Biological and clinical aspects of the myelodysplastic syndrome – Magnus Tobiasson group

The Magnus Tobiasson research group is studying biological and clinical aspects of the myelodysplastic syndrome (MDS).

About our research

The group is part of the Center for Hematology and Regenerative Medicine (HERM).

Mission of the research group

Allogeneic stem cell transplantation (HSCT) is the only curative treatment for patients with myelodysplastic syndrome (MDS). Unfortunately, approximately 25% of these patients will experience relapse, and the prognosis in such cases is exceedingly poor. 

Our research group has set a primary goal: to enhance the outcomes for MDS patients who have undergone HSCT. The concept of using measurable residual disease (MRD) assessments to guide treatment is well-established in diseases like chronic myeloid leukemia and acute myeloid leukemia. In n contrast, it has not yet been integrated into clinical routine for MDS patients due to the absence of well-defined MRD targets. In recent years, there has been a comprehensive characterization of the MDS. The focus of our research is to develop MRD methods and implement the use of MRD assessments before and after HSCT, and to develop treatment strategies in patients with relapsing disease. 

Illustration of the transplantation process and how measurable residual disease assessment can guide treatment during the process
Illustration of the transplantation process and how measurable residual disease assessment can guide treatment during the process. Made by Magnus Tobiasson

Publications

Selected publications

Funding

  • Tobias Stiftelsen
  • Strategic research area (SRA) in stem cells and regenerative medicine
  • Region Stockholm (SLL)
  • Centrum för innovativ medicin (CIMED)