Lou Brundins research group

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Stemcells and inflammation

The effects of inflammation on neural stem cells

During injuries and inflammation in the central nervous system neural stem/progenitor cells are activated to migrate into the injury. A limited replacement of the injured tissue can be achieved by differentiation of the progenitor cells. The replacement of oligodendrocytes which occurs in the early phases of multiple sclerosis is an example of this mechanism.

Our group works to identify mechanisms important for the regeneration from progenitor cells and how these mechanisms are affected by inflammatory mediators. We have demonstrated that some components in the inflammatory cascade such as nitric oxide can change the fate of the progenitor cells and hampers neurogenesis. We have also demonstrated that progenitor cells carry receptors which on stimulation can cause the release of proinflammatory cytokines from these cells. The aim of our research is to improve the restoration and limit the injury by preservation of restorative mechanisms in the CNS. Our research group consists of neurologists, neurosurgeons and neurobiologists .

Brundin and Svensson research groups. Lou Brundin , Cynthia Perez Estrada, Maria Bergsland, Jonathan Nordblom, Nasren Jaff, Sebastian Thams, Lisa Arvidsson, Per Mattson, Arvid Frosell, Sreenivasa Sankavaram, Mikael Svensson Missing: Ruxandra Covacu, Elle

Brundin and Svenssons research groups. From the right: Lou Brundin, Cynthia Perez  EstradaMaria BergslandJonathan NordblomNasren Jaff, Sebastian ThamsLisa ArvidssonPer MattsonArvid FrostellSreenivasa SankavaramMikael Svensson Missing: Ruxandra CovacuEllen IacobaeusJonas Gripenland, Pendar Khalili, Britt MeijerBiljana Milovac

Research Projects

  •     Adult neural stem cells in neuroinflammation
  •     Neural stem cells a potential source of remyelination in neuroinflammatory disease
  •     Neurogenesis in the adult spinal cord experimental models of multiple sclerosis
  •     Effects of nitric oxide on neurogenesis from adult neural stem cells
  •     Proliferation, migration and differentiation of neural progenitor cells
  •     Biomarkers for disease activity in multiple sclerosis
  •     Mesenchymal stem cell transplantation in multiple sclerosis

Selected Publications

Nitric oxide-induced neuronal to glial lineage fate-change depends on NRSF/REST function in neural progenitor cells.
Bergsland M, Covacu R, Perez Estrada C, Svensson M, Brundin L
Stem Cells 2014 Sep;32(9):2539-49

Oxidative stress increases neurogenesis and oligodendrogenesis in adult neural progenitor cells.
Pérez Estrada C, Covacu R, Sankavaram S, Svensson M, Brundin L
Stem Cells Dev. 2014 Oct;23(19):2311-27

Dynamics of oligodendrocyte generation and myelination in the human brain.
Yeung M, Zdunek S, Bergmann O, Bernard S, Salehpour M, Alkass K, et al
Cell 2014 Nov;159(4):766-74

Change of fate commitment in adult neural progenitor cells subjected to chronic inflammation.
Covacu R, Perez Estrada C, Arvidsson L, Svensson M, Brundin L
J. Neurosci. 2014 Aug;34(35):11571-82

Oral teriflunomide for patients with relapsing multiple sclerosis (TOWER): a randomised, double-blind, placebo-controlled, phase 3 trial.
Confavreux C, O'Connor P, Comi G, Freedman M, Miller A, Olsson T, et al
Lancet Neurol 2014 Mar;13(3):247-56

Group members

Snjolaug ArnardottirAnknuten
Lisa ArvidssonAnknuten
Lou BrundinProfessor/överläkare
Ruxandra CovacuForskarassistent
Ellen Viveka IacobaeusAnknuten
Caroline IngrePostdoc
Susanne NeumannFOU-praktikant
Cynthia Perez EstradaAnknuten
Sreenivasa SankavaramDoktorand
Sreenivasa SankavaramForskarstuderande
Sebastian ThamsForskar-AT