Rydén & Mejhert group

The Mikael Rydén & Niklas Mejhert group studies multiple features of the human white adipocyte, in particular lipid and carbohydrate metabolism, energy storage capacity and immunometabolism, and has a long-standing track record with publications in top ranked journals.

Most studies conducted within the group are translational and based on results from human tissue samples obtained from unique cross-sectional and longitudinal clinical cohorts. We have a vast national and international network of collaborators due to our participation in multiple projects and current/previous EU-funded collaborations. In the next six years our focus will to a large degree be on the role of the adipocyte lipid droplet in driving metabolic diseases. This is thanks to a large ERC-Synergy (ERCSyG) grant obtained in collaboration with Dominique Langin in Toulouse and Bruno Antonny in Nice.

Group members 

Jesper Bäckdahl, Ph.D. student, M.D.
Jesper Bäckdahl has an M.D. and is currently pursuing his residency in Internal Medicine and Endocrinology at the Karolinska University Hospital. He is a registered PhD student with Mikael Rydén as his main supervisor and his project revolves around the link between dysfunctional adipose tissue and cardiovascular disease.

Simon Lecoutre, Ph.D.
Simon Lecoutre joined the Lipid laboratory in 2017 after receiving his Ph.D. from the University of Lille. At Karolinska Institutet, Simon is investigating how adipocyte metabolic processes regulate epigenetic and transcriptional mechanisms.

Alison Ludzki, Ph.D.
Alison Ludzki completed her PhD at the University of Michigan, studying the effects of exercise on adipose tissue remodeling. Alison has a background in applied human metabolism and her project in the Lipid laboratory is to identify transcriptional determinants of adipocyte lipid storage capacity.

Salwan Maqdasy, Ph.D., M.D.
Prior to joining the Lipid laboratory, Salwan Maqdasy worked as an M.D. in the Clermont-Ferrand University Hospital and obtained his PhD from University Clermont Auvergne. Salwan became a member of the Lipid laboratory in 2019 and his project is to identify mechanisms by which adipocyte metabolic anomalies in obese patients drive inflammation and insulin resistance.

Morgane Couchet, Ph.D.
Morgane Couchet obtained her PhD degree at the University of Grenoble-Alpes where she investigated the role of the intestinal OCT enzyme in metabolism using in vitro and in vivo models. At the Lipid laboratory, Morgane is studying the relationship between adipocyte dysfunction and cardiometabolic diseases development.

Technical staff

Thais De Castro Barbosa, Ph.D, research technician

Katarina Hertel, research nurse

Lena Lindberg, Secretary

Ana Maria Suzuki, Ph.D, research technician

Yvonne Widlund, research nurse

Selected publications

Age-induced reduction in human lipolysis: a role for adipocyte noradrenaline degradation?
Gao H, Arner P, Beauchef G, Guere C, Vie, K, Dahlman I, Mejhert N, Rydén M
Cell Metab. 2020, in press.

Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression.
Mejhert N, Kuruvilla L, Gabriel KR, Elliott SD, Guie MA, Wang H, Lai ZW, Lane EA, Christiano R, Danial NN, Farese RV Jr, Walther TC.
Mol Cell. 2020 Mar 19;77(6):1251-1264.e9. doi: 10.1016/j.molcel.2020.01.014. Epub 2020 Feb 4.

Glutamine Links Obesity to Inflammation in Human White Adipose Tissue.
Petrus P, Lecoutre S, Dollet L, Wiel C, Sulen A, Gao H, et al
Cell Metab. 2020 Feb 4;31(2):375-390.e11​​​​​​​

Transforming Growth Factor-β3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue.
Petrus P, Mejhert N, Corrales P, Lecoutre S, Li Q, Maldonado E, et al
Cell Rep 2018 10;25(3):551-560.e5

Weight Gain and Impaired Glucose Metabolism in Women Are Predicted by Inefficient Subcutaneous Fat Cell Lipolysis.
Arner P, Andersson DP, Bäckdahl J, Dahlman I, Rydén M
Cell Metab. 2018 Jul;28(1):45-54.e3