Research group - Ingemar Björkhem & Ulf Diczfalusy
Oxysterols in health and disease: The role of oxysterols in connection with cholesterol homeostasis in the brain and their importance in relation to neurodegeneration. Oxysterols as biomarkers for neurological diseases, oxidative stress, inflammation and drug metabolism.
Research group leader Ingemar Björkhem
Research group leader Ulf Diczfalusy
|Ingemar Björkhem||Professor, senior|
|Ulf Diczfalusy||Adjunct professor|
|Magnus Daniel Hansson||Senior researcher|
|Anita Lövgren Sandblom||Laboratory technician|
- Gas chromatography
- Mass spectrometry
- Molecular biology techniques
- Transgenic animal models.
Science Council, Swedish Brain Power, Wallenbergstiftelsen, Stockholm County Council, Alzheimerfonden, Hjärnfonden, Astra Zeneca
Study programme in medicine
Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo.
J. Intern. Med. 2011 Oct;270(4):377-87
4β-Hydroxycholesterol, an endogenous marker of CYP3A4/5 activity in humans.
Br J Clin Pharmacol 2011 Feb;71(2):183-9
Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide.
J. Lipid Res. 2009 Nov;50(11):2258-64
Studies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1): marked insensitivity toward different regulatory axes.
J. Biol. Chem. 2006 Feb;281(7):3810-20
Oxysterols: friends, foes, or just fellow passengers?
Arterioscler. Thromb. Vasc. Biol. 2002 May;22(5):734-42