Our research
Our lab investigates the immunological mechanisms that drive multiple sclerosis (MS) and other neurological diseases with an inflammatory component, with a particular focus on autoreactive T and B cell responses and their intersection with viral triggers. We have uncovered novel MS‑associated autoantigens and mapped personalised autoreactive T cell profiles, advancing understanding of how adaptive immunity targets the CNS.
A major emphasis of our work is defining how Epstein–Barr virus (EBV) shapes MS risk and pathogenesis, including identifying cross‑reactive and pathogenic immune responses — such as EBNA1‑driven T and B cell reactivity — and recently demonstrating that ANO2‑specific T cells link EBV infection to MS.
Together, our research aims to delineate the mechanisms by which infection‑induced immunity transitions into chronic neuroinflammation, ultimately guiding the development of targeted diagnostics and interventions for MS.