We are interested in the development of the brain in health and disease, in particular brain regions involved in social, emotional/affective and cognitive processes. We are specifically interested in molecular mechanisms underlying the regulation of stem cell and progenitor characteristics and differentiation into functional neurons and other cell types. To investigate these topics, we use advanced molecular techniques, including genome-wide analyses of chromatin, and the most relevant cell types, involving translational collaborations with clinicians. Our activities can be divided into three main, overlapping branches:
- Transcriptional and epigenetic regulation of stem cell state and fate to generate functional systems for repair of a damaged nervous system, for example after surgery, and increased understanding of psychiatric disease;
- Transcriptional and epigenetic regulation of tumor cell and cancer-derived stem cell state and fate, especially in glioma and medulloblastoma;
- Biomedical engineering and studies of microenvironment (see, e.g., Biomaterials, 2007; 2009; 2012) to provide novel approaches for stem and cancer cell biology and clinical applications in regenerative medicine.
We participate actively in several networks of neuroscience, cancer, bioengineering, stem cells, and regenerative medicine. In addition, we are dedicated fans of basic science and are involved in many outreach activities.
A SNP in the HTT promoter alters NF-κB binding and is a bidirectional genetic modifier of Huntington disease.
Bečanović K, Nørremølle A, Neal SJ, Kay C, Collins JA, Arenillas D, et al
Nat. Neurosci. 2015 Jun;18(6):807-16
Neural stem cell differentiation is dictated by distinct actions of nuclear receptor corepressors and histone deacetylases.
Castelo-Branco G, Lilja T, Wallenborg K, Falcão AM, Marques SC, Gracias A, et al
Stem Cell Reports 2014 Sep;3(3):502-15
CtBPs sense microenvironmental oxygen levels to regulate neural stem cell state.
Dias JM, Ilkhanizadeh S, Karaca E, Duckworth JK, Lundin V, Rosenfeld MG, et al
Cell Rep 2014 Aug;8(3):665-70
NCoR controls glioblastoma tumor cell characteristics.
Heldring N, Nyman U, Lönnerberg P, Onnestam S, Herland A, Holmberg J, et al
Neuro-oncology 2014 Jan;16(2):241-9
The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy.
Füllgrabe J, Lynch-Day MA, Heldring N, Li W, Struijk RB, Ma Q, et al
Nature 2013 Aug;500(7463):468-71