Research group Peder Olofsson

Peder Olofsson

Associate Professor, Group leader

Visiting address

Laboratory of Immunobiology
Akademiska Stråket 1
Bioclinicum J8:20
17164 Solna
Stockholm, Sweden

Research teams

Peder Olofsson

Associate Professor

Nailin Li

Senior research specialist

Team Nailin Li


The Fourth Bioelectronic Medicine Summit "Technology Targeting Molecular Mechanisms": current progress, challenges, and charting the future.
Datta-Chaudhuri T, Zanos T, Chang EH, Olofsson PS, Bickel S, Bouton C, Grande D, Rieth L, Aranow C, Bloom O, Mehta AD, Civillico G, Stevens MM, Głowacki E, Bettinger C, Schüettler M, Puleo C, Rennaker R, Mohanta S, Carnevale D, Conde SV, Bonaz B, Chernoff D, Kapa S, Berggren M, Ludwig K, Zanos S, Miller L, Weber D, Yoshor D, Steinman L, Chavan SS, Pavlov VA, Al-Abed Y, Tracey KJ
Bioelectron Med 2021 May;7(1):7.

AMPA-Type Glutamate Receptors Associated With Vascular Smooth Muscle Cell Subpopulations in Atherosclerosis and Vascular Injury.
Gallina AL, Rykaczewska U, Wirka RC, Caravaca AS, Shavva VS, Youness M, Karadimou G, Lengquist M, Razuvaev A, Paulsson-Berne G, Quertermous T, Gisterå A, Malin SG, Tarnawski L, Matic L, Olofsson PS
Front Cardiovasc Med 2021 ;8:655869.

The brain-gut axis, inflammatory bowel disease and bioelectronic medicine.
Eberhardson M, Levine YA, Tarnawski L, Olofsson PS
Int Immunol 2021 Jun;33(6):349-356.

The Cholinergic Drug Galantamine Alleviates Oxidative Stress Alongside Anti-inflammatory and Cardio-Metabolic Effects in Subjects With the Metabolic Syndrome in a Randomized Trial.
Sangaleti CT, Katayama KY, De Angelis K, Lemos de Moraes T, Araújo AA, Lopes HF, Camacho C, Bortolotto LA, Michelini LC, Irigoyen MC, Olofsson PS, Barnaby DP, Tracey KJ, Pavlov VA, Consolim Colombo FM
Front Immunol 2021;12:613979.

Developing a vaccine against atherosclerosis.
Hansson GK, Nilsson J
Nat Rev Cardiol 2020 08;17(8):451-452

Expression of CARD8 in human atherosclerosis and its regulation of inflammatory proteins in human endothelial cells.
Paramel GV, Karadimou G, Eremo AG, Ljungberg LU, Hedin U, Olofsson PS, Folkersen L, Berne GP, Sirsjö A, Fransén K
Sci Rep 2020 11;10:19108. And Sci Rep. 2021 Apr 19;11(1):8852.

Treatment with a Toll‐like Receptor 7 ligand evokes protective immunity against atherosclerosis in hypercholesterolaemic mice.
Karadimou G, Gisterå A, Gallina AL, Caravaca AS, Centa M, Salagianni M, Andreakos E, Hansson GK, Malin S, Olofsson PS, Paulsson-Berne G.
J Inter Med 2020 Sep;288:321-334.

Vaccination Strategies and Immune Modulation of Atherosclerosis
Nilsson J, Hansson GK
Circ Res 2020 04;126(9):1281-1296.

Prolonged elevation of plasma HMGB1 is associated with cognitive impairment in intensive care unit survivors. 
Bruck E, Lasselin J, The HICUS Study Group, Andersson U, Sackey PV, Olofsson PS.
Intensive Care Med 2020 46:811–812.

Functions of acetylcholine-producing lymphocytes in immunobiology.
Malin SG, Shavva V, Tarnawski L, Olofsson PS.
Curr Opin Neurobiol. 2020 Jun;62:115-121.

Neural reflex control of vascular inflammation.
Caravaca AS, Centa M, Gallina AL, Tarnawski L, Olofsson PS.
Bioelectron Med. 2020 Jan 31;6:3.

Dietary nitrate attenuates high-fat diet-induced obesity via mechanisms involving higher adipocyte respiration and alterations in inflammatory status.
Peleli M, Ferreira DMS, Tarnawski L, McCann Haworth S, Xuechen L, Zhuge Z, et al
Redox Biol 2020 Jan;28:101387.

An Effective Method for Acute Vagus Nerve Stimulation in Experimental Inflammation.
Caravaca AS, Gallina AL, Tarnawski L, Tracey KJ, Pavlov VA, Levine YA, Olofsson PS
Front Neurosci 2019 ;13:877.

Bioelectronic medicine: an unexpected path to new therapies.
Olofsson PS, Bouton C
J Intern Med 2019 Sep;286(3):237-239.

Neural Control of Inflammation: Bioelectronic Medicine in Treatment of Chronic Inflammatory Disease.
Eberhardson M, Tarnawski L, Centa M, Olofsson PS
Cold Spring Harb Perspect Med 2020 03;10(3):a034181.

Lack of clinically relevant correlation between subjective and objective cognitive function in ICU survivors: a prospective 12-month follow-up study.
Brück E, Larsson JW, Lasselin J, Bottai M, Hirvikoski T, Sundman E, et al
Crit Care 2019 07;23(1):253.

Libby P, Buring JE, Badimon L, Hansson GK, Deanfield J, Bittencourt MS, et al
Nat Rev Dis Primers 2019 Aug;5(1):56.

Inflammasome-Driven Interleukin-1α and Interleukin-1β Production in Atherosclerotic Plaques Relates to Hyperlipidemia and Plaque Complexity.
Jiang X, Wang F, Wang Y, Gisterå A, Roy J, Paulsson-Berne G, et al
JACC Basic Transl Sci 2019 Jun;4(3):304-317.

Quantification of Atherosclerosis in Mice.
Centa M, Ketelhuth DFJ, Malin S, Gisterå A
J Vis Exp 2019 Jun;(148).

Forebrain Cholinergic Signaling Regulates Innate Immune Responses and Inflammation.
Lehner KR, Silverman HA, Addorisio ME, Roy A, Al-Onaizi MA, Levine Y, et al
Front Immunol 2019 ;10:585.

Prevention of radiotherapy-induced arterial inflammation by interleukin-1 blockade.
Christersdottir T, Pirault J, Gisterå A, Bergman O, Gallina AL, Baumgartner R, et al
Eur Heart J 2019 Aug;40(30):2495-2503.

Germinal Center-Derived Antibodies Promote Atherosclerosis Plaque Size and Stability.
Centa M, Jin H, Hofste L, Hellberg S, Busch A, Baumgartner R, et al
Circulation 2019 May;139(21):2466-2482

Choline acetyltransferase-expressing T cells are required to control chronic viral infection.
Cox MA, Duncan GS, Lin GHY, Steinberg BE, Yu LX, Brenner D, et al
Science 2019 02;363(6427):639-644.

Towards improved control of inflammatory bowel disease.
Eberhardson M, Hedin CRH, Carlson M, Tarnawski L, Levine YA, Olofsson PS
Scand J Immunol 2019 Mar;89(3):e12745

Inflammation, protection, and the problems of translation.
Hansson GK
Nat Rev Cardiol 2018 Dec;15(12):729-730.

Adenylyl Cyclase 6 Mediates Inhibition of TNF in the Inflammatory Reflex.
Tarnawski L, Reardon C, Caravaca AS, Rosas-Ballina M, Tusche MW, Drake AR, et al
Front Immunol 2018 ;9():2648.

Low-Density Lipoprotein-Reactive T Cells Regulate Plasma Cholesterol Levels and Development of Atherosclerosis in Humanized Hypercholesterolemic Mice.
Gisterå A, Klement ML, Polyzos KA, Mailer RKW, Duhlin A, Karlsson MCI, et al
Circulation 2018 Nov;138(22):2513-2526.

CD137: A checkpoint regulator involved in atherosclerosis.
Söderström LÅ, Tarnawski L, Olofsson PS
Atherosclerosis 2018 May;272:66-72.

Activation of the Regulatory T-Cell/Indoleamine 2,3-Dioxygenase Axis Reduces Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice.
Forteza MJ, Polyzos KA, Baumgartner R, Suur BE, Mussbacher M, Johansson DK, et al
Front Immunol 2018;9:950.

ERV1/ChemR23 Signaling Protects Against Atherosclerosis by Modifying Oxidized Low-Density Lipoprotein Uptake and Phagocytosis in Macrophages.
Laguna-Fernandez A, Checa A, Carracedo M, Artiach G, Petri MH, Baumgartner R, et al
Circulation 2018 Oct;138(16):1693-1705.

Forebrain Cholinergic Dysfunction and Systemic and Brain Inflammation in Murine Sepsis Survivors.
Zaghloul N, Addorisio ME, Silverman HA, Patel HL, Valdés-Ferrer SI, Ayasolla KR, et al
Front Immunol 2017 ;8:1673.

Increased Carotid Artery Lesion Inflammation Upon Treatment With the CD137 Agonistic Antibody 2A.
Söderström LÅ, Jin H, Caravaca AS, Klement ML, Li Y, Gisterå A, et al
Circ J 2017 Nov;81(12):1945-1952.

Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population.
Mailer RKW, Gisterå A, Polyzos KA, Ketelhuth DFJ, Hansson GK
Sci Rep 2017 Nov;7(1):15655.

Galantamine alleviates inflammation and insulin resistance in patients with metabolic syndrome in a randomized trial.
Consolim-Colombo FM, Sangaleti CT, Costa FO, Morais TL, Lopes HF, Motta JM, et al
JCI Insight 2017 Jul;2(14):e93340.

Dietary nitrate attenuates renal ischemia-reperfusion injuries by modulation of immune responses and reduction of oxidative stress.
Yang T, Zhang XM, Tarnawski L, Peleli M, Zhuge Z, Terrando N, et al
Redox Biol 2017 Oct;13:320-330.

Bioelectronic medicine: technology targeting molecular mechanisms for therapy.
Olofsson PS, Tracey KJ
J Intern Med 2017 07;282(1):3-4.

Clinical studies and anti-inflammatory mechanisms of treatments.
French JA, Koepp M, Naegelin Y, Vigevano F, Auvin S, Rho JM, et al
Epilepsia 2017 07;58 Suppl 3:69-82.

Blood pressure regulation by CD4+ lymphocytes expressing choline acetyltransferase.
Olofsson PS, Steinberg BE, Sobbi R, Cox MA, Ahmed MN, Oswald M, et al
Nat. Biotechnol. 2016 Oct;34(10):1066-1071

A novel flexible cuff-like microelectrode for dual purpose, acute and chronic electrical interfacing with the mouse cervical vagus nerve.
Caravaca AS, Tsaava T, Goldman L, Silverman H, Riggott G, Chavan SS, et al
J Neural Eng 2017 Dec;14(6):066005.

Emetine Di-HCl Attenuates Type 1 Diabetes Mellitus in Mice.
Hudson LK, Dancho ME, Li J, Bruchfeld JB, Ragab AA, He MM, et al
Mol Med 2016 Oct;22:585-596.

Identification of CD163 as an antiinflammatory receptor for HMGB1-haptoglobin complexes.
Yang H, Wang H, Levine YA, Gunasekaran MK, Wang Y, Addorisio M, et al
JCI Insight 2018 Dec 20; 3(24): e126617.

Neural Control of Inflammation: Implications for Perioperative and Critical Care.
Steinberg BE, Sundman E, Terrando N, Eriksson LI, Olofsson PS
Anesthesiology 2016 May;124(5):1174-89.