Benjamin Nilsson-Payant

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Articles

Journal article: PLOS PATHOGENS. 2024;20(12):e1012781
Structural characterization of the full-length Hantaan virus polymerase
Keown JR; Carrique L; Nilsson-Payant BE; Fodor E; Grimes JM
Journal article: NATURE. 2024;630(8016):e7
Identification of SARS-CoV-2 inhibitors using lung and colonic organoids (Vol 589, pg 270, 2021)
Han Y; Duan X; Yang L; Nilsson-Payant BE; Wang P; Duan F; Tang X; Yaron TM; Zhang T; Uhl S; Bram Y; Richardson C; Zhu J; Zhao Z; Redmond D; Houghton S; Nguyen D-HT; Xu D; Wang X; Jessurun J; Borczuk A; Huang Y; Johnson JL; Liu Y; Xiang J; Wang H; Cantley LC; Tenoever BR; Ho DD; Pan FC; Evans T; Chen HJ; Schwartz RE; Chen S
Article: MBIO. 2023;14(4):e01007-e01023
SARS-CoV-2 hijacks p38ß/MAPK11 to promote virus replication
Higgins CA; Nilsson-Payant BE; Bonaventure B; Kurland AP; Ye C; Yaron TM; Johnson JL; Adhikary P; Golynker I; Panis M; Danziger O; Rosenberg BR; Cantley LC; Martinez-Sobrido L; tenOever B; Johnson JR
Journal article: JOURNAL OF IMMUNOLOGY. 2023;210(1_Supplement):75.13
Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19
Laurent P; Yang C; Rendeiro AL; Nilsson-Payant B; Carrau L; Chandar V; Bram Y; tenOever B; Elemento O; Ivashkiv L; Schwartz R; Barrat FJ
Article: NATURE CELL BIOLOGY. 2023;25(3):381-389
A multi-organoid platform identifies CIART as a key factor for SARS-CoV-2 infection
Tang X; Xue D; Zhang T; Nilsson-Payant BEE; Carrau L; Duan X; Gordillo M; Tan AYY; Qiu Y; Xiang J; Schwartz REE; tenOever BRR; Evans T; Chen S
Article: FRONTIERS IN MICROBIOLOGY. 2023;14:1267078
Modulation of Influenza A virus NS1 expression reveals prioritization of host response antagonism at single-cell resolution
Yang Q; Elz AE; Panis M; Liu T; Nilsson-Payant BE; Blanco-Melo D
Article: ACS BIO & MED CHEM AU. 2022;2(6):627-641
Dual-Reporter System for Real-Time Monitoring of SARS-CoV-2 Main Protease Activity in Live Cells Enables Identification of an Allosteric Inhibition Path
Bram Y; Duan X; Nilsson-Payant BE; Chandar V; Wu H; Shore D; Fajardo A; Sinha S; Hassan N; Weinstein H; TenOever BR; Chen S; Schwartz RE
Article: SCIENCE SIGNALING. 2022;15(757):eabm0808
Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication
Yaron TM; Heaton BE; Levy TM; Johnson JL; Jordan TX; Cohen BM; Kerelsky A; Lin T-Y; Liberatore KM; Bulaon DK; Nest SJV; Koundouros N; Kastenhuber ER; Mercadante MN; Shobana-Ganesh K; He L; Schwartz RE; Chen S; Weinstein H; Elemento O; Piskounova E; Nilsson-Payant BE; Lee G; Trimarco JD; Burke KN; Hamele CE; Chaparian RR; Harding AT; Tata A; Zhu X; Tata PR; Smith CM; Possemato AP; Tkachev SL; V. Hornbeck P; Beausoleil SA; Anand SK; Aguet F; Getz G; Davidson AD; Heesom K; Kavanagh-Williamson M; Matthews DA; tenOever BR; Cantley LC; Blenis J; Heaton NS
Article: CELL STEM CELL. 2022;29(10):1475-1490.e6
A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants
Han Y; Tan L; Zhou T; Yang L; Carrau L; Lacko LA; Saeed M; Zhu J; Zhao Z; Nilsson-Payant BE; Neto FTL; Cahir C; Giani AM; Chai JC; Li Y; Dong X; Moroziewicz D; Paull D; Zhang T; Koo S; Tan C; Danziger R; Ba Q; Feng L; Chen Z; Zhong A; Wise GJ; Xiang JZ; Wang H; Schwartz RE; tenOever BR; Noggle SA; Rice CM; Qi Q; Evans T; Chen S
Article: SCIENCE IMMUNOLOGY. 2022;7(75):eadd4906
Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19
Laurent P; Yang C; Rendeiro AF; Nilsson-Payant BE; Carrau L; Chandar V; Bram Y; tenOever BR; Elemento O; Ivashkiv LB; Schwartz RE; Barrat FJ
Article: CIRCULATION RESEARCH. 2022;130(7):963-977
SARS-CoV-2 Infection Induces Ferroptosis of Sinoatrial Node Pacemaker Cells
Han Y; Zhu J; Yang L; Nilsson-Payant BE; Hurtado R; Lacko LA; Sun X; Gade AR; Higgins CA; Sisso WJ; Dong X; Wang M; Chen Z; Ho DD; Pitt GS; Schwartz RE; TenOever BR; Evans T; Chen S
Article: ELIFE. 2022;11:e77444
Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry
Kastenhuber ER; Mercadante M; Nilsson-Payant B; Johnson JL; Jaimes JA; Muecksch F; Weisblum Y; Bram Y; Chandar V; Whittaker GR; tenOever BR; Schwartz RE; Cantley L
Article: JOURNAL OF VIROLOGY. 2022;96(4):e02092-e02021
The Host Factor ANP32A Is Required for Influenza A Virus vRNA and cRNA Synthesis
Nilsson-Payant BE; TenOever BR; te Velthuis AJW
Article: JOURNAL OF VIROLOGY. 2021;95(23):10.1128/jvi.01257-10.1128/jvi.01221
The NF-κB Transcriptional Footprint Is Essential for SARS-CoV-2 Replication
Nilsson-Payant BE; Uhl S; Grimont A; Doane AS; Cohen P; Patel RS; Higgins CA; Acklin JA; Bram Y; Chandar V; Blanco-Melo D; Panis M; Lim JK; Elemento O; Schwartz RE; Rosenberg BR; Chandwani R; TenOever BR
Article: STEM CELL REPORTS. 2021;16(9):2274-2288
Cardiomyocytes recruit monocytes upon SARS-CoV-2 infection by secreting CCL2
Yang L; Nilsson-Payant BE; Han Y; Jaffre F; Zhu J; Wang P; Zhang T; Redmond D; Houghton S; Moller R; Hoagland D; Carrau L; Horiuchi S; Goff M; Lim JK; Bram Y; Richardson C; Chandar V; Borczuk A; Huang Y; Xiang J; Ho DD; Schwartz RE; TenOever BR; Evans T; Chen S
Article: NATURE BIOMEDICAL ENGINEERING. 2021;5(8):815-829
A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics
Si L; Bai H; Rodas M; Cao W; Oh CY; Jiang A; Moller R; Hoagland D; Oishi K; Horiuchi S; Uhl S; Blanco-Melo D; Albrecht RA; Liu W-C; Jordan T; Nilsson-Payant BE; Golynker I; Frere J; Logue J; Haupt R; McGrath M; Weston S; Zhang T; Plebani R; Soong M; Nurani A; Kim SM; Zhu DY; Benam KH; Goyal G; Gilpin SE; Prantil-Baun R; Gygi SP; Powers RK; Carlson KE; Frieman M; TenOever BR; Ingber DE
Journal article: BLOOD. 2021;138(1):1-2
Letermovir and HCT: too much of a good thing?
Schleiss MR
Article: ACS APPLIED MATERIALS & INTERFACES. 2021;13(26):30317-30325
Zinc-Embedded Polyamide Fabrics Inactivate SARS-CoV-2 and Influenza A Virus
Gopal V; Nilsson-Payant BE; French H; Siegers JY; Yung W-S; Hardwick M; te Velthuis AJW
Article: CIRCULATION RESEARCH. 2021;129(1):33-46
An Immuno-Cardiac Model for Macrophage-Mediated Inflammation in COVID-19 Hearts
Yang L; Han Y; Jaffre F; Nilsson-Payant BE; Bram Y; Wang P; Zhu J; Zhang T; Redmond D; Houghton S; Uhl S; Borczuk A; Huang Y; Richardson C; Chandar V; Acklin JA; Lim JK; Chen Z; Xiang J; Ho DD; tenOever BR; Schwartz RE; Evans T; Chen S
Article: JOURNAL OF VIROLOGY. 2021;95(9):10.1128/jvi.02274-10.1128/jvi.02220
Reduced Nucleoprotein Availability Impairs Negative-Sense RNA Virus Replication and Promotes Host Recognition
Nilsson-Payant BE; Blanco-Melo D; Uhl S; Escudero-Perez B; Olschewski S; Thibault P; Panis M; Rosenthal M; Munoz-Fontela C; Lee B; tenOever BR
Article: NATURE. 2021;589(7841):270-275
Identification of SARS-CoV-2 inhibitors using lung and colonic organoids
Han Y; Duan X; Yang L; Nilsson-Payant BE; Wang P; Duan F; Tang X; Yaron TM; Zhang T; Uhl S; Bram Y; Richardson C; Zhu J; Zhao Z; Redmond D; Houghton S; Nguyen D-HT; Xu D; Wang X; Jessurun J; Borczuk A; Huang Y; Johnson JL; Liu Y; Xiang J; Wang H; Cantley LC; TenOever BR; Ho DD; Pan FC; Evans T; Chen HJ; Schwartz RE; Chen S
Article: CELL. 2020;182(3):685-712.e19
The Global Phosphorylation Landscape of SARS-CoV-2 Infection
Bouhaddou M; Memon D; Meyer B; White KM; Rezelj VV; Marrero MC; Polacco BJ; Melnyk JE; Ulferts S; Kaake RM; Batra J; Richards AL; Stevenson E; Gordon DE; Rojc A; Obernier K; Fabius JM; Soucheray M; Miorin L; Moreno E; Koh C; Quang DT; Hardy A; Robinot R; Vallet T; Nilsson-Payant BE; Hernandez-Armenta C; Dunham A; Weigang S; Knerr J; Modak M; Quintero D; Zhou Y; Dugourd A; Valdeolivas A; Patil T; Li Q; Huttenhain R; Cakir M; Muralidharan M; Kim M; Jang G; Tutuncuoglu B; Hiatt J; Guo JZ; Xu J; Bouhaddou S; Mathy CJP; Gaulton A; Manners EJ; Felix E; Shi Y; Goff M; Lim JK; McBride T; O'Neal MC; Cai Y; Chang JCJ; Broadhurst DJ; Klippsten S; De Wit E; Leach AR; Kortemme T; Shoichet B; Ott M; Saez-Rodriguez J; TenOever BR; Mullins RD; Fischer ER; Kochs G; Grosse R; Garcia-Sastre A; Vignuzzi M; Johnson JR; Shokat KM; Swaney DL; Beltrao P; Krogan NJ
Article: CELL STEM CELL. 2020;27(1):125-136.e7
A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
Yang L; Han Y; Nilsson-Payant BE; Gupta V; Wang P; Duan X; Tang X; Zhu J; Zhao Z; Jaffre F; Zhang T; Kim TW; Harschnitz O; Redmond D; Houghton S; Liu C; Naji A; Ciceri G; Guttikonda S; Bram Y; Nguyen D-HT; Cioffi M; Chandar V; Hoagland DA; Huang Y; Xiang J; Wang H; Lyden D; Borczuk A; Chen HJ; Studer L; Pan FC; Ho DD; tenOever BR; Evans T; Schwartz RE; Chen S
Article: CELL. 2020;181(5):1036-1045.e9
Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19
Blanco-Melo D; Nilsson-Payant BE; Liu W-C; Uhl S; Hoagland D; Moller R; Jordan TX; Oishi K; Panis M; Sachs D; Wang TT; Schwartz RE; Lim JK; Albrecht RA; tenOever BR
Article: JOURNAL OF VIROLOGY. 2018;92(16):10.1128/jvi.00687-10.1128/jvi.00618
The Surface-Exposed PA^51-72-Loop of the Influenza A Virus Polymerase Is Required for Viral Genome Replication
Nilsson-Payant BE; Sharps J; Hengrung N; Fodor E
Article: PLOS ONE. 2018;13(1):e0191226
Amino acid substitutions affecting aspartic acid 605 and valine 606 decrease the interaction strength between the influenza virus RNA polymerase PB2 '627' domain and the viral nucleoprotein
Hsia H-P; Yang Y-H; Szeto W-C; Nilsson BE; Lo C-Y; Ng AK-L; Fodor E; Shaw P-C
Article: JOURNAL OF VIROLOGY. 2017;91(7):10.1128/jvi.02467-10.1128/jvi.02416
Role of the PB2 627 Domain in Influenza A Virus Polymerase Function
Nilsson BE; te Velthuis AJW; Fodor E
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Preprint: BIORXIV. 2023
Structural Characterization of the Full-length Hantaan Virus Polymerase
Keown J; Carrique L; Nilsson-Payant B; Fodor E; Grimes J
Corrigendum: STEM CELL REPORTS. 2021;16(10):2565
Cardiomyocytes recruit monocytes upon SARS-CoV-2 infection by secreting CCL2.
Yang L; Nilsson-Payant BE; Han Y; Jaffré F; Zhu J; Wang P; Zhang T; Redmond D; Houghton S; Møller R; Hoagland D; Carrau L; Horiuchi S; Goff M; Lim JK; Bram Y; Richardson C; Chandar V; Borczuk A; Huang Y; Xiang J; Ho DD; Schwartz RE; tenOever BR; Evans T; Chen S
Preprint: BIORXIV. 2021
SARS-CoV-2 hijacks p38β/MAPK11 to promote virus replication
Higgins C; Nilsson-Payant B; Kurland A; Ye C; Yaron T; Yaron T; Johnson J; Bonaventure B; Adhikary P; Golynker I; Panis M; Danziger O; Rosenberg B; Cantley L; Martinez-Sobrido L; tenOever B; Johnson J
Preprint: BIORXIV. 2021
The host factor ANP32A is required for influenza A virus vRNA and cRNA synthesis
Nilsson-Payant B; tenOever B; te Velthuis AJW
Preprint: BIORXIV. 2021;BIORXIV
Zinc-embedded fabrics inactivate SARS-CoV-2 and influenza A virus.
Gopal V; Nilsson-Payant BE; French H; Siegers JY; Yung W-S; Hardwick M; Te Velthuis AJW
Preprint: BIORXIV. 2020;BIORXIV
The FDA-approved drug Alectinib compromises SARS-CoV-2 nucleocapsid phosphorylation and inhibits viral infection in vitro.
Yaron TM; Heaton BE; Levy TM; Johnson JL; Jordan TX; Cohen BM; Kerelsky A; Lin T-Y; Liberatore KM; Bulaon DK; Kastenhuber ER; Mercadante MN; Shobana-Ganesh K; He L; Schwartz RE; Chen S; Weinstein H; Elemento O; Piskounova E; Nilsson-Payant BE; Lee G; Trimarco JD; Burke KN; Hamele CE; Chaparian RR; Harding AT; Tata A; Zhu X; Tata PR; Smith CM; Possemato AP; Tkachev SL; Hornbeck PV; Beausoleil SA; Anand SK; Aguet F; Getz G; Davidson AD; Heesom K; Kavanagh-Williamson M; Matthews D; tenOever BR; Cantley LC; Blenis J; Heaton NS
Preprint: RES SQ. 2020;RES SQ
SARS-CoV-2 Infected Cardiomyocytes Recruit Monocytes by Secreting CCL2.
Chen S; Yang L; Nilsson-Payant B; Han Y; Jaffré F; Zhu J; Wang P; Zhang T; Redmond D; Houghton S; Møller R; Hoagland D; Horiuchi S; Acklin J; Lim J; Bram Y; Richardson C; Chandar V; Borczuk A; Huang Y; Xiang J; Ho D; Schwartz R; tenOever B; Evans T
Preprint: RESEARCH SQUARE. 2020
Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2
Duan F; Guo L; Yang L; Han Y; Thakur A; Nilsson-Payant B; Wang P; Zhang Z; Ma CY; Zhou X; Han T; Zhang T; Wang X; Xu D; Duan X; Xiang J; Tse H-F; Liao C; Luo W; Huang F-P; Chen Y-W; Evans T; Schwartz R; tenOever B; Ho D; Chen S; Na J; Lian Q; Chen HJ
Preprint: RES SQ. 2020;RES SQ
Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2.
Duan F; Guo L; Yang L; Han Y; Thakur A; Nilsson-Payant BE; Wang P; Zhang Z; Yan Ma C; Zhou X; Han T; Zhang T; Wang X; Xu D; Duan X; Xiang J; Tse H-F; Liao C; Luo W; Huang F-P; Chen Y-W; Evans T; Schwartz RE; tenOever B; Ho DD; Chen S; Na J; Lian Q; Chen HJ
Preprint: BIORXIV. 2020;BIORXIV
Identification of Candidate COVID-19 Therapeutics using hPSC-derived Lung Organoids.
Han Y; Yang L; Duan X; Duan F; Nilsson-Payant BE; Yaron TM; Wang P; Tang X; Zhang T; Zhao Z; Bram Y; Redmond D; Houghton S; Nguyen D; Xu D; Wang X; Uhl S; Huang Y; Johnson JL; Xiang J; Wang H; Pan FC; Cantley LC; tenOever BR; Ho DD; Evans T; Schwartz RE; Chen HJ; Chen S
Preprint: BIORXIV. 2020
Identification of Drugs Blocking SARS-CoV-2 Infection using Human Pluripotent Stem Cell-derived Colonic Organoids
Duan X; Han Y; Yang L; Nilsson-Payant B; Wang P; Zhang T; Xiang J; Xu D; Wang X; Uhl S; Huang Y; Chen HJ; Wang H; tenOever B; Schwartz R; Ho D; Evans T; Pan FC; Chen S
Preprint: RESEARCH SQUARE. 2020
Identification of Drugs Blocking SARS-CoV-2 Infection using Human Pluripotent Stem Cell-derived Colonic Organoids
Duan X; Han Y; Yang L; Nilsson-Payant B; Wang P; Zhang T; Xiang J; Xu D; Wang X; Uhl S; Huang Y; Chen HJ; Wang H; tenOever B; Schwartz R; Ho D; Evans T; Pan FC; Chen S
Preprint: BIORXIV. 2020
Human organ chip-enabled pipeline to rapidly repurpose therapeutics during viral pandemics
Si L; Bai H; Rodas M; Cao W; Oh CY; Jiang A; Moller R; Hoagland D; Oishi K; Horiuchi S; Uhl S; Blanco-Melo D; Blanco-Melo D; Albrecht R; Liu W-C; Jordan T; Nilsson-Payant B; Logue J; Haupt R; McGrath M; Weston S; Nurani A; Kim SM; Zhu D; Benam K; Goyal G; Gilpin S; Prantil-Baun R; Powers R; Carlson K; Frieman M; tenOever B; Ingber D
Preprint: BIORXIV. 2020
SARS-CoV-2 launches a unique transcriptional signature from in vitro, ex vivo, and in vivo systems
Blanco-Melo D; Nilsson-Payant B; Liu W-C; Møller R; Panis M; Sachs D; Albrecht R; tenOever B
Preprint: BIORXIV. 2020
An inability to maintain the ribonucleoprotein genomic structure is responsible for host detection of negative-sense RNA viruses
Blanco-Melo D; Nilsson-Payant B; Uhl S; Escudero-Pèrez B; Olschewski S; Thibault P; Panis M; Rosenthal M; Muñoz-Fontela C; Lee B; tenOever B
Corrigendum: JOURNAL OF VIROLOGY. 2017;91(12):10.1128/jvi.00523-10.1128/jvi.00517
Erratum for Nilsson et al., "Role of the PB2 627 Domain in Influenza A Virus Polymerase Function".
Nilsson BE; Te Velthuis AJW; Fodor E

Grants

Characterisation of the molecular mechanisms of hantavirus polymerase function
Swedish Research Council
1 December 2024 - 30 November 2027
Defective hantavirus genomes as a determinant of the host immune response and pathogenesis
Swedish Research Council
1 January 2024 - 31 December 2027

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