Guro Gafvelin

About me
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About me

I am an immunologist, active in allergy research since 1997. My own research
has conserned allergens and immune regulation in allergy and inflammatory
diseases. My main present research interests are 1) immune modulation by
vaccination, in particular allergen specific immunotherapy, and 2)
characterisation of T-cell responses to autoantigens. Competence in protein
chemistry, molecular biology, cell biology, immunology and clinical
evaluation. Experience on characterisation of T-cell responses, allergen
characterisation, experimental allergy/asthma models, vaccine-/adjuvant
research and clinical trials.
PhD in medical science (biochemistry) at Karolinska Institutet 1990, thesis
title: “Isolation and characterization of variant forms of secretin and
vasoactive intestinal peptide -with special emphasis on their biosynthesis”
Postdoc at Karolinska Institutet and Stockholm University: Molecular biology,
membrane protein biology
Postdoc, scientist and senior scientist at Karolinska Institutet, Dept of
Medicine, Clin Immunology and Allergy Unit. Allergy research, Associate
professor in molecular immunology 2001.
Director of Immunology and coordinator of FP7 EU project at Viscogel AB
2010-2014.

Articles

Article: EUROPEAN JOURNAL OF NEUROLOGY. 2023;30(12):3789-3798
The impact of hybrid immunity on immune responses after SARS-CoV-2 vaccination in persons with multiple sclerosis treated with disease-modifying therapies
Rabenstein M; Thomas OG; Carlin G; Khademi M; Hogelin KA; Malmestrom C; Axelsson M; Brandt AF; Gafvelin G; Gronlund H; Kockum I; Piehl F; Lycke J; Olsson T; Hessa T
Article: SCIENCE ADVANCES. 2023;9(20):eadg3032
Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis
Thomas OG; Bronge M; Tengvall K; Akpinar B; Nilsson OB; Holmgren E; Hessa T; Gafvelin G; Khademi M; Alfredsson L; Martin R; Guerreiro-Cacais AO; Groenlund H; Olsson T; Kockum I
Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2022;77(10):2987-3001
Recombinant multimeric dog allergen prevents airway hyperresponsiveness in a model of asthma marked by vigorous T_H2 and T_H17 cell responses
Stark JM; Liu J; Tibbitt CA; Christian M; Ma J; Wintersand A; Dunst J; Kreslavsky T; Murrell B; Adner M; Gronlund H; Gafvelin G; Coquet JM
Article: SCIENCE ADVANCES. 2022;8(17):eabn1823
Identification of four novel T cell autoantigens and personal autoreactive profiles in multiple sclerosis
Bronge M; Hogelin KA; Thomas OG; Ruhrmann S; Carvalho-Queiroz C; Nilsson OB; Kaiser A; Zeitelhofer M; Holmgren E; Linnerbauer M; Adzemovic MZ; Hellstrom C; Jelcic I; Liu H; Nilsson P; Hillert J; Brundin L; Fink K; Kockum I; Tengvall K; Martin R; Tegel H; Graslund T; Al Nimer F; Guerreiro-Cacais AO; Khademi M; Gafvelin G; Olsson T; Gronlund H
Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2022;183(11):1166-1177
Measurement of Horse Allergens Equ c 1 and Equ c 2: A Comparison among Breeds
Victor S; Lampa E; Andersen AR; Gafvelin G; Gronlund H; Elfman L
Article: ISCIENCE. 2021;24(9):103078
Development of humoral and cellular immunological memory against SARS-CoV-2 despite B cell depleting treatment in multiple sclerosis
Hogelin KA; Ruffin N; Pin E; Manberg A; Hober S; Gafvelin G; Gronlund H; Nilsson P; Khademi M; Olsson T; Piehl F; Al Nimer F
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2020;145(3):1005-1007.e7
Intralymphatic immunotherapy in pollen-allergic young adults with rhinoconjunctivitis and mild asthma: A randomized trial
Konradsen JR; Grundstr J; Hellkvist L; Thi ATT; Andersson N; Gafvelin G; Kiewiet MBG; Hamsten C; Tang J; Parkin RV; Shamji MH; Hedlin G; Cardell L-O; van Hage M
Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019;74(12):2461-2478
A hypoallergenic peptide mix containing T cell epitopes of the clinically relevant house dust mite allergens
Huang H-J; Curin M; Banerjee S; Chen K-W; Garmatiuk T; Resch-Marat Y; Carvalho-Queiroz C; Blatt K; Gafvelin G; Groenlund H; Valent P; Campana R; Focke-Tejkl M; Valenta R; Vrtala S
Article: JOURNAL OF AUTOIMMUNITY. 2019;102:38-49
Myelin oligodendrocyte glycoprotein revisited-sensitive detection of MOG-specific T-cells in multiple sclerosis
Bronge M; Ruhrrnann S; Carvalho-Queiroz C; Nilsson OB; Kaiser A; Holmgren E; Macrini C; Winkhneier S; Meinl E; Brundin L; Khademi M; Olsson T; Gafvelin G; Gronlund H
Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019;74(8):1472-1479
Allergens in dog extracts: Implication for diagnosis and treatment
Wintersand A; Asplund K; Binnmyr J; Holmgren E; Nilsson OB; Gafvelin G; Gronlund H
Article: METHODSX. 2019;6:1635-1641
Sensitive detection of antigen-specific T-cells using bead-bound antigen for in vitro re-stimulation
Bronge M; Kaiser A; Carvalho-Queiroz C; Nilsson OB; Ruhrmann S; Holmgren E; Olsson T; Gafvelin G; Gronlund H
Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2016;71(10):1490-1495
The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1
Apostolovic D; Sanchez-Vidaurre S; Waden K; Curin M; Grundstrom J; Gafvelin G; Velickovic TC; Gronlund H; Thomas WR; Valenta R; Hamsten C; van Hage M
Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2016;71(9):1366-1370
IgG4 but no IgG1 antibody production after intralymphatic immunotherapy with recombinant MAT-Feld1 in human
Freiberger SN; Zehnder M; Gafvelin G; Gronlund H; Kuendig TM; Johansen P
Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2016;170(1):57-61
Selective COX-2 Inhibition Exerts No Negative Effects on Peripheral Blood Lymphocytes in Allergic Asthmatics
Gafvelin G; Grundstrom J; Grimheden ME; Vidaurre SS; Daham K; Dahlen S-E; Dahlen B; van Hage M
Article: VACCINE. 2014;32(45):5967-5974
Evaluation of safety and efficacy as an adjuvant for the chitosan-based vaccine delivery vehicle ViscoGel in a single-blind randomised Phase I/IIa clinical trial
Neimert-Andersson T; Binnmyr J; Enoksson M; Langeback J; Zettergren L; Hallgren A-C; Franzen H; Enoksson SL; Lafolie P; Lindberg A; Al-Tawil N; Andersson M; Singer P; Gronlund H; Gafvelin G
Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2014;165(3):195-205
Development of a Mouse Model for Chronic Cat Allergen-Induced Asthma
Grundstrom J; Saarne T; Kemi C; Gregory JA; Waden K; Pils MC; Adner M; Gafvelin G; van Hage M
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2012;169(2):137-147
Altered immunoregulatory profile during anti-tumour necrosis factor treatment of patients with inflammatory bowel disease
Grundstroem J; Linton L; Thunberg S; Forsslund H; Janczewska I; Befrits R; van Hage M; Gafvelin G; Eberhardson M
Article: PLOS ONE. 2012;7(3):e33780
Allergic Asthmatics Show Divergent Lipid Mediator Profiles from Healthy Controls Both at Baseline and following Birch Pollen Provocation
Lundstrom SL; Yang J; Kallberg HJ; Thunberg S; Gafvelin G; Haeggstrom JZ; Gronneberg R; Grunewald J; van Hage M; Hammock BD; Eklund A; Wheelock AM; Wheelock CE
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2012;42(1):58-65
Conjunctival provocation with airborne allergen in patients with atopic keratoconjunctivitis
Nivenius E; Van der Ploeg I; Gafvelin G; Van Hage M; Montan PG
Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2012;157(2):136-146
Covalent Coupling of Vitamin D3 to the Major Cat Allergen Fel d 1 Improves the Effects of Allergen-Specific Immunotherapy in a Mouse Model for Cat Allergy
Grundstrom J; Neimert-Andersson T; Kemi C; Nilsson OB; Saarne T; Andersson M; van Hage M; Gafvelin G
Article: VACCINE. 2011;29(48):8965-8973
Improved immune responses in mice using the novel chitosan adjuvant ViscoGel, with a Haemophilus influenzae type b glycoconjugate vaccine
Neimert-Andersson T; Hallgren A-C; Andersson M; Langeback J; Zettergren L; Nilsen-Nygaard J; Draget KI; van Hage M; Lindberg A; Gafvelin G; Gronlund H
Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2011;66(2):255-263
Treatment with a Fel d 1 hypoallergen reduces allergic responses in a mouse model for cat allergy
Saarne T; Neimert-Andersson T; Gronlund H; Jutel M; Gafvelin G; van Hage M
Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2011;155(2):111-118
Non-Proteolytic Aeroallergens from Mites, Cat and Dog Exert Adjuvant-Like Activation of Bronchial Epithelial Cells
Osterlund C; Gronlund H; Gafvelin G; Bucht A
Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2010;65(3):311-318
Allergen provocation increases TH2-cytokines and FOXP3 expression in the asthmatic lung
Thunberg S; Gafvelin G; Nord M; Gronneberg R; Grunewald J; Eklund A; van Hage M
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2009;39(8):1199-1208
The non-proteolytic house dust mite allergen Der p 2 induce NF-κB and MAPK dependent activation of bronchial epithelial cells
Osterlund C; Gronlund H; Polovic N; Sundstrom S; Gafvelin G; Bucht A
Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2009;64(6):919-926
Prolonged antigen-exposure with carbohydrate particle based vaccination prevents allergic immune responses in sensitized mice
Thunberg S; Neimert-Andersson T; Cheng Q; Wermeling F; Bergstrom U; Swedin L; Dahlen S-E; Arner E; Scheynius A; Karlsson MCI; Gafvelin G; van Hage M; Gronlund H
Article: LAKARTIDNINGEN. 2008;105(26-27):1942-1945
[Biological engineering for new asthma therapy].
Van Hage M; Grönlund H; Gafvelin G
Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2008;63(5):518-526
Carbohydrate-based particles reduce allergic inflammation in a mouse model for cat allergy
Neimert-Andersson T; Thunberg S; Swedin L; Wiedermann U; Jacobsson-Ekman G; Dahlen S-E; Scheynius A; Gronlund H; van Hage M; Gafvelin G
Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2008;146(1):1-10
Low levels of endotoxin enhance allergen-stimulated proliferation and reduce the threshold for activation in human peripheral blood cells
Velickovic TC; Thunberg S; Polovic N; Neimert-Andersson T; Gronlund H; van Hage M; Gafvelin G
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2007;37(8):1127-1136
Immune regulation by CD4⁺CD25⁺ T cells and interleukin-10 in birch pollen-allergic patients and non-allergic controls
Thunberg S; Akdis M; Akdis CA; Gronneberg R; Malmstrom V; Trollmo C; van Hage M; Gafvelin G
Article: JOURNAL OF MOLECULAR BIOLOGY. 2007;370(4):714-727
Structural characterization of the tetrameric form of the major cat allergen Fel d 1
Kaiser L; Velickovic TC; Badia-Martinez D; Adedoyin J; Thunberg S; Hallen D; Berndt K; Gronlund H; Gafvelin G; van Hage M; Achour A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(6):3778-3787
Hypoallergens for allergen-specific immunotherapy by directed molecular evolution of mite group 2 allergens
Gafvelin G; Parmley S; Neimert-Andersson T; Blank U; Eriksson TLJ; van Hage M; Punnonen J
Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2005;138(1):59-66
Cytokine and antibody responses in birch-pollen-allergic patients treated with genetically modified derivatives of the major birch pollen allergen Bet v 1
Gafvelin G; Thunberg S; Kronqvist M; Grönlund H; Grönneberg R; Troye-Blomberg M; Akdis M; Fiebig H; Purohit A; Horak F; Reisinger J; Niederberger V; Akdis CA; Cromwell O; Pauli G; Valenta R; van Hage M
Article: THE FEBS JOURNAL. 2005;272(13):3449-3460
A mouse model for in vivo tracking of the major dust mite allergen Der p 2 after inhalation
Johansson L; Svensson L; Bergström U; Jacobsson-Ekman G; Arnér ESJ; van Hage M; Bucht A; Gafvelin G
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2005;35(5):657-663
Rational design of hypoallergens applied to the major cat allergen Fel d 1
Saarne T; Kaiser L; Grönlund H; Rasool O; Gafvelin G; van Hage-Hamsten M
Article: NATURE METHODS. 2004;1(1):61-66
Exploiting the 21st amino acid -: purifying and labeling proteins by selenolate targeting
Johansson L; Chen CY; Thorell JO; Fredriksson A; Stone-Elander S; Gafvelin G; Arnér ESJ
Article: IMMUNOLOGY. 2004;113(2):253-259
A novel adjuvant-allergen complex, CBP-rFel d 1, induces up-regulation of CD86 expression and enhances cytokine release by human dendritic cells in vitro
Andersson TN; Ekman GJ; Grönlund H; Buentke E; Eriksson TLJ; Scheynius A; Van Hage-Hamsten M; Gafvelin G
Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2003;130(4):258-265
Cloning and characterisation of two IgE-binding proteins, homologous to tropomyosin and α-tubulin, from the mite Lepidoglyphus destructor
Saarne T; Kaiser L; Rasool O; Huecas S; van Hage-Hamsten M; Gafvelin G
Article: THE FEBS JOURNAL. 2003;270(4):646-653
Lep d 2 polymorphisms in wild and cultured Lepidoglyphus destructor mites
Kaiser L; Gafvelin G; Johansson E; van Hage-Hamsten M; Rasool O
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2001;31(12):1881-1890
T cell responses to recombinant isoforms, synthetic peptides and a mutant variant of Lep d 2, a major allergen from the dust mite Lepidoglyphus destructor
Eriksson TLJ; Gafvelin G; Elfman LHM; Johansson C; Van Hage-Hamsten M; Olsson S
Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2001;126(1):41-49
A hypoallergenic derivative of the major allergen of the dust mite Lepidoglyphus destructor, Lep d 2.6Cys, induces less IgE reactivity and cellular response in the skin than recombinant Lep d 2
Kronqvist M; Johansson E; Whitley P; Olsson S; Gafvelin G; Scheynius A; van Hage-Hamsten M
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2001;107(3):511-518
Cross-reactivity studies of a new group 2 allergen from the dust mite Glycyphagus domesticus, Gly d 2, and group 2 allergens from Dermatophagoides pteronyssinus, Lepidoglyphus destructor, and Tyrophagus putrescentiae with recombinant allergens
Gafvelin G; Johansson E; Lundin A; Smith AM; Chapman MD; Benjamin DC; Derewenda U; van Hage-Hamsten M
Article: THE FEBS JOURNAL. 2001;268(2):287-294
Cloning of three new allergens from the dust mite Lepidoglyphus destructor using phage surface display technology
Eriksson TLJ; Rasool O; Huecas S; Whitley P; Crameri R; Appenzeller U; Gafvelin G; van Hage-Hamsten M
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2000;30(5):670-676
Skin prick test and serological analysis with recombinant group 2 allergens of the dust mites L-destructor and T-putrescentiae
Kronqvist M; Johansson E; Magnusson CGM; Olsson S; Eriksson TLJ; Gafvelin G; Van Hage-Hamsten M
Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 1999;120(1):43-49
Evaluation of specific IgE to the recombinant group 2 mite allergens Lep d 2 and Tyr p 2 in the pharmacia CAP system
Johansson E; Eriksson TLJ; Olsson S; Kronqvist M; Whitley P; Johansson SGO; Gafvelin G; van Hage-Hamsten M
Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 1999;119(4):275-281
Identification and characterisation of two allergens from the dust mite Acarus siro, homologous with fatty acid-binding proteins
Eriksson TLJ; Whitley P; Johansson E; van Hage-Hamsten M; Gafvelin G
Article: THE FEBS JOURNAL. 1999;263(1):264-269
N-tail translocation in a eukaryotic polytopic membrane protein -: Synergy between neighboring transmembrane segments
Monné M; Gafvelin G; Nilsson R; von Heijne G
Article: JOURNAL OF MOLECULAR BIOLOGY. 1998;284(4):1165-1175
Proline-induced disruption of a transmembrane α-helix in its natural environment
Nilsson I; Sääf A; Whitley P; Gafvelin G; Waller C; von Heijne G
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 1998;28(8):984-991
Expression of two isoforms of Lep d 2, the major allergen of Lepidoglyphus destructor, in both prokaryotic and eukaryotic systems
Olsson S; Van Hage-Hamsten M; Whitley P; Johansson E; Hoffman DR; Gafvelin G; Schmidt M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(10):6119-6127
Topological rules for membrane protein assembly in eukaryotic cells
Gafvelin G; Sakaguchi M; Andersson H; vonHeijne G
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1995;270(50):29831-29835
SECA-INDEPENDENT TRANSLOCATION OF THE PERIPLASMIC N-TERMINAL TAIL OF AN ESCHERICHIA-COLI INNER MEMBRANE-PROTEIN - POSITION-SPECIFIC EFFECTS ON TRANSLOCATION OF POSITIVELY CHARGED RESIDUES AND CONSTRUCTION OF A PROTEIN WITH A C-TERMINAL TRANSLOCATION SIGNAL
WHITLEY P; GAFVELIN G; VONHEIJNE G
Article: REGULATORY PEPTIDES. 1995;57(2):99-104
RESCUE OF THYMOCYTES FROM CELL-DEATH BY VASOACTIVE-INTESTINAL-PEPTIDE
ERNSTROM U; GAFVELIN G; MUTT V
Article: MOLECULAR MEMBRANE BIOLOGY. 1995;12(2):209-215
SECA-DEPENDENCE OF THE TRANSLOCATION OF A LARGE PERIPLASMIC LOOP IN THE ESCHERICHIA-COLI MALF INNER MEMBRANE-PROTEIN IS A FUNCTION OF SEQUENCE CONTEXT
SAAF A; ANDERSSON H; GAFVELIN G; VONHEIJNE G
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All other publications

Letter: CLINICAL AND EXPERIMENTAL ALLERGY. 2021;51(9):1221-1224
Individual airborne characteristics of dog allergens
Wintersand A; Alsved M; Jakobsson J; Sadrizadeh S; Gronlund H; Londahl J; Gafvelin G
Published conference paper: JOURNAL OF THE SERBIAN CHEMICAL SOCIETY. 2013;78(3):353-363
Vitamin D and allergies
Gafvelin G
Review: HUMAN VACCINES. 2010;6(12):970-977
Recombinant Bet v 1 vaccine for treatment of allergy to birch pollen
Gronlund H; Gafvelin G
Editorial comment: CLINICAL AND EXPERIMENTAL ALLERGY. 2010;40(4):528-530
Bypassing T cells using a B cell mimotope allergy vaccine
Gafvelin G
Review: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2010;151(4):265-274
The Major Cat Allergen, Fel d 1, in Diagnosis and Therapy
Gronlund H; Saarne T; Gafvelin G; van Hage M
Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2005;1726(1):1-13
Selenocysteine in proteins -: properties and biotechnological use
Johansson L; Gafvelin G; Arnér ESJ
Published conference paper: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(Suppl 2):14677-14682
Vaccination with genetically engineered allergens prevents progression of allergic disease
Niederberger V; Horak F; Vrtala S; Spitzauer S; Krauth MT; Valent P; Reisinger J; Pelzmann M; Hayek B; Kronqvist M; Gafvelin G; Grönlund H; Purohit A; Suck R; Fiebig H; Cromwell O; Pauli G; van Hage-Hamsten M; Valenta R
Published conference paper: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2001;107(6):977-984
The molecular basis of antigenic cross-reactivity between the group 2 mite allergens
Smith AM; Benjamin DC; Hozic N; Derewenda U; Smith WA; Thomas WR; Gafvelin G; van Hage-Hamsten M; Chapman MD
Published conference paper: BIOCHEMICAL SOCIETY TRANSACTIONS. 1995;23(4):965-967
Membrane protein anchors and polytopic determinants
Whitley P; Saaf A; Gafvelin G; Johansson M; Wallin E; vonHeijne G

Employments

Affiliated to Research, Department of Clinical Neuroscience, Karolinska Institutet, 2023-2026

Degrees and Education

Docent, Karolinska Institutet, 2001

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