z; Roudi S; Bost JPP; Goergens A; Zhao Y; Mamand DRR; Liang X; Wiklander OPB; Lehto T; Gupta D; Nordin JZZ; EL Andaloussi S
Article: CELL DEATH DISCOVERY. 2023;9(1):260
Cutaneous squamous cell carcinoma-derived extracellular vesicles exert an oncogenic role by activating cancer-associated fibroblasts
Li C; Sun C; Lohcharoenkal W; Ali MM; Xing P; Zheng W; Gorgens A; Gustafsson MO; EL Andaloussi S; Sonkoly E; Pivarcsi A
Article: NANOSCALE ADVANCES. 2023;5(6):1691-1705
The potential role of serum extracellular vesicle derived small RNAs in AML research as non-invasive biomarker
Li L; Mussack V; Goergens A; Pepeldjiyska E; Hartz AS; Aslan H; Rackl E; Rank A; Schmohl J; El Andaloussi S; Pfaffl MW; Schmetzer H
Journal article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(12):s266
496 Comprehensive analysis of extracellular vesicles surface markers produced by normal keratinocytes human cutaneous squamous cell carcinoma cell lines reveals phenotypic heterogeneity
Li C; Sun C; Elton JJ; Lohcharoenkal W; Görgens A; Andaloussi SE; Sonkoly E; Pivarcsi A
Article: CANCER GENE THERAPY. 2022;29(11):1600-1615
Description and optimization of a multiplex bead-based flow cytometry method (MBFCM) to characterize extracellular vesicles in serum samples from patients with hematological malignancies
Li L; Gorgens A; Mussack V; Pepeldjiyska E; Hartz AS; Rank A; Schmohl J; Kra''mer D; Andaloussi SE; Pfaffl MW; Schmetzer H
Journal article: 2022
ESDR496 - Comprehensive analysis of extracellular vesicles surface markers produced by normal keratinocytes human cutaneous squamous cell carcinoma cell lines reveals phenotypic heterogeneity
Li C; Sun C; Elton J; Lohcharoenkal W; Sonkoly E; Pivarcsi A; Görgens A; El Andaloussi S
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2022;11(6):e12238
Identification of storage conditions stabilizing extracellular vesicles preparations
Gorgens A; Corso G; Hagey DW; Wiklander RJ; Gustafsson MO; Felldin U; Lee Y; Bostancioglu RB; Sork H; Liang X; Zheng W; Mohammad DK; van DWSI; Vader P; Zickler AM; Mamand DR; Ma L; Holme MN; Stevens MM; Wiklander OPB; El Andaloussi S
Article: ADVANCED HEALTHCARE MATERIALS. 2022;11(5):e2101658
Growth Media Conditions Influence the Secretion Route and Release Levels of Engineered Extracellular Vesicles
Bost JP; Saher O; Hagey D; Mamand DR; Liang X; Zheng W; Corso G; Gustafsson O; Gorgens A; Smith CIE; Zain R; El Andaloussi S; Gupta D
Article: CELL REPORTS: METHODS. 2022;2(1):100136
MPA_PASS software enables stitched multiplex, multidimensional EV repertoire analysis and a standard framework for reporting bead-based assays
Welsh JA; Killingsworth B; Kepley J; Traynor T; Cook S; Savage J; Marte J; Lee M-J; Maeng HM; Pleet ML; Magana S; Gorgens A; Maire CL; Lamszus K; Ricklefs FL; Merino MJ; Linehan WM; Greten T; Cooks T; Harris CC; Apolo A; Abdel-Mageed A; Ivanov AR; Trepel JB; Roth M; Tkach M; Milosavljevic A; Thery C; LeBlanc A; Berzofsky JA; Ruppin E; Aldape K; Camphausen K; Gulley JL; Ghiran I; Jacobson S; Jones JC
Article: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 2022;170:59-69
Influence of short term storage conditions, concentration methods and excipients on extracellular vesicle recovery and function
van DWSI; van Oudheusden J; Mol EA; Roefs MT; Zheng W; Gorgens A; El Andaloussi S; Sluijter JPG; Vader P
Article: NATURE COMMUNICATIONS. 2021;12(1):6666
GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain
Dar GH; Mendes CC; Kuan W-L; Speciale AA; Conceicao M; Gorgens A; Uliyakina I; Lobo MJ; Lim WF; El Andaloussi S; Mager I; Roberts TC; Barker RA; Goberdhan DCI; Wilson C; Wood MJA
Article: BIOMOLECULES. 2021;11(11):1606
Diagnostic and Prognostic Utility of the Extracellular Vesicles Subpopulations Present in Pleural Effusion
Javadi J; Goergens A; Vanky H; Gupta D; Hjerpe A; EL-Andaloussi S; Hagey D; Dobra K
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2021;10(12):e12142
Extracellular vesicles are the primary source of blood-borne tumour-derived mutant KRAS DNA early in pancreatic cancer
Hagey DW; Kordes M; Gorgens A; Mowoe MO; Nordin JZ; Moro CF; Lohr J-M; El Andaloussi S
Article: NATURE BIOMEDICAL ENGINEERING. 2021;5(9):1084-1098
Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles.
Gupta D; Wiklander OPB; Görgens A; Conceição M; Corso G; Liang X; Seow Y; Balusu S; Feldin U; Bostancioglu B; Jawad R; Mamand DR; Lee YXF; Hean J; Mäger I; Roberts TC; Gustafsson M; Mohammad DK; Sork H; Backlund A; Lundin P; de Fougerolles A; Smith CIE; Wood MJA; Vandenbroucke RE; Nordin JZ; El-Andaloussi S
Article: NEURO-ONCOLOGY. 2021;23(7):1087-1099
Genome-wide methylation profiling of glioblastoma cell-derived extracellular vesicle DNA allows tumor classification
Maire CL; Fuh MM; Kaulich K; Fita KD; Stevic I; Heiland DH; Welsh JA; Jones JC; Goergens A; Ricklefs T; Duehrsen L; Sauvigny T; Joosse SA; Reifenberger G; Pantel K; Glatzel M; Miklosi AG; Felce JH; Caselli M; Pereno V; Reimer R; Schlueter H; Westphal M; Schueller U; Lamszus K; Ricklefs FL
Article: JOURNAL OF IMMUNOLOGY. 2021;206(12):2839-2851
Human Cord Blood B Cells Differ from the Adult Counterpart by Conserved Ig Repertoires and Accelerated Response Dynamics
Budeus B; Kibler A; Brauser M; Homp E; Bronischewski K; Ross JA; Gorgens A; Weniger MA; Dunst J; Kreslavsky T; da Conceicao Castro SV; Murke F; Oakes CC; Rusch P; Andrikos D; Kern P; Koeninger A; Lindemann M; Johansson P; Hansen W; Lundell A-C; Rudin A; Duerig J; Giebel B; Hoffmann D; Kueppers R; Seifert M
Article: SMALL. 2021;17(14):e2008155
Multiparametric Profiling of Single Nanoscale Extracellular Vesicles by Combined Atomic Force and Fluorescence Microscopy: Correlation and Heterogeneity in Their Molecular and Biophysical Features
Cavallaro S; Pevere F; Stridfeldt F; Gorgens A; Paba C; Sahu SS; Mamand DR; Gupta D; El Andaloussi S; Linnros J; Dev A
Article: BIOMATERIALS. 2021;266:120435
Engineered extracellular vesicle decoy receptor-mediated modulation of the IL6 trans-signalling pathway in muscle
Conceica M; Forcina L; Wiklander OPB; Gupta D; Nordin JZ; Vrellaku B; McClorey G; Mager I; Gorgens A; Lundin P; Musaro A; Wood MJA; Andaloussi SEL; Roberts TC
Journal article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2021;09:639162
Depletion of Numb and Numblike in Murine Lung Epithelial Cells Ameliorates Bleomycin-Induced Lung Fibrosis by Inhibiting the β-Catenin Signaling Pathway
Ianni A; Hofmann M; Kumari P; Tarighi S; Al-Tamari HM; Goergens A; Giebel B; Nolte H; Krueger M; Salwig I; Pullamsetti SS; Guenther A; Schneider A; Braun T
Article: CELLS. 2020;9(9):E2123-2123
Human Amnion Epithelial Cells Impair T Cell Proliferation: The Role of HLA-G and HLA-E Molecules
Morandi F; Marimpietri D; Goergens A; Gallo A; Srinivasan RC; El-Andaloussi S; Gramignoli R
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2020;9(1):1808281
Salivary extracellular vesicles inhibit Zika virus but not SARS-CoV-2 infection
Conzelmann C; Gross R; Zou M; Krueger F; Goergens A; Gustafsson MO; El Andaloussi S; Muench J; Mueller JA
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2020;9(1):1800222
Quantification of extracellular vesicles in vitro and in vivo using sensitive bioluminescence imaging
Gupta D; Liang X; Pavlova S; Wiklander OPB; Corso G; Zhao Y; Saher O; Bost J; Zickler AM; Piffko A; Maire CL; Ricklefs FL; Gustafsson O; Llorente VC; Gustafsson MO; Bostancioglu RB; Mamand DR; Hagey DW; Goergens A; Nordin JZ; EL Andaloussi S
Article: CYTOMETRY. PART A : THE JOURNAL OF THE INTERNATIONAL SOCIETY FOR ANALYTICAL CYTOLOGY. 2020;97(6):602-609
High-Resolution Imaging Flow Cytometry Reveals Impact of Incubation Temperature on Labeling of Extracellular Vesicles with Antibodies
Tertel T; Bremer M; Maire C; Lamszus K; Peine S; Jawad R; Andaloussi SEL; Giebel B; Ricklefs FL; Goergens A
Article: CANCERS. 2020;12(5):E1143-1143
Differential B-Cell Receptor Signaling Requirement for Adhesion of Mantle Cell Lymphoma Cells to Stromal Cells
Sadeghi L; Arvidsson G; Merrien M; Wasik AM; Gorgens A; Smith CIE; Sander B; Wright AP
Article: BONE MARROW TRANSPLANTATION. 2020;55(1):100-109
Allogeneic transplantation of peripheral blood stem cell grafts results in a massive decrease of primitive hematopoietic progenitor frequencies in reconstituted bone marrows
Kordelas L; Goergens A; Radtke S; Horn PA; Beelen DW; Giebel B
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2020;9(1):1713526
MIFlowCyt-EV: a framework for standardized reporting of extracellular vesicle flow cytometry experiments
Welsh JA; Van Der Pol E; Arkesteijn GJA; Bremer M; Brisson A; Coumans F; Dignat-George F; Duggan E; Ghiran I; Giebel B; Goergens A; Hendrix A; Lacroix R; Lanniga J; Libregtse SFWM; Lozano-Andres E; Morales-Kastresana A; Robert S; De Rond L; Tertel T; Tigges J; De Wever O; Yan X; Nieuwland R; Wauben MHM; Nolan JP; Jones JC
Article: PLOS ONE. 2020;15(2):e0228674
CpG stimulation of chronic lymphocytic leukemia cells induces a polarized cell shape and promotes migration in vitro and in vivo
Dampmann M; Gorgens A; Mollmann M; Murke F; Duhrsen U; Giebel B; Durig J
Article: SCIENTIFIC REPORTS. 2019;9(1):12914
Human multipotent hematopoietic progenitor cell expansion is neither supported in endothelial and endothelial/mesenchymal co-cultures nor in NSG mice
Radtke S; Goergens A; da Conceicao Castro SV; Kordelas L; Koeninger A; Duerig J; Moellmann M; Horn PA; Gebel B
Article: ACS SENSORS. 2019;4(5):1399-1408
Label-Free Surface Protein Profiling of Extracellular Vesicles by an Electrokinetic Sensor
Cavallaro S; Horak J; Haag P; Gupta D; Stiller C; Sahu SS; Gorgens A; Gatty HK; Viktorsson K; El Andaloussi S; Lewensohn R; Karlstrom AE; Linnros J; Dev A
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2019;8(1):1663043
Systematic characterization of extracellular vesicles sorting domains and quantification at the single molecule - single vesicle level by fluorescence correlation spectroscopy and single particle imaging
Corso G; Heusermann W; Trojer D; Goergens A; Steib E; Voshol J; Graff A; Genoud C; Lee Y; Hean J; Nordin JZ; Wiklander OPB; El Andaloussi S; Meisner-Kober N
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2019;8(1):1588555
Imaging flow cytometry facilitates multiparametric characterization of extracellular vesicles in malignant brain tumours
Ricklefs FL; Maire CL; Reimer R; Duehrsen L; Kolbe K; Holz M; Schneider E; Rissiek A; Babayan A; Hille C; Pantel K; Krasemann S; Glatzel M; Heiland DH; Flitsch J; Martens T; Schmidt NO; Peine S; Breakefield XO; Lawler S; Chiocca EA; Fehse B; Giebel B; Goergens A; Westphal M; Lamszus K
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2019;8(1):1587567
Optimisation of imaging flow cytometry for the analysis of single extracellular vesicles by using fluorescence-tagged vesicles as biological reference material
Goergens A; Bremer M; Ferrer-Tur R; Murke F; Tertel T; Horn PA; Thalman S; Welsh JA; Probst C; Guerin C; Boulanger CM; Jones JC; Hanenber H; Erdbrugger U; Lannigan J; Ricklefs FL; El-Andaloussi S; Giebel B
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1419
Distinct Spatio-Temporal Dynamics of Tumor-Associated Neutrophils in Small Tumor Lesions
Sody S; Uddin M; Grueneboom A; Goergens A; Giebel B; Gunzer M; Brandau S
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2018;504(4):749-752
Translocation-generated ITK-FER and ITK-SYK fusions induce STAT3 phosphorylation and CD69 expression
Fathi NN; Mohammad DK; Gorgens A; El Andaloussi S; Zain R; Nore BF; Smith CIE
Article: HAEMATOLOGICA. 2018;103(4):614-625
Gfi1b: a key player in the genesis and maintenance of acute myeloid leukemia and myelodysplastic syndrome
Thivakaran A; Botezatu L; Hoenes JM; Schuette J; Vassen L; Al-Matary YS; Patnana P; Zeller A; Heuser M; Thol F; Gabdoulline R; Olberding N; Frank D; Suslo M; Koester R; Lennartz K; Gorgens A; Giebel B; Opalka B; Duehrsen U; Khandanpour C
Article: FRONTIERS IN IMMUNOLOGY. 2018;9:1326
Systematic Methodological Evaluation of a Multiplex Bead-Based Flow Cytometry Assay for Detection of Extracellular Vesicle Surface Signatures
Wiklander OPB; Bostancioglu RB; Welsh JA; Zickler AM; Murke F; Corso G; Felldin U; Hagey DW; Evertsson B; Liang X-M; Gustafsson MO; Mohammad DK; Wiek C; Hanenberg H; Bremer M; Gupta D; Bjornstedt M; Giebel B; Nordin JZ; Jones JC; EL Andaloussi S; Goergens A
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2018;7(1):1535750
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
Thery C; Witwer KW; Aikawa E; Jose Alcaraz M; Anderson JD; Andriantsitohaina R; Antoniou A; Arab T; Archer F; Atkin-Smith GK; Ayre DC; Bach J-M; Bachurski D; Baharvand H; Balaj L; Baldacchino S; Bauer NN; Baxter AA; Bebawy M; Beckham C; Zavec AB; Benmoussa A; Berardi AC; Bergese P; Bielska E; Blenkiron C; Bobis-Wozowicz S; Boilard E; Boireau W; Bongiovanni A; Borras FE; Bosch S; Boulanger CM; Breakefield X; Breglio AM; Brennan MA; Brigstock DR; Brisson A; Broekman MLD; Bromberg JF; Bryl-Gorecka P; Buch S; Buck AH; Burger D; Busatto S; Buschmann D; Bussolati B; Buzas EI; Byrd JB; Camussi G; Carter DRF; Caruso S; Chamley LW; Chang Y-T; Chen C; Chen S; Cheng L; Chin AR; Clayton A; Clerici SP; Cocks A; Cocucci E; Coffey RJ; Cordeiro-da-Silva A; Couch Y; Coumans FAW; Coyle B; Crescitelli R; Criado MF; D'Souza-Schorey C; Das S; Chaudhuri AD; de Candia P; De Santana Junior EF; De Wever O; del Portillo HA; Demaret T; Deville S; Devitt A; Dhondt B; Di Vizio D; Dieterich LC; Dolo V; Dominguez Rubio AP; Dominici M; Dourado MR; Driedonks TAP; Duarte FV; Duncan HM; Eichenberger RM; Ekstrom K; Andaloussi SEL; Elie-Caille C; Erdbrugger U; Falcon-Perez JM; Fatima F; Fish JE; Flores-Bellver M; Forsonits A; Frelet-Barrand A; Fricke F; Fuhrmann G; Gabrielsson S; Gamez-Valero A; Gardiner C; Gaertner K; Gaudin R; Gho YS; Giebel B; Gilbert C; Gimona M; Giusti I; Goberdhan DCI; Goergens A; Gorski SM; Greening DW; Gross JC; Gualerzi A; Gupta GN; Gustafson D; Handberg A; Haraszti RA; Harrison P; Hegyesi H; Hendrix A; Hill AF; Hochberg FH; Hoffmann KF; Holder B; Holthofer H; Hosseinkhani B; Hu G; Huang Y; Huber V; Hunt S; Ibrahim AG-E; Ikezu T; Inal JM; Isin M; Ivanova A; Jackson HK; Jacobsen S; Jay SM; Jayachandran M; Jenster G; Jiang L; Johnson SM; Jones JC; Jong A; Jovanovic-Talisman T; Jung S; Kalluri R; Kano S-I; Kaur S; Kawamura Y; Keller ET; Khamari D; Khomyakova E; Khvorova A; Kierulf P; Kim KP; Kislinger T; Klingeborn M; Klinke DJII; Kornek M; Kosanovic MM; Kovacs AF; Kraemer-Albers E-M; Krasemann S; Krause M; Kurochkin IV; Kusuma GD; Kuypers S; Laitinen S; Langevin SM; Languino LR; Lannigan J; Lasser C; Laurent LC; Lavieu G; Lazaro-Ibanez E; Le Lay S; Lee M-S; Lee YXF; Lemos DS; Lenassi M; Leszczynska A; Li ITS; Liao K; Libregts SF; Ligeti E; Lim R; Lim SK; Line A; Linnemannstoens K; Llorente A; Lombard CA; Lorenowicz MJ; Lorincz AM; Lotvall J; Lovett J; Lowry MC; Loyer X; Lu Q; Lukomska B; Lunavat TR; Maas SLN; Malhi H; Marcilla A; Mariani J; Mariscal J; Martens-Uzunova ES; Martin-Jaular L; Martinez MC; Martins VR; Mathieu M; Mathivanan S; Maugeri M; McGinnis LK; McVey MJ; Meckes DGJ; Meehan KL; Mertens I; Minciacchi VR; Moller A; Jorgensen MM; Morales-Kastresana A; Morhayim J; Mullier F; Muraca M; Musante L; Mussack V; Muth DC; Myburgh KH; Najrana T; Nawaz M; Nazarenko I; Nejsum P; Neri C; Neri T; Nieuwland R; Nimrichter L; Nolan JP; Nolte-'t Hoen ENM; Noren Hooten N; O'Driscoll L; O'Grady T; O'Loghlen A; Ochiya T; Olivier M; Ortiz A; Ortiz LA; Osteikoetxea X; Ostegaard O; Ostrowski M; Park J; Pegtel DM; Peinado H; Perut F; Pfaffl MW; Phinney DG; Pieters BCH; Pink RC; Pisetsky DS; von Strandmann EP; Polakovicova I; Poon IKH; Powell BH; Prada I; Pulliam L; Quesenberry P; Radeghieri A; Raffai RL; Raimondo S; Rak J; Ramirez MI; Raposo G; Rayyan MS; Regev-Rudzki N; Ricklefs FL; Robbins PD; Roberts DD; Rodrigues SC; Rohde E; Rome S; Rouschop KMA; Rughetti A; Russell AE; Saa P; Sahoo S; Salas-Huenuleo E; Sanchez C; Saugstad JA; Saul MJ; Schiffelers RM; Schneider R; Schoyen TH; Scott A; Shahaj E; Sharma S; Shatnyeva O; Shekari F; Shelke GV; Shetty AK; Shiba K; Siljander PR-M; Silva AM; Skowronek A; Snyder OLII; Soares RP; Sodar BW; Soekmadji C; Sotillo J; Stahl PD; Stoorvogel W; Stott SL; Strasser EF; Swift S; Tahara H; Tewari M; Timms K; Tiwari S; Tixeira R; Tkach M; Toh WS; Tomasini R; Torrecilhas AC; Pablo Tosar J; Toxavidis V; Urbanelli L; Vader P; van Balkom BWM; van der Grein SG; Van Deun J; van Herwijnen MJC; Van Keuren-Jensen K; van Niel G; van Royen ME; van Wijnen AJ; Helena Vasconcelos M; Vechetti IJJ; Veit TD; Vella LJ; Velot E; Verweij FJ; Vestad B; Vinas JL; Visnovitz T; Vukman KV; Wahlgren J; Watson DC; Wauben MHM; Weaver A; Webber JP; Weber V; Wehman AM; Weiss DJ; Welsh JA; Wendt S; Wheelock AM; Wiener Z; Witte L; Wolfram J; Xagorari A; Xander P; Xu J; Yan X; Yanez-Mo M; Yin H; Yuana Y; Zappulli V; Zarubova J; Zekas V; Zhang J-Y; Zhao Z; Zheng L; Zheutlin AR; Zickler AM; Zimmermann P; Zivkovic AM; Zocco D; Zuba-Surma EK
Article: SCIENTIFIC REPORTS. 2017;7(1):15720
Enforced GFI1 expression impedes human and murine leukemic cell growth
Hoenes JM; Thivakaran A; Botezatu L; Patnana P; da Conceicao Castro SV; Al-Matary YS; Schuette J; Fischer KBI; Vassen L; Goergens A; Duehrsen U; Giebel B; Khandanpour C
Article: SCIENTIFIC REPORTS. 2017;7(1):11561
Reproducible and scalable purification of extracellular vesicles using combined bind-elute and size exclusion chromatography
Corso G; Mager I; Lee Y; Gorgens A; Bultema J; Giebel B; Wood MJA; Nordin JZ; Andaloussi SEL
Article: STEM CELL REPORTS. 2017;8(4):919-932
In Vitro Generation of Vascular Wall-Resident Multipotent Stem Cells of Mesenchymal Nature from Murine Induced Pluripotent Stem Cells
Steens J; Zuk M; Benchellal M; Bornemann L; Teichweyde N; Hess J; Unger K; Goergens A; Klump H; Klein D
Article: FRONTIERS IN MICROBIOLOGY. 2017;8:2115
A Therapeutic Antiviral Antibody Inhibits the Anterograde Directed Neuron-to-Cell Spread of Herpes Simplex Virus and Protects against Ocular Disease
Bauer D; Alt M; Dirks M; Buch A; Heilingloh CS; Dittmer U; Giebel B; Goergens A; Palapys V; Kasper M; Eis-Huebinger AM; Sodeik B; Heiligenhaus A; Roggendorf M; Krawczyk A
Article: MOLECULAR THERAPY. 2016;24(8):1423-1434
Superior Therapeutic Index in Lymphoma Therapy: CD30⁺ CD34⁺ Hematopoietic Stem Cells Resist a Chimeric Antigen Receptor T-cell Attack
Hombach AA; Goergens A; Chmielewski M; Murke F; Kimpel J; Giebel B; Abken H
Article: EXPERIMENTAL HEMATOLOGY. 2016;44(8):713-726
Epigenetic therapy as a novel approach for GFI136N-associated murine/human AML
Botezatu L; Michel LC; Helness A; Vadnais C; Makishima H; Hoenes JM; Robert F; Vassen L; Thivakaran A; Al-Matary Y; Lams RF; Schuette J; Giebel B; Goergens A; Heuser M; Medyouf H; Maciejewski J; Duehrsen U; Moeroey T; Khandanpour C
Article: LEUKEMIA. 2016;30(6):1237-1245
GFI1 as a novel prognostic and therapeutic factor for AML/MDS
Hoenes JM; Botezatu L; Helness A; Vadnais C; Vassen L; Robert F; Hergenhan SM; Thivakaran A; Schuette J; Al-Matary YS; Lams RF; Fraszscak J; Makishima H; Radivoyevitch T; Przychodzen B; Castro SVDC; Goergens A; Giebel B; Klein-Hitpass L; Lennartz K; Heuser M; Thiede C; Ehninger G; Duehrsen U; Maciejewski JP; Moeroey T; Khandanpour C
Article: CELL CYCLE. 2016;15(4):540-545
Human mesenchymal and murine stromal cells support human lympho-myeloid progenitor expansion but not maintenance of multipotent haematopoietic stem and progenitor cells
Radtke S; Goergens A; Liu B; Horn PA; Giebel B
Journal article: ISBT SCIENCE SERIES. 2016;11(S1):228-234
Mesenchymal stem/stromal cell‐derived extracellular vesicles as a new approach in stem cell therapy
Börger V; Bremer M; Görgens A; Giebel B
Article: PLOS ONE. 2016;11(4):e0153018
Circulating Tumor Cell Composition in Renal Cell Carcinoma
Nel I; Gauler TC; Bublitz K; Lazaridis L; Goergens A; Giebel B; Schuler M; Hoffmann A-C
Article: CELLULAR REPROGRAMMING. 2015;17(6):415-418
From Basic Biology to Engineering and Clinical Translation of Stem Cells: Meeting Report on the 8th International Meeting of the Stem Cell Network North Rhine Westphalia
Goergens A; Horn PA
Article: STEM CELLS TRANSLATIONAL MEDICINE. 2015;4(10):1131-1143
Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression
Doeppner TR; Herz J; Goergens A; Schlechter J; Ludwig A-K; Radtke S; de Miroschedji K; Horn PA; Giebel B; Hermann DM
Article: STEM CELLS AND DEVELOPMENT. 2015;24(17):2018-2031
Age-Related Increase of EED Expression in Early Hematopoietic Progenitor Cells is Associated with Global Increase of the Histone Modification H3K27me3
Graffmann N; Brands J; Goergens A; da Conceicao Castro SV; Santourlidis S; Reckert A; Michele I; Ritz-Timme S; Fischer JC; Adjaye J; Koegler G; Giebel B; Uhrberg M
Journal article: TRANSFUSIONSMEDIZIN. 2015;5(03):131-137
Therapeutisches Potenzial von extrazellulären Vesikeln aus mesenchymalen Stamm- bzw. Stromazellen
Börger V; Görgens A; Rohde E; Giebel B
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2015;169(6):868-878
CD133 allows elaborated discrimination and quantification of haematopoietic progenitor subsets in human haematopoietic stem cell transplants
Radtke S; Goergens A; Kordelas L; Schmidt M; Kimmig KR; Koeninger A; Horn PA; Giebel B
Journal article: BIOSPEKTRUM. 2015;21(3):290-293
Wie unser Blut entsteht – neue Erkennt nisse zur Hämatopoese
Görgens A; Giebel B
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2015;4:30087
Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper.
Lener T; Gimona M; Aigner L; Börger V; Buzas E; Camussi G; Chaput N; Chatterjee D; Court FA; Del Portillo HA; O'Driscoll L; Fais S; Falcon-Perez JM; Felderhoff-Mueser U; Fraile L; Gho YS; Görgens A; Gupta RC; Hendrix A; Hermann DM; Hill AF; Hochberg F; Horn PA; de Kleijn D; Kordelas L; Kramer BW; Krämer-Albers E-M; Laner-Plamberger S; Laitinen S; Leonardi T; Lorenowicz MJ; Lim SK; Lötvall J; Maguire CA; Marcilla A; Nazarenko I; Ochiya T; Patel T; Pedersen S; Pocsfalvi G; Pluchino S; Quesenberry P; Reischl IG; Rivera FJ; Sanzenbacher R; Schallmoser K; Slaper-Cortenbach I; Strunk D; Tonn T; Vader P; van Balkom BWM; Wauben M; Andaloussi SE; Théry C; Rohde E; Giebel B
Article: FRONTIERS IN ONCOLOGY. 2015;5:234
CEACAM1-4L promotes anchorage-independent growth in melanoma
Loeffek S; Ullrich N; Goergens A; Murke F; Eilebrecht M; Menne C; Giebel B; Schadendorf D; Singer BB; Helfrich I
Article: PLOS ONE. 2015;10(1):e0116800
Prevention of Herpes Simplex Virus Induced Stromal Keratitis by a Glycoprotein B-Specific Monoclonal Antibody
Krawczyk A; Dirks M; Kasper M; Buch A; Dittmer U; Giebel B; Wildschuetz L; Busch M; Goergens A; Schneweis KE; Eis-Huebinger AM; Sodeik B; Heiligenhaus A; Roggendorf M; Bauer D
Journal article: SYMMETRY. 2015;7(4):2025-2037
Concise Review: Asymmetric Cell Divisions in Stem Cell Biology
Murke F; da Conceicao Castro SV; Giebel B; Goergens A
Article: STEM CELL REPORTS. 2014;3(6):1058-1072
Multipotent Hematopoietic Progenitors Divide Asymmetrically to Create Progenitors of the Lymphomyeloid and Erythromyeloid Lineages
Goergens A; Ludwig A-K; Moellmann M; Krawczyk A; Duerig J; Hanenberg H; Horn PA; Giebel B
Journal article: BLOOD. 2013;122(21):3795
Gfi1b-A Novel Tumor Suppressor In Acute Myeloid Leukemia
Botezatu L; Hönes J; Zeller A; Michel LC; Görgens A; Lennartz K; Köster R; Opalka B; Giebel B; Dührsen U; Khandanpour C
Article: CELL CYCLE. 2013;12(22):3478-3482
New relationships of human hematopoietic lineages facilitate detection of multipotent hematopoietic stem and progenitor cells
Goergens A; Radtke S; Horn PA; Giebel B
Article: INTERNATIONAL JOURNAL OF CANCER. 2013;133(7):1653-1663
Vemurafenib reverses immunosuppression by myeloid derived suppressor cells
Schilling B; Sucker A; Griewank K; Zhao F; Weide B; Goergens A; Giebel B; Schadendorf D; Paschen A
Article: CELL REPORTS. 2013;3(5):1539-1552
Revision of the Human Hematopoietic Tree: Granulocyte Subtypes Derive from Distinct Hematopoietic Lineages
Goergens A; Radtke S; Moellmann M; Cross M; Duerig J; Horn PA; Giebel B
Article: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND CELL BIOLOGY. 2012;44(7):1121-1132
Lipid raft redistribution and morphological cell polarization are separable processes providing a basis for hematopoietic stem and progenitor cell migration
Goergens A; Beckmann J; Ludwig A-K; Moellmann M; Duerig J; Horn PA; Rajendran L; Giebel B
Article: JOURNAL OF STEM CELLS AND REGENERATIVE MEDICINE. 2010;6(2):103
Analysis of transcription factors differentially expressed in the primitive human hematopoietic compartment.
Jansen S; von Levetzow G; Goergens A; Hanenberg H; Horn P; Giebel B
Article: JOURNAL OF STEM CELLS AND REGENERATIVE MEDICINE. 2010;6(2):48
Establishment of an extended in vitro assay to detect the most primitive human hematopoietic cells at a clonal level.
Radtke S; Görgens A; Punzel M; Horn P; Giebel B
Journal article: JOURNAL OF STEM CELLS AND REGENERATIVE MEDICINE. 2010;6(2):74
Functional analyses of cell polarity organization in human hematopoietic stem and progenitor cells.
Goergens A; Beckmann J; Rajendran L; Horn PA; Giebel B
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Preprint: BIORXIV. 2024
Imaging single particle profiler to study nanoscale bioparticles using conventional confocal microscopy
Sych T; Görgens A; Steiner L; Gucluer G; Huge Y; Alamdari F; Johansson M; Aljabery F; Sherif A; Gabrielsson S; EL Andaloussi S; Sezgin E
Preprint: BIORXIV. 2024
Snorkel-tag Based Affinity Chromatography for Recombinant Extracellular Vesicle Purification
Bobbili MR; Görgen A; Yan Y; Vogt S; Gupta D; Corso G; Barbaria S; Patrioli C; Weilner S; Pultar M; Jacak J; Hackl M; Schosserer M; Grillari R; Kjems J; EL Andaloussi S; Grillari J
Preprint: BIORXIV. 2024
Histones are exosome membrane proteins regulated by cell stress
Singh B; Sundbom MF; Muthukrishnan U; Natarajan B; Stransky S; Görgens A; Nordin J; Wiklander O; Sandblad L; Sidoli S; Andaloussi SEL; Haney M; Gilthorpe J
Preprint: BIORXIV. 2024
Surface adhesion and membrane fluctuations influence the elastic modulus of extracellular vesicles
Stridfeldt F; Kylhammar H; Metem P; Pandey V; Agrawal V; Görgens A; Mamand D; Gustafsson O; El Andaloussi S; Mitra D; Dev A
Conference publication: HUMAN REPRODUCTION. 2024;39:I152
Multi-omics landscape of uterine fluid -derived extracellular vesicles across the menstrual cycle
Apostolov A; Mladenovic D; Baev V; Yahubyan G; Tilk K; Gorgens A; Bergamelli M; Kalinina A; Saare M; Lohmus A; Milov A; Nikolova M; Milova N; Salumets A; Aleksejeva E
Preprint: RESEARCH SQUARE. 2023
Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors
Liang X; Gupta D; Xie J; Wonterghem E; Hoecke L; Hean J; Niu Z; Wiklander O; Zheng W; Wiklander R; He R; Mammad D; Bost J; Zhou G; Zhou H; Roudi S; Zickler A; Gorgens A; Hagey D; de Jong O; Uy A; Zong Y; Mager I; Perez C; Roberts T; Vader P; Fougerolles A; Wood M; Vandenbroucke R; Nordin J; El-Andaloussi S
Preprint: RESEARCH SQUARE. 2023
Role of EVs as promotors for activation of leukemia-derived dendritic cell (DCleu)-mediated antileukemic immune response against AML-blasts
Lin L; Görgens A; Mussack V; Pepeldjiyska E; Hartz A; Aslan H; Rackl E; Rank A; Schmohl J; Krämer D; El-Andaloussi S; Pfaffl M; schmetzer H
Preprint: BIORXIV. 2023
Identification of Novel Scaffold Proteins for Improved Endogenous Engineering of Extracellular Vesicles
Zheng W; Rädler J; Sork H; Niu Z; Roudi S; Bost J; Görgens A; Zhao Y; Mamand D; Liang X; Wiklander O; Lehto T; Gupta D; Nordin J; EL Andaloussi S
Preprint: BIORXIV. 2023
Multimodal engineering of extracellular vesicles for efficient intracellular protein delivery
Liang X; Gupta D; Xie J; Wonterghem EV; Hoecke LV; Hean J; Niu Z; Wiklander O; Zheng W; Wiklander RJ; He R; Mamand D; Bost J; Zhou G; Zhou H; Roudi S; Zickler AM; Gorgens A; Hagey D; de Jong O; Uy AG; Zong Y; Mager I; Perez CM; Roberts T; Vader P; Fougerolles AD; Wood M; Vandenbroucke R; Nordin J; EL Andaloussi S
Preprint: BIORXIV. 2023
Novel Endogenous Engineering Platform for Robust Loading and Delivery of Functional mRNA by Extracellular Vesicles
Zickler A; Liang X; Gupta D; Mamand D; Luca MD; Corso G; Errichelli L; Hean J; Sen T; Elsharkasy O; Kamei N; Niu Z; Zhou G; Zhou H; Roudi S; Wiklander O; Görgens A; Nordin J; Castilla-Llorente V; Andaloussi SEL
Review: JOURNAL OF EXTRACELLULAR VESICLES. 2023;12(2):e12299
A compendium of single extracellular vesicle flow cytometry
Welsh JA; Arkesteijn GJA; Bremer M; Cimorelli M; Dignat-George F; Giebel B; Goergens A; Hendrix A; Kuiper M; Lacroix R; Lannigan J; van Leeuwen TG; Lozano-Andres E; Rao S; Robert S; de Rond L; Tang VA; Tertel T; Yan X; Wauben MHM; Nolan JP; Jones JC; Nieuwland R; van der Pol E
Conference publication: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2022;10:a24.2-a2a25
THE POTENTIAL ROLE OF EXTRACELLULAR VESICLE-DERIVED SMALL RNAS IN AML RESEARCH AS NON-INVASIVE BIOMARKER
Li L; Mussack V; Goergens A; Pepeldjiyska E; Hartz AS; Aslan H; Rackl E; Rank A; Schmohl J; Pfaffl MW; Schmetzer H
Conference publication: ANNALS OF ONCOLOGY. 2022;33(7):S950
Improved proteome coverage for cancer plasma-derived extracellular vesicles (pEVs) using high-resolution isoelectric focusing (HiRIEF) LC-MS
Sharma N; Mermelekas G; Lehtio J; Wiklander OPB; Gorgens A; Andaloussi S; Pernemalm M; Eriksson H
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(12):S266
Comprehensive analysis of extracellular vesicles surface markers produced by normal keratinocytes human cutaneous squamous cell carcinoma cell lines reveals phenotypic heterogeneity
Li C; Sun C; Elton JJ; Lohcharoenkal W; Gorgens A; El Andaloussi S; Sonkoly E; Pivarcsi A
Conference publication: TISSUE ENGINEERING - PART A.. 2022;28:S250
CHARACTERIZATION OF P16INK4A PROMOTER DRIVEN EXTRACELLULAR VESICLES PURIFIED BY STEVAC METHOD
Bobbili MR; Schosserer M; Holnthoner W; Redl H; Gorgens A; EL Andaloussi S; Grillari J
Corrigendum: NATURE COMMUNICATIONS. 2021;12(1):7357
GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain (vol 12, 6666, 2021)
Dar GH; Mendes CC; Kuan W-L; Speciale AA; Conceicao M; Gorgens A; Uliyakina I; Lobo MJ; Lim WF; El Andaloussi S; Mager I; Roberts TC; Barker RA; Goberdhan DCI; Wilson C; Wood MJA
Editorial comment: CYTOMETRY. PART A : THE JOURNAL OF THE INTERNATIONAL SOCIETY FOR ANALYTICAL CYTOLOGY. 2021;99(4):365-368
MIFlowCyt-EV: The Next Chapter in the Reporting and Reliability of Single Extracellular Vesicle Flow Cytometry Experiments
Welsh JA; Tang VA; van Der Pol E; Gorgens A
Preprint: BIORXIV. 2021
Multiparametric Profiling of Single Nanoscale Extracellular Vesicles by Combined Atomic Force and Fluorescence Microscopy: Correlation and Heterogeneity in Their Molecular and Biophysical Features
Cavallaro S; Pevere F; Stridfeldt F; Görgens A; Paba C; Sahu SS; Mamand DR; Gupta D; Andaloussi SE; Linnros J; Dev A
Preprint: SSRN ELECTRONIC JOURNAL. 2021
MPA _PASS Enables Stitched Multiplex Multi-Dimensional EV Repertoire Analysis
Welsh J; Killingsworth B; Kepley J; Traynor T; Cook S; Savage J; Marte J; Lee M-J; Maeng H; Pleet M; Magana S; Gorgens A; Maire C; Lamszus K; Ricklefs F; Merino MJ; Linehan WM; Greten T; Cooks T; Harris C; Apolo A; Abdel-Mageed A; Ivanov AR; Trepel J; Roth M; Tkach M; Milosavljevic A; Théry C; LeBlanc A; Berzofsky J; Ruppin E; Aldape K; Camphausen K; Gulley J; Ghiran I; Jacobson S; Jones JC
Conference publication: MOLECULAR THERAPY. 2021;29(4):332-333
Antibody Displaying Extracellular Vesicles (Fc-EVs) for Delivery of Tumor Targeted Therapeutics
Wiklander OPB; Jawad R; Mamand DR; Sharma H; Liang X; Gupta D; Bost J; Zickler AM; Zheng W; Nordin JZ; Gorgens A; Andaloussi SEL
Conference publication: MOLECULAR THERAPY. 2021;29(4):220
Albumin-Decorated Exosomes Demonstrate Extended Circulation Time In Vivo
Liang X; Gupta D; Galli V; Zheng W; Davies C; Hean J; Kyriakopoulou E; Yang X; de Andres J; Mamand DR; Amin R; Niu Z; Jawad R; Wiklander O; Zickler A; Gustafsson M; Gorgens A; Nordin JZ; EL Andaloussi S
Preprint: BIORXIV. 2020
Human neonatal B cell immunity differs from the adult version by conserved Ig repertoires and rapid, but transient response dynamics
Budeus B; Kibler A; Brauser M; Homp E; Bronischewski K; Ross A; Görgens A; Weniger M; Dunst J; Kreslavsky T; da Conceição Castro SV; Murke F; Oakes C; Rusch P; Andrikos D; Kern P; Köninger A; Lindemann M; Johansson P; Hansen W; Lundell A-C; Rudin A; Dürig J; Giebel B; Hoffmann D; Küppers R; Seifert M
Preprint: BIORXIV. 2020
Engineering of extracellular vesicles for display of protein biotherapeutics
Gupta D; Wiklander OPB; Görgens A; Conceição M; Corso G; Liang X; Seow Y; Balsu S; Felldin U; Bostancioglu B; Fiona Lee YX; Hean J; Mäger I; Roberts T; Gustafsson M; Mohammad D; Sork H; Bäcklund A; Edvard Smith CI; Wood MJA; Vandenbroucke R; Nordin J; Andaloussi SEL
Preprint: BIORXIV. 2020
Engineered extracellular vesicle decoy receptor-mediated modulation of the IL6 trans-signalling pathway in muscle
Conceição M; Forcina L; Wiklander O; Gupta D; Nordin J; McClorey G; Mäger I; Görgens A; Lundin P; Musarò A; Wood M; Andaloussi SEL; Roberts T
Editorial comment: CYTOMETRY. PART A : THE JOURNAL OF THE INTERNATIONAL SOCIETY FOR ANALYTICAL CYTOLOGY. 2020;97(6):566-568
Aiming to Compare Apples to Apples: Analysis of Extracellular Vesicles and Other Nanosized Particles by Flow Cytometry
Gorgens A; Nolan JP
Preprint: BIORXIV. 2020
Differential B-cell receptor signaling requirement for adhesion of mantle cell lymphoma cells to stromal cells
Sadeghi L; Arvidsson G; Merrien M; Wasik AM; Görgens A; Smith CIE; Sander B; Wright AP
Book chapter: ESSENTIAL CURRENT CONCEPTS IN STEM CELL BIOLOGY: LEARNING MATERIALS IN BIOSCIENCES. 2020;p. 219-229
Extracellular Vesicles
Görgens A; Giebel B
Review: METHODS IN ENZYMOLOGY. 2020;645:55-78
Analysis of individual extracellular vesicles by imaging flow cytometry
Tertel T; Goergens A; Giebel B
Conference publication: EXPERIMENTAL HEMATOLOGY. 2017;53:S76
DISSECTING THE ORIGIN OF DENDRITIC CELL AND MACROPHAGE SUBSETS IN HUMAN HEMATOPOIESIS
Murke F; Goergens A; Horn P; Giebel B
Conference publication: BLOOD. 2017;130
Wave-Complex-Dependent Actin Dynamics Controls Hematopoietic Stem Cell Bone Marrow Retention and Orderly Differentiation into Mature Hematopoietic Lineages
Wiercinska E; de Gorter D; Danner E; Harenkamp S; Gorgens A; Schwiebs A; Stradal T; Bonig H
Conference publication: TRANSFUSION MEDICINE AND HEMOTHERAPY. 2017;44:86-87
Mesenchymal stem/stromal cells release different subtypes of extracellular vesicles
Ferrer-Tur R; Goergens A; Boerger V; Horn PA; Giebel B
Conference publication: TRANSFUSION MEDICINE AND HEMOTHERAPY. 2017;44:73
yDissecting the origin of dendritic cell and macrophage subsets in human hematopoiesis
Murke F; Goergens A; Horn PA; Giebel B
Editorial comment: BONE MARROW TRANSPLANTATION. 2016;51(8):1073-1075
Lost in Transplantation? Unexpected shift from multipotent to late lymphomyeloid hematopoietic stem and progenitor cells in patients 1 year after hematopoietic stem cell transplantation
Goergens A; Murke F; Kordelas L; Giebel B
Conference publication: BONE MARROW TRANSPLANTATION. 2016;51:S126-S127
Shift in progenitor subset composition in bone marrow of stem cell transplant recipients in comparison to stem cell graft composition
Kordelas L; Goergens A; Horn P; Beelen D; Giebel B
Conference publication: EXPERIMENTAL DERMATOLOGY. 2016;25(3):E36-E37
CEACAM1: a novel target of MITF in malignant melanoma
Loeffek S; Ullrich N; Horn S; Goergens A; Davidson I; Singer BB; Schadendorf D; Goding CR; Helfrich I
Conference publication: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2016;57(12)
A monoclonal antibody targeting the HSV-1/2 glycoprotein B inhibits the development herpes simplex virus type 1 retinitis in mice
Bauer D; Alt M; Dirks M; Kasper M; Buch A; Dittmer U; Goergens A; Sodeik B; Heiligenhaus A; Michael R; Krawczyk A
Conference publication: ACTA OPHTHALMOLOGICA. 2015;93
Prevention of herpes simplex stromal keratitis by a glycoprotein B-specific monoclonal
Bauer D; Dirks M; Kasper M; Buch A; Dittmer U; Giebel B; Wildschutz L; Busch M; Goergens A; Schneweis KE; Eis-Hubinger AM; Sodeik B; Heiligenhaus A; Roggendorf M; Krawczyk A
Corrigendum: STEM CELL REPORTS. 2015;5(1):154-155
Multipotent Hematopoietic Progenitors Divide Asymmetrically to Create Progenitors of the Lymphomyeloid and Erythromyeloid Lineages (vol 3, 1058, 2014)
Goergens A; Ludwig A-K; Moellmann M; Krawczyk A; Duerig J; Hanenberg H; Horn PA; Giebel B
Conference publication: ONCOLOGY RESEARCH AND TREATMENT. 2015;38:259-260
The human GFI136N variant is a novel prognostic marker that offers potential for personalized treatment approach for Myelodysplastic (MDS) and Acute Myeloid Leukemia (AML) patients
Botezatu L; Makishima H; Michel L; Hoenes JM; Vassen L; Vadnais C; Helness A; Mameth A; van der Reijden B; Radiovoyevich T; Germing U; Hass R; Schroeder T; Platzbecker U; Ehninger G; Lindberg E; Cazzola M; Boultwood J; Goergens A; Giebel B; Duehrsen U; Maciejewski J; Moray T; Khandanpour C
Conference publication: ONCOLOGY RESEARCH AND TREATMENT. 2015;38:7-8
Gfi1b plays an important role in initiation and progression of murine and human acute myeloid leukemia (AML) by regulating key oncogenic pathways
Thivakaran A; Botezatu L; Hoenes JM; Zeller A; Michel L; Goergens A; Lennartz K; Koester R; Opalka B; Giebel B; Duehrsen U; Khandanpour C
Conference publication: BLOOD. 2014;124(21):3245
Gfi136N As a Novel Marker and Therapeutic Target of MDS and AML
Michel LC; Botezatu L; Hoenes JM; Marneth A; Grapton D; Vadnais C; Germing U; Platzbecker U; Schroeder T; Haas R; van der Reijden BA; Ehninger G; Maciejewski JP; Radivoyevitch T; Goergens A; Giebel B; Fleckhaus J; Makishima H; Moroy T; Duehrsen U; Khandanpour C
Conference publication: JOURNAL OF NEUROLOGY. 2014;261:S70
Exosomes reduce brain injury in a rodent stroke model via immunomodulatory actions and stimulation of post-ischemic neuroregeneration
Doeppner TR; Herz J; Goergens A; Schlechter J; Ludwig A-K; de Mirochedji K; Giebel B; Hermann DM
Conference publication: EUROPEAN JOURNAL OF NEUROLOGY. 2014;21:97
Exosomes reduce brain injury in a rodent stroke model via immunomodulatory actions and stimulation of post-ischemic neuroregeneration
Doeppner TR; Herz J; Goergens A; Schlechter J; Ludwig A-K; de Mirochedji K; Giebel B; Hermann DM
Conference publication: BLOOD. 2013;122(21):2879
Preclinical Testing Of a Novel Axl-Kinase Inhibitor In Chronic Lymphocytic Leukemia
Goebel M; Moellmann M; Goergens A; Duehrsen U; Goethert JR; Giebel B; Schultz-Fademrecht C; Unger A; Klebl B; Choidas A; Duerig J
Conference publication: BLOOD. 2013;122(21):2516
Gfi1 As a Novel Prognostic Marker and Tumor Suppressor In Acute Myeloid Leukemia
Hones J; Botezatu L; Zeller A; Michel LC; Thiede C; Koester R; Goergens A; van der Reijden BA; Opalka B; Lennartz K; Valk PJM; Giebel B; Fischer K; Adiprasito B; Heuser M; Lowenberg B; Jansen JH; Ehninger G; Duehrsen U; Khandanpour C
Conference publication: BLOOD. 2013;122(21):2491
A Single Nucleotide Polymorphism Of Growth Factor Independence 1 (GFI136N) is a Novel Prognostic Marker For The Progression Of Myelodysplastic Syndrome To Acute Myeloid Leukemia
Michel LCY; Botezatu L; Hoenes J; Grapton D; Vadnais C; Germing U; Platzbecker U; Zeller A; Goergens A; Giebel B; Schroeder T; Rudolph R; von Verschuer U; Sengpiel J; Van der Reijden BA; Jansen JH; Haas R; Ehninger G; Moroy T; Duehrsen U; Khandanpour C
Conference publication: CANCER RESEARCH. 2013;73(8):4714
Vemurafenib reverses immunosuppression by myeloid derived suppressor cells.
Schilling B; Sucker A; Griewank K; Zhao F; Weide B; Goergens A; Giebel B; Schadendorf D; Paschen A
Conference publication: ONKOLOGIE. 2013;36:172
Preclinical testing of a novel Axl-kinase inhibitor in Chronic Lymphocytic Leukemia
Goebel M; Moellmann M; Goergens A; Huettmann A; Duehrsen U; Giebel B; Unger A; Choidas A; Duerig J
Conference publication: JDDG - JOURNAL OF THE GERMAN SOCIETY OF DERMATOLOGY. 2013;11:66-67
Vemurafenib Reverses Immunosuppression by Myeloid Derived Suppressor Cells
Schilling B; Sucker A; Griewank K; Zhao F; Weide B; Goergens A; Giebel B; Schadendorf D; Paschen A
Conference publication: BLOOD. 2012;120(21):1799
Preclinical Testing of a Novel Axl-Kinase Inhibitor in Chronic Lymphocytic Leukemia
Goebel M; Moellmann M; Goergens A; Duehrsen U; Huettmann A; Giebel B; Unger A; Choidas A; Duerig J
Conference publication: ONKOLOGIE. 2012;35:106
Toll-like receptor 9 agonists induce polarization and migration of chronic lymphocytic leukemia cells
Goebel M; Moellmann M; Goergens A; Giebel B; Duehrsen U; Duerig J
Conference publication: EXPERIMENTAL HEMATOLOGY. 2012;40(8):S124
FUNCTIONAL ANALYSES OF HUMAN HEMATOPOIETIC CD133⁺CD34⁺ AND CD133^LOW/-CD34⁺ CELLS CHALLENGE THE EXISTENCE OF HUMAN COMMON MYELOID PROGENITOR CELLS
Goergens A; Radtke S; Moellmann M; Duerig J; Horn P; Giebel B
Conference publication: EXPERIMENTAL HEMATOLOGY. 2012;40(8):S106-S107
MOLECULAR AND MORPHOLOGICAL CELL POLARIZATION IS REQUIRED FOR HUMAN HEMATOPOIETIC STEM AND PROGENITOR CELL MIGRATION AND HOMING
Goergens A; Goebel M; Moellmann M; Ludwig A-K; Duehrsen U; Horn P; Duerig J; Giebel B
Book chapter: UMBILICAL CORD BLOOD. 2010;p. 51-75
Self-Renewal of Primitive Hematopoietic Cells: A Focus on Asymmetric Cell Division
Görgens A; Giebel B
Conference publication: BLOOD. 2010;116(21):253
Obligatory Asymmetric Cell Division Regulates Self-Renewal In Hematopoietic Progenitor/Stem Cells
Tse WT; Soetedjo L; Lax T; Wang L; Kennedy PJ
Conference publication: VOX SANGUINIS. 2010;99:502
IMPACTS OF TETRASPANINS ON PRIMITIVE HUMAN HEMATOPOIETIC CELLS
Jansen S; Goergens A; Horn P; Giebel B
Conference publication: HUMAN GENE THERAPY. 2009;20(11):1469
Role of tetraspanins on primitive human hematopoietic cells
Zeidler S; Goergens A; Hanenberg H; Horn P; Giebel B
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