Jaakko Patrakka group

Renal glomerulus biology and diseases

Glomerular diseases are the most common cause of end-stage renal disease. We investigate the molecular profile of healthy and diseased glomeruli with the aim to discover molecular pathways that drive the progression of glomerular disorders. We use transgenic mouse and zebrafish models to understand the role of identified pathways in the biology and diseases of the kidney.

Research group leader

Senior researcher

Jaakko Patrakka

Organizational unit: Division of Pathology
E-mail: Jaakko.Patrakka@ki.se


Jaakko Patrakka, Group leader  
Elisabeth Raschperger, Lab manager  
Maria Johansson, Lab technician  
Lwaki Ebarasi, Assistant professor  
Xiaojie Ma, Postdoc  
Katja Möller-Hackbarth, Postdoc  
Sonia Zambrano Sevilla, Postdoc  
Patricia Rodriguez, PhD student  
Angelina Schwarz, PhD student  
Jing Guo, PhD student  

Financial support

  • KI/AZ Integrated Cardio Metabolic Center
  • Marianne and Marcus Wallenberg Foundation
  • Swedish Research Council
  • Swedish Diabetes Foundation
  • Swedish Juvenile Diabetes Foundation
  • KI Foundations
  • Westmans Foundation

Research techniques

  • Generation and characterization of transgenic mouse lines
  • Morpholino and CRISPR/Cas-9 technology in zebrafish. Phenotypic analysis of zebrafish.
  • Cell culture
  • RNA sequencing
  • Expressional profiling by RNAscope, qPCR, immunohistochemistry, Western blot

Selected publications

Schip1 is a novel podocyte foot process protein that mediates actin cytoskeleton rearrangements and forms a complex with Nherf2 and ezrin.
Perisic L, Rodriguez P, Hultenby K, Sun Y, Lal M, Betsholtz C, et al
PLoS ONE 2015 ;10(3):e0122067

Wtip- and gadd45a-interacting protein dendrin is not crucial for the development or maintenance of the glomerular filtration barrier.
Xiao Z, Rodriguez P, He L, Betsholtz C, Tryggvason K, Patrakka J
PLoS ONE 2013 ;8(12):e83133

Neuronal proteins are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent formation.
Sistani L, Rodriguez P, Hultenby K, Uhlen M, Betsholtz C, Jalanko H, et al
Kidney Int. 2013 Jan;83(1):63-71

Pdlim2 is a novel actin-regulating protein of podocyte foot processes.
Sistani L, Dunér F, Udumala S, Hultenby K, Uhlen M, Betsholtz C, et al
Kidney Int. 2011 Nov;80(10):1045-54

New insights into the role of podocytes in proteinuria.
Patrakka J, Tryggvason K
Nat Rev Nephrol 2009 Aug;5(8):463-8

Expression and subcellular distribution of novel glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and 2310066E14Rik.
Patrakka J, Xiao Z, Nukui M, Takemoto M, He L, Oddsson A, et al
J. Am. Soc. Nephrol. 2007 Mar;18(3):689-97

Hereditary proteinuria syndromes and mechanisms of proteinuria.
Tryggvason K, Patrakka J, Wartiovaara J
N. Engl. J. Med. 2006 Mar;354(13):1387-401

Proteinuria and prenatal diagnosis of congenital nephrosis in fetal carriers of nephrin gene mutations.
Patrakka J, Martin P, Salonen R, Kestilä M, Ruotsalainen V, Männikkö M, et al
Lancet 2002 May;359(9317):1575-7