Itziar Martinez Gonzalez

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Publications
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About me

Our research interests are focused in the study of the biology of memory
Group 2 Innate Lymphoid Cells (ILC2s) in type 2 immunity.

Articles

Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2024;221(8):e20231827
Human CD127 negative ILC2s show immunological memory
Matha L; Krabbendam L; Hoyer SM; Heesters BA; Golebski K; Kradolfer C; Ghaedi M; Ma J; Stadhouders R; Bachert C; Cardell L-O; Zhang N; Holtappels G; Reitsma S; Helgers LC; Geijtenbeek TBH; Coquet JM; Takei F; Spits H; Martinez-Gonzalez I
Article: SCIENCE IMMUNOLOGY. 2023;8(87):eadf7702
Laboratory mice with a wild microbiota generate strong allergic immune responses
Ma J; Urgard E; Runge S; Classon CH; Mathae L; Stark JM; Cheng L; Alvarez JA; Von Zedtwitz S; Baleviciute A; Hoyer SM; Li M; Gernand AM; Osbelt L; Bielecka AA; Lesker TR; Huang H-J; Vrtala S; Boon L; Beyaert R; Adner M; Gonzalez IM; Strowig T; Du J; Nylen S; Rosshart SP; Coquet JM
Article: ANTIOXIDANTS. 2021;10(12):1936
Genome-Wide RNAi Screening Identifies Novel Pathways/Genes Involved in Oxidative Stress and Repurposable Drugs to Preserve Cystic Fibrosis Airway Epithelial Cell Integrity
Checa J; Martinez-Gonzalez I; Maqueda M; Mosquera JL; Aran JM
Article: COMMUNICATIONS BIOLOGY. 2021;4(1):590
Genome-wide bioinformatic analyses predict key host and viral factors in SARS-CoV-2 pathogenesis.
Ferrarini MG; Lal A; Rebollo R; Gruber AJ; Guarracino A; Gonzalez IM; Floyd T; de Oliveira DS; Shanklin J; Beausoleil E; Pusa T; Pickett BE; Aguiar-Pulido V
Article: SCIENCE IMMUNOLOGY. 2021;6(55):eabd3489
Steroid-resistant human inflammatory ILC2s are marked by CD45RO and elevated in type 2 respiratory diseases
van der Ploeg EK; Golebski K; van Nimwegen M; Fergusson JR; Heesters BA; Martinez-Gonzalez I; Kradolfer CMA; van Tol S; Scicluna BP; de Bruijn MJW; de Boer GM; Tramper-Stranders GA; Braunstahl G-J; van IJcken WFJ; Nagtegaal AP; van Drunen CM; Fokkens WJ; Huylebroeck D; Spits H; Hendriks RW; Stadhouders R; Bal SM
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2020;217(3):e20182293
Single-cell analysis of RORα tracer mouse lung reveals ILC progenitors and effector ILC2 subsets
Ghaedi M; Shen ZY; Orangi M; Martinez-Gonzalez I; Wei L; Lu X; Das A; Heravi-Moussavi A; Marra MA; Bhandoola A; Takei F
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2019;216(8):1762-1776
KLRG1 and NKp46 discriminate subpopulations of human CD117⁺CRTH2^- ILCs biased toward ILC2 or ILC3
Nagasawa M; Heesters BA; Kradolfer CMA; Krabbendam L; Martinez-Gonzalez I; de Bruijn MJW; Golebski K; Hendriks RW; Stadhouders R; Spits H; Bal SM
Article: PLOS ONE. 2019;14(3):e0214286
Female and male mouse lung group 2 innate lymphoid cells differ in gene expression profiles and cytokine production
Matha L; Shim H; Steer CA; Yin YH; Martinez-Gonzalez I; Takei F
Article: ONCOIMMUNOLOGY. 2019;8(2):e1527497
IL-33 increases ST2⁺ Tregs and promotes metastatic tumour growth in the lungs in an amphiregulin-dependent manner
Halvorsen EC; Franks SE; Wadsworth BJ; Harbourne BT; Cederberg RA; Steer CA; Martinez-Gonzalez I; Calder J; Lockwood WW; Bennewith KL
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2018;141(1):300-310.e11
Type 2 innate lymphoid cells disrupt bronchial epithelial barrier integrity by targeting tight junctions through IL-13 in asthmatic patients
Sugita K; Steer CA; Martinez-Gonzalez I; Altunbulakli C; Morita H; Castro-Giner F; Kubo T; Wawrzyniak P; Ruckert B; Sudo K; Nakae S; Matsumoto K; O'Mahony L; Akdis M; Takei F; Akdis CA
Article: IMMUNITY. 2016;45(1):198-208
Allergen-Experienced Group 2 Innate Lymphoid Cells Acquire Memory-like Properties and Enhance Allergic Lung Inflammation
Martinez-Gonzalez I; Matha L; Steer CA; Ghaedi M; Poon GFT; Takei F
Article: CELL REPORTS. 2016;15(3):471-480
Common-Lymphoid-Progenitor-Independent Pathways of Innate and T Lymphocyte Development
Ghaedi M; Steer CA; Martinez-Gonzalez I; Halim TYF; Abraham N; Takei F
Article: STEM CELLS AND DEVELOPMENT. 2014;23(19):2352-2363
Human Mesenchymal Stem Cells Resolve Airway Inflammation, Hyperreactivity, and Histopathology in a Mouse Model of Occupational Asthma
Martinez-Gonzalez I; Cruz M-J; Moreno R; Morell F; Munoz X; Aran JM
Article: IMMUNITY. 2014;40(3):425-435
Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation
Halim TYF; Steer CA; Mathae L; Gold MJ; Martinez-Gonzalez I; McNagny KM; McKenzie ANJ; Takei F
Article: AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. 2013;49(4):552-562
Human Mesenchymal Stem Cells Overexpressing the IL-33 Antagonist Soluble IL-1 Receptor-Like-1 Attenuate Endotoxin-Induced Acute Lung Injury
Martinez-Gonzalez I; Roca O; Masclans JR; Moreno R; Salcedo MT; Baekelandt V; Cruz MJ; Rello J; Aran JM
Article: STEM CELLS AND DEVELOPMENT. 2012;21(18):3270-3277
Engraftment Potential of Adipose Tissue-Derived Human Mesenchymal Stem Cells After Transplantation in the Fetal Rabbit
Martinez-Gonzalez I; Moreno R; Petriz J; Gratacos E; Aran JM
Article: STEM CELLS AND DEVELOPMENT. 2012;21(2):284-295
Fetal Liver-Derived Mesenchymal Stem Cell Engraftment After Allogeneic In Utero Transplantation into Rabbits
Moreno R; Martinez-Gonzalez I; Rosal M; Nadal M; Petriz J; Gratacos E; Aran JM
Article: TISSUE ENGINEERING - PART C: METHODS. 2011;17(3):275-287
The β-Interferon Scaffold Attachment Region Confers High-Level Transgene Expression and Avoids Extinction by Epigenetic Modifications of Integrated Provirus in Adipose Tissue-Derived Human Mesenchymal Stem Cells
Moreno R; Martinez I; Petriz J; Nadal M; Tintore X; Ramon Gonzalez J; Gratacos E; Aran JM
Article: STEM CELLS AND DEVELOPMENT. 2010;19(10):1579-1588
Characterization of Mesenchymal Stem Cells Isolated from the Rabbit Fetal Liver
Moreno R; Martinez-Gonzalez I; Rosal M; Farwati A; Gratacos E; Aran JM
Article: BLOOD CELLS, MOLECULES, AND DISEASES. 2009;43(2):214-220
Boundary sequences stabilize transgene expression from subtle position effects in retroviral vectors
Moreno R; Martinez I; Petriz J; Ramon Gonzalez J; Gratacos E; Aran JM
Article: JOURNAL OF GENE MEDICINE. 2008;10(9):951-964
Restricted transgene persistence after lentiviral vector-mediated fetal gene transfer in the pregnant rabbit model
Moreno R; Rosal M; Martinez I; Vilardell F; Ramon Gonzalez J; Petriz J; Hernandez-Andrade E; Gratacos E; Aran JM
Article: HUMAN MUTATION. 2008;29(5):738-749
N-terminal CFTR missense variants severely affect the behavior of the CFTR chloride channel
Gene GG; Llobet A; Larriba S; de Semiri D; Martinez I; Escalada A; Solsona C; Casals T; Aran JM
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All other publications

Review: IMMUNOLOGICAL REVIEWS. 2024;323(1):118-125
New insights into ILC2 memory
Martinez-Gonzalez I; Takei F
Review: FRONTIERS IN IMMUNOLOGY. 2022;13:877005
Tissue Resident and Migratory Group 2 Innate Lymphoid Cells
Mathae L; Takei F; Martinez-Gonzalez I
Review: FRONTIERS IN IMMUNOLOGY. 2021;12:671966
The Fate of Activated Group 2 Innate Lymphoid Cells
Matha L; Martinez-Gonzalez I; Steer CA; Takei F
Corrigendum: PLOS ONE. 2021;16(5):e0252257
Female and male mouse lung group 2 innate lymphoid cells differ in gene expression profiles and cytokine production (vol 14, e0214286, 2019)
Mathae L; Shim H; Steer CA; Yin YH; Martinez-Gonzalez I; Takei F
Corrigendum: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2019;216(9):2221-2222
KLRG1 and NKp46 discriminate subpopulations of human CD117⁺CRTH2^- ILCs biased toward ILC2 or ILC3 (vol 216, 1762, 2019)
Nagasawa M; Heesters BA; Kradolfer CMA; Krabbendam L; Martinez-Gonzalez I; de Bruijn MJW; Golebski K; Hendriks RW; Stadhouders R; Spits H; Bal SM
Review: IMMUNOLOGICAL REVIEWS. 2018;283(1):41-53
ILC2 memory: Recollection of previous activation
Martinez-Gonzalez I; Ghaedi M; Steer CA; Matha L; Vivier E; Takei F
Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;140(2):593-595.e3
Group 2 innate lymphoid cell activation in the neonatal lung drives type 2 immunity and allergen sensitization
Steer CA; Martinez-Gonzalez I; Ghaedi M; Allinger P; Mathae L; Takei F
Review: TRENDS IN IMMUNOLOGY. 2017;38(6):423-431
Immunological Memory of Group 2 Innate Lymphoid Cells
Martinez-Gonzalez I; Matha L; Steer CA; Takei F
Review: TRENDS IN IMMUNOLOGY. 2015;36(3):189-195
Lung ILC2s link innate and adaptive responses in allergic inflammation
Martinez-Gonzalez I; Steer CA; Takei F

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