Gerald McInerney Group

Regulation of Gene Expression during Viral Infection

All viruses, regardless of their host tropism, genome structure or any other properties, must use components of the host cell gene expression machinery in order to propagate. This reliance has led to the development of an evolutionary arms-race between viruses and hosts. Viral strategies have evolved to ensure access to this machinery while host cells have developed means to recognize viruses as foreign entities and to restrict their expression. In turn, viruses have developed methods to counteract these restrictions and to reduce the cells ability to communicate with its neighbouring cells. Our work concerns the mechanisms of regulation of gene expression during the early stages of viral infections. Using Semliki Forest virus as a model, we are studying viral interactions with diverse cellular pathways and systems including the translation machinery, the type I interferon system and protein degradation systems.

Group Members

Benjamin Götte	Doktorand, Forskarstuderande	benjamin.gotte@ki.se
Leo Hanke	Anknuten	leo.hanke@ki.se
Peter Liljeström	Professor, senior	Peter.Liljestrom@ki.se
Lifeng Liu	Doktorand, Forskarstuderande	lifeng.liu@ki.se
Karl Ljungberg	Senior lab manager	karl.ljungberg@ki.se
Gerald McInerney	Forskare	Gerald.McInerney@ki.se 08-524 869 51
Ainhoa Moliner Morro	Doktorand, Forskarstuderande	ainhoa.moliner.morro@ki.se
Marc Panas	Anknuten	marc.panas@ki.se 762258603
Lina Poulain	Anknuten	lina.poulain@ki.se
Inga Szurgot	Postdoc	inga.szurgot@ki.se
Timothy Tan	Anknuten	timothy.tan@ki.se
Eline van Huizen	Anknuten	eline.van.huizen@ki.se