Molecular Vascular Medicine – Team Lars Maegdefessel

Publications

Selected publications

• Article: MOLECULAR THERAPY. 2023;31(6):1775-1790

  Targeting long non-coding RNA NUDT6 enhances smooth muscle cell survival and limits vascular disease progression

  Winter H; Winski G; Busch A; Chernogubova E; Fasolo F; Wu Z; Baecklund A; Khomtchouk BB; Booven DJV; Sachs N; Eckstein H-H; Wittig I; Boon RA; Jin H; Maegdefessel L
• Review: CARDIOVASCULAR RESEARCH. 2021;117(14):2742-2754

  Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases

  Paloschi V; Sabater-Lleal M; Middelkamp H; Vivas A; Johansson S; van der Meer A; Tenje M; Maegdefessel L
• Article: CIRCULATION. 2021;144(19):1567-1583

  Long Noncoding RNA MIAT Controls Advanced Atherosclerotic Lesion Formation and Plaque Destabilization

  Fasolo F; Jin H; Winski G; Chernogubova E; Pauli J; Winter H; Li DY; Glukha N; Bauer S; Metschl S; Wu Z; Koschinsky ML; Reilly M; Pelisek J; Kempf W; Eckstein H-H; Soehnlein O; Matic L; Hedin U; Baecklund A; Bergmark C; Paloschi V; Maegdefessel L
• Article: NATURE. 2019;569(7755):236-240

  Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death

  Silvestre-Roig C; Braster Q; Wichapong K; Lee EY; Marie Teulon J; Berrebeh N; Winter J; Adrover JM; Santos GS; Froese A; Lemnitzer P; Ortega-Gomez A; Chevre R; Marschner J; Schumski A; Winter C; Perez-Olivares L; Pan C; Paulin N; Schoufour T; Hartwig H; Gonzalez-Ramos S; Kamp F; Megens RTA; Mowen KA; Gunzer M; Maegdefessel L; Hackeng T; Lutgens E; Daemen M; von Blume J; Anders H-J; Nikolaev VO; Pellequer J-L; Weber C; Hidalgo A; Nicolaes GAF; Wong GCL; Soehnlein O
• Article: JACC-BASIC TO TRANSLATIONAL SCIENCE. 2019;4(1):72-82

  miR-29b Mediates the Chronic Inflammatory Response in Radiotherapy-Induced Vascular Disease

  Eken SM; Christersdottir T; Winski G; Sangsuwan T; Jin H; Chernogubova E; Pirault J; Sun C; Simon N; Winter H; Backlund A; Haghdoost S; Hansson GK; Halle M; Maegdefessel L
• Article: CIRCULATION. 2018;138(15):circulationaha.117.032184-1568

  H19 Induces Abdominal Aortic Aneurysm Development and Progression

  Li DY; Busch A; Jin H; Chernogubova E; Pelisek J; Karlsson J; Sennblad B; Liu S; Lao S; Hofmann P; Baecklund A; Eken SM; Roy J; Eriksson P; Dacken B; Ramanujam D; Dueck A; Engelhardt S; Boon RA; Eckstein H-H; Spin JM; Tsao PS; Maegdefessel L
• Article: MOLECULAR THERAPY. 2018;26(4):1040-1055

  Local Delivery of miR-21 Stabilizes Fibrous Caps in Vulnerable Atherosclerotic Lesions

  Jin H; Li DY; Chernogubova E; Sun C; Busch A; Eken SM; Saliba-Gustafsson P; Winter H; Winski G; Raaz U; Schellinger IN; Simon N; Hegenloh R; Matic LP; Jagodic M; Ehrenborg E; Pelisek J; Eckstein H-H; Hedin U; Backlund A; Maegdefessel L
• Article: CIRCULATION RESEARCH. 2017;120(4):633-644

  MicroRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions

  Eken SM; Jin H; Chernogubova E; Li Y; Simon N; Sun C; Korzunowicz G; Busch A; Backlund A; Osterholm C; Razuvaev A; Renne T; Eckstein HH; Pelisek J; Eriksson P; Diez MG; Matic LP; Schellinger IN; Raaz U; Leeper NJ; Hansson GK; Paulsson-Berne G; Hedin U; Maegdefessel L
• Article: NATURE. 2016;536(7614):86-90

  CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis

  Kojima Y; Volkmer J-P; McKenna K; Civelek M; Lusis AJ; Miller CL; Direnzo D; Nanda V; Ye J; Connolly AJ; Schadt EE; Quertermous T; Betancur P; Maegdefessel L; Matic LP; Hedin U; Weissman IL; Leeper NJ
• Article: NATURE. 2014;509(7502):641-644

  Dichloroacetate prevents restenosis in preclinical animal models of vessel injury

  Deuse T; Hua X; Wang D; Maegdefessel L; Heeren J; Scheja L; Bolanos JP; Rakovic A; Spin JM; Stubbendorff M; Ikeno F; Laenger F; Zeller T; Schulte-Uentrop L; Stoehr A; Itagaki R; Haddad F; Eschenhagen T; Blankenberg S; Kiefmann R; Reichenspurner H; Velden J; Klein C; Yeung A; Robbins RC; Tsao PS; Schrepfer S

Funding

Staff and contact

Group leader

• 

  Lars Maegdefessel

  Principal Researcher

  E-mail lars.maegdefessel@ki.se

Contact persons

• 

  Ekaterina Chernogubova

  Laboratory Engineer

  E-mail ekaterina.chernogubova@ki.se

All members of the group

• 

  Ekaterina Chernogubova

  Laboratory Engineer

  E-mail ekaterina.chernogubova@ki.se
• 

  Lars Maegdefessel

  Principal Researcher

  E-mail lars.maegdefessel@ki.se
• Greg Winski

  Affiliated to Research

  E-mail greg.winski@ki.se

Consortia and Networks

Prizes and Awards