Frida Holm

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Articles

Article: EXPERIMENTAL CELL RESEARCH. 2024;437(2):114015
The CNS microenvironment promotes leukemia cell survival by disrupting tumor suppression and cell cycle regulation in pediatric T-cell acute lymphoblastic leukemia
Enlund S; Sinha I; Neofytou C; Amor AR; Papadakis K; Nilsson A; Jiang Q; Hermanson O; Holm F
Journal article: CANCER RESEARCH. 2024;84(6_Supplement):5448
Abstract 5448: Malignant RNA editing by inflammation-responsive RNA editase ADAR1 drives T-cell leukemia relapse via attenuating dsRNA sensing
Rivera MD; Zhang H; Zhou Q; Pham J; Isquith J; Sasik R; Mark A; Enlund S; Holm F; Wenxue M; Fisch K; Kuo D; Jamieson C; Jiang Q
Article: CELL REPORTS. 2024;43(2):113704
Malignant A-to-I RNA editing by ADAR1 drives T cell acute lymphoblastic leukemia relapse via attenuating dsRNA sensing
Rivera M; Zhang H; Pham J; Isquith J; Zhou QJ; Balaian L; Sasik R; Enlund S; Mark A; Ma W; Holm F; Fisch KM; Kuo DJ; Jamieson C; Jiang Q
Journal article: BLOOD. 2023;142:4346
The CNS Microenvironment Promotes Leukemia Cell Survival By Disrupting Tumour Suppression and Cell Cycle Regulation in Pediatric T-Cell Acute Lymphoblastic Leukemia
Enlund S; Neofytou C; Sinha I; Amor AR; Nilsson AB; Jiang Q; Hermanson O; Holm F
Journal article: BLOOD. 2023;142:4147
Malignant a-to-I RNA Editing By ADAR1 Drives T-Cell Acute Lymphoblastic Leukemia Relapse Via Attenuating dsRNA Sensing
Rivera MD; Pham J; Isquith J; Zhang H; Zhou J; Sasik R; Mark A; Ma W; Holm F; Fisch K; Kuo DJ; Jamieson C; Jiang Q
Article: EJHAEM. 2023;4(1):115-124
Malignant DFFB isoform switching promotes leukemia survival in relapse pediatric T-cell acute lymphoblastic leukemia
Enlund S; Sinha I; Amor AR; Fard SS; Tamm EP; Jiang Q; Lundin V; Nilsson A; Holm F
Article: CELL REPORTS. 2021;34(4):108670
Inflammation-driven deaminase deregulation fuels human pre-leukemia stem cell evolution
Jiang Q; Isquith J; Ladel L; Mark A; Holm F; Mason C; He Y; Mondala P; Oliver I; Pham J; Ma W; Reynoso E; Ali S; Morris IJ; Diep R; Nasamran C; Xu G; Sasik R; Rosenthal SB; Birmingham A; Coso S; Pineda G; Crews L; Donohoe ME; Venter JC; Whisenant T; Mesa RA; Alexandrov LB; Fisch KM; Jamieson C
Article: CANCER CELL. 2019;35(1):81-94.e7
Hyper-Editing of Cell-Cycle Regulatory and Tumor Suppressor RNA Promotes Malignant Progenitor Propagation.
Jiang Q; Isquith J; Zipeto MA; Diep RH; Pham J; Delos Santos N; Reynoso E; Chau J; Leu H; Lazzari E; Melese E; Ma W; Fang R; Minden M; Morris S; Ren B; Pineda G; Holm F; Jamieson C
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(50):15444-15449
Reversion to an embryonic alternative splicing program enhances leukemia stem cell self-renewal.
Holm F; Hellqvist E; Mason CN; Ali SA; Delos-Santos N; Barrett CL; Chun H-J; Minden MD; Moore RA; Marra MA; Runza V; Frazer KA; Sadarangani A; Jamieson CHM
Article: PLOS ONE. 2015;10(3):e0116668
Selective MicroRNA-Offset RNA Expression in Human Embryonic Stem Cells
Asikainen S; Heikkinen L; Juhila J; Holm F; Weltner J; Trokovic R; Mikkola M; Toivonen S; Balboa D; Lampela R; Icay K; Tuuri T; Otonkoski T; Wong G; Hovatta O
Article: STEM CELLS AND DEVELOPMENT. 2013;22(13):1883-1892
Passaging Techniques and ROCK Inhibitor Exert Reversible Effects on Morphology and Pluripotency Marker Gene Expression of Human Embryonic Stem Cell Lines
Holm F; Nikdin H; Kjartansdottir KR; Gaudenzi G; Fried K; Aspenstrom P; Hermanson O; Bergstrom-Tengzelius R
Article: STEM CELLS AND DEVELOPMENT. 2012;21(18):3363-3371
In Vivo Differentiated Human Embryonic Stem Cells Can Acquire Chromosomal Aberrations More Frequently Than In Vitro During the Same Period
Zucchelli M; Strom S; Holm F; Malmgren H; Sahlen S; Religa P; Hovatta O; Kere J; Inzunza J
Article: WORLD JOURNAL OF HEPATOLOGY. 2012;4(5):176-183
Improved cryopreservation of human hepatocytes using a new xeno free cryoprotectant solution.
Saliem M; Holm F; Tengzelius RB; Jorns C; Nilsson L-M; Ericzon B-G; Ellis E; Hovatta O
Article: NATURE BIOTECHNOLOGY. 2011;29(12):1132-1144
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage
Amps K; Andrews PW; Anyfantis G; Armstrong L; Avery S; Baharvand H; Baker J; Baker D; Munoz MB; Beil S; Benvenisty N; Ben-Yosef D; Biancotti J-C; Bosman A; Brena RM; Brison D; Caisander G; Camarasa MV; Chen J; Chiao E; Choi YM; Choo ABH; Collins D; Colman A; Crook JM; Daley GQ; Dalton A; De Sousa PA; Denning C; Downie J; Dvorak P; Montgomery KD; Feki A; Ford A; Fox V; Fraga AM; Frumkin T; Ge L; Gokhale PJ; Golan-Lev T; Gourabi H; Gropp M; Lu G; Hampl A; Harron K; Healy L; Herath W; Holm F; Hovatta O; Hyllner J; Inamdar MS; Irwanto AK; Ishii T; Jaconi M; Jin Y; Kimber S; Kiselev S; Knowles BB; Kopper O; Kukharenko V; Kuliev A; Lagarkova MA; Laird PW; Lako M; Laslett AL; Lavon N; Lee DR; Lee JE; Li C; Lim LS; Ludwig TE; Ma Y; Maltby E; Mateizel I; Mayshar Y; Mileikovsky M; Minger SL; Miyazaki T; Moon SY; Moore H; Mummery C; Nagy A; Nakatsuji N; Narwani K; Oh SKW; Oh SK; Olson C; Otonkoski T; Pan F; Park I-H; Pells S; Pera MF; Pereira LV; Qi O; Raj GS; Reubinoff B; Robins A; Robson P; Rossant J; Salekdeh GH; Schulz TC; Sermon K; Mohamed JS; Shen H; Sherrer E; Sidhu K; Sivarajah S; Skottman H; Spits C; Stacey GN; Strehl R; Strelchenko N; Suemori H; Sun B; Suuronen R; Takahashi K; Tuuri T; Venu P; Verlinsky Y; Ward-van Oostwaard D; Weisenberger DJ; Wu Y; Yamanaka S; Young L; Zhou Q
Article: METHODS IN MOLECULAR BIOLOGY. 2011;767:125-136
Xeno-free culture of human pluripotent stem cells.
Bergström R; Ström S; Holm F; Feki A; Hovatta O
Article: PLOS ONE. 2010;5(12):e15329
No Relationship between Embryo Morphology and Successful Derivation of Human Embryonic Stem Cell Lines
Strom S; Rodriguez-Wallberg K; Holm F; Bergstrom R; Eklund L; Stromberg A-M; Hovatta O
Article: HUMAN REPRODUCTION. 2010;25(5):1271-1279
An effective serum- and xeno-free chemically defined freezing procedure for human embryonic and induced pluripotent stem cells
Holm F; Strom S; Inzunza J; Baker D; Stromberg A-M; Rozell B; Feki A; Bergstrom R; Hovatta O
Article: PLOS ONE. 2010;5(4):e10263
A Teratocarcinoma-Like Human Embryonic Stem Cell (hESC) Line and Four hESC Lines Reveal Potentially Oncogenic Genomic Changes
Hovatta O; Jaconi M; Tohonen V; Bena F; Gimelli S; Bosman A; Holm F; Wyder S; Zdobnov EM; Irion O; Andrews PW; Antonarakis SE; Zucchelli M; Kere J; Feki A
Article: IN VITRO CELLULAR AND DEVELOPMENTAL BIOLOGY - ANIMAL. 2010;46(3-4):337-344
Derivation of 30 human embryonic stem cell lines-improving the quality
Strom S; Holm F; Bergstrom R; Stromberg A-M; Hovatta O
Article: IN VITRO CELLULAR AND DEVELOPMENTAL BIOLOGY - ANIMAL. 2010;46(3-4):247-258
Comparison of defined culture systems for feeder cell free propagation of human embryonic stem cells
Akopian V; Andrews PW; Beil S; Benvenisty N; Brehm J; Christie M; Ford A; Fox V; Gokhale PJ; Healy L; Holm F; Hovatta O; Knowles BB; Ludwig TE; McKay RDG; Miyazaki T; Nakatsuji N; Oh SKW; Pera MF; Rossant J; Stacey GN; Suemori H
Article: STEM CELL REVIEWS AND REPORTS. 2009;5(4):301-314
Consensus Guidance for Banking and Supply of Human Embryonic Stem Cell Lines for Research Purposes
Andrews PW; Arias-Diaz J; Auerbach J; Alvarez M; Ahrlund-Richter L; Baker D; Benvenisty N; Ben-Josef D; Blin G; Borghese L; Borstlap J; Bruce K; Bruestle O; Buckle R; Camby C; Choo A; Chen W; Collins D; Colman A; Crombie C; Crook J; Cypess R; De Sousa P; Dhawan J; Douay L; Dvorak P; Dyke T; Eriksson L; Firpo M; Fitzgerald C; Glover C; Gokhale P; Greene M; Ha H-Y; Hampl A; Healy L; Hei D; Holm F; Hovatta O; Hunt C; Hwang S-M; Inamdar M; Isasi R; Itskovitz-Eldor J; Jessie N; Kim D-W; Kirzner R; Kiatpongsan S; Knowles B; Kuo H-C; Laughlin M; Lavon N; Ludwig T; Lakov M; Lee D-R; Macauley J; McKay R; Menasche P; Menendez P; Michalska A; Mileikovskaia M; Minger S; Mishra G; Moody J; Montgomery K; Morris C; Mummery C; Nagy A; Nakamura Y; Nakatsuji N; Nishikawa S-I; Oh S; Oh SK; Olson P; Otonkoski T; Patole M; Park H-S; Pei X; Pera M; Puceat M; Rajala K; Reubinoff B; Robins A; Rooke H; Rumayor V; Scotman H; Sherlock J; Simon C; Sipp D; Skinner R; Smith D; Stacey G; Stefanovic S; Strehl R; Taft R; Takahashi T; Talib S; Terstegge S; Turner R; Tuuri T; Yu J; Zandstra P; Zapata A; Zeng F; Zhou Q; Tannenbaum S
Article: HUMAN REPRODUCTION. 2009;24(10):2567-2581
Immortalized human skin fibroblast feeder cells support growth and maintenance of both human embryonic and induced pluripotent stem cells
Unger C; Gao S; Cohen M; Jaconi M; Bergstrom R; Holm F; Galan A; Sanchez E; Irion O; Dubuisson JB; Giry-Laterriere M; Salmon P; Simon C; Hovatta O; Feki A
Journal article: DRUG DISCOVERY TODAY: TECHNOLOGIES. 2008;5(4):e131-e137
Derivation, maintenance and cryostorage of human embryonic stem cells.
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Preprint: BIORXIV. 2024
A Distinct Alternative mRNA Splicing Profile Identifies the Oncogenic CD44 Transcript Variant 3 in KMT2A-Rearranged Pediatric T-cell Acute Lymphoblastic Leukemia Cells
Amor AR; Enlund S; Sinha I; Jiang Q; Hermanson O; Nilsson A; Shirazi Fard S; Holm F
Preprint: BIORXIV. 2023
The CNS Microenvironment Promotes Leukemia Cell Survival by Disrupting Tumor Suppression and Cell Cycle Regulation in Pediatric T-cell Acute Lymphoblastic Leukemia
Enlund S; Sinha I; Neofytou C; Amor AR; Papadakis K; Nilsson A; Jiang Q; Hermanson O; Holm F
Preprint: RES SQ. 2023;RES SQ
Malignant A-to-I RNA editing by ADAR1 drives T-cell acute lymphoblastic leukemia relapse via attenuating dsRNA sensing.
Rivera M; Zhang H; Pham J; Isquith J; Zhou QJ; Sasik R; Mark A; Ma W; Holm F; Fisch KM; Kuo DJ; Jamieson C; Jiang Q
Preprint: RESEARCH SQUARE. 2023
Malignant A-to-I RNA editing by ADAR1 drives T-cell acute lymphoblastic leukemia relapse via attenuating dsRNA sensing
Rivera M; Zhang H; Pham J; Isquith J; Zhou QJ; Sasik R; Mark A; Ma W; Holm F; Fisch KM; Kuo DJ; Jamieson C; Jiang Q
Preprint: RESEARCH SQUARE. 2023
ADAR1 drives stemness of leukemia initiating cells in T-cell acute lymphoblastic leukemia via attenuating immunogenic dsRNA sensing
Pham J; Isquith J; Rivera M; Zhang H; Zhou Q; Sasik R; Mark A; Ma W; Holm F; Fisch K; Kuo D; Jamieson C; Jiang Q
Conference publication: CANCER RESEARCH. 2019;79(13):3675
Elucidating the role and function of APOBEC3 DNA deaminases in myeloproliferative neoplasms
Isquith J; Jiang Q; Diep R; Pham J; Holm F; Jamieson C
Review: NATURE REVIEWS CANCER. 2017;17(6):381-392
RNA editing-dependent epitranscriptome diversity in cancer stem cells.
Jiang Q; Crews LA; Holm F; Jamieson CHM
Conference publication: BLOOD. 2015;126(23):1227
Reversion to an Embryonic Alternative Splicing Program Enhances Leukemia Stem Cell Self-Renewal
Holm FL; Hellqvist E; Mason CN; Ali S; Delos Santos N; Barrett C; Chun H-J; Minden MD; Richard M; Marra MA; Frazer KA; Sadarangani A; Jamieson C
Book chapter: HUMAN EMBRYONIC AND INDUCED PLURIPOTENT STEM CELLS: SPRINGER PROTOCOLS HANDBOOKS. 2011;p. 85-90
Cryopreservation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells
Holm F

Employments

Research Specialist, Department of Neuroscience, Karolinska Institutet, 2024-2025
Assistant Professor, Department of Women's and Children's Health, Karolinska Institutet, 2018-2024

Degrees and Education

Docent, Karolinska Institutet, 2024
Degree Of Doctor Of Philosophy, Department of neuroscience, Karolinska Institutet, 2012
Bachelor Of Medical Science, Karolinska Institutet, 2007
Bachelor Of Science In Biomedical Laboratory Science, Karolinska Institutet, 2007

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