Rydén & Mejhert group
The Mikael Rydén & Niklas Mejhert group studies multiple features of the human white adipocyte, in particular lipid and carbohydrate metabolism, energy storage capacity and immunometabolism, and has a long-standing track record with publications in top ranked journals.
Most studies conducted within the group are translational and based on results from human tissue samples obtained from unique cross-sectional and longitudinal clinical cohorts. We have a vast national and international network of collaborators due to our participation in multiple projects and current/previous EU-funded collaborations. In the next six years our focus will to a large degree be on the role of the adipocyte lipid droplet in driving metabolic diseases. This is thanks to a large ERC-Synergy (ERCSyG) grant obtained in collaboration with Dominique Langin in Toulouse and Bruno Antonny in Nice.
Jesper Bäckdahl, Ph.D. student, M.D.
Jesper Bäckdahl has an M.D. and is currently pursuing his residency in Internal Medicine and Endocrinology at the Karolinska University Hospital. He is a registered PhD student with Mikael Rydén as his main supervisor and his project revolves around the link between dysfunctional adipose tissue and cardiovascular disease.
Simon Lecoutre, Ph.D.
Simon Lecoutre joined the Lipid laboratory in 2017 after receiving his Ph.D. from the University of Lille. At Karolinska Institutet, Simon is investigating how adipocyte metabolic processes regulate epigenetic and transcriptional mechanisms.
Alison Ludzki, Ph.D.
Alison Ludzki completed her PhD at the University of Michigan, studying the effects of exercise on adipose tissue remodeling. Alison has a background in applied human metabolism and her project in the Lipid laboratory is to identify transcriptional determinants of adipocyte lipid storage capacity.
Salwan Maqdasy, Ph.D., M.D.
Prior to joining the Lipid laboratory, Salwan Maqdasy worked as an M.D. in the Clermont-Ferrand University Hospital and obtained his PhD from University Clermont Auvergne. Salwan became a member of the Lipid laboratory in 2019 and his project is to identify mechanisms by which adipocyte metabolic anomalies in obese patients drive inflammation and insulin resistance.
In addition to these members, we are currently in the process of recruiting two post-doctoral fellows within our ERCSyG program SPEHERES.
Thais De Castro Barbosa, Ph.D, research technician
Katarina Hertel, research nurse
Lena Lindberg, Secretary
Ana Maria Suzuki, Ph.D, research technician
Yvonne Widlund, research nurse
- Mejhert N, Kuruvilla L, Gabriel KR, Elliott, Guie MA, Wang H, Lai ZW, Lane EA, Christiano R, Danial NN, Farese RV Jr., Walther TC. Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression. Molecular Cell. 2020, in press.
- Glutamine Links Obesity to Inflammation in Human White Adipose Tissue.
Petrus P, Lecoutre S, Dollet L, Wiel C, Sulen A, Gao H, et al
Cell Metab. 2019 Dec;():
- Transforming Growth Factor-β3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue.
Petrus P, Mejhert N, Corrales P, Lecoutre S, Li Q, Maldonado E, et al
Cell Rep 2018 10;25(3):551-560.e5
- Weight Gain and Impaired Glucose Metabolism in Women Are Predicted by Inefficient Subcutaneous Fat Cell Lipolysis.
Arner P, Andersson DP, Bäckdahl J, Dahlman I, Rydén M
Cell Metab. 2018 Jul;28(1):45-54.e3
- Adipocyte Expression of SLC19A1 Links DNA Hypermethylation to Adipose Tissue Inflammation and Insulin Resistance.
Petrus P, Bialesova L, Checa A, Kerr A, Naz S, Bäckdahl J, et al
J. Clin. Endocrinol. Metab. 2018 02;103(2):710-721