Gonçalo Castelo-Branco
About me
Professor of Glial Cell Biology at Karolinska Institutet (KI), Stockholm, Sweden
Distinguished Professor of the Swedish Research Council within Medicine and Health
Wallenberg Scholar
Deputy Head and Chair of the Senate of the Department of Medical Biochemistry and Biophysics
Member of the Nobel Assembly at Karolinska Institutet
Gonçalo Castelo Branco was born in Cantanhede, Portugal, in 1976. He is educated in Biochemistry at the University of Coimbra with a B.Sc.. degree in 1999 and defended his PhD at KI in 2005. He did postdocs at KI 2005-2008 and at the Gurdon Institute, University of Cambridge, Great Britain, 2009-2012.- Gonçalo Castelo Branco started his research group at KI in 2012. He became a docent (associate professor) in 2016. In 2019 he was awarded the Swedish Society for Medical Research Jubilee Prize and in 2021 with both the Göran Gustafsson Prize in Medicine and the Eric K Fernström Prize for young, particularly promising and successful researchers, and he was elected to the Nobel Assembly at Karolinska Institutet in 2023.. Gonçalo Castelo Branco is Professor of Glial Cell Biology at Karolinska Institutet since 1 November 2021.
Main interests: Single cell and spatial transcriptomics and epigenomics, oligodendroglia, remyelination, multiple sclerosis, neuroimmunology
Education
Associate Professor (Docent), Karolinska Institutet, Stockholm, Sweden
Post-doctoral fellow, The Gurdon Institute, University of Cambridge, United Kingdom Kouzarides' lab
Post-doctoral fellow, Department of Neuroscience, Karolinska Institutet, Sweden, Hermanson's lab
PhD, Medical Biochemistry, Karolinska Institutet, Sweden, Arenas's lab
B.Sc., Biochemistry, University of Coimbra, Portugal, B.Sc. student at Saraiva's lab, Institute for Molecular and Cellular Biology, University of Porto, Portugal
Academic honours, awards and prizes
2023- Member of Nobel Assembly at Karolinska Institutet
2022 Hans Wigzell Prize
2021 Eric K. Fernström Prize
2021 Göran Gustafsson Prize in Medicine
2019 Swedish Society for Medical Research (SSMF) Jubileum Prize
Research
Our research group is interested in the molecular mechanisms defining the epigenetic state of oligodendrocyte lineage cells. We are particularly focused on how interplay between transcription factors, non-coding RNAs and chromatin modifying enzymes contributes to the transition between epigenetic states in oligodendrocyte precursor cells, and could thereby lead to targeted therapies for illnesses such as multiple sclerosis.
Visit our research group's webpage: https://ki.se/en/mbb/goncalo-castelo-branco-group
Selected publications
- Article: CELL. 2024;187(8):1990-2009.e19
- Article: NATURE BIOTECHNOLOGY. 2023;41(6):794-805
- Article: NATURE. 2022;609(7926):375-383
- Article: NEURON. 2022;110(7):1193-1210.e13
- Article: SCIENCE. 2022;375(6581):681-686
- Article: NATURE BIOTECHNOLOGY. 2021;39(7):825-835
- Article: NATURE. 2019;566(7745):543-547
- Article: NATURE MEDICINE. 2018;24(12):1837-1844
- Article: DEVELOPMENTAL CELL. 2018;46(4):504-517.e7
- Article: SCIENCE. 2016;352(6291):1326-1329
Articles
- Journal article: TRENDS IN IMMUNOLOGY. 2024;45(10):750-759
- Journal article: NATURE NEUROSCIENCE. 2024;27(9):1668-1674
- Journal article: NATURE NEUROSCIENCE. 2024;27(8):1545-1554
- Article: NATURE PROTOCOLS. 2024;19(3):791-830
- Article: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON. BIOLOGICAL SCIENCES. 2023;378(1890):20220451
- Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2023;11(1):84
- Article: NATURE. 2023;616(7955):113-122
- Article: NATURE NEUROSCIENCE. 2022;25(8):1104-1112
- Article: DEVELOPMENTAL CELL. 2022;57(11):1421-1436.e5
- Article: BMC BIOLOGY. 2022;20(1):122
- Article: NATURE. 2021;599(7886):684-691
- Article: NATURE COMMUNICATIONS. 2020;11(1):5860
- Article: NATURE COMMUNICATIONS. 2020;11(1):4071
- Article: GLIA. 2020;68(8):1619-1630
- Article: NATURE NEUROSCIENCE. 2020;23(3):363-374
- Article: NATURE COMMUNICATIONS. 2020;11(1):1018
- Article: CELL REPORTS. 2019;29(4):904-919.e9
- Article: EXPERIMENTAL CELL RESEARCH. 2019;381(1):129-138
- Article: CELL REPORTS. 2019;27(8):2508-2523.e4
- Article: CELL REPORTS. 2019;27(4):1090-1102.e10
- Article: METHODS IN MOLECULAR BIOLOGY. 2019;1936:1-21
- Article: NATURE. 2018;560(7719):494-498
- Article: SCIENCE. 2015;347(6226):1138-1142
- Article: NEUROBIOLOGY OF DISEASE. 2014;71:220-233
- Article: STEM CELL REPORTS. 2014;3(3):502-515
- Article: NATURE. 2014;507(7490):104-108
- Article: GENOME BIOLOGY. 2013;14(9):R98
- Article: PLOS ONE. 2013;8(8):e72409
- Article: EMBO JOURNAL. 2012;31(18):3718-3729
- Article: CURRENT BIOLOGY. 2011;21(1):65-71
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(10):7246-7253
- Article: DEVELOPMENTAL DYNAMICS. 2010;239(1):211-221
- Article: MOLECULAR BIOLOGY OF THE CELL. 2008;19(7):3008-3019
- Article: NEUROSCIENCE LETTERS. 2008;435(1):11-16
- Article: NATURE. 2008;451(7177):460-464
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2008;118(1):149-160
- Article: CELL DEATH AND DIFFERENTIATION. 2007;14(2):381-383
- Article: JOURNAL OF NEUROCHEMISTRY. 2006;99(1):343-352
- Article: EXPERIMENTAL CELL RESEARCH. 2006;312(9):1626-1636
- Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2006;31(2):251-262
- Article: NEURODEGENERATIVE DISEASES. 2006;3(1-2):5-11
- Article: JOURNAL OF NEUROCHEMISTRY. 2005;92(6):1550-1553
- Article: JOURNAL OF CELL SCIENCE. 2004;117(24):5731-5737
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(22):12747-12752
- Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2002;21(2):205-222
- Show more
All other publications
- Preprint: BIORXIV. 2024
- Book chapter: NEUROPSYCHIATRIC DISORDERS AND EPIGENETICS. 2024;p. 183-223
- Preprint: BIORXIV. 2023
- Editorial comment: NATURE BIOTECHNOLOGY. 2023;41(6):767-768
- Editorial comment: NATURE. 2022;611(7937):670-671
- Editorial comment: SEMINARS IN CELL AND DEVELOPMENTAL BIOLOGY. 2021;116:1-2
- Review: SEMINARS IN CELL AND DEVELOPMENTAL BIOLOGY. 2021;116:45-52
- Corrigendum: NATURE COMMUNICATIONS. 2021;12(1):3128
- Editorial comment: CELL STEM CELL. 2019;24(5):677-679
- Review: SEMINARS IN CELL AND DEVELOPMENTAL BIOLOGY. 2018;79:143-152
- Review: CURRENT OPINION IN NEUROBIOLOGY. 2017;47:168-175
- Editorial comment: BRIEFINGS IN FUNCTIONAL GENOMICS. 2013;12(3):161-163
- Thesis / dissertation: 2004
- Corrigendum: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(46):16390
Grants
- Swedish Research Council1 January 2024 - 31 December 2031
- Swedish Research Council1 January 2020 - 31 December 2024
- Swedish Research Council1 January 2016 - 31 December 2019
Employments
- Professor, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2021-
Degrees and Education
- Docent, Karolinska Institutet, 2016
- Doctor Of Philosophy, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2005