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Research Group Peder Olofsson

Peder S Olofsson Group

Follow us on Twitter @immunBiologyLab

Visiting address:

Laboratory of Immunobiology
Akademiska Stråket 1
Bioclinicum J8:20
17164 Solna
Stockholm, Sweden

Research teams

Team Hansson, T cells in atherosclerosis

Team Ketelhuth, Immunometabolism in atherosclerosis

Team Olofsson, Neural control of inflammation

Recent Publications

Lehner KR, Silverman H, Adorissio M, Roay A, Al-Onaizi M, Levine YA, Olofsson PS, Chavan SS, Gros R, Nathanson N, Al-abed Y, Metz CN, Prado VF, Prado MAM, Tracey KJ, Pavlov VA. Forebrain cholinergic signaling regulates innate immune responses and inflammation. Front Immunol. In press.

Christersdottir T, Pirault J, Gisterå A, Bergman O, Gallina AL, Baumgartner R, Lundberg AM, Eriksson P, Yan ZQ, Paulsson-Berne G, Hansson GK, Olofsson PS, Halle M. Prevention of radiotherapy-induced arterial inflammation by IL-1 blockade. Eur Heart J. In press.

 

Germinal Center-Derived Antibodies Promote Atherosclerosis Plaque Size and Stability.
Centa M, Jin H, Hofste L, Hellberg S, Busch A, Baumgartner R, et al
Circulation 2019 May;139(21):2466-2482

Choline acetyltransferase-expressing T cells are required to control chronic viral infection.
Cox MA, Duncan GS, Lin GHY, Steinberg BE, Yu LX, Brenner D, et al
Science 2019 02;363(6427):639-644

Towards improved control of inflammatory bowel disease.
Eberhardson M, Hedin CRH, Carlson M, Tarnawski L, Levine YA, Olofsson PS
Scand. J. Immunol. 2019 Mar;89(3):e12745

Inflammation, protection, and the problems of translation.
Hansson GK
Nat Rev Cardiol 2018 Dec;15(12):729-730

Adenylyl Cyclase 6 Mediates Inhibition of TNF in the Inflammatory Reflex.
Tarnawski L, Reardon C, Caravaca AS, Rosas-Ballina M, Tusche MW, Drake AR, et al
Front Immunol 2018 ;9():2648

Low-Density Lipoprotein-Reactive T Cells Regulate Plasma Cholesterol Levels and Development of Atherosclerosis in Humanized Hypercholesterolemic Mice.
Gisterå A, Klement ML, Polyzos KA, Mailer RKW, Duhlin A, Karlsson MCI, et al
Circulation 2018 Nov;138(22):2513-2526

Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis.
Centa M, Prokopec KE, Garimella MG, Habir K, Hofste L, Stark JM, et al
Arterioscler. Thromb. Vasc. Biol. 2018 Aug;38(8):e145-e158

CD137: A checkpoint regulator involved in atherosclerosis.
Söderström LÅ, Tarnawski L, Olofsson PS
Atherosclerosis 2018 May;272():66-72

Activation of the Regulatory T-Cell/Indoleamine 2,3-Dioxygenase Axis Reduces Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice.
Forteza MJ, Polyzos KA, Baumgartner R, Suur BE, Mussbacher M, Johansson DK, et al
Front Immunol 2018 ;9():950

ERV1/ChemR23 Signaling Protects Against Atherosclerosis by Modifying Oxidized Low-Density Lipoprotein Uptake and Phagocytosis in Macrophages.
Laguna-Fernandez A, Checa A, Carracedo M, Artiach G, Petri MH, Baumgartner R, et al
Circulation 2018 Oct;138(16):1693-1705

Forebrain Cholinergic Dysfunction and Systemic and Brain Inflammation in Murine Sepsis Survivors.
Zaghloul N, Addorisio ME, Silverman HA, Patel HL, Valdés-Ferrer SI, Ayasolla KR, et al
Front Immunol 2017 ;8():1673

Increased Carotid Artery Lesion Inflammation Upon Treatment With the CD137 Agonistic Antibody 2A.
Söderström LÅ, Jin H, Caravaca AS, Klement ML, Li Y, Gisterå A, et al
Circ. J. 2017 Nov;81(12):1945-1952

Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population.
Mailer RKW, Gisterå A, Polyzos KA, Ketelhuth DFJ, Hansson GK
Sci Rep 2017 Nov;7(1):15655

Galantamine alleviates inflammation and insulin resistance in patients with metabolic syndrome in a randomized trial.
Consolim-Colombo FM, Sangaleti CT, Costa FO, Morais TL, Lopes HF, Motta JM, et al
JCI Insight 2017 Jul;2(14):

Dietary nitrate attenuates renal ischemia-reperfusion injuries by modulation of immune responses and reduction of oxidative stress.
Yang T, Zhang XM, Tarnawski L, Peleli M, Zhuge Z, Terrando N, et al
Redox Biol 2017 10;13():320-330

Bioelectronic medicine: technology targeting molecular mechanisms for therapy.
Olofsson PS, Tracey KJ
J. Intern. Med. 2017 07;282(1):3-4

Clinical studies and anti-inflammatory mechanisms of treatments.
French JA, Koepp M, Naegelin Y, Vigevano F, Auvin S, Rho JM, et al
Epilepsia 2017 07;58 Suppl 3():69-82

A novel flexible cuff-like microelectrode for dual purpose, acute and chronic electrical interfacing with the mouse cervical vagus nerve.
Caravaca AS, Tsaava T, Goldman L, Silverman H, Riggott G, Chavan SS, et al
J Neural Eng 2017 12;14(6):066005

Blood pressure regulation by CD4+ lymphocytes expressing choline acetyltransferase.
Olofsson PS, Steinberg BE, Sobbi R, Cox MA, Ahmed MN, Oswald M, et al
Nat. Biotechnol. 2016 Oct;34(10):1066-1071

A novel flexible cuff-like microelectrode for dual purpose, acute and chronic electrical interfacing with the mouse cervical vagus nerve.
Caravaca AS, Tsaava T, Goldman L, Silverman H, Riggott G, Chavan SS, et al
J Neural Eng 2017 12;14(6):066005

Emetine Di-HCl Attenuates Type 1 Diabetes Mellitus in Mice.
Hudson LK, Dancho ME, Li J, Bruchfeld JB, Ragab AA, He MM, et al
Mol. Med. 2016 Oct;22():585-596

Identification of CD163 as an antiinflammatory receptor for HMGB1-haptoglobin complexes.
Yang H, Wang H, Levine YA, Gunasekaran MK, Wang Y, Addorisio M, et al
JCI Insight ;1(7):

Neural Control of Inflammation: Implications for Perioperative and Critical Care.
Steinberg BE, Sundman E, Terrando N, Eriksson LI, Olofsson PS
Anesthesiology 2016 May;124(5):1174-89

Contact

Peder Olofsson

Senior researcher
Group P Olofsson
Department of Medicine, Solna (MedS), K2

Senior researcher

Peder Olofsson

Phone: +46-(0)8-517 716 67
Organizational unit: Group P Olofsson
E-mail: Peder.Olofsson@ki.se