Ulf Diczfalusy

Publications
CV
Public outreach and news

Articles

Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(23):15168
Pregnancy Increases CYP3A Enzymes Activity as Measured by the 4β-Hydroxycholesterol/Cholesterol Ratio
Mlugu EM; Minzi OM; Kamuhabwa AAR; Diczfalusy U; Aklillu E
Article: PHARMACOLOGY RESEARCH & PERSPECTIVES. 2021;9(6):e00884
Studies on CYP3A activity during the menstrual cycle as measured by urinary 6β-hydroxycortisol/cortisol
Bergstrom H; Lindahl A; Warnqvist A; Diczfalusy U; Ekstrom L; Bjorkhem-Bergman L
Article: CANCERS. 2021;13(18):4689
CYP3A Activity in End-of-Life Cancer Patients Measured by 4β-Hydroxycholesterol/cholesterol Ratio, in Men and Women
Bergstrom H; Frankling MH; Klasson C; Sandblom AL; Diczfalusy U; Bjorkhem-Bergman L
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2021;178(16):3294-3308
Early or deferred initiation of efavirenz during rifampicin-based TB therapy has no significant effect on CYP3A induction in TB-HIV infected patients
Aklillu E; Zumla A; Habtewold A; Amogne W; Makonnen E; Yimer G; Burhenne J; Diczfalusy U
Article: JOURNAL OF PERSONALIZED MEDICINE. 2021;11(6):457
Evaluation of 1β-Hydroxylation of Deoxycholic Acid as a Non-Invasive Urinary Biomarker of CYP3A Activity in the Assessment of Inhibition-Based Drug-Drug Interaction in Healthy Volunteers
Li X-Q; Thelingwani RS; Bertilsson L; Diczfalusy U; Andersson TB; Masimirembwa C
Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2019;190:115-125
First international descriptive and interventional survey for cholesterol and non-cholesterol sterol determination by gas- and liquid-chromatography-Urgent need for harmonisation of analytical methods
Luetjohann D; Bjorkhem I; Friedrichs S; Kerksiek A; Lovgren-Sandblom A; Geilenkeuser W-J; Ahrends R; Andrade I; Ansorena D; Astiasaran I; Baila-Rueda L; Barriuso B; Becker S; Bretillon L; Browne RW; Caccia C; Ceglarek UH; Cenarro A; Crick PJ; Fauler G; Garcia-Llatas G; Gray R; Griffiths WJ; Gylling H; Harding S; Helmschrodt C; Iuliano L; Janssen H-G; Jones P; Kaipiainen L; Kannenberg F; Jesus Lagarda M; Leoni V; Lottenberg AM; MacKay DS; Matysik S; McDonald J; Menendez-Carreno M; Myrie SB; Nunes VS; Ostlund RE; Polisecki E; Ramos F; Rideout TC; Schaefer EJ; Schmitz G; Wang Y; Zerbinati C; Diczfalusy U; Schoett H-F
Article: AAPS JOURNAL. 2019;21(4):58
Effect of Grapefruit Juice Intake on Serum Level of the Endogenous CYP3A4 Metabolite 4-Hydroxycholesterolan Interaction Study in Healthy Volunteers
Gjestad C; Hole K; Haslemo T; Diczfalusy U; Molden E
Article: BIOCHIMIE. 2018;153:26-32
International descriptive and interventional survey for oxycholesterol determination by gas- and liquid-chromatographic methods
Luetjohann D; Bjorkhem I; Friedrichs S; Kerksiek A; Geilenkeuser W-J; Lovgren-Sandblom A; Ansorena D; Astiasaran I; Baila-Rueda L; Barriuso B; Bretillon L; Browne RW; Caccia C; Cenarro A; Crick PJ; Fauler G; Garcia-Llatas G; Griffiths WJ; Iuliano L; Jesus Lagarda M; Leoni V; Lottenberg AM; Matysik S; McDonald J; Rideout TC; Schmitz G; Nunes VS; Wang Y; Zerbinati C; Diczfalusy U; Schoett H-F
Article: BMC PHARMACOLOGY AND TOXICOLOGY. 2018;19(1):33
Inflammation down-regulates CYP3A4-catalysed drug metabolism in hemodialysis patients
Molanaei H; Qureshi AR; Heimburger O; Lindholm B; Diczfalusy U; Anderstam B; Bertilsson L; Stenvinkel P
Article: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 2016;82(6):1539-1549
Comparative performance of oral midazolam clearance and plasma 4-hydroxycholesterol to explain interindividual variability in tacrolimus clearance
Vanhove T; de Jonge H; de Loor H; Annaert P; Diczfalusy U; Kuypers DRJ
Article: DRUG METABOLISM AND DISPOSITION. 2016;44(9):1480-1489
CYP3A Specifically Catalyzes 1β-Hydroxylation of Deoxycholic Acid: Characterization and Enzymatic Synthesis of a Potential Novel Urinary Biomarker for CYP3A Activity
Hayes MA; Li X-Q; Gronberg G; Diczfalusy U; Andersson TB
Article: MEDICINE (UNITED KINGDOM). 2016;95(34):e4631
Prevalence and risk factors for efavirenz-based antiretroviral treatment-associated severe vitamin D deficiency: A prospective cohort study
Nylen H; Habtewold A; Makonnen E; Yimer G; Bertilsson L; Burhenne J; Diczfalusy U; Aklillu E
Article: BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. 2016;118(6):499-502
Effect of Statin Treatment on Plasma 4β-Hydroxycholesterol Concentrations
Bjorkhem-Bergman L; Nylen H; Eriksson M; Parini P; Diczfalusy U
Article: PHARMACOLOGY RESEARCH & PERSPECTIVES. 2015;3(6):e00192
miRNA-27b levels are associated with CYP3A activity in vitro and in vivo.
Ekström L; Skilving I; Ovesjö M-L; Aklillu E; Nylén H; Rane A; Diczfalusy U; Björkhem-Bergman L
Article: PLOS ONE. 2015;10(4):e0121984
No Impact of Vitamin D on the CYP3A Biomarker 4β-Hydroxycholesterol in Patients with Abnormal Glucose Regulation
Mannheimer B; Wagner H; Otstenson C-G; Diczfalusy U
Article: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. 2014;69(12):3311-3319
Pharmacokinetic and pharmacogenomic modelling of the CYP3A activity marker 4β-hydroxycholesterol during efavirenz treatment and efavirenz/rifampicin co-treatment
Ngaimisi E; Minzi O; Mugusi S; Sasi P; Riedel K-D; Suda A; Ueda N; Bakari M; Janabi M; Mugusi F; Bertilsson L; Burhenne J; Aklillu E; Diczfalusy U
Article: MICROCIRCULATION. 2014;21(7):587-592
Immediate Effect of Passive Smoking on Microcirculatory Flow
Henriksson P; Lu Q; Diczfalusy U; Freyschuss A
Article: BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. 2014;115(4):366-371
Plasma Levels of 25-Hydroxyvitamin D₃ and In Vivo Markers of Cytochrome P450 3A Activity in Swedes and Koreans: Effects of a Genetic Polymorphism and Oral Contraceptives
Nylen H; Bjorkhem-Bergman L; Ekstrom L; Roh H-K; Bertilsson L; Eliasson E; Lindh JD; Diczfalusy U
Article: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. 2014;69(7):1933-1937
Reduction of nevirapine-driven HIV mutations by carbamazepine is modulated by CYP3A activity
Baranyai D; Muro E; Goedtel-Armbrust U; Schirmer MA; Kisanga E; Diczfalusy U; Fillekes Q; Schuurman R; Burger D; Wojnowski L
Article: JOURNAL OF LIPID RESEARCH. 2014;55(6):1165-1172
On the formation of 7-ketocholesterol from 7-dehydrocholesterol in patients with CTX and SLO
Bjorkhem I; Diczfalusy U; Lovgren-Sandblom A; Starck L; Jonsson M; Tallman K; Schirmer H; Ousager LB; Crick PJ; Wang Y; Griffiths WJ; Guengerich FP
Article: DRUG METABOLISM AND PHARMACOKINETICS. 2014;29(4):352-355
Quinine Compared to 4β-Hydroxycholesterol and Midazolam as Markers for CYP3A Induction by Rifampicin
Bjorkhem-Bergman L; Backstrom T; Nylen H; Ronquist-Nii Y; Bredberg E; Andersson TB; Bertilsson L; Diczfalusy U
Article: PHARMACOGENOMICS JOURNAL. 2013;13(6):484-489
Pharmacogenetic and pharmacokinetic aspects of CYP3A induction by efavirenz in HIV patients
Habtewold A; Amogne W; Makonnen E; Yimer G; Nylen H; Riedel K-D; Aderaye G; Bertilsson L; Burhenne J; Diczfalusy U; Aklillu E
Article: DRUG METABOLISM AND DISPOSITION. 2013;41(8):1488-1493
Comparison of Endogenous 4β-Hydroxycholesterol with Midazolam as Markers for CYP3A4 Induction by Rifampicin
Bjorkhem-Bergman L; Backstrom T; Nylen H; Ronquist-Nii Y; Bredberg E; Andersson TB; Bertilsson L; Diczfalusy U
Article: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 2013;75(6):1536-1540
A comparison of 4-hydroxycholesterol:cholesterol and 6-hydroxycortisol:cortisol as markers of CYP3A4 induction
Arrhen YM; Nylen H; Lovgren-Sandblom A; Kanebratt KP; Wide K; Diczfalusy U
Article: DRUG METABOLISM AND DISPOSITION. 2013;41(4):704-708
Serum Levels of 25-Hydroxyvitamin D and the CYP3A Biomarker 4β-Hydroxycholesterol in a High-Dose Vitamin D Supplementation Study
Bjorkhem-Bergman L; Nylen H; Norlin A-C; Lindh JD; Ekstrom L; Eliasson E; Bergman P; Diczfalusy U
Article: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2012;68(5):571-577
Metabolism of alprazolam (a marker of CYP3A4) in hemodialysis patients with persistent inflammation
Molanaei H; Stenvinkel P; Qureshi AR; Carrero JJ; Heimburger O; Lindholm B; Diczfalusy U; Odar-Cederlof I; Bertilsson L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(9):6307-6317
Amidoxime Reductase System Containing Cytochrome b₅ Type B (CYB5B) and MOSC2 Is of Importance for Lipid Synthesis in Adipocyte Mitochondria
Neve EPA; Nordling A; Andersson TB; Hellman U; Diczfalusy U; Johansson I; Ingelman-Sundberg M
Article: MICROCIRCULATION. 2012;19(1):86-93
Microvascular Reactivity in Response to Smoking and Oral Antioxidants in Humans
Henriksson P; Diczfalusy U; Freyschuss A
Article: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2011;67(7):715-722
Cytochrome P450 3A activity in mothers and their neonates as determined by plasma 4β-hydroxycholesterol
Nylen H; Sergel S; Forsberg L; Lindemalm S; Bertilsson L; Wide K; Diczfalusy U
Article: PHARMACOGENOMICS JOURNAL. 2011;11(2):130-137
Sex and CYP3A5 genotype influence total CYP3A activity: high CYP3A activity and a unique distribution of CYP3A5 variant alleles in Ethiopians
Gebeyehu E; Engidawork E; Bijnsdorp A; Aminy A; Diczfalusy U; Aklillu E
Article: JOURNAL OF LIPID RESEARCH. 2011;52(1):170-174
High levels of 15-oxygenated steroids in circulation of patients with multiple sclerosis: fact or fiction?
Bjorkhem I; Lovgren-Sandblom A; Piehl F; Khademi M; Pettersson H; Leoni V; Olsson T; Diczfalusy U
Article: CIRCULATION RESEARCH. 2010;106(4):720-729
FTY720 Stimulates 27-Hydroxycholesterol Production and Confers Atheroprotective Effects in Human Primary Macrophages
Blom T; Back N; Mutka A-L; Bittman R; Li Z; de Lera A; Kovanen PT; Diczfalusy U; Ikonen E
Article: INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS. 2009;47(12):709-715
4β-hydroxycholesterol as a marker of CYP3A4 inhibition in vivo - effects of itraconazole in man
Luetjohann D; Marinova M; Schneider B; Oldenburg J; von Bergmann K; Bieber T; Bjorkhem I; Diczfalusy U
Article: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2009;50(12):5712-5717
Primary Open-Angle Glaucoma: Association with Cholesterol 24S-Hydroxylase (CYP46A1) Gene Polymorphism and Plasma 24-Hydroxycholesterol Levels
Fourgeux C; Martine L; Bjoerkhem I; Diczfalusy U; Joffre C; Acar N; Creuzot-Garcher C; Bron A; Bretillon L
Article: JOURNAL OF LIPID RESEARCH. 2009;50(11):2258-2264
Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide
Diczfalusy U; Olofsson KE; Carlsson A-M; Gong M; Golenbock DT; Rooyackers O; Flaring U; Bjorkbacka H
Article: BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. 2009;105(5):339-344
Human Exposure to Triclosan via Toothpaste does not change CYP3A4 Activity or Plasma Concentrations of Thyroid Hormones
Allmyr M; Panagiotidis G; Sparve E; Diczfalusy U; Sandborgh-Englund G
Article: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 2009;67(1):38-43
4β-Hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicin
Diczfalusy U; Kanebratt KP; Bredberg E; Andersson TB; Bottiger Y; Bertilsson L
Article: CLINICAL PHARMACOLOGY AND THERAPEUTICS. 2008;84(5):589-594
Cytochrome P450 Induction by Rifampicin in Healthy Subjects: Determination Using the Karolinska Cocktail and the Endogenous CYP3A4 Marker 4β-Hydroxycholesterol
Kanebratt KP; Diczfalusy U; Backstrom T; Sparve E; Bredberg E; Bottiger Y; Andersson TB; Bertilsson L
Article: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2008;64(8):775-781
CYP3A induction and inhibition by different antiretroviral regimens reflected by changes in plasma 4β-hydroxycholesterol levels
Josephson F; Bertilsson L; Bottiger Y; Flamholc L; Gisslen M; Ormaasen V; Sonnerborg A; Diczfalusy U
Article: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 2008;65(5):708-715
Time course of the increase in 4β-hydroxycholesterol concentration during carbamazepine treatment of paediatric patients with epilepsy
Wide K; Larsson H; Bertilsson L; Diczfalusy U
Article: PHARMACOGENETICS AND GENOMICS. 2008;18(3):201-208
4β-Hydroxycholesterol is a new endogenous CYP3A marker:: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians
Diczfalusy U; Miura J; Roh H-K; Mirghani RA; Sayi J; Larsson H; Bodin KG; Allqvist A; Jande M; Kim J-W; Aklillu E; Gustafsson LL; Bertilsson L
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2007;27(10):2191-2197
Studies on the cholesterol-free mouse -: Strong activation of LXR-regulated hepatic genes when replacing cholesterol with desmosterol
Heverin M; Meaney S; Brafman A; Shafir M; Olin M; Shafaati M; von Bahr S; Larsson L; Loevgren-Sandblom A; Diczfalusy U; Parini P; Feinstein E; Bjoerkhem I
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2007;43(5):695-701
In vivo interconversion of 7β-hydroxycholesterol and 7-ketocholesterol, potential surrogate markers for oxidative stress
Larsson H; Bottiger Y; Iuliano L; Diczfalusy U
Article: JOURNAL OF CHROMATOGRAPHY B: ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. 2007;856(1-2):15-19
Novel LC-MS/MS method for assay of 7α-hydroxy-4-cholesten-3-one in human plasma evidence for a significant extrahepatic metabolism
Lovgren-Sandblom A; Heverin M; Larsson H; Lundstrom E; Wahren J; Diczfalusy U; Bjorkhem I
Article: INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS. 2007;45(7):377-384
Effects of high-dose itraconazole treatment on lipoproteins in men
Schneider B; Gerdsen R; Plat J; Dullens S; Bjorkhem I; Diczfalusy U; Neuvonen PJ; Bieber T; von Bergmann K; Lutjohann D
Article: CURRENT EYE RESEARCH. 2007;32(4):361-366
Cholesterol-24S-hydroxylase (CYP46A1) is specifically expressed in neurons of the neural retina
Bretillon L; Diczfalusy U; Bjoerkhem I; Maire MA; Martine L; Joffre C; Acar N; Bron A; Creuzot-Garcher C
Article: JOURNAL OF LIPID RESEARCH. 2007;48(4):944-951
Novel route for elimination of brain oxysterols across the blood-brain barrier:: conversion into 7α-hydroxy-3-oxo-4-cholestenoic acid
Meaney S; Heverin M; Panzenboeck U; Ekstrom L; Axelsson M; Andersson U; Diczfalusy U; Pikuleva I; Wahren J; Sattler W; Bjorkhem I
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2007;42(5):698-705
Increased plasma levels of oxysterols, in vivo markers of oxidative stress, in patients with familial combined hyperlipidemia: Reduction during atorvastatin and fenofibrate therapy
Arca M; Natoli S; Micheletta F; Riggi S; Di Angelantonio E; Montali A; Antonini TM; Antonini R; Diczfalusy U; Iuliano L
Article: PHARMACOGENETICS AND GENOMICS. 2006;16(8):565-568
Effect of SLCO1B1 polymorphism on induction of CYP3A4 by rifampicin
Niemi M; Kivistoe KT; Diczfalusy U; Bodin K; Bertilsson L; Fromm MF; Eichelbaum M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(7):3810-3820
Studies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1) -: Marked insensitivity toward different regulatory axes
Ohyama Y; Meaney S; Heverin M; Ekström L; Brafman A; Shafir M; Andersson U; Olin M; Eggertsen G; Diczfalusy U; Feinstein E; Björkhem I
Article: LIVER TRANSPLANTATION. 2005;11(12):1494-1504
High preoperative recipient plasma 7β-hydroxycholesterol is associated with initial poor graft function after liver transplantation
Corradini SG; Micheletta F; Natoli S; Iappelli M; Di Angelantonio E; De Marco R; Elisei W; Siciliano M; Rossi M; Berloco P; Attili AF; Diczfalusy U; Juliano L
Article: GASTROENTEROLOGY. 2005;129(2):476-485
Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans
Marschall HU; Wagner M; Zollner G; Fickert P; Diczfalusy U; Gumhold J; Silbert D; Fuchsbichler A; Benthin L; Grundström R; Gustafsson U; Sahlin S; Einarsson C; Trauner M
Article: CLINICAL SCIENCE. 2005;108(6):507-513
Effect of ascorbic acid on microcirculation in patients with Type II diabetes:: a randomized placebo-controlled cross-over study
Lu Q; Björkhem I; Wretlind B; Diczfalusy U; Henriksson P; Freyschuss A
Article: JOURNAL OF LIPID RESEARCH. 2005;46(5):1047-1052
Crossing the barrier:: net flux of 27-hydroxycholesterol into the human brain
Heverin M; Meaney S; Lütjohann D; Diczfalusy U; Wahren J; Björkhem I
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2005;1687(1-3):84-93
Novel pathways of bile acid metabolism involving CYP3A4
Bodin K; Lindbom U; Diczfalusy U
Article: SCANDINAVIAN JOURNAL OF CLINICAL AND LABORATORY INVESTIGATION. 2005;65(5):365-375
Patients with atherosclerosis may have increased circulating levels of 27-hydroxycholesterol and cholestenoic acid
Babiker A; Dzeletovic S; Wiklund B; Pettersson N; Salonen J; Nyyssönen K; Eriksson M; Diczfalusy U; Björkhem I
Article: MOLECULAR AND CELLULAR BIOLOGY. 2004;24(18):8154-8166
Transcriptional regulation of human CYP27 integrates retinoid, peroxisome proliferator-activated receptor, and liver X receptor signaling in macrophages
Szanto A; Benko S; Szatmari I; Balint BL; Furtos I; Rühl R; Molnar S; Csiba L; Garuti R; Calandra S; Larsson H; Diczfalusy U; Nagy L
Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2004;19(4):972-976
Phospholipid plasmalogen, a surrogate marker of oxidative stress, is associated with increased cardiovascular mortality in patients on renal replacement therapy
Stenvinkel P; Diczfalusy U; Lindholm B; Heimbürger O
Article: JOURNAL OF AOAC INTERNATIONAL. 2004;87(2):467-473
Analysis of cholesterol oxidation products in biological samples
Diczfalusy U
Article: CLINICAL CHEMISTRY AND LABORATORY MEDICINE. 2004;42(2):186-191
Diagnostic use of cerebral and extracerebral oxysterols
Leoni V; Masterman T; Mousavi FS; Wretlind B; Wahlund LO; Diczfalusy U; Hillert J; Björkhem I
Article: JOURNAL OF LIPID RESEARCH. 2004;45(1):186-193
Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease
Heverin M; Bogdanovic N; Lütjohann D; Bayer T; Pikuleva I; Bretillon L; Diczfalusy U; Winblad B; Björkhem I
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2004;24(1):136-140
Vitamin e supplementation in patients with carotid atherosclerosis - Reversal of altered oxidative stress status in plasma but not in plaque
Micheletta F; Natoli S; Misuraca M; Sbarigia E; Diczfalusy U; Iuliano L
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2003;35(8):922-928
Serum ferritin concentration is associated with plasma levels of cholesterol oxidation products in man
Tuomainen TP; Diczfalusy U; Kaikkonen J; Nyyssönen K; Salonen JT
Article: STEROIDS. 2003;68(7-8):595-601
On the origin of the cholestenoic acids in human circulation
Meaney S; Babiker A; Lütjohann D; Diczfalusy U; Axelson M; Bjrökhem I
Article: JOURNAL OF LIPID RESEARCH. 2003;44(4):793-799
Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers
Leoni V; Masterman T; Patel P; Meaney S; Diczfalusy U; Björkhem I
Article: ANALYTICAL BIOCHEMISTRY. 2003;312(2):217-223
Measurement of oxysterols and α-tocopherol in plasma and tissue samples as indices of oxidant stress status
Iuliano L; Micheletta F; Natoli S; Corradini SG; Iappelli M; Elisei W; Giovannelli L; Violi F; Diczfalusy U
Article: JOURNAL OF LIPID RESEARCH. 2002;43(12):2130-2135
On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation:: critical importance of the position of the oxygen function
Meaney S; Bodin K; Diczfalusy U; Björkhem I
Article: NEUROSCIENCE LETTERS. 2002;331(3):163-166
Changes in human plasma levels of the brain specific oxysterol 24S-hydroxycholesterol during progression of multiple sclerosis
Leoni V; Masterman T; Diczfalusy U; De Luca G; Hillert J; Björkhem I
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(35):31534-31540
Metabolism of 4β-hydroxycholesterol in Humans
Bodin K; Andersson U; Rystedt E; Ellis E; Norlin M; Pikuleva I; Eggertsen G; Björkhem I; Diczfalusy U
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2002;22(7):1129-1135
Mechanism of accumulation of cholesterol and cholestanol in tendons and the role of sterol 27-hydroxylase (CYP27A1)
von Bahr S; Movin T; Papadogiannakis N; Pikuleva I; Rönnow P; Diczfalusy U; Björkhem I
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2002;22(5):734-742
Oxysterols -: Friends, foes, or just fellow passengers?
Björkhem I; Diczfalusy U
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2001;1534(2-3):129-138
On the anti-atherogenic effect of the antioxidant BHT in cholesterol-fed rabbits:: inverse relation between serum triglycerides and atheromatous lesions
Freyschuss A; Al-Schurbaji A; Björkhem B; Babiker A; Diczfalusy U; Berglund L; Henriksson P
Article: NEUROSCIENCE LETTERS. 2001;314(1-2):45-48
On the turnover of brain cholesterol in patients with Alzheimer's disease.: Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells
Bogdanovica N; Bretillon L; Lund EG; Diczfalusy U; Lannfelt L; Winblad B; Russell DW; Björkhem I
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(42):38685-38689
Antiepileptic drugs increase plasma levels of 4β-hydroxycholesterol in humans -: Evidence for involvement of cytochrome P450 3A4
Bodin K; Bretillon L; Aden Y; Bertilsson L; Broomé U; Einarsson C; Diczfalusy U
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(40):37004-37010
From brain to bile -: Evidence that conjugation and ω-hydroxylation are important for elimination of 24S-hydroxycholesterol (cerebrosterol) in humans
Björkhem I; Andersson U; Ellis E; Alvelius G; Ellegård L; Diczfalusy U; Sjövall J; Einarsson C
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2001;21(10):E34-E37
Bioavailability of vitamin E as function of food intake in healthy subjects - Effects on plasma peroxide-scavenging activity and cholesterol-oxidation products
Iuliano L; Micheletta F; Maranghi M; Frati G; Diczfalusy U; Violi F
Article: JOURNAL OF LIPID RESEARCH. 2001;42(3):366-371
Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome:: abnormal levels of 24S-and 27-hydroxycholesterol
Björkhem I; Starck L; Andersson U; Lütjohann D; von Bahr S; Pikuleva I; Babiker A; Diczfalusy U
Article: JOURNAL OF CLINICAL INVESTIGATION. 2001;107(5):565-573
Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRβ-deficient mice
Alberti S; Schuster G; Parini P; Feltkamp D; Diczfalusy U; Rudling M; Angelin B; Björkhem I; Pettersson S; Gustafsson J
Article: JOURNAL OF LIPID RESEARCH. 2001;42(1):70-78
Evidence that the major oxysterols in human circulation originate from distinct pools of cholesterol:: a stable isotope study
Meaney S; Hassan M; Sakinis A; Lütjohann D; von Bergmann K; Wennmalm Å; Diczfalusy U; Björkhem I
Article: NEUROSCIENCE LETTERS. 2000;293(2):87-90
Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases
Bretillon L; Sidén Å; Wahlund LO; Lütjohann D; Minthon L; Crisby M; Hillert J; Groth CG; Diczfalusy U; Björkhem I
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2000;20(9):2087-2093
Long-term effects of vitamin E, vitamin C, and combined supplementation on urinary 7-hydro-8-oxo-2′-deoxyguanosine, serum cholesterol oxidation products, and oxidation resistance of lipids in nondepleted men
Porkkala-Sarataho E; Salonen JT; Nyyssönen K; Kaikkonen J; Salonen R; Ristonmaa U; Diczfalusy U; Brigelius-Flohe R; Loft S; Poulsen HE
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2000;1486(2-3):293-298
Formation of oxysterols from different pools of cholesterol as studied by stable isotope technique:: cerebral origin of most circulating 24S-hydroxycholesterol in rats, but not in mice
Meaney S; Lütjohann D; Diczfalusy U; Björkhem I
Article: JOURNAL OF LIPID RESEARCH. 2000;41(5):840-845
Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface
Bretillon L; Lütjohann D; Ståhle L; Widhe T; Bindl L; Eggertsen G; Diczfalusy U; Björkhem I
Article: JOURNAL OF LIPID RESEARCH. 2000;41(5):814-823
Involvement of the peroxisome proliferator-activated receptor α in regulating long-chain acyl-CoA thioesterases
Hunt MC; Lindquist PJG; Peters JM; Gonzalez FJ; Diczfalusy U; Alexson SEH
Article: JOURNAL OF LIPID RESEARCH. 1999;40(8):1417-1425
Elimination of cholesterol as cholestenoic acid in human lung by sterol 27-hydroxylase:: evidence that most of this steroid in the circulation is of pulmonary origin
Babiker A; Andersson O; Lindblom D; van der Linden J; Wiklund B; Lütjohann D; Diczfalusy U; Björkhem I
Article: KIDNEY INTERNATIONAL. 1999;55(5):1899-1911
Strong association between malnutrition, inflammation, and atherosclerosis in chronic renal failure
Stenvinkel P; Heimbürger O; Paultre F; Diczfalusy U; Wang T; Berglund L; Jogestrand T
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 1999;19(4):967-971
Increased plasma 7β-hydroxycholesterol concentrations in a population with a high risk for cardiovascular disease
Ziedén B; Kaminskas A; Kristenson M; Kucinskienê Z; Vessby B; Olsson AG; Diczfalusy U
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 1998;18(11):1679-1685
Unsaturated fatty acids increase plasminogen activator inhibitor-1 expression in endothelial cells
Nilsson L; Banfi C; Diczfalusy U; Tremoli E; Hamsten A; Eriksson P
Article: JOURNAL OF LIPID RESEARCH. 1998;39(8):1594-1600
Cholesterol homeostasis in human brain:: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation
Björkhem I; Lütjohann D; Diczfalusy U; Ståhle L; Ahlborg G; Wahren J
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1998;1392(2-3):333-339
Transport of side-chain oxidized oxysterols in the human circulation
Babiker A; Diczfalusy U
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 1998;18(6):884-893
An animal model to study local oxidation of LDL and its biological effects in the arterial wall
Calara F; Dimayuga P; Niemann A; Thyberg J; Diczfalusy U; Witztum JL; Palinski W; Shah PK; Cercek B; Nilsson J; Regnström J
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 1998;18(4):554-561
Sterol 27-hydroxylase- and ApoAI/phospholipid-mediated efflux of cholesterol from cholesterol-laden macrophages -: Evidence for an inverse relation between the two mechanisms
Westman J; Kallin B; Björkhem I; Nilsson J; Diczfalusy U
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(42):26253-26261
Elimination of cholesterol in macrophages and endothelial cells by the sterol 27-hydroxylase mechanism - Comparison with high density lipoprotein-mediated reverse cholesterol transport
Babiker A; Andersson O; Lund E; Xiu RJ; Deeb S; Reshef A; Leitersdorf E; Diczfalusy U; Bjorkhem I
Article: JOURNAL OF LIPID RESEARCH. 1997;38(10):2049-2061
Ca2+ channel blockers verapamil and nifedipine inhibit apoptosis induced by 25-hydroxycholesterol in human aortic smooth muscle cells
Ares MPS; PornAres MI; Thyberg J; JunttiBerggren L; Berggren PO; Diczfalusy U; Kallin B; Bjorkhem I; Orrenius S; Nilsson J
Article: ATHEROSCLEROSIS. 1997;133(2):183-192
Effect of the oxidation state of LDL on the modulation of arterial vasomotor response in vitro.
Mougenot N; Lesnik P; RamirezGil JF; Nataf P; Diczfalusy U; Chapman MJ; Lechat P
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 1997;17(6):1178-1184
Vitamin C reduces cholesterol-induced microcirculatory changes in rabbits
Freyschuss A; Xiu RJ; Zhang J; Ying XY; Diczfalusy U; Joestrand T; Henriksson P; Bjorkhem I
Article: JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION. 1997;24(3):264-270
Vitamin A concentration in the liver decreases with age in patients with cystic fibrosis
Lindblad A; Diczfalusy U; Hultcrantz R; Thorell A; Strandvik B
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1997;1344(3):278-285
Localization of sterol 27-hydroxylase immuno-reactivity in human atherosclerotic plaques
Crisby M; Nilsson J; Kostulas V; Bjorkhem I; Diczfalusy U
Article: CIRCULATION. 1997;95(4):840-845
Lipoprotein oxidation and progression of carotid atherosclerosis
Salonen JT; Nyyssonen K; Salonen R; PorkkalaSarataho E; Tuomainen TP; Diczfalusy U; Bjorkhem I
Article: JOURNAL OF LIPID RESEARCH. 1996;37(11):2361-2371
Formation of oxysterols during oxidation of low density lipoprotein by peroxynitrite, myoglobin, and copper
Patel RP; Diczfalusy U; Dzeletovic S; Wilson MT; DarleyUsmar VM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1996;93(18):9799-9804
Cholesterol homeostasis in human brain: Evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation
Lutjohann D; Breuer O; Ahlborg G; Nennesmo I; Siden A; Diczfalusy U; Bjorkhem I
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1996;1302(2):145-152
The oxysterols cholest-5-ene-3 beta,4 alpha-diol, cholest-5-ene-3 beta,4 beta-diol and cholestane-3 beta,5 alpha,6 alpha-triol are formed during in vitro oxidation of low density lipoprotein, and are present in human atherosclerotic plaques
Breuer O; Dzeletovic S; Lund E; Diczfalusy U
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 1996;16(2):208-212
Importance of a novel oxidative mechanism for elimination of intracellular cholesterol in humans
Lund E; Andersson O; Zhang J; Babiker A; Ahlborg G; Diczfalusy U; Einarsson K; Sjovall J; Bjorkhem I
Article: JOURNAL OF CLINICAL INVESTIGATION. 1996;97(2):461-468
Oxysterols present in atherosclerotic tissue decrease the expression of lipoprotein lipase messenger RNA in human monocyte-derived macrophages
Hulten LM; Lindmark H; Diczfalusy U; Bjorkhem I; Ottosson M; Liu Y; Bondjers G; Wiklund O
Journal article: SCANDINAVIAN JOURNAL OF CLINICAL AND LABORATORY INVESTIGATION, SUPPLEMENT. 1996;56:9-17
Novel pathways for elimination of cholesterol by extrahepatic formation of side-chain oxidized oxysterols
Diczfalusy U; Lund E; Lotjohann D; Bjorkhem I
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1995;1259(3):313-316
Clofibrate treatment increases stearoyl-CoA desaturase mRNA level and enzyme activity in mouse liver
Diczfalusy U; Eggertsen G; Alexson SEH
Article: CHEMISTRY AND PHYSICS OF LIPIDS. 1995;78(2):119-128
Time course of oxysterol formation during in vitro oxidation of low density lipoprotein
Dzeletovic S; Babiker A; Lund E; Diczfalusy U
Article: ANALYTICAL BIOCHEMISTRY. 1995;225(1):73-80
DETERMINATION OF CHOLESTEROL OXIDATION-PRODUCTS IN HUMAN PLASMA BY ISOTOPE-DILUTION MASS-SPECTROMETRY
DZELETOVIC S; BREUER O; LUND E; DICZFALUSY U
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1994;91(18):8592-8596
ATHEROSCLEROSIS AND STEROL 27-HYDROXYLASE - EVIDENCE FOR A ROLE OF THIS ENZYME IN ELIMINATION OF CHOLESTEROL FROM HUMAN MACROPHAGES
BJORKHEM I; ANDERSSON O; DICZFALUSY U; SEVASTIK B; XIU RJ; DUAN CG; LUND E
Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1994;269(25):17118-17124
MOLECULAR-CLONING AND IDENTIFICATION OF A RAT SERUM CARBOXYLESTERASE EXPRESSED IN THE LIVER
ALEXSON SEH; FINLAY TH; HELLMAN U; SVENSSON LT; DICZFALUSY U; EGGERTSEN G
Journal article: CLINICAL NEPHROLOGY. 1994;41(4):183-190
TREATMENT OF IGA NEPHROPATHY WITH OMEGA-3-POLYUNSATURATED FATTY-ACIDS - A PROSPECTIVE, DOUBLE-BLIND, RANDOMIZED STUDY
PETTERSSON EE; REKOLA S; BERGLUND L; SUNDQVIST KG; ANGELIN B; DICZFALUSY U; BJORKHEM I; BERGSTROM J
Journal article: PROGRESS IN LIPID RESEARCH. 1994;33(4):403-428
BETA-OXIDATION OF EICOSANOIDS
DICZFALUSY U
Journal article: JOURNAL OF LIPID RESEARCH. 1993;34(7):1107-1113
PEROXISOMAL CHAIN-SHORTENING OF THROMBOXANE-B(2) - EVIDENCE FOR IMPAIRED DEGRADATION OF THROMBOXANE-B(2) IN ZELLWEGER-SYNDROME
DICZFALUSY U; VESTERQVIST O; KASE BF; LUND E; ALEXSON SEH
Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1992;267(18):12462-12467
ON THE MECHANISM OF OXIDATION OF CHOLESTEROL AT C-7 IN A LIPOXYGENASE SYSTEM
LUND E; DICZFALUSY U; BJORKHEM I
Journal article: PROGRESS IN CLINICAL AND BIOLOGICAL RESEARCH. 1992;375:253-261
Role of peroxisomes in the degradation of prostaglandins.
Diczfalusy UG; Alexson SE
Journal article: JOURNAL OF CLINICAL INVESTIGATION. 1991;88(3):978-984
Metabolism of prostaglandin F2 alpha in Zellweger syndrome. Peroxisomal beta-oxidation is a major importance for in vivo degradation of prostaglandins in humans.
Diczfalusy U; Kase BF; Alexson SE; Björkhem I
Journal article: DIABETOLOGIA. 1991;34(2):114-118
IMPAIRED INTRARENAL DOPAMINE PRODUCTION FOLLOWING INTRAVENOUS-SODIUM CHLORIDE INFUSION IN TYPE-1 (INSULIN-DEPENDENT) DIABETES-MELLITUS
STENVINKEL P; SAGGARMALIK AK; WAHRENBERG H; DICZFALUSY U; BOLINDER J; ALVESTRAND A
Journal article: ARTERIOSCLEROSIS AND THROMBOSIS. 1991;11(1):15-22
THE ANTIOXIDANT BUTYLATED HYDROXYTOLUENE PROTECTS AGAINST ATHEROSCLEROSIS
BJORKHEM I; HENRIKSSONFREYSCHUSS A; BREUER O; DICZFALUSY U; BERGLUND L; HENRIKSSON P
Journal article: SCANDINAVIAN JOURNAL OF CLINICAL AND LABORATORY INVESTIGATION. 1990;50(6):693-696
Stanozolol and experimental atherosclerosis: atherosclerotic development and blood lipids during anabolic steroid therapy of New Zealand white rabbits.
Fogelberg M; Björkhem I; Diczfalusy U; Henriksson P
Journal article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1990;1043(2):182-188
Identification of intermediates in the peroxisomal beta-oxidation of linoleic acid.
Diczfalusy U; Alexson SE; Sisfontes L; Olund J; Björkhem I
Journal article: JOURNAL OF LIPID RESEARCH. 1990;31(2):307-314
Identification of metabolites from peroxisomal beta-oxidation of prostaglandins.
Diczfalusy U; Alexson SE
Journal article: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 1990;20(1):105-110
EXPERIMENTAL ATHEROSCLEROSIS - EFFECTS OF ESTROGEN AND ATHEROSCLEROSIS ON THROMBOXANE AND PROSTACYCLIN FORMATION
FOGELBERG M; VESTERQVIST O; DICZFALUSY U; HENRIKSSON P
Journal article: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 1989;19(4):395-403
ESTROGEN-INDUCED CHANGES IN LIPOPROTEIN METABOLISM - ROLE IN PREVENTION OF ATHEROSCLEROSIS IN THE CHOLESTEROL-FED RABBIT
HENRIKSSON P; STAMBERGER M; ERIKSSON M; RUDLING M; DICZFALUSY U; BERGLUND L; ANGELIN B
Journal article: JOURNAL OF LIPID RESEARCH. 1988;29(12):1629-1636
Peroxisomal chain-shortening of prostaglandin F2 alpha.
Diczfalusy U; Alexson SE
Journal article: ACTA OPHTHALMOLOGICA. 1988;66(3):341-348
ATTEMPTS TO DEFINE THE MINIMAL SERUM LEVEL OF VITAMIN-A REQUIRED FOR NORMAL VISUAL FUNCTION IN A PATIENT WITH SEVERE FAT MALABSORPTION
WACHTMEISTER L; BJORKHEM I; DICZFALUSY U; EMAMI A
Journal article: PROSTAGLANDINS LEUKOTRIENES AND MEDICINE. 1987;29(1):71-77
INCREASED AORTIC THROMBOXANE PRODUCTION IN EXPERIMENTAL ATHEROSCLEROSIS
HENRIKSSON P; STAMBERGER M; DICZFALUSY U
Journal article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1987;144(3):1206-1213
Chain-shortening of prostaglandin F2 alpha by rat liver peroxisomes.
Diczfalusy U; Alexson SE; Pedersen JI
Journal article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 1987;254(1):124-135
PRODUCTS, KINETICS, AND SUBSTRATE-SPECIFICITY OF HOMOGENEOUS THROMBOXANE SYNTHASE FROM HUMAN-PLATELETS - DEVELOPMENT OF A NOVEL ENZYME ASSAY
HECKER M; HAURAND M; ULLRICH V; DICZFALUSY U; HAMMARSTROM S
Journal article: BIOMEDICAL CHROMATOGRAPHY. 1987;2(5):226-227
Determination of 4-methylpyrazole in plasma using solid phase extraction and HPLC.
Diczfalusy U; Eklöf R
Journal article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1986;878(3):387-393
IDENTIFICATION OF THE MAJOR URINARY METABOLITE OF PROSTAGLANDIN E-3 IN THE RAT
DICZFALUSY U; HAMBERG M
Journal article: LIPIDS. 1985;20(5):283-295
INFLUENCE OF DIETARY PARTIALLY HYDROGENATED VEGETABLE AND MARINE OILS ON MEMBRANE-COMPOSITION AND FUNCTION OF LIVER-MICROSOMES AND PLATELETS IN THE RAT
BLOMSTRAND R; DICZFALUSY U; SISFONTES L; SVENSSON L
Journal article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1985;834(2):272-274
FORMATION OF 15-HETE AS A MAJOR HYDROXYEICOSATETRAENOIC ACID IN THE ATHEROSCLEROTIC VESSEL WALL
HENRIKSSON P; HAMBERG M; DICZFALUSY U
Journal article: CLINICA CHIMICA ACTA. 1983;135(2):189-201
VALIDATION OF RADIOIMMUNOASSAY FOR ESTRADIOL-17-BETA BY ISOTOPE DILUTION-MASS SPECTROMETRY AND BY A TEST OF RADIOCHEMICAL PURITY
XING SM; CEKAN SZ; DICZFALUSY U; FALK O; GUSTAFSSON SA; AKERLOF E; BJORKHEM I
Journal article: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1982;10:15-58
THROMBOXANE-A2 - BIOSYNTHESIS AND EFFECTS ON PLATELETS
GRANSTROM E; DICZFALUSY U; HAMBERG M; HANSSON G; MALMSTEN C; SAMUELSSON B
Journal article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1980;94(4):1417-1423
ENZYMATIC CONVERSION OF C21 ENDOPEROXIDES TO THROMBOXANES AND HYDROXY-ACIDS
DICZFALUSY U; HAMMARSTROM S
Journal article: ADVANCES IN PROSTAGLANDIN AND THROMBOXANE RESEARCH. 1980;6:267-274
Biosynthesis of thromboxanes.
Hammarström S; Diczfalusy U
Journal article: FEBS LETTERS. 1979;105(2):291-295
STRUCTURAL REQUIREMENT FOR THE CONVERSION OF PROSTAGLANDIN ENDOPEROXIDES TO THROMBOXANES
DICZFALUSY U; HAMMARSTROM S
Journal article: FEBS LETTERS. 1977;84(2):271-274
CONVERSION OF PROSTAGLANDIN ENDOPEROXIDES TO HYDROXY-C-17 ACIDS CATALYZED BY HUMAN PLATELET THROMBOXANE SYNTHASE
DICZFALUSY U; FALARDEAU P; HAMMARSTROM S
Show more

All other publications

Book chapter: MAMMALIAN STEROLS. 2020;p. 41-79
Side-Chain Oxidized Oxysterols in Health and Disease
Björkhem I; Diczfalusy U
Editorial comment: BIOANALYSIS. 2017;9(9):675-681
Feedback from the EBF - Focus Workshop: Bringing Assay Validation and Analysis of Biomarkers into Practice
Timmerman P; Fjording MS; Allinson J; Arfvidsson C; Barroso B; Diczfalusy U; Freeman A; Hickford E; Kandousi H; Katugampola S; Kunz U; Nelson R; Smeraglia J
Editorial comment: AAPS JOURNAL. 2016;18(5):1056-1066
Recommendations on the Development of a Bioanalytical Assay for 4β-Hydroxycholesterol, an Emerging Endogenous Biomarker of CYP3A Activity
Aubry A-F; Dean B; Diczfalusy U; Goodenough A; Iffland A; McLeod J; Weng N; Yang Z
Review: BIOCHIMIE. 2013;95(3):455-460
On the formation and possible biological role of 25-hydroxycholesterol
Diczfalusy U
Editorial comment: JOURNAL OF LIPID RESEARCH. 2011;52(8):1447-1449
Still another activity by the highly promiscuous enzyme CYP3A4: 25-hydroxylation of cholesterol
Diczfalusy U; Bjorkhem I
Letter: NATURE IMMUNOLOGY. 2011;12(7):577
Detecting oxysterols in the human circulation
Bjorkhem I; Diczfalusy U; Olsson T; Russell DW; McDonald JG; Wang Y; Griffiths WJ
Review: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 2011;71(2):183-189
4β-hydroxycholesterol, an endogenous marker of CYP3A4/5 activity in humans
Diczfalusy U; Nylen H; Elander P; Bertilsson L
Book chapter: BIOMARKERS FOR ANTIOXIDANT DEFENSE AND OXIDATIVE DAMAGE: PRINCIPLES AND PRACTICAL APPLICATIONS. 2010;p. 99-115
Oxysterols: Potential Biomarkers of Oxidative Stress
Iuliano L; Diczfalusy U
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2006;7(3):562
Effects of high-dosage itraconazole treatment on synthesis, transport and metabolism of cholesterol in men
Schneider B; Plat J; Gerdsen R; Diczfalusy U; Björkhem I; Neuvonen PJ; Bieber T; Von Bergmann K; L tjohann D
Published conference paper: ACTA NEUROLOGICA SCANDINAVICA, SUPPLEMENT. 2006;114:43-49
Oxysterols and Alzheimer's disease
Bjorkhem I; Heverin M; Leoni V; Meaney S; Diczfalusy U
Book chapter: BILE ACID BIOLOGY AND ITS THERAPEUTIC IMPLICATIONS: FALK SYMPOSIUM. 2005;p. 219-224
Comprehensive study of the effects of rifampicin and ursodeoxycholic acid on genes and proteins involved in regulation, transport and detoxification of biliary compounds in gallstone patients
Marschall H-U; Wagner M; Zollner G; Fickert P; Gumhold J; Silbert D; Diczfalusy U; Benthin L; Grundström R; Gustafsson U; Sahlin S; Einarsson C; Trauner M
Book chapter: BILE ACID BIOLOGY AND ITS THERAPEUTIC IMPLICATIONS: FALK SYMPOSIUM. 2005;p. 37-40
Role of CYP3A4 as a cholesterol and bile acid metabolizing enzyme
Bodin K; Diczfalusy U
Editorial comment: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2004;24(12):2209-2210
24(S),25-epoxycholesterol - A potential friend
Bjorkhem I; Diczfalusy U
Meeting abstract: JOURNAL OF HEPATOLOGY. 2004;40:93
Comprehensive study of the effects of rifampicin and ursodeoxycholic acid on genes and proteins involved in regulation, transport and detoxification of biliary compounds in gallstone patients
Marschall HU; Wagner M; Zollner G; Fickert P; Gumholdt J; Silbert D; Diczfalusy U; Benthin L; Grundstrom R; Sahlin S; Einarsson C; Trauner M
Review: METHODS IN ENZYMOLOGY. 2003;364:24-37
Quantitation of receptor Ligands by mass Spectrometry
Lund EG; Diczfalusy U
Editorial comment: EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY. 2002;104(7):435-439
Analysis of cholesterol oxidation products in plasma, tissues and food
Bodin K; Diczfalusy U
Review: CURRENT OPINION IN LIPIDOLOGY. 2002;13(3):247-253
Oxysterols in human circulation:: which role do they have?
Björkhem I; Meaney S; Diczfalusy U
Published conference paper: CELL BIOCHEMISTRY AND BIOPHYSICS. 2000;32:317-324
Acyl-CoA thioesterases belong to a novel gene family of peroxisome proliferator-regulated enzymes involved in lipid metabolism
Hunt MC; Lindquist PJG; Nousiainen S; Huttunen M; Orii K; Svensson TLT; Aoyama T; Hashimoto T; Diczfalusy U; Alexson SEH
Meeting abstract: ATHEROSCLEROSIS. 1999;144:121
The lung is the major source of 27-oxygenated cholesterol in the human circulation
Babiker A; Björkhem I; Diczfalusy U
Review: CURRENT OPINION IN LIPIDOLOGY. 1999;10(2):161-165
Removal of cholesterol from extrahepatic sources by oxidative mechanisms
Björkhem I; Diczfalusy U; Lütjohann D
Book chapter: NATURAL ANTIOXIDANTS AND ANTICARCINOGENS IN NUTRITION, HEALTH AND DISEASE. 1999;p. 309-315
MEASUREMENTS OF CHOLESTEROL OXIDES IN FOODS: RESULTS OF AN INTERLABORATORY COMPARISON STUDY
Dutta PC; Caboni MF; Diczfalusy U; Dionisi F; Dzeletovic S; Grandgirard A; Guardiola F; Kumpulainen J; Lebovics VK; Pihlava J-M; Rodriguez-Estrada MT; Ulberth F
Published conference paper: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 1999;466:195-200
Cloning and regulation of peroxisome proliferator-induced acyl-CoA thioesterases from mouse liver
Hunt M; Lindquist PJG; Nousiainen S; Svensson TLT; Diczfalusy U; Alexson SEH
Published conference paper: NEPHROLOGY DIALYSIS TRANSPLANTATION. 1998;13(10):2594-2600
A study of plasmalogen as an index of oxidative stress in patients with chronic renal failure. Evidence of increased oxidative stress in malnourished patients
Stenvinkel P; Holmberg I; Heimburger O; Diczfalusy U
Meeting abstract: ATHEROSCLEROSIS. 1997;134(1-2):172
Higher 7 beta-hydroxycholesterol in high cardiovascular risk population
Zieden B; Diczfalusy U
Meeting abstract: ATHEROSCLEROSIS. 1997;134(1-2):217
Lipid peroxidation and progression of carotid atherosclerosis: A prospective 3-year follow-up study
Salonen JT; Nyyssonen K; Salonen R; Luoma J; YlaHerttuala S; Diczfalusy U; Bjorkhem I
Book chapter: NATURAL ANTIOXIDANTS AND FOOD QUALITY IN ATHEROSCLEROSIS AND CANCER PREVENTION. 1996;p. 11-17
OXYSTEROLS AND ATHEROSCLEROSIS - A MINIREVIEW
Björkhem I; Breuer O; Diczfalusy U; Lund E
Book chapter: NATURAL ANTIOXIDANTS AND FOOD QUALITY IN ATHEROSCLEROSIS AND CANCER PREVENTION. 1996;p. 11-17
Oxysterols and Atherosclerosis - A Minireview
Björkhem I; Breuer O; Diczfalusy U; Lund E
Published conference paper: SCANDINAVIAN JOURNAL OF CLINICAL AND LABORATORY INVESTIGATION, SUPPLEMENT. 1996;56:9-17
Novel pathways for elimination of cholesterol by extrahepatic formation of side-chain oxidized oxysterols
Diczfalusy U; Lund E; Lutjohann D; Bjorkhem I
Book chapter: PROSTAGLANDINS AND RELATED SUBSTANCES: NEW COMPREHENSIVE BIOCHEMISTRY. 1983;p. 45-94
Chapter 2 The thromboxanes
Granström E; Diczfalusy U; Hamberg M
Show more

Employments

Affiliated to Research, Department of Laboratory Medicine, Karolinska Institutet, 2024-2027

Degrees and Education

Docent, 1993

Articles

All other publications

Employments

Degrees and Education

News from KI

Events from KI