Anton Gisterå

About me
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About me

I am a physician-scientist pursuing research in the field of atherosclerosis
immunology. Currently appointed assistant professor in experimental
cardiovascular research.
2004-2010, Medical degree, Uppsala University
2010-2016, PhD in Cardiovascular Medicine and Immunology, Karolinska
Institutet

Research

Investigating how the adaptive immune system is specifically involved in the
atherosclerosis process as well as in other related cardiovascular diseases.

Teaching

Teaches in the medical program, the biomedicine program, for master students
and doctoral students. Member of the steering group for the cardiovascular
research doctoral program (CVR).

Articles

Journal article: CURRENT ATHEROSCLEROSIS REPORTS. 2024;27(1):4
Erosion of the Atheroma: Wicked T Cells at the Culprit Site
Lin S; Yu Y; Soderstrom LA; Gistera A
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2024;44(8):1852-1872
CD8⁺ T Cells Drive Plaque Smooth Muscle Cell Dedifferentiation in Experimental Atherosclerosis
Schaefer S; Gogiraju R; Roesch M; Kerstan Y; Beck L; Garbisch J; Saliba A-E; Gistera A; Hermanns HM; Boon L; Kastenmueller W; Schaefer K; Cochain C; Zernecke A
Article: JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH. 2024;17(4):768-778
Dysregulation of micro-RNA 143-3p as a Biomarker of Carotid Atherosclerosis and the Associated Immune Reactions During Disease Progression
Gonzalez-Lopez P; Yu Y; Lin S; Escribano O; Gomez-Hernandez A; Gistera A
Article: NATURE CARDIOVASCULAR RESEARCH. 2024;3(3):356-371
Kupffer cells dictate hepatic responses to the atherogenic dyslipidemic insult
Di Nunzio G; Hellberg S; Zhang Y; Ahmed O; Wang J; Zhang X; Bjoerck HM; Chizh V; Schipper R; Aulin H; Francis R; Fagerberg L; Gistera A; Metso J; Manfe V; Franco-Cereceda A; Eriksson P; Jauhiainen M; Hagberg CE; Olofsson PS; Malin SG
Article: CARDIOVASCULAR RESEARCH (CVR). 2023;119(11):2061-2073
Transforming growth factor-β2 is associated with atherosclerotic plaque stability and lower risk for cardiovascular events
Edsfeldt A; Singh P; Matthes F; Tengryd C; Cavalera M; Bengtsson E; Duner P; Volkov P; Karadimou G; Gistera A; Orho-Melander M; Nilsson J; Sun J; Goncalves I
Journal article: ATHEROSCLEROSIS. 2023;379:s23
PCSK6 ABLATION INCREASES ATHEROSCLEROTIC BURDEN, BUT PROVIDES PLAQUE STABILITY BY REGULATING TH17 AND SMOOTH MUSCLE CELL CONTENT
Matic L; Suur B; Karadimou G; Willems C; Bergman O; Lengquist M; Kronqvist M; Baumgartner R; Malin S; Gistera A; Hansson G; Malarstig A; Hedin U; Ketelhuth D
Journal article: ATHEROSCLEROSIS. 2023;379:s11
INDUCTION OF LIPID-LOWERING IMMUNE REACTIONS BY APOLIPOPROTEIN B-SPECIFIC T-HELPER CELLS IN HYPERCHOLESTEROLEMIC MICE
Lin S; Yu Y; Centa M; Malin S; Hansson G; Gistera A
Article: CARDIOVASCULAR RESEARCH (CVR). 2023;119(7):1524-1536
Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk
Forteza MJ; Berg M; Edsfeldt A; Sun J; Baumgartner R; Kareinen I; Casagrande FB; Hedin U; Zhang S; Vuckovic I; Dzeja PP; Polyzos KA; Gistera A; Trauelsen M; Schwartz TW; Dib L; Herrmann J; Monaco C; Matic L; Goncalves I; Ketelhuth DFJ
Journal article: JOURNAL OF IMMUNOLOGY. 2023;210(1):64.03
PD1 blockade promotes IFN-γ production by progenitor exhausted PD1-expressing T cells in atherosclerotic plaques
Mulholland M; Yu Y; Lin S; Jakobsson G; Schiopu A; Bjorkbacka H; Lichtman AH; Gistera A; Engelbertsen D
Journal article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2023;43
A Possible Role Of Apolipoprotein B In Degenerative Ascending Aortic Aneurysm Formation And Progression
Freiholtz D; Bergman O; Corbascio CO; Lang K; Olsson C; Franco-Cereceda A; Eriksson P; Gistera A; Bjorck HM
Article: JOURNAL OF PLASTIC, RECONSTRUCTIVE AND AESTHETIC SURGERY. 2023;76:18-26
Capsular inflammation after immediate breast reconstruction-Gene expression patterns and inflammatory cell infiltration in irradiated and non-irradiated breasts
Frisell A; Bergman O; Khan A; Gistera A; Fisher RM; Lagergren J; de Boniface J; Halle M
Article: CIRCULATION RESEARCH. 2022;130(12):1869-1887
Animal Models of Atherosclerosis-Supportive Notes and Tricks of the Trade
Gistera A; Ketelhuth DFJ; Malin SG; Hansson GK
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(9):5203
Genetic Deficiency of Indoleamine 2,3-dioxygenase Aggravates Vascular but Not Liver Disease in a Nonalcoholic Steatohepatitis and Atherosclerosis Comorbidity Model
Arora A; Tripodi GL; Kareinen I; Berg M; Forteza MJ; Gistera A; Griepke S; Casagrande FB; Martins JO; Abdalla DSP; Cole J; Monaco C; Ketelhuth DFJ
Journal article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2022;42:a217
PCSK6 Is A Key Regulator Of Immune Status In Mice And Its Ablation Increases Atherosclerotic Plaque Burden In A Bone Marrow Transplant Model
Suur BE; Karadimou G; Lengquist M; Kronqvist M; Gistera A; Malarstig A; Hedin U; Ketelhuth DF; Matic L
Article: PLATELETS. 2022;33(3):360-370
Platelets enhance CD4+central memory T cell responses via platelet factor 4-dependent mitochondrial biogenesis and cell proliferation
Tan S; Zhang J; Sun Y; Gistera A; Sheng Z; Malmstrom RE; Hou M; Peng J; Ma C; Liao W; Li N
Article: FRONTIERS IN CARDIOVASCULAR MEDICINE. 2022;9:831039
Inhibition of IL17A Using an Affibody Molecule Attenuates Inflammation in ApoE-Deficient Mice
Kumawat AK; Zegeye MM; Paramel GV; Baumgartner R; Gistera A; Amegavie O; Hellberg S; Jin H; Caravaca AS; Soderstrom LA; Gudmundsdotter L; Frejd FY; Ljungberg LU; Olofsson PS; Ketelhuth DFJ; Sirsjo A
Article: FRONTIERS IN CARDIOVASCULAR MEDICINE. 2021;8:655869
AMPA-Type Glutamate Receptors Associated With Vascular Smooth Muscle Cell Subpopulations in Atherosclerosis and Vascular Injury
Gallina AL; Rykaczewska U; Wirka RC; Caravaca AS; Shavva VS; Youness M; Karadimou G; Lengquist M; Razuvaev A; Paulsson-Berne G; Quertermous T; Gistera A; Malin SG; Tarnawski L; Matic L; Olofsson PS
Article: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2020;18(10):2685-2700
Platelet factor 4 enhances CD4⁺T effector memory cell responses via Akt-PGC1α-TFAM signaling-mediated mitochondrial biogenesis
Tan S; Li S; Min Y; Gistera A; Moruzzi N; Zhang J; Sun Y; Andersson J; Malmstrom RE; Wang M; Berggren P-O; Schlisio S; Liao W; Ketelhuth DFJ; Ma C; Li N
Article: CARDIOVASCULAR RESEARCH (CVR). 2020;116(12):1948-1957
3-Hydroxyanthralinic acid metabolism controls the hepatic SREBP/lipoprotein axis, inhibits inflammasome activation in macrophages, and decreases atherosclerosis in Ldlr^-/- mice
Berg M; Polyzos KA; Agardh H; Baumgartner R; Forteza MJ; Kareinen I; Gistera A; Bottcher G; Hurt-Camejo E; Hansson GK; Ketelhuth DFJ
Article: JOURNAL OF INTERNAL MEDICINE. 2020;288(3):321-334
Treatment with a Toll-like Receptor 7 ligand evokes protective immunity against atherosclerosis in hypercholesterolaemic mice
Karadimou G; Gistera A; Gallina AL; Caravaca AS; Centa M; Salagianni M; Andreakos E; Hansson GK; Malin S; Olofsson PS; Paulsson-Berne G
Article: INTERNATIONAL JOURNAL OF NANOMEDICINE. 2020;15:6137-6152
ORIGINAL RESEARCH Molecular Imaging of Inflammation in a Mouse Model of Atherosclerosis Using a Zirconium-89-Labeled Probe
Ahmed M; Tegnebratt T; Tran TA; Damberg P; Gistera A; Tarnawski L; Bone D; Hedin U; Eriksson P; Holmin S; Gustafsson B; Caidahl K
Journal article: EUROPEAN HEART JOURNAL. 2019;40(Supplement_1):ehz748.0689
P1942A trait of inflammation pathogenesis in human atherosclerosis: inflammasome driven interleukin-1 signaling in complex atherosclerotic plaques via hyperlipidemia trained innate immunity
Jiang X; Wang F; Wang J; Gistera A; Roy J; Berne GP; Hedin U; Lerman A; Hansson GK; Herrmann J; Yan Z
Journal article: EUROPEAN HEART JOURNAL. 2019;40(Supplement_1):ehz748.0176
P1217Zirconium-89 labelled probe for molecular imaging of inflammation in experimental atherosclerosis
Ahmed M; Tegnebratt T; Tran T; Damberg P; Bone D; Lu L; Gistera A; Tarnawski L; Hedin U; Eriksson P; Holmin S; Gustafsson B; Caidahl K
Article: EUROPEAN HEART JOURNAL. 2019;40(30):2495-2503
Prevention of radiotherapy-induced arterial inflammation by interleukin-1 blockade
Christersdottir T; Pirault J; Gistera A; Bergman O; Gallina AL; Baumgartner R; Lundberg AM; Eriksson P; Yan Z-Q; Paulsson-Berne G; Hansson GK; Olofsson PS; Halle M
Journal article: JOURNAL OF VISUALIZED EXPERIMENTS. 2019;(148)
Quantification of Atherosclerosis in Mice
Centa M; Ketelhuth DFJ; Malin S; Gisterå A
Article: JOURNAL OF VISUALIZED EXPERIMENTS. 2019;(148)
Quantification of Atherosclerosis in Mice
Centa M; Ketelhuth DFJ; Malin S; Gistera A
Article: JACC: BASIC TO TRANSLATIONAL SCIENCE. 2019;4(3):304-317
Inflammasome-Driven Interleukin-1α and Interleukin-1β Production in Atherosclerotic Plaques Relates to Hyperlipidemia and Plaque Complexity
Jiang X; Wang F; Wang Y; Gistera A; Roy J; Paulsson-Berne G; Hedin U; Lerman A; Hansson GK; Herrmann J; Yan Z-Q
Article: CIRCULATION. 2018;138(22):2513-2526
Low-Density Lipoprotein-Reactive T Cells Regulate Plasma Cholesterol Levels and Development of Atherosclerosis in Humanized Hypercholesterolemic Mice
Gistera A; Klement ML; Polyzos KA; Mailer RKW; Duhlin A; Karlsson MCI; Ketelhuth DFJ; Hansson GK
Article: CIRCULATION. 2018;138(16):1693-1705
ERV1/ChemR23 Signaling Protects Against Atherosclerosis by Modifying Oxidized Low-Density Lipoprotein Uptake and Phagocytosis in Macrophages
Laguna-Fernandez A; Checa A; Carracedo M; Artiach G; Petri MH; Baumgartner R; Forteza MJ; Jiang X; Andonova T; Walker ME; Dalli J; Arnardottir H; Gistera A; Thul S; Wheelock CE; Paulsson-Berne G; Ketelhuth DFJ; Hansson GK; Back M
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2018;38(8):e145-e158
Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis
Centa M; Prokopec KE; Garimella MG; Habir K; Hofste L; Stark JM; Dahdah A; Tibbitt CA; Polyzos KA; Gistera A; Johansson DK; Maeda NN; Hansson GK; Ketelhuth DFJ; Coquet JM; Binder CJ; Karlsson MCI; Malin S
Article: EUROPEAN HEART JOURNAL. 2018;39(27):2562-2573
Susceptibility of low-density lipoprotein particles to aggregate depends on particle lipidome, ismodifiable, and associates with future cardiovascular deaths
Ruuth M; Su DN; Vihervaara T; Hilvo M; Laajala TD; Kondadi PK; Gistera A; Lahteenmaki H; Kittila T; Huusko J; Uusitupa M; Schwab U; Savolainen MJ; Sinisalo J; Lokki M-L; Nieminen MS; Jula A; Perola M; Yla-Herttula S; Rudel L; Oorni A; Baumann M; Baruch A; Laaksonen R; Ketelhuth DFJ; Aittokallio T; Jauhiainen M; Kakela R; Boren J; Williams KJ; Kovanen PT; Oorni K
Article: CIRCULATION JOURNAL. 2017;81(12):1945-1952
Increased Carotid Artery Lesion Inflammation Upon Treatment With the CD137 Agonistic Antibody 2A
Soderstrom LA; Jin H; Caravaca AS; Klement ML; Li Y; Gistera A; Hedin U; Maegdefessel L; Hansson GK; Olofsson PS
Article: SCIENTIFIC REPORTS. 2017;7(1):15655
Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population
Mailer RKW; Gistera A; Polyzos KA; Ketelhuth DFJ; Hansson GK
Article: CIRCULATION RESEARCH. 2017;120(11):1740-1753
Hypercholesterolemia Induces Differentiation of Regulatory T Cells in the Liver
Mailer RKW; Gistera A; Polyzos KA; Ketelhuth DFJ; Hansson GK
Article: JOURNAL OF INTERNAL MEDICINE. 2017;281(4):383-397
Vaccination against T-cell epitopes of native ApoB100 reduces vascular inflammation and disease in a humanized mouse model of atherosclerosis
Gistera A; Hermansson A; Strodthoff D; Klement ML; Hedin U; Fredrikson GN; Nilsson J; Hansson GK; Ketelhuth DFJ
Journal article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2015;35(suppl_1)
Abstract 368: Inhibition of Ido-mediated Tryptophan Metabolism Aggravates Atherosclerosis in Hypercholesterolemic Mice
Polyzos KA; Ovchinnikova O; Berg M; Baumgartner R; Agardh H; Pirault J; Gisterå A; Assinger A; Laguna Fernandez A; Bäck M; Hansson GK; Ketelhuth DF
Article: CARDIOVASCULAR RESEARCH (CVR). 2015;106(2):295-302
Inhibition of indoleamine 2,3-dioxygenase promotes vascular inflammation and increases atherosclerosis in Apoe-/- mice
Polyzos KA; Ovchinnikova O; Berg M; Baumgartner R; Agardh H; Pirault J; Gistera A; Assinger A; Laguna-Fernandez A; Baeck M; Hansson GK; Ketelhuth DFJ
Article: METHODS IN MOLECULAR BIOLOGY. 2015;1339:149-159
Immunostaining of Lymphocytes in Mouse Atherosclerotic Plaque.
Gisterå A; Ketelhuth DFJ
Article: CURRENT PHARMACEUTICAL DESIGN. 2013;19(33):5850-5858
T Cell-based Therapies for Atherosclerosis
Ketelhuth DFJ; Gistera A; Johansson DK; Hansson GK
Article: SCIENCE TRANSLATIONAL MEDICINE. 2013;5(196):196ra100
Transforming Growth Factor-β Signaling in T Cells Promotes Stabilization of Atherosclerotic Plaques Through an Interleukin-17-Dependent Pathway
Gistera A; Robertson A-KL; Andersson J; Ketelhuth DFJ; Ovchinnikova O; Nilsson SK; Lundberg AM; Li MO; Flavell RA; Hansson GK
Article: JOURNAL OF CLINICAL INVESTIGATION. 2013;123(3):1323-1334
Depletion of FOXP3⁺ regulatory T cells promotes hypercholesterolemia and atherosclerosis
Klingenberg R; Gerdes N; Badeau RM; Gistera A; Strodthoff D; Ketelhuth DFJ; Lundberg AM; Rudling M; Nilsson SK; Olivecrona G; Zoller S; Lohmann C; Luescher TF; Jauhiainen M; Sparwasser T; Hansson GK
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All other publications

Editorial comment: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2024;44(6):1315-1317
Virus-Specific T Cells in the Atheroma Crime Scene: Guilty Accomplices or Innocent Bystanders?
Gistera A
Preprint: BIORXIV. 2023
Platelet-specific TGFβ1 deficiency aggravates atherosclerosis, vascular inflammation, and hypercholesterolemia in mice
Tan S; Sun Y; Sheng Z; Min Y; Gisterå A; Zhang J; Ketelhuth DFJ; Liao W; Andersson J; Hu H; Wang M; Hou M; Zhang M; Peng J; Ma C; Li N
Preprint: BIORXIV. 2022
Kupffer cells dictate hepatic responses to the atherogenic dyslipidemic insult
Hellberg S; Ahmed O; Zhang Y; Di Nunzio G; Björck HM; Francis R; Fagerberg L; Gisterå A; Zhang X; Metso J; Manfé V; Soto Y; Franco-Cereceda A; Eriksson P; Jauhiainen M; Olofsson PS; Malin SG
Review: FRONTIERS IN CARDIOVASCULAR MEDICINE. 2022;9:864602
The Spectrum of B Cell Functions in Atherosclerotic Cardiovascular Disease
Smeets D; Gistera A; Malin SG; Tsiantoulas D
Conference publication: EUROPEAN HEART JOURNAL. 2020;41:3832
Treating ApoE-/- mice with Toll-like receptor 7 ligand lead to expansion of marginal zone B cells, reduced plasma cholesterol and decreased atherosclerosis
Paulsson-Berne G; Karadimou G; Gistera A; Gallina A; Centa M; Salagianni M; Andreakos E; Hansson GK; Malin S; Olofsson P
Conference publication: EUROPEAN HEART JOURNAL. 2019;40:1232
A trait of inflammation pathogenesis in human atherosclerosis: inflammasome driven interleukin-1 signaling in complex atherosclerotic plaques via hyperlipidemia trained innate immunity
Jiang X; Wang F; Wang J; Gistera A; Roy J; Berne GP; Hedin U; Lerman A; Hansson GK; Herrmann J; Yan Z
Conference publication: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2019;39
In vivo Effects of Toll like Receptor 7 Ligand in Experimental Atherosclerosis
Karadimou G; Gistera A; Centa M; Hansson GK; Paulsson-Berne G
Conference publication: EUROPEAN HEART JOURNAL. 2019;40:674
Zirconium-89 labelled probe for molecular imaging of inflammation in experimental atherosclerosis
Ahmed M; Tegnebratt T; Tran T; Damberg P; Bone D; Lu L; Gistera A; Tarnawski L; Hedin U; Eriksson P; Holmin S; Gustafsson B; Caidahl K
Review: CURRENT OPINION IN LIPIDOLOGY. 2018;29(5):375-380
Lipid-driven immunometabolic responses in atherosclerosis
Gistera A; Ketelhuth DFJ
Meeting abstract: ATHEROSCLEROSIS. 2017;263:E12
INSTABILITY OF LDL PARTICLES PREDICTS FUTURE CARDIOVASCULAR DEATHS
Ruuth M; Nguyen SD; Vihervaara T; Hilvo M; Laajala TD; Kondadi PK; Anton G; Huusko J; Uusitupa M; Schwab U; Lawrence R; Ketelhuth D; Laaksonen R; Baumann M; Aittokallio T; Jauhiainen M; Jan B; Williams KJ; Kovanen P; Oorni K
Review: NATURE REVIEWS NEPHROLOGY. 2017;13(6):368-380
The immunology of atherosclerosis
Gistera A; Hansson GK
Thesis / dissertation: 2015
T-cell specificity and regulation in atherosclerosis
Gisterå, Anton
Meeting abstract: ATHEROSCLEROSIS. 2014;235(2):e88-e89
TRANSFORMING GROWTH FACTOR-BETA SIGNALING IN T CELLS PROMOTES STABILIZATION OF ATHEROSCLEROTIC PLAQUES THROUGH AN INTERLEUKIN-17 DEPENDENT PATHWAY
Gistera A; Robertson AK; Andersson J; Ketelhuth DFJ; Oychinnikova O; Nilsson SK; Lundberg AM; Li MO; Flavell RA; Hansson GK
Meeting abstract: ATHEROSCLEROSIS. 2014;235(2):E140
INHIBITION OF INDOLEAMINE 2,3-DIOXYGENASE-MEDIATED TRYPTOPHAN CATABOLISM ACCELERATES ATHEROSCLEROSIS IN HYPERCHOLESTEROLEMIC MICE
Polyzos K; Agardh H; Ovchinnikova O; Pirault J; Berg M; Gistera A; Assinger A; Laguna-Fernandez A; Back M; Hansson GK; Ketelhuth DFJ
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2011;12(1):61-62
TARGETED GENE DELETION IN THE TGF-BETA SIGNALING PATHWAY AFFECTS ATHEROSCLEROSIS AND TH17 CELL DIFFERENTIATION IN HYPERCHOLESTEROLEMIC MICE
Gistera A; Robertson AK; Andersson J; Ketelhuth DFJ; Lundberg AM; Li MO; Flavell RA; Hansson GK

Grants

Inflammation, ateroskleros och hjärtkärlsjukdom
Swedish Heart-Lung Foundation
1 January 2021 - 31 December 2023
Immune-Vascular Interactions in Atherosclerosis
Swedish Research Council
1 January 2021 - 31 December 2024
Nya läkemedel genom studier av LDL-autoimmunitet vid ateroskleros
Swedish Heart-Lung Foundation
1 January 2019 - 31 December 2021
Immune-Vascular Interactions in Atherosclerosis
Swedish Research Council
1 January 2017 - 31 December 2020

Employments

Assistant Professor, Department of Medicine, Karolinska Institutet, 2021-2025

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Medicine, Solna, Karolinska Institutet, 2016

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