Gonçalo Castelo-Branco
About me
Professor of Glial Cell Biology at Karolinska Institutet (KI), Stockholm, Sweden
Distinguished Professor of the Swedish Research Council within Medicine and Health
Wallenberg Scholar
Deputy Head and Chair of the Senate of the Department of Medical Biochemistry and Biophysics
Member of the Nobel Assembly at Karolinska Institutet
Gonçalo Castelo Branco is a Swedish and Portuguese citizen and he was born in Cantanhede, Portugal, in 1976. He is educated in Biochemistry at the University of Coimbra with a B.Sc.. degree in 1999 and defended his PhD at KI in 2005. He did postdocs at KI 2005-2008 and at the Gurdon Institute, University of Cambridge, Great Britain, 2009-2012. He started his research group at KI in 2012. He became a docent (associate professor) in 2016. His group focuses on the molecular mechanisms regulating the epigenomic states of oligodendrocyte lineage cells in neuroinflammatory and demyelinating diseases such as multiple sclerosis (MS), using technologies such as single cell and spatial transcriptomics and epigenomics, among others. His research group has identified novel distinct oligodendroglia cell states in development and multiple sclerosis, including distinct disease-associated states, found that oligodendroglia is already primed at an epigenomic level at immune genes, to allow their transcription in neuroinflammatory environments, and developed new single-cell and spatial epigenomics technologies. Prof. Castelo- Branco has received many prestigious honors/awards, including being elected member of the Nobel Assembly at Karolinska Institutet from 2023, Distinguished Professor within Medicine and Health of the Swedish Research Council (from 2024), Wallenberg Scholar (from 2024), the Hans Wigzell prize 2022, the Royal Swedish Academy of Sciences Göran Gustafsson Prize 2021 in Medicine, the Eric K. Fernström Prize 2021, the Swedish Society for Medical Research (SSMF) 100 years Jubileum Prize 2019 and European Research Council Consolidator (2015) and Advanced Grants (2023).
Main interests: Single cell and spatial transcriptomics and epigenomics, oligodendroglia, remyelination, multiple sclerosis, neuroimmunology
Education
Associate Professor (Docent), Karolinska Institutet, Stockholm, Sweden
Post-doctoral fellow, The Gurdon Institute, University of Cambridge, United Kingdom Kouzarides' lab
Post-doctoral fellow, Department of Neuroscience, Karolinska Institutet, Sweden, Hermanson's lab
PhD, Medical Biochemistry, Karolinska Institutet, Sweden, Arenas's lab
B.Sc., Biochemistry, University of Coimbra, Portugal, B.Sc. student at Saraiva's lab, Institute for Molecular and Cellular Biology, University of Porto, PortugalAcademic tree: https://neurotree.org/neurotree/tree.php?pid=60471
Academic honours, awards and prizes2024 Clarivate Highly Cited Researcher 2024
2024 Nicholson Lecture, The Rockefeller University, NY, USA
2023- Member of Nobel Assembly at Karolinska Institutet
2022 Hans Wigzell Prize
2021 Eric K. Fernström Prize
2021 Göran Gustafsson Prize in Medicine
2019 Swedish Society for Medical Research (SSMF) Jubileum PrizeRecent interviews:
Research
Our research group is interested in the molecular mechanisms defining the epigenetic state of oligodendrocyte lineage cells. We are particularly focused on how interplay between transcription factors, non-coding RNAs and chromatin modifying enzymes contributes to the transition between epigenetic states in oligodendrocyte precursor cells, and could thereby lead to targeted therapies for illnesses such as multiple sclerosis.
Visit our research group's webpage: https://ki.se/en/mbb/goncalo-castelo-branco-group
Selected publications
- Article: CELL. 2024;187(8):1990-2009.e19Kukanja P; Langseth CM; Rodriguez-Kirby LAR; Agirre E; Zheng C; Raman A; Yokota C; Avenel C; Tiklova K; Guerreiro-Cacais AO; Olsson T; Hilscher MM; Nilsson M; Castelo-Branco G
- Article: NATURE BIOTECHNOLOGY. 2023;41(6):794-805Bartosovic M; Castelo-Branco G
- Article: NATURE. 2022;609(7926):375-383Deng Y; Bartosovic M; Ma S; Zhang D; Kukanja P; Xiao Y; Su G; Liu Y; Qin X; Rosoklija GB; Dwork AJ; Mann JJ; Xu ML; Halene S; Craft JE; Leong KW; Boldrini M; Castelo-Branco G; Fan R
- Article: NEURON. 2022;110(7):1193-1210.e13Meijer M; Agirre E; Kabbe M; van Tuijn CA; Heskol A; Zheng C; Falcao AM; Bartosovic M; Kirby L; Calini D; Johnson MR; Corces MR; Montine TJ; Chen X; Chang HY; Malhotra D; Castelo-Branco G
- Article: SCIENCE. 2022;375(6581):681-686Deng Y; Bartosovic M; Kukanja P; Zhang D; Liu Y; Su G; Enninful A; Bai Z; Castelo-Branco G; Fan R
- Article: NATURE BIOTECHNOLOGY. 2021;39(7):825-835Bartosovic M; Kabbe M; Castelo-Branco G
- Article: NATURE. 2019;566(7745):543-547Jakel S; Agirre E; Falcao AM; Van Bruggen D; Lee KW; Knuesel I; Malhotra D; Ffrench-Constant C; Williams A; Castelo-Branco G
- Article: NATURE MEDICINE. 2018;24(12):1837-1844Falcao AM; van Bruggen D; Marques S; Meijer M; Jakel S; Agirre E; Samudyata; Floriddia EM; Vanichkina DP; Ffrench-Constant C; Williams A; Guerreiro-Cacais AO; Castelo-Branco G
- Article: DEVELOPMENTAL CELL. 2018;46(4):504-517.e7Marques S; van Bruggen D; Vanichkina DP; Floriddia EM; Munguba H; Varemo L; Giacomello S; Falcao AM; Meijer M; Bjorklund AK; Hjerling-Leffler J; Taft RJ; Castelo-Branco G
- Article: SCIENCE. 2016;352(6291):1326-1329Marques S; Zeisel A; Codeluppi S; van Bruggen D; Falcao AM; Xiao L; Li H; Haring M; Hochgerner H; Romanov RA; Gyllborg D; Munoz-Manchado AB; La Manno G; Lonnerberg P; Floriddia EM; Rezayee F; Ernfors P; Arenas E; Hjerling-Leffler J; Harkany T; Richardson WD; Linnarsson S; Castelo-Branco G
Articles
- Article: NATURE GENETICS. 2025;57(4):897-909Birk S; Bonafonte-Pardas I; Feriz AM; Boxall A; Agirre E; Memi F; Maguza A; Yadav A; Armingol E; Fan R; Castelo-Branco G; Theis FJ; Bayraktar OA; Talavera-Lopez C; Lotfollahi M
- Article: NEURON. 2025;113(3):396-410.e9Macnair W; Calini D; Agirre E; Bryois J; Jaekel S; Smith RS; Kukanja P; Stokar-Regenscheit N; Ott V; Foo LC; Collin L; Schippling S; Urich E; Nutma E; Marzin M; Ansaloni F; Amor S; Magliozzi R; Heidari E; Robinson MD; ffrench-Constant C; Castelo-Branco G; Williams A; Malhotra D
- Journal article: NATURE NEUROSCIENCE. 2024;27(12):2267-2268Ernfors P; Castelo-Branco G; Uhlen P; Linnarsson S; Marklund U; Hjerling-Leffler J; Dagliyan O
- Article: SCIENCE. 2024;386(6724):907-915Kanatani S; Kreutzmann JC; Li Y; West Z; Larsen LL; Nikou DV; Eidhof I; Walton A; Zhang S; Rodriguez-Kirby LR; Skytte JL; Salinas CG; Takamatsu K; Li X; Tanaka DH; Kaczynska D; Fukumoto K; Karamzadeh R; Xiang Y; Uesaka N; Tanabe T; Adner M; Hartman J; Miyakawa A; Sundstrom E; Castelo-Branco G; Roostalu U; Hecksher-Sorensen J; Uhlen P
- Article: NATURE NEUROSCIENCE. 2024;27(9):1668-1674Sasmita AO; Depp C; Nazarenko T; Sun T; Siems SB; Ong EC; Nkeh YB; Boehler C; Yu X; Bues B; Evangelista L; Mao S; Morgado B; Wu Z; Ruhwedel T; Subramanian S; Boerensen F; Overhoff K; Spieth L; Berghoff SA; Sadleir KR; Vassar R; Eggert S; Goebbels S; Saito T; Saido T; Saher G; Moebius W; Castelo-Branco G; Klafki H-W; Wirths O; Wiltfang J; Jaekel S; Yan R; Nave K-A
- Article: NATURE NEUROSCIENCE. 2024;27(8):1545-1554Foerster S; Floriddia EM; van Bruggen D; Kukanja P; Herve B; Cheng S; Kim E; Phillips BU; Heath CJ; Tripathi RB; Call C; Bartels T; Ridley K; Neumann B; Lopez-Cruz L; Crawford AH; Lynch CJ; Serrano M; Saksida L; Rowitch DH; Moebius W; Nave K-A; Rasband MN; Bergles DE; Kessaris N; Richardson WD; Bussey TJ; Zhao C; Castelo-Branco G; Franklin RJM
- Article: NATURE PROTOCOLS. 2024;19(3):791-830Barcenas-Walls JR; Ansaloni F; Herve B; Strandback E; Nyman T; Castelo-Branco G; Bartosovic M
- Article: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES. 2023;378(1890):20220451Patil KV; Meijer M; Mak KH-M; Yang W; Falcao AM; Castelo-Branco G; Genander M
- Journal article: NATURE BIOTECHNOLOGY. 2023;41(6):767-768Bartosovic M; Castelo-Branco G
- Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2023;11(1):84Seeker LA; Bestard-Cuche N; Jaekel S; Kazakou N-L; Bostrand SMK; Wagstaff LJ; Cholewa-Waclaw J; Kilpatrick AM; Van Bruggen D; Kabbe M; Baldivia Pohl F; Moslehi Z; Henderson NC; Vallejos CA; La Manno G; Castelo-Branco G; Williams A
- Article: NATURE. 2023;616(7955):113-122Zhang D; Deng Y; Kukanja P; Agirre E; Bartosovic M; Dong M; Ma C; Ma S; Su G; Bao S; Liu Y; Xiao Y; Rosoklija GB; Dwork AJ; Mann JJ; Leong KW; Boldrini M; Wang L; Haeussler M; Raphael BJ; Kluger Y; Castelo-Branco G; Fan R
- Journal article: NATURE. 2022;611(7937):670-671Carlstrom K; Castelo-Branco G
- Article: NATURE NEUROSCIENCE. 2022;25(8):1104-1112Bryois J; Calini D; Macnair W; Foo L; Urich E; Ortmann W; Iglesias VA; Selvaraj S; Nutma E; Marzin M; Amor S; Williams A; Castelo-Branco G; Menon V; De Jager P; Malhotra D
- Article: DEVELOPMENTAL CELL. 2022;57(11):1421-1436.e5van Bruggen D; Pohl F; Langseth CM; Kukanja P; Lee H; Albiach AM; Kabbe M; Meijer M; Linnarsson S; Hilscher MM; Nilsson M; Sundstrom E; Castelo-Branco G
- Article: BMC BIOLOGY. 2022;20(1):122Hilscher MM; Langseth CM; Kukanja P; Yokota C; Nilsson M; Castelo-Branco G
- Article: NATURE. 2021;599(7886):684-691Winick-Ng W; Kukalev A; Harabula I; Zea-Redondo L; Szabo D; Meijer M; Serebreni L; Zhang Y; Bianco S; Chiariello AM; Irastorza-Azcarate I; Thieme CJ; Sparks TM; Carvalho S; Fiorillo L; Musella F; Irani E; Triglia ET; Kolodziejczyk AA; Abentung A; Apostolova G; Paul EJ; Franke V; Kempfer R; Akalin A; Teichmann SA; Dechant G; Ungless MA; Nicodemi M; Welch L; Castelo-Branco G; Pombo A
- Journal article: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. 2021;116:1-2Chrast R; Castelo-Branco G
- Journal article: NATURE COMMUNICATIONS. 2021;12(1):3128Bonetti A; Agostini F; Suzuki AM; Hashimoto K; Pascarella G; Gimenez J; Roos L; Nash AJ; Ghilotti M; Cameron CJF; Valentine M; Medvedeva YA; Noguchi S; Agirre E; Kashi K; Samudyata; Luginbuehl J; Cazzoli R; Agrawal S; Luscombe NM; Blanchette M; Kasukawa T; de Hoon M; Arner E; Lenhard B; Plessy C; Castelo-Branco G; Orlando V; Carninci P
- Article: NATURE COMMUNICATIONS. 2020;11(1):5860Floriddia EM; Lourenco T; Zhang S; van Bruggen D; Hilscher MM; Kukanja P; dos Santos JPG; Altinkok M; Yokota C; Llorens-Bobadilla E; Mulinyawe SB; Graos M; Sun LO; Frisen J; Nilsson M; Castelo-Branco G
- Article: NATURE COMMUNICATIONS. 2020;11(1):4071Carlstrom KE; Zhu K; Ewing E; Krabbendam IE; Harris RA; Falcao AM; Jagodic M; Castelo-Branco G; Piehl F
- Article: GLIA. 2020;68(8):1619-1630Samudyata; Castelo-Branco G; Liu J
- Article: NATURE NEUROSCIENCE. 2020;23(3):363-374Marisca R; Hoche T; Agirre E; Hoodless LJ; Barkey W; Auer F; Castelo-Branco G; Czopka T
- Article: NATURE COMMUNICATIONS. 2020;11(1):1018Bonetti A; Agostini F; Suzuki AM; Hashimoto K; Pascarella G; Gimenez J; Roos L; Nash AJ; Ghilotti M; Cameron CJF; Valentine M; Medvedeva YA; Noguchi S; Agirre E; Kashi K; Samudyata; Luginbuhl J; Cazzoli R; Agrawal S; Luscombe NM; Blanchette M; Kasukawa T; de Hoon M; Arner E; Lenhard B; Plessy C; Castelo-Branco G; Orlando V; Carninci P
- Article: CELL REPORTS. 2019;29(4):904-919.e9Tripathi A; Volsko C; Garcia JP; Agirre E; Allan KC; Tesar PJ; Trapp BD; Castelo-Branco G; Sim FJ; Dutta R
- Article: EXPERIMENTAL CELL RESEARCH. 2019;381(1):129-138Samudyata; Amaral PP; Engstrom PG; Robson SC; Nielsen ML; Kouzarides T; Castelo-Branco G
- Article: CELL REPORTS. 2019;27(8):2508-2523.e4Kupari J; Haring M; Agirre E; Castelo-Branco G; Ernfors P
- Journal article: CELL STEM CELL. 2019;24(5):677-679Floriddia EM; Castelo-Branco G
- Article: CELL REPORTS. 2019;27(4):1090-1102.e10Falcao AM; Meijer M; Scaglione A; Rinwa P; Agirre E; Liang J; Larsen SC; Heskol A; Frawley R; Klingener M; Varas-Godoy M; Raposo AASF; Ernfors P; Castro DS; Nielsen ML; Casaccia P; Castelo-Branco G
- Article: METHODS IN MOLECULAR BIOLOGY. 2019;1936:1-21Marques S; van Bruggen D; Castelo-Branco G
- Article: NATURE. 2018;560(7719):494-498La Manno G; Soldatov R; Zeisel A; Braun E; Hochgerner H; Petukhov V; Lidschreiber K; Kastriti ME; Lonnerberg P; Furlan A; Fan J; Borm LE; Liu Z; van Bruggen D; Guo J; He X; Barker R; Sundstrom E; Castelo-Branco G; Cramer P; Adameyko I; Linnarsson S; Kharchenko PV
- Article: SCIENCE. 2015;347(6226):1138-1142Zeisel A; Munoz-Manchado AB; Codeluppi S; Lonnerberg P; La Manno G; Jureus A; Marques S; Munguba H; He L; Betsholtz C; Rolny C; Castelo-Branco G; Hjerling-Leffler J; Linnarsson S
- Article: NEUROBIOLOGY OF DISEASE. 2014;71:220-233Castelo-Branco G; Stridh P; Guerreiro-Cacais AO; Adzemovic MZ; Falcao AM; Marta M; Berglund R; Gillett A; Hamza KH; Lassmann H; Hermanson O; Jagodic M
- Article: STEM CELL REPORTS. 2014;3(3):502-515Castelo-Branco GG; Lilja T; Wallenborg K; Falcao AM; Marques SC; Gracias A; Solum D; Paap R; Walfridsson J; Teixeira AI; Rosenfeld MG; Jepsen K; Hermanson O
- Article: NATURE. 2014;507(7490):104-108Christophorou MA; Castelo-Branco G; Halley-Stott RP; Oliveira CS; Loos R; Radzisheuskaya A; Mowen KA; Bertone P; Silva JCR; Zernicka-Goetz M; Nielsen ML; Gurdon JB; Kouzarides T
- Article: PLOS ONE. 2013;8(8):e72409Abdelhady S; Kitambi SS; Lundin V; Aufschnaiter R; Sekyrova P; Sinha I; Lundgren KT; Castelo-Branco G; Linnarsson S; Wedlich-Soeldner R; Teixeira A; Andang M
- Journal article: BRIEFINGS IN FUNCTIONAL GENOMICS. 2013;12(3):161-163Castelo-Branco G; Bannister AJ
- Article: GENOME BIOLOGY. 2013;14(9):R98Castelo-Branco G; Amaral PP; Engstroem PG; Robson SC; Marques SC; Bertone P; Kouzarides T
- Article: EMBO JOURNAL. 2012;31(18):3718-3729Lallemend F; Sterzenbach U; Hadjab-Lallemend S; Aquino JB; Castelo-Branco G; Sinha I; Villaescusa JC; Levanon D; Wang Y; Franck MCM; Kharchenko O; Adameyko I; Linnarsson S; Groner Y; Turner E; Ernfors P
- Article: CURRENT BIOLOGY. 2011;21(1):65-71Theunissen TW; van Oosten AL; Castelo-Branco G; Hall J; Smith A; Silva JCR
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(10):7246-7253Sousa KM; Villaescusa JC; Cajanek L; Ondr JK; Castelo-Branco G; Hofstra W; Bryja V; Palmberg C; Bergman T; Wainwright B; Lang RA; Arenas E
- Article: DEVELOPMENTAL DYNAMICS. 2010;239(1):211-221Castelo-Branco G; Andersson ER; Minina E; Sousa KM; Ribeiro D; Kokubu C; Imai K; Prakash N; Wurst W; Arenas E
- Article: MOLECULAR BIOLOGY OF THE CELL. 2008;19(7):3008-3019Raju CS; Goritz C; Nord Y; Hermanson O; Lopez-Iglesias C; Visa N; Castelo-Branco G; Percipalle P
- Article: NEUROSCIENCE LETTERS. 2008;435(1):11-16Stenqvist A; Lundgren TK; Smith MJ; Hermanson O; Castelo-Branco G; Pawson T; Emfors P
- Article: NATURE. 2008;451(7177):460-464Andang M; Hjerling-Leffler J; Moliner A; Lundgren TK; Castelo-Branco G; Nanou E; Pozas E; Bryja V; Halliez S; Nishimaru H; Wilbertz J; Arenas E; Koltzenburg M; Charnay P; El Manira A; Ibanez CF; Ernfors P
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2008;118(1):149-160Parish CL; Castelo-Branco G; Rawal N; Tonnesen J; Sorensen AT; Salto C; Kokaia M; Lindvall O; Arenas E
- Article: CELL DEATH AND DIFFERENTIATION. 2007;14(2):381-383Rawal N; Parish C; Castelo-Branco G; Arenas E
- Article: JOURNAL OF NEUROCHEMISTRY. 2006;99(1):343-352Holm PC; Rodriguez FJ; Kele J; Castelo-Branco G; Kitajewski J; Arenas E
- Article: EXPERIMENTAL CELL RESEARCH. 2006;312(9):1626-1636Rawal N; Castelo-Branco G; Sousa KM; Sousa KM; Kele J; Kobayashi K; Okano H; Arenas E
- Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2006;31(2):251-262Castelo-Branco GA; Sousa KM; Bryja V; Pinto L; Wagner J; Arenas E
- Article: NEURODEGENERATIVE DISEASES. 2006;3(1-2):5-11Castelo-Branco G; Arenas E
- Article: JOURNAL OF NEUROCHEMISTRY. 2005;92(6):1550-1553Schulte G; Bryja V; Rawal N; Castelo-Branco G; Sousa KM; Arenas E
- Article: JOURNAL OF CELL SCIENCE. 2004;117(24):5731-5737Castelo-Branco G; Rawal N; Arenas E
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(22):12747-12752Castelo-Branco GA; Wagner J; Rodriguez FJ; Kele J; Sousa K; Rawal N; Pasolli HA; Fuchs E; Kitajewski J; Arenas E
- Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2002;21(2):205-222Åkerud P; Holm PC; Castelo-Branco G; Sousa K; Rodriguez FJ; Arenas E
- Show more
All other publications
- Review: NATURE NEUROSCIENCE. 2024;27(12):2292-2309Bonev B; Goncalo C-B; Chen F; Codeluppi S; Corces MR; Fan J; Heiman M; Harris K; Inoue F; Kellis M; Levine A; Lotfollahi M; Luo C; Maynard KR; Nitzan M; Ramani V; Satijia R; Schirmer L; Shen Y; Sun N; Green GS; Theis F; Wang X; Welch JD; Gokce O; Konopka G; Liddelow S; Macosko E; Bayraktar O; Habib N; Nowakowski TJ
- Review: TRENDS IN IMMUNOLOGY. 2024;45(10):750-759Castelo-Branco G; Kukanja P; Guerreiro-Cacais AO; Rodriguez-Kirby LAR
- Preprint: BIORXIV. 2024Rodríguez-López C; Hernández IH; Terrón-Bautista J; Agirre E; Pose-Utrilla J; Lozano-Muñoz D; Ruiz-Blas I; Arroyo AM; García-Ortiz I; Lucas-Santamaría M; González-Bermejo M; Ortega MC; Machín-Díaz I; Chara JC; Morrema THJ; Zheng C; Martínez Z; Pérez-Cerdá F; Martínez-Jiménez M; Sancho-González B; Pérez-Samartín A; Kabbe M; Casado-Barbero M; Santos-Galindo M; Borroto A; Alarcón B; Paradela A; de Castro F; Fransen NL; Hoozemans JJM; Toma C; Matute C; Clemente D; Cortés-Ledesma F; Castelo-Branco G; Lucas JJ
- Preprint: BIORXIV. 2024;BIORXIVZhang D; Rubio Rodríguez-Kirby LA; Lin Y; Song M; Wang L; Wang L; Kanatani S; Jimenez-Beristain T; Dang Y; Zhong M; Kukanja P; Wang S; Chen XL; Gao F; Wang D; Xu H; Lou X; Liu Y; Chen J; Sestan N; Uhlén P; Kriegstein A; Zhao H; Castelo-Branco G; Fan R
- Book chapter: NEUROPSYCHIATRIC DISORDERS AND EPIGENETICS. 2024;p. 183-223Kular L; Castelo-Branco G; Jagodic M
- Preprint: BIORXIV. 2023Zheng C; Hervé B; Meijer M; Rubio Rodríguez-Kirby LA; Guerreiro Cacais AO; Kukanja P; Kabbe M; Olsson T; Agirre E; Castelo-Branco G
- Preprint: BIORXIV. 2023Sasmita AO; Depp C; Nazarenko T; Sun T; Siems S; Yu X; Boehler C; Ong EC; Bues B; Evangelista L; Morgado B; Wu Z; Ruhwedel T; Subramanian S; Börensen F; Overhoff K; Spieth L; Berghoff S; Sadleir KR; Vassar R; Eggert S; Goebbels S; Saito T; Saido T; Möbius W; Castelo-Branco G; Klafki H-W; Wirths O; Wiltfang J; Jäkel S; Yan R; Nave K-A
- Preprint: BIORXIV. 2023Langseth CM; Kukanja P; Rubio Rodríguez-Kirby LA; Agirre E; Raman A; Yokota C; Avenel C; Tiklová K; Guerreiro-Cacais AO; Olsson T; Hilscher MM; Nilsson M; Castelo-Branco G
- Preprint: BIORXIV. 2022Macnair W; Calini D; Agirre E; Bryois J; Jäkel S; Kukanja P; Stokar N; Ott V; Foo L; Collin L; Schippling S; Urich E; Nutma E; Marzin M; Amor S; Magliozzi R; Heidari E; Robinson M; ffrench-Constant C; Castelo-Branco G; Williams A; Malhotra D
- Review: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. 2021;116:45-52Kirby L; Castelo-Branco G
- Review: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. 2018;79:143-152Samudyata; Castelo-Branco G; Bonetti A
- Review: CURRENT OPINION IN NEUROBIOLOGY. 2017;47:168-175van Bruggen D; Agirre E; Castelo-Branco G
- Doctoral thesis: 2004Castelo-Branco GDSESD
- Corrigendum: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(46):16390Castelo-Branco G; Wagner J; Rodriguez FJ; Kele J; Sousa K; Rawal N; Pasolli HA; Fuchs E; Kitajewski J; Arenas E
Grants
- KAW ScholarKnut and Alice Wallenberg foundation1 September 2024 - 31 August 2029
- Swedish Research Council1 January 2024 - 31 December 2031Multiple sclerosis (MS) is a neurological disease characterized by autoimmune attack in the central nervous system, targeting oligodendroglia (OLG), and their myelin, which ensheaths neuronal axons. Environment factors and genetic susceptibility play important roles in the etiology of MS. Immune genes harbors MS risk single nucleotide polymorphisms (SNPs)/variants. Thus, genetic predisposition affecting the adaptive immune system is currently thought to be involved in MS. Despite the extraordinary progress in immune-based therapies for MS, these have limited efficacy in the progression of MS. While OLG are mostly considered as mere passive targets in MS, our research indicates that OLG might have an active role in MS and that risk SNPs/variants might contribute to MS by affecting OLG biology. My research group aims to investigate the role of OLG in disease etiology and progression in MS. We aim to perform detailed single-cell and spatial mapping of the transcriptomic and epigenomic landscapes of OLG in MS. We will assess functional roles of OLG in MS etiology and progression, by developing humanized models to study OLG biology in neuroinflammation, and by performing functional analysis of candidate MS-risk SNPs in OLG. Combining single-cell/spatial omics, genome-editing and functional assays in humanized mice models of MS will lead to unique insights on the role of OLG and SNPs in MS etiology and progression, and advances in the discovery of novel targets for MS therapies.
- ERC Advanced GrantEuropean Research Council1 January 2024 - 31 December 2028
- Swedish Research Council1 January 2020 - 31 December 2024
- Swedish Research Council1 January 2016 - 31 December 2019
Employments
- Professor, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2021-
Degrees and Education
- Docent, Karolinska Institutet, 2016
- Doctor Of Philosophy, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2005
Leadership and responsibility assignments
- Head of department administration, Deputy Head of Department, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2024-
- Head of department administration, Chair of Senate, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2024-
Committee work
- Member, Nobel Assembly at Karolinska Institutet, Karolinska Institutet, 2023-