Mikael Ryden

About me
Publications
CV
Public outreach and news

About me

Professor of Clinical and Experimental Fat Tissue Research since 2013 and Head of the Endocrinology Unit with the Lipid laboratory at the Department of Medicine, Huddinge.

Research

Mikael Rydén's research involves cell and molecular biotechnologies in various cell culture systems along with clinical studies.

The adipose tissue is the most plastic organ in the human body, and its main producer of hormones. While it was previously regarded primarily as an energy-storing tissue, we now know that it plays a central role in the development of insulin resistance, dyslipidemia and atherosclerosis in clinical conditions such as overweight/obesity, type 2 diabetes, familial combined hyperlipidaemia, chronic renal failure, cancer, cachexia and polycystic ovary syndrome.

Articles

Journal article: CARDIOVASCULAR RESEARCH (CVR). 2024;120(14):e54-e56
The double-edged impact of obesity on cancer risk and treatment response: implications for atherosclerosis?
van der Vorst EPC; Ryden M
Article: NATURE. 2024;636(8042):457-465
Adipose tissue retains an epigenetic memory of obesity after weight loss
Hinte LC; Castellano-Castillo D; Ghosh A; Melrose K; Gasser E; Noe F; Massier L; Dong H; Sun W; Hoffmann A; Wolfrum C; Ryden M; Mejhert N; Blueher M; von Meyenn F
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2024;300(12):108004
Impaired branched-chain amino acid (BCAA) catabolism during adipocyte differentiation decreases glycolytic flux.
Green CR; Alaeddine LM; Wessendorf-Rodriguez KA; Turner R; Elmastas M; Hover JD; Murphy AN; Ryden M; Mejhert N; Metallo CM; Wallace M
Article: SLEEP. 2024;47(11):zsae160
Circadian transcriptome oscillations in human adipose tissue depend on napping status and link to metabolic and inflammatory pathways
Rodriguez-Martin M; Perez-Sanz F; Zambrano C; Lujan J; Ryden M; Scheer FAJL; Garaulet M
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(21):11566
Weight Changes Are Linked to Adipose Tissue Genes in Overweight Women with Polycystic Ovary Syndrome
Hellberg A; Salamon D; Ujvari D; Ryden M; Hirschberg AL
Article: SCIENCE TRANSLATIONAL MEDICINE. 2024;16(768):eado3022
Decreased mitochondrial creatine kinase 2 impairs skeletal muscle mitochondrial function independently of insulin in type 2 diabetes
Rizo-Roca D; Guimaraes DSPSF; Pendergrast LA; Di Leo N; Chibalin AV; Maqdasy S; Ryden M; Naslund E; Zierath JR; Krook A
Article: OBESITY. 2024;32(8):1526-1540
The subcutaneous adipose transcriptome identifies a molecular signature of insulin resistance shared with visceral adipose
Mashayekhi M; Sheng Q; Bailin SS; Massier L; Zhong J; Shi M; Wanjalla CN; Wang TJ; Ikizler TA; Niswender KD; Gabriel CL; Palacios J; Turgeon-Jones R; Reynolds CF; Luther JM; Brown NJ; Das S; Dahlman I; Mosley JD; Koethe JR; Ryden M; Bachmann KN; Shah RV
Article: INTERNATIONAL JOURNAL OF OBESITY. 2024;48(7):934-940
Sex differences in adipose insulin resistance are linked to obesity, lipolysis and insulin receptor substrate 1
Arner P; Viguerie N; Massier L; Ryden M; Astrup A; Blaak E; Langin D; Andersson DP
Article: NATURE METABOLISM. 2024;6(7):1329-1346
Reduced adipocyte glutaminase activity promotes energy expenditure and metabolic health
Lecoutre S; Maqdasy S; Rizo-Roca D; Renzi G; Vlassakev I; Alaeddine LM; Higos R; Jalkanen J; Zhong J; Zareifi DS; Frendo-Cumbo S; Massier L; Hodek O; Juvany M; Moritz T; de Castro Barbosa T; Omar-Hmeadi M; Lopez-Yus M; Merabtene F; Abatan JB; Marcelin G; El Hachem E-J; Rouault C; Bergo MO; Petrus P; Zierath JR; Clement K; Krook A; Mejhert N; Ryden M
Journal article: CLINICAL OBESITY. 2024;14(3):e12659
IMPROVE 2022 International Meeting on Pathway-Related Obesity: Vision of Excellence
Kuehnen P; Argente J; Clement K; Dollfus H; Dubern B; Farooqi S; de Groot C; Grueters A; Holm J-C; Hopkins M; Kleinendorst L; Koerner A; Meeker D; Ryden M; von Schnurbein J; Tschoep M; Yeo GSH; Zorn S; Wabitsch M
Article: NATURE METABOLISM. 2024;6(5):861-879
A spatiotemporal proteomic map of human adipogenesis
Klingelhuber F; Frendo-Cumbo S; Omar-Hmeadi M; Massier L; Kakimoto P; Taylor AJ; Couchet M; Ribicic S; Wabitsch M; Messias AC; Iuso A; Mueller TD; Ryden M; Mejhert N; Krahmer N
Article: JCI INSIGHT. 2024;9(8):e175623
P2Y 13 receptor deficiency favors adipose tissue lipolysis and worsens insulin resistance and fatty liver disease
Duparc T; Gore E; Combes G; Beuzelin D; Da Silva JP; Bouguetoch V; Marques M-A; Velazquez A; Viguerie N; Travernier G; Arner P; Ryden M; Langin D; Sioufi N; Nasser M; Cabou C; Najib S; Martinez LO
Article: NATURE METABOLISM. 2024;6(2):273-289
Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation
Xia W; Veeragandham P; Cao Y; Xu Y; Rhyne TE; Qian J; Hung C-W; Zhao P; Jones Y; Gao H; Liddle C; Yu RT; Downes M; Evans RM; Ryden M; Wabitsch M; Wang Z; Hakozaki H; Schoneberg J; Reilly SM; Huang J; Saltiel AR
Article: CLINICAL NUTRITION. 2024;43(2):468-475
Insulin resistance in adipocytes: Novel insights into the pathophysiology of metabolic syndrome
Kerr AG; Andersson DP; Ryden M; Arner P
Article: CIRCULATION. GENOMIC AND PRECISION MEDICINE. 2024;17(1):e004192
Targeted Proteomics Reveals Functional Targets for Early Diabetes Susceptibility in Young Adults
Shah RV; Zhong J; Massier L; Tanriverdi K; Hwang S-J; Haessler J; Nayor M; Zhao S; Perry AS; Wilkins JT; Shadyab AH; Manson JE; Martin L; Levy D; Kooperberg C; Freedman JE; Ryden M; Murthy VL
Article: CELL REPORTS MEDICINE. 2024;5(1):101348
Exercise-induced crosstalk between immune cells and adipocytes in humans: Role of oncostatin-M
Dollet L; Lundell LS; Chibalin AV; Pendergrast LA; Pillon NJ; Lansbury EL; Elmastas M; Frendo-Cumbo S; Jalkanen J; Barbosa TDC; Cervone DT; Caidahl K; Dmytriyeva O; Deshmukh AS; Barres R; Ryden M; Wallberg-Henriksson H; Zierath JR; Krook A
Article: SCIENCE ADVANCES. 2024;10(1):eadi2689
Transcriptional determinants of lipid mobilization in human adipocytes
Ludzki AC; Hansen M; Zareifi D; Jalkanen J; Huang Z; Omar-Hmeadi M; Renzi G; Klingelhuber F; Boland S; Ambaw YA; Wang N; Damdimopoulos A; Liu J; Jernberg T; Petrus P; Arner P; Krahmer N; Fan R; Treuter E; Gao H; Ryden M; Mejhert N
Article: ADIPOCYTE. 2023;:2283213
Adipogenic characterization of immortalized CD55+ progenitor cells from human white adipose tissue.
Couchet M; Gao H; Klingelhuber F; Jalkanen J; De Castro Barbosa T; Omar-Hmeadi M; Massier L; Krahmer N; Mejhert N; Rydén M
Article: AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY. 2023;325(5):C1178-C1189
CRISPR/Cas9-mediated deletion of adipocyte genes associated with NAFLD alters adipocyte lipid handling and reduces steatosis in hepatocytes in vitro
Lopez-Yus M; Frendo-Cumbo S; del Moral-Bergos R; Garcia-Sobreviela MP; Bernal-Monterde V; Ryden M; Lorente-Cebrian S; Arbones-Mainar JM
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2023;43(6):1054-1065
Adipose Insulin Resistance Associates With Dyslipidemia Independent of Liver Resistance and Involves Early Hormone Signaling
Kerr AG; Andersson DP; Dahlman I; Ryden M; Arner P
Article: LAKARTIDNINGEN. 2023;120:22140
Paradigmskifte i behandlingen av fetma och typ 2-diabetes.
Rydén M
Article: NATURE COMMUNICATIONS. 2023;14(1):1438
An integrated single cell and spatial transcriptomic map of human white adipose tissue
Massier L; Jalkanen J; Elmastas M; Zhong J; Wang T; Nankam PAN; Frendo-Cumbo S; Backdahl J; Subramanian N; Sekine T; Kerr AG; Tseng BTP; Laurencikiene J; Buggert M; Lourda M; Kublickiene K; Bhalla N; Andersson A; Valsesia A; Astrup A; Blaak EE; Stahl PL; Viguerie N; Langin D; Wolfrum C; Blueher M; Ryden M; Mejhert N
Article: DIABETES. 2023;72(3):316-325
Relationship Between a Sedentary Lifestyle and Adipose Insulin Resistance
Andersson DP; Kerr AG; Dahlman I; Ryden M; Arner P
Article: FRONTIERS IN ENDOCRINOLOGY. 2023;14:1166961
Habitual nappers and non-nappers differ in circadian rhythms of LIPE expression in abdominal adipose tissue explants
Zambrano C; Kulyte A; Lujan J; Rivero-Gutierrez B; Sanchez de Medina F; Martinez-Augustin O; Ryden M; Scheer FAJL; Garaulet M
Article: SCIENTIFIC REPORTS. 2022;12(1):20519
Associations between subcutaneous adipocyte hypertrophy and nonalcoholic fatty liver disease
Holmer M; Hagstrom H; Chen P; Danielsson O; Aouadi M; Ryden M; Stal P
Article: JOURNAL OF INTERNAL MEDICINE. 2022;292(4):667-678
Lipolysis defect in people with obesity who undergo metabolic surgery
Ryden M; Andersson DP; Kotopouli MI; Stenberg E; Naslund E; Thorell A; Sorensen TIA; Arner P
Article: JOURNAL OF INTERNAL MEDICINE. 2022;292(2):296-307
Soat2 ties cholesterol metabolism to β-oxidation and glucose tolerance in male mice
Pramfalk C; Ahmed O; Pedrelli M; Minniti ME; Luquet S; Denis RG; Olin M; Hardfeldt J; Vedin L-L; Steffensen KR; Ryden M; Hodson L; Eriksson M; Parini P
Article: INTERNATIONAL JOURNAL OF OBESITY. 2022;46(6):1196-1203
Subcutaneous adipose tissue expansion mechanisms are similar in early and late onset overweight/obesity
Arner P; Andersson DP; Arner E; Ryden M; Kerr AG
Article: JOURNAL OF INTERNAL MEDICINE. 2022;291(5):611-621
Human white adipose tissue: A highly dynamic metabolic organ
Arner P; Ryden M
Article: DIABETES. 2022;71(4):624-636
Glutamine Regulates Skeletal Muscle Immunometabolism in Type 2 Diabetes
Dollet L; Kuefner M; Caria E; Rizo-Roca D; Pendergrast L; Abdelmoez AM; Karlsson HKR; Bjornholm M; Dalbram E; Treebak JT; Harada J; Naslund E; Ryden M; Zierath JR; Pillon NJ; Krook A
Article: DEVELOPMENTAL CELL. 2022;57(3):387-397.e4
The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology
Mejhert N; Gabriel KR; Frendo-Cumbo S; Krahmer N; Song J; Kuruvilla L; Chitraju C; Boland S; Jang D-K; von Grotthuss M; Costanzo MC; Ryden M; Olzmann JA; Flannick J; Burtt NP; Farese RVJ; Walther TC
Article: NATURE METABOLISM. 2022;4(2):190-202
Impaired phosphocreatine metabolism in white adipocytes promotes inflammation
Maqdasy S; Lecoutre S; Renzi G; Frendo-Cumbo S; Rizo-Roca D; Moritz T; Juvany M; Hodek O; Gao H; Couchet M; Witting M; Kerr A; Bergo MO; Choudhury RP; Aouadi M; Zierath JR; Krook A; Mejhert N; Ryden M
Article: JOURNAL OF CLINICAL INVESTIGATION. 2022;132(2):e153357
β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity
Valentine JM; Ahmadian M; Keinan O; Abu-Odeh M; Zhao P; Zhou X; Keller MP; Gao H; Yu RT; Liddle C; Downes M; Zhang J; Lusis AJ; Attie AD; Evans RM; Ryden M; Saltier AR
Article: FRONTIERS IN ENDOCRINOLOGY. 2022;13:996954
Sex-specific regulation of IL-10 production in human adipose tissue in obesity
Subramanian N; Tavira B; Hofwimmer K; Gutsmann B; Massier L; Abildgaard J; Juul A; Ryden M; Arner P; Laurencikiene J
Article: INTERNATIONAL JOURNAL OF OBESITY. 2021;45(12):2675-2678
A longitudinal study of the antilipolytic effect of insulin in women following bariatric surgery
Kwok KHM; Andersson DP; Ryden M; Arner P
Article: GASTROENTEROLOGY. 2021;161(6):1982-1997.e11
Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity
Azzimato V; Chen P; Barreby E; Morgantini C; Levi L; Vankova A; Jager J; Sulen A; Diotallevi M; Shen JX; Miller A; Ellis E; Ryden M; Naslund E; Thorell A; Lauschke VM; Channon KM; Crabtree MJ; Haschemi A; Craige SM; Mori M; Spallotta F; Aouadi M
Article: NATURE. 2021;599(7884):296-301
Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes.
Keinan O; Valentine JM; Xiao H; Mahata SK; Reilly SM; Abu-Odeh M; Deluca JH; Dadpey B; Cho L; Pan A; Yu RT; Dai Y; Liddle C; Downes M; Evans RM; Lusis AJ; Laakso M; Chouchani ET; Rydén M; Saltiel AR
Article: SCIENCE ADVANCES. 2021;7(43):eabi9654
Disrupted circadian oscillations in type 2 diabetes are linked to altered rhythmic mitochondrial metabolism in skeletal muscle
Gabriel BM; Smith JAB; Sardon-Puig L; Zhang X; Basse AL; Laker RC; Gao H; Liu Z; Dollet L; Treebak JT; Zorzano A; Huo Z; Ryden M; Lanner JT; Esser KA; Barres R; Pillon NJ; Krook A; Zierath JR
Article: CIRCULATION. 2021;144(12):961-982
Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis
Edgar L; Akbar N; Braithwaite AT; Krausgruber T; Gallart-Ayala H; Bailey J; Corbin AL; Khoyratty TE; Chai JT; Alkhalil M; Rendeiro AF; Ziberna K; Arya R; Cahill TJ; Bock C; Laurencikiene J; Crabtree MJ; Lemieux ME; Riksen NP; Netea MG; Wheelock CE; Channon KM; Ryden M; Udalova IA; Carnicer R; Choudhury RP
Article: ELIFE. 2021;10:e65996
Impaired mRNA splicing and proteostasis in preadipocytes in obesity-related metabolic disease
Sanchez-Ceinos J; Guzman-Ruiz R; Alberto Rangel-Zuniga O; Lopez-Alcala J; Moreno-Cano E; Del Rio-Moreno M; Luis Romero-Cabrera J; Perez-Martinez P; Maymo-Masip E; Vendrell J; Fernandez-Veledo S; Manuel Fernandez-Real J; Laurencikiene J; Ryden M; Membrives A; Luque RM; Lopez-Miranda J; Malagon MM
Article: CELL METABOLISM. 2021;33(9):1869-1882.e6
Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin
Baeckdahl J; Franzen L; Massier L; Li Q; Jalkanen J; Gao H; Andersson A; Bhalla N; Thorell A; Ryden M; Stahl PL; Mejhert N
Article: DISEASE MODELS & MECHANISMS. 2021;14(9):dmm048249
Transforming growth factor β3 deficiency promotes defective lipid metabolism and fibrosis in murine kidney
Escasany E; Lanzon B; Garcia-Carrasco A; Izquierdo-Lahuerta A; Torres L; Corrales P; Rodriguez AER; Luis-Lima S; Alvarez CM; Ruperez FJ; Ros M; Porrini E; Ryden M; Medina-Gomez G
Article: ADVANCED SCIENCE. 2021;8(16):e2100106
3D Adipose Tissue Culture Links the Organotypic Microenvironment to Improved Adipogenesis
Shen JX; Couchet M; Dufau J; de Castro Barbosa T; Ulbrich MH; Helmstadter M; Kemas AM; Zandi Shafagh R; Marques M-A; Hansen JB; Mejhert N; Langin D; Ryden M; Lauschke VM
Article: DIABETES. 2021;70(7):1486-1497
Human White Adipose Tissue Displays Selective Insulin Resistance in the Obese State
Mileti E; Kwok KHM; Andersson DP; Mathelier A; Raman A; Backdahl J; Jalkanen J; Massier L; Thorell A; Gao H; Arner P; Mejhert N; Daub CO; Ryden M
Article: CELL. 2021;184(13):3502-3518.e33
Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis
Johansen OS; Ma T; Hansen JB; Markussen LK; Schreiber R; Reverte-Salisa L; Dong H; Christensen DP; Sun W; Gnad T; Karavaeva I; Nielsen TS; Kooijman S; Cero C; Dmytriyeva O; Shen Y; Razzoli M; O'Brien SL; Kuipers EN; Nielsen CH; Orchard W; Willemsen N; Jespersen NZ; Lundh M; Sustarsic EG; Hallgren CM; Frost M; McGonigle S; Isidor MS; Broholm C; Pedersen O; Hansen JB; Grarup N; Hansen T; Kjaer A; Granneman JG; Babu MM; Calebiro D; Nielsen S; Ryden M; Soccio R; Rensen PCN; Treebak JT; Schwartz TW; Emanuelli B; Bartolomucci A; Pfeifer A; Zechner R; Scheele C; Mandrup S; Gerhart-Hines Z
Article: METABOLISM: CLINICAL AND EXPERIMENTAL. 2021;118:154726
Quantitative phosphoproteomic analysis of IRS1 in skeletal muscle from men with normal glucose tolerance or type 2 diabetes: A case-control study
Karlsson HKR; Kasahara A; Ikeda M; Chibalin AV; Harada J; Ryden M; Krook A; Kato M; Kubota K; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY. 2021;320(5):C822-C841
In vitro and ex vivo models of adipocytes
Dufau J; Shen JX; Couchet M; Barbosa TDC; Mejhert N; Massier L; Griseti E; Mouisel E; Amri E-Z; Lauschke VM; Ryden M; Langin D
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2021;106(5):1312-1324
Differential Mitochondrial Gene Expression in Adipose Tissue Following Weight Loss Induced by Diet or Bariatric Surgery
van der Kolk BW; Muniandy M; Kaminska D; Alvarez M; Ko A; Miao Z; Valsesia A; Langin D; Vaittinen M; Paakkonen M; Jokinen R; Kaye S; Heinonen S; Virtanen KA; Andersson DP; Mannisto V; Saris WH; Astrup A; Ryden M; Blaak EE; Pajukanta P; Pihlajamaki J; Pietilainen KH
Article: DIABETES. 2021;70(3):680-695
Role of the Neutral Amino Acid Transporter SLC7A10 in Adipocyte Lipid Storage, Obesity, and Insulin Resistance
Jersin RA; Tallapragada DSP; Madsen A; Skartveit L; Fjaere E; McCann A; Dyer L; Willems A; Bjune J-I; Bjune MS; Vage V; Nielsen HJ; Thorsen HL; Nedrebo BG; Busch C; Steen VM; Blueher M; Jacobson P; Svensson P-A; Ferno J; Ryden M; Arner P; Nygard O; Claussnitzer M; Ellingsen S; Madsen L; Sagen JV; Mellgren G; Dankel SN
Article: PLOS ONE. 2021;16(6):e0249666
Enhanced virulence of Plasmodium falciparum in blood of diabetic patients
Ch'ng J-H; Moll K; Wyss K; Hammar U; Ryden M; Kampe O; Farnert A; Wahlgren M
Article: INTERNATIONAL JOURNAL OF OBESITY. 2020;44(12):2436-2443
Usefulness of surrogate markers to determine insulin action in fat cells
Ryden M; Andersson DP; Arner P
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2020;105(12):dgaa492-e4416
Circadian Rhythms in Hormone-sensitive Lipase in Human Adipose Tissue: Relationship to Meal Timing and Fasting Duration
Arredondo-Amador M; Zambrano C; Kulyte A; Juan L; Kun H; Sanchez de Medina F; Scheer FAJL; Arner P; Ryden M; Martinez-Augustin O; Garaulet M
Article: JOURNAL OF INTERNAL MEDICINE. 2020;288(2):219-233
Long-term changes in adipose tissue gene expression following bariatric surgery
Kerr AG; Andersson DP; Ryden M; Arner P; Dahlman I
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2020;105(4):dgz245-e962
Influence of Aging and Menstrual Status on Subcutaneous Fat Cell Lipolysis
Ryden M; Gao H; Arner P
Article: OBESITY SURGERY. 2020;30(3):1086-1092
Metabolic Impact of Body Fat Percentage Independent of Body Mass Index in Women with Obesity Remission After Gastric Bypass
Eriksson Hogling D; Backdahl J; Thorell A; Ryden M; Andersson DP
Article: SCIENCE TRANSLATIONAL MEDICINE. 2020;12(532):eaaw9709
Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance
Azzimato V; Jager J; Chen P; Morgantini C; Levi L; Barreby E; Sulen A; Oses C; Willerbrords J; Xu C; Li X; Shen JX; Akbar N; Haag L; Ellis E; Walhen K; Naslund E; Thorell A; Choudhury RP; Lauschke VM; Ryden M; Craige SM; Aouadi M
Article: CELL METABOLISM. 2020;31(2):375-390.e11
Glutamine Links Obesity to Inflammation in Human White Adipose Tissue
Petrus P; Lecoutre S; Dollet L; Wiel C; Sulen A; Gao H; Tavira B; Laurencikiene J; Rooyackers O; Checa A; Douagi I; Wheelock CE; Arner P; McCarthy M; Bergo MO; Edgar L; Choudhury RP; Aouadi M; Krook A; Ryden M
Article: INTERNATIONAL JOURNAL OF OBESITY. 2020;44(2):377-387
Prospective analyses of white adipose tissue gene expression in relation to long-term body weight changes
Kwok KHM; Ryden M; Andersson DP; Beauchef G; Guere C; Vie K; Bergman O; Lundback V; Arner P; Dahlman I
Article: OBESITY FACTS. 2020;13(1):1-28
OBEDIS Core Variables Project: European Expert Guidelines on a Minimal Core Set of Variables to Include in Randomized, Controlled Clinical Trials of Obesity Interventions
Alligier M; Barres R; Blaak EE; Boirie Y; Bouwman J; Brunault P; Campbell K; Clement K; Farooqi IS; Farpour-Lambert NJ; Fruhbeck G; Goossens GH; Hager J; Halford JCG; Hauner H; Jacobi D; Julia C; Langin D; Natali A; Neovius M; Oppert JM; Pagotto U; Palmeira AL; Roche H; Ryden M; Scheen AJ; Simon C; Sorensen TIA; Tappy L; Yki-Jarvinen H; Ziegler O; Laville M
Article: METABOLISM: CLINICAL AND EXPERIMENTAL. 2019;101:153999
The Rho GTPase RND3 regulates adipocyte lipolysis
Dankel SN; Rost TH; Kulyte A; Fandalyuk Z; Skurk T; Hauner H; Sagen JV; Ryden M; Arner P; Mellgren G
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2019;104(10):4552-4562
Human-Specific Function of IL-10 in Adipose Tissue Linked to Insulin Resistance
Acosta JR; Tavira B; Douagi I; Kulyte A; Arner P; Ryden M; Laurencikiene J
Article: NATURE MEDICINE. 2019;25(9):1385-1389
Adipose lipid turnover and long-term changes in body weight
Arner P; Bernard S; Appelsved L; Fu K-Y; Andersson DP; Salehpour M; Thorell A; Ryden M; Spalding KL
Article: EBIOMEDICINE. 2019;46:368-380
The imprinted gene Delta like non-canonical notch ligand 1 (Dlk1) associates with obesity and triggers insulin resistance through inhibition of skeletal muscle glucose uptake
Jensen CH; Kosmina R; Ryden M; Baun C; Hvidsten S; Andersen MS; Christensen LL; Gastaldelli A; Marraccini P; Arner P; Jorgensen CD; Laborda J; Holst JJ; Andersen DC
Article: EBIOMEDICINE. 2019;44:489-501
Specific loss of adipocyte CD248 improves metabolic health via reduced white adipose tissue hypoxia, fibrosis and inflammation
Petrus P; Fernandez TL; Kwon MM; Huang JL; Lei V; Safikhan NS; Karunakaran S; O'Shannessy DJ; Zheng X; Catrina S-B; Albone E; Laine J; Virtanen K; Clee SM; Kieffer TJ; Noll C; Carpentier AC; Johnson JD; Ryden M; Conway EM
Article: JOURNAL OF INTERNAL MEDICINE. 2019;285(5):578-588
Insulin action is severely impaired in adipocytes of apparently healthy overweight and obese subjects
Ryden M; Petrus P; Andersson DP; Medina-Gomez G; Escasany E; Corrales Cordon P; Dahlman I; Kulyte A; Arner P
Article: NATURE METABOLISM. 2019;1(4):445-459
Liver macrophages regulate systemic metabolism through non-inflammatory factors
Morgantini C; Jager J; Li X; Levi L; Azzimato V; Sulen A; Barreby E; Xu C; Tencerova M; Naslund E; Kumar C; Verdeguer F; Straniero S; Hultenby K; Bjorkstrom NK; Ellis E; Ryden M; Kutter C; Hurrell T; Lauschke VM; Boucher J; Tomcala A; Krejcova G; Bajgar A; Aouadi M
Article: TRANSPLANTATION. 2019;103(3):630-637
Open Randomized Multicenter Study to Evaluate Safety and Efficacy of Low Molecular Weight Sulfated Dextran in Islet Transplantation
von Zur-Muhlen B; Lundgren T; Bayman L; Berne C; Bridges N; Eggerman T; Foss A; Goldstein J; Jenssen T; Jorns C; Morrison Y; Ryden M; Schwieger T; Tufveson G; Nilsson B; Korsgren O
Article: NATURE METABOLISM. 2019;1(1):133-146
Interaction between hormone-sensitive lipase and ChREBP in fat cells controls insulin sensitivity
Morigny P; Houssier M; Mairal A; Ghilain C; Mouisel E; Benhamed F; Masri B; Recazens E; Denechaud P-D; Tavernier G; Caspar-Bauguil S; Virtue S; Sramkova V; Monbrun L; Mazars A; Zanoun M; Guilmeau S; Barquissau V; Beuzelin D; Bonnel S; Marques M; Monge-Roffarello B; Lefort C; Fielding B; Sulpice T; Astrup A; Payrastre B; Bertrand-Michel J; Meugnier E; Ligat L; Lopez F; Guillou H; Ling C; Holm C; Rabasa-Lhoret R; Saris WHM; Stich V; Arner P; Ryden M; Moro C; Viguerie N; Harms M; Hallen S; Vidal-Puig A; Vidal H; Postic C; Langin D
Article: JOURNAL OF INTERNAL MEDICINE. 2019;285(1):92-101
Improved metabolism and body composition beyond normal levels following gastric bypass surgery: a longitudinal study
Andersson DP; Dahlman I; Hogling DE; Backdahl J; Toft E; Qvisth V; Naslund E; Thorell A; Ryden M; Arner P
Article: INTERNATIONAL JOURNAL OF OBESITY. 2018;42(12):2047-2056
Screening of potential adipokines identifies S100A4 as a marker of pernicious adipose tissue and insulin resistance
Arner P; Petrus P; Esteve D; Boulomie A; Naslund E; Thorell A; Gao H; Dahlman I; Ryden M
Article: CELL REPORTS. 2018;25(3):551-560.e5
Transforming Growth Factor-β3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue
Petrus P; Mejhert N; Corrales P; Lecoutre S; Li Q; Maldonado E; Kulyte A; Lopez Y; Campbell M; Acosta JR; Laurencikiene J; Douagi I; Gao H; Martinez-Alvarez C; Heden P; Spalding KL; Vidal-Puig A; Medina-Gomez G; Arner P; Ryden M
Article: DIABETES, OBESITY AND METABOLISM. 2018;20(10):2416-2425
Mapping of biguanide transporters in human fat cells and their impact on lipolysis
Arner P; Kulyte A; Batchelor K; Laurencikiene J; Livingston J; Ryden M
Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2018;472:50-56
MicroRNAs-361-5p and miR-574-5p associate with human adipose morphology and regulate EBF1 expression in white adipose tissue
Belarbi Y; Mejhert N; Gao H; Arner P; Ryden M; Kulyte A
Article: CELL METABOLISM. 2018;28(1):45-54.e3
Weight Gain and Impaired Glucose Metabolism in Women Are Predicted by Inefficient Subcutaneous Fat Cell Lipolysis
Arner P; Andersson DP; Backdahl J; Dahlman I; Ryden M
Article: SURGERY FOR OBESITY AND RELATED DISEASES. 2018;14(7):936-942
Body fat mass and distribution as predictors of metabolic outcome and weight loss after Roux-en-Y gastric bypass
Hogling DE; Ryden M; Backdahl J; Thorell A; Arner P; Andersson DP
Article: DIABETOLOGIA. 2018;61(5):1112-1123
FAM13A and POM121C are candidate genes for fasting insulin: functional follow-up analysis of a genome-wide association study
Lundback V; Kulyte A; Strawbridge RJ; Ryden M; Arner P; Marcus C; Dahlman I
Article: EBIOMEDICINE. 2018;30:248-260
Long Non-Coding RNAs Associated with Metabolic Traits in Human White Adipose Tissue
Gao H; Kerr A; Jiao H; Hon C-C; Ryden M; Dahlman I; Arner P
Article: AMERICAN JOURNAL OF HYPERTENSION. 2018;31(4):450-457
Long-Term Improvement in Aortic Pulse Wave Velocity After Weight Loss Can Be Predicted by White Adipose Tissue Factors
Backdahl J; Andersson DP; Eriksson-Hogling D; Caidahl K; Thorell A; Mileti E; Daub CO; Arner P; Ryden M
Article: DIABETES AND METABOLISM. 2018;44(2):155-159
Family history of diabetes is associated with enhanced adipose lipolysis: Evidence for the implication of epigenetic factors
Dahlman I; Ryden M; Arner P
Article: LAKARTIDNINGEN. 2018;115:EYWU
Nya glukossänkande läkemedel är kardiovaskulärt säkra - Enstaka diabetesläkemedel har även visats skydda mot kardiovaskulära och renala komplikationer.
Toft E; Rydén M
Article: BIO-PROTOCOL. 2018;8(3):e2711
Ex vivo Analysis of Lipolysis in Human Subcutaneous Adipose Tissue Explants
Decaunes P; Bouloumie A; Ryden M; Galitzky J
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2018;103(2):710-721
Adipocyte Expression of SLC19A1 Links DNA Hypermethylation to Adipose Tissue Inflammation and Insulin Resistance
Petrus P; Bialesova L; Checa A; Kerr A; Naz S; Backdahl J; Gracia A; Toft S; Dahlman-Wright K; Heden P; Dahlman I; Wheelock CE; Arner P; Mejhert N; Gao H; Ryden M
Article: SCIENTIFIC REPORTS. 2018;8(1):1097
Natriuretic peptides promote glucose uptake in a cGMP-dependent manner in human adipocytes
Coue M; Barquissau V; Morigny P; Louche K; Lefort C; Mairal A; Carpene C; Viguerie N; Arner P; Langin D; Ryden M; Moro C
Article: INTERNATIONAL JOURNAL OF OBESITY. 2017;41(12):1815-1823
Repin1 deficiency in adipose tissue improves whole-body insulin sensitivity, and lipid metabolism
Hesselbarth N; Kunath A; Kern M; Gericke M; Mejhert N; Ryden M; Stumvoll M; Blueher M; Kloeting N
Article: STEM CELL RESEARCH AND THERAPY. 2017;8(1):250
Single cell transcriptomics suggest that human adipocyte progenitor cells constitute a homogeneous cell population
Acosta JR; Joost S; Karlsson K; Ehrlund A; Li X; Aouadi M; Kasper M; Arner P; Ryden M; Laurencikiene J
Article: INTERNATIONAL JOURNAL OF OBESITY. 2017;41(10):1564-1569
Abdominal subcutaneous adipose tissue cellularity in men and women
Andersson DP; Arner E; Hogling DE; Ryden M; Arner P
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2017;37(9):1782-1787
Subcutaneous Adipocyte Lipolysis Contributes to Circulating Lipid Levels
Ryden M; Arner P
Article: JOURNAL OF INTERNAL MEDICINE. 2017;282(3):220-228
Cardiovascular risk score is linked to subcutaneous adipocyte size and lipid metabolism
Ryden M; Arner P
Article: INTERNATIONAL JOURNAL OF OBESITY. 2017;41(8):1295-1298
Depot-specific differences in fatty acid composition and distinct associations with lipogenic gene expression in abdominal adipose tissue of obese women
Petrus P; Edholm D; Rosqvist F; Dahlman I; Sundbom M; Arner P; Ryden M; Riserus U
Article: STEM CELLS. 2017;35(7):1799-1814
CD36 Is a Marker of Human Adipocyte Progenitors with Pronounced Adipogenic and Triglyceride Accumulation Potential
Gao H; Volat F; Sandhow L; Galitzky J; Thuy N; Esteve D; Astrom G; Mejhert N; Ledoux S; Thalamas C; Arner P; Guillemot J-C; Qian H; Ryden M; Bouloumie A
Article: NATURE COMMUNICATIONS. 2017;8:15253
Impact of fat mass and distribution on lipid turnover in human adipose tissue
Spalding KL; Bernard S; Naslund E; Salehpour M; Possnert G; Appelsved L; Fu K-Y; Alkass K; Druid H; Thorell A; Ryden M; Arner P
Article: OBESITY SURGERY. 2017;27(4):1115-1118
mentectomy in Addition to Bariatric Surgery-a 5-Year Follow-up
Andersson DP; Eriksson-Hogling D; Backdahl J; Thorell A; Lofgren P; Ryden M; Arner P; Hoffstedt J
Article: LAKARTIDNINGEN. 2017;114:ECLS
[Metabolic surgery is an effective treatment for type 2 diabetes--but several questions remains to be answered].
Olbers T; Rydén M
Article: DIABETES CARE. 2017;40(1):77-84
Long-term Protective Changes in Adipose Tissue After Gastric Bypass
Hoffstedt J; Andersson DP; Hogling DE; Theorell J; Naslund E; Thorell A; Ehrlund A; Ryden M; Arner P
Article: DIABETES. 2017;66(1):218-230
Transcriptional Dynamics During Human Adipogenesis and Its Link to Adipose Morphology and Distribution
Ehrlund A; Mejhert N; Bjork C; Andersson R; Kulyte A; Astrom G; Itoh M; Kawaji H; Lassmann T; Daub CO; Carninci P; Forrest ARR; Hayashizaki Y; Sandelin A; Ingelsson E; Ryden M; Laurencikiene J; Arner P; Arner E
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2016;101(11):4021-4029
Adipose and Circulating CCL18 Levels Associate With Metabolic Risk Factors in Women
Hogling DE; Petrus P; Gao H; Backdahl J; Dahlman I; Laurencikiene J; Acosta J; Ehrlund A; Naslund E; Kulyte A; Mejhert N; Andersson DP; Arner P; Ryden M
Article: DIABETOLOGIA. 2016;59(11):2393-2405
The epigenetic signature of systemic insulin resistance in obese women
Arner P; Sahlqvist A-S; Sinha I; Xu H; Yao X; Waterworth D; Rajpal D; Loomis AK; Freudenberg JM; Johnson T; Thorell A; Naslund E; Ryden M; Dahlman I
Article: NATURE MEDICINE. 2016;22(10):1120-1130
An AMP-activated protein kinase-stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice
Rohm M; Schaefer M; Laurent V; Uestuenel BE; Niopek K; Algire C; Hautzinger O; Sijmonsma TP; Zota A; Medrikova D; Pellegata NS; Ryden M; Kulyte A; Dahlman I; Arner P; Petrovic N; Cannon B; Amri E-Z; Kemp BE; Steinberg GR; Janovska P; Kopecky J; Wolfrum C; Blueher M; Diaz MB; Herzig S
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2016;101(10):3765-3771
Circulating and Adipose Levels of Adipokines Associated With Insulin Sensitivity in Nonobese Subjects With Type 2 Diabetes
Andersson DP; Laurencikiene J; Acosta JR; Ryden M; Arner P
Article: CELL REPORTS. 2016;16(9):2317-2326
The Adipose Transcriptional Response to Insulin Is Determined by Obesity, Not Insulin Sensitivity
Ryden M; Hrydziuszko O; Mileti E; Raman A; Bornholdt J; Boyd M; Toft E; Qvist V; Naslund E; Thorell A; Andersson DP; Dahlman I; Gao H; Sandelin A; Daub CO; Arner P
Article: SCIENTIFIC REPORTS. 2016;6:28080
Thioredoxin reductase 1 suppresses adipocyte differentiation and insulin responsiveness
Peng X; Gimenez-Cassina A; Petrus P; Conrad M; Ryden M; Arner ESJ
Article: INTERNATIONAL JOURNAL OF OBESITY. 2016;40(4):714-720
Impaired atrial natriuretic peptide-mediated lipolysis in obesity
Ryden M; Backdahl J; Petrus P; Thorell A; Gao H; Coue M; Langin D; Moro C; Arner P
Article: DIABETOLOGIA. 2016;59(3):560-570
Increased fat cell size: a major phenotype of subcutaneous white adipose tissue in non-obese individuals with type 2 diabetes
Acosta JR; Douagi I; Andersson DP; Backdahl J; Ryden M; Arner P; Laurencikiene J
Article: DIABETES. 2016;65(2):433-437
Numerous Genes in Loci Associated With Body Fat Distribution Are Linked to Adipose Function
Dahlman I; Ryden M; Brodin D; Grallert H; Strawbridge RJ; Amer P
Article: NUTRITION AND METABOLISM. 2016;13:4
Effects of selected bioactive food compounds on human white adipocyte function
Bjork C; Wilhelm U; Mandrup S; Larsen BD; Bordoni A; Heden P; Ryden M; Arner P; Laurencikiene J
Article: DIABETES AND METABOLISM. 2015;41(6):509-512
Low early B-cell factor 1 (EBF1) activity in human subcutaneous adipose tissue is linked to a pernicious metabolic profile
Petrus P; Mejhert N; Gao H; Backdahl J; Arner E; Arner P; Ryden M
Article: CELL METABOLISM. 2015;22(3):408-417
Transplanted Bone Marrow-Derived Cells Contribute to Human Adipogenesis
Ryden M; Uzunel M; Hard JL; Borgstrom E; Mold JE; Arner E; Mejhert N; Andersson DP; Widlund Y; Hassan M; Jones CV; Spalding KL; Svahn B-M; Ahmadian A; Frisen J; Bernard S; Mattsson J; Arner P
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2015;100(8):E1084-E1088
MicroRNA-193b Controls Adiponectin Production in Human White Adipose Tissue
Belarbi Y; Mejhert N; Lorente-Cebrian S; Dahlman I; Arner P; Ryden M; Kulyte A
Article: OBESITY. 2015;23(7):1371-1378
MFAP5 is related to obesity-associated adipose tissue and extracellular matrix remodeling and inflammation
Vaittinen M; Kolehmainen M; Ryden M; Eskelinen M; Wabitsch M; Pihlajamaeki J; Uusitupa M; Pulkkinen L
Article: LAKARTIDNINGEN. 2015;112:DF6D
[Skin lightening products are a part of everyday life in many parts of the world. Corticosteroids, hydroquinone and mercury are common ingredients].
Wallander M; Löfgren P; Rydén M
Article: NATURE COMMUNICATIONS. 2015;6:7433
Cidea improves the metabolic profile through expansion of adipose tissue
Abreu-Vieira G; Fischer AW; Mattsson C; de Jong JMA; Shabalina IG; Ryden M; Laurencikiene J; Arner P; Cannon B; Nedergaard J; Petrovic N
Article: INTERNATIONAL JOURNAL OF OBESITY. 2015;39(6):893-898
Adipose tissue morphology predicts improved insulin sensitivity following moderate or pronounced weight
Eriksson-Hogling D; Andersson DP; Backdahl J; Hoffstedt J; Rossner S; Thorell A; Arner E; Arner P; Ryden M
Article: INTERNATIONAL JOURNAL OF OBESITY. 2015;39(6):910-919
The fat cell epigenetic signature in post-obese women is characterized by global hypomethylation and differential DNA methylation of adipogenesis genes
Dahlman I; Sinha I; Gao H; Brodin D; Thorell A; Ryden M; Andersson DP; Henriksson J; Perfilyev A; Ling C; Dahlman-Wright K; Arner P
Article: LIPIDS IN HEALTH AND DISEASE. 2015;14:42
Saturated fatty acids in human visceral adipose tissue are associated with increased 11-β-hydroxysteroid-dehydrogenase type 1 expression
Petrus P; Rosqvist F; Edholm D; Mejhert N; Arner P; Dahlman I; Ryden M; Sundbom M; Riserus U
Article: INTERNATIONAL JOURNAL OF OBESITY. 2015;39(2):222-227
Regional variations in the relationship between arterial stiffness and adipocyte volume or number in obese subjects
Arner P; Backdahl J; Hemmingsson P; Stenvinkel P; Eriksson-Hogling D; Naslund E; Thorell A; Andersson DP; Caidahl K; Ryden M
Article: OBESITY FACTS. 2015;8(2):147-155
Fatty Acids, Obesity and Insulin Resistance
Arner P; Ryden M
Article: CLINICAL EPIGENETICS. 2015;7(1):93
The epigenetic signature of subcutaneous fat cells is linked to altered expression of genes implicated in lipid metabolism in obese women
Arner P; Sinha I; Thorell A; Ryden M; Dahlman-Wright K; Dahlman I
Article: PLOS ONE. 2015;10(4):e0123566
Circulating Carnosine Dipeptidase 1 Associates with Weight Loss and Poor Prognosis in Gastrointestinal Cancer
Arner P; Henjes F; Schwenk JM; Darmanis S; Dahlman I; Iresjo B-M; Naredi P; Agustsson T; Lundholm K; Nilsson P; Ryden M
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2014;99(10):E1870-E1876
Adipose Tissue and Metabolic Alterations: Regional Differences in Fat Cell Size and Number Matter, But Differently: A Cross-Sectional Study
Ryden M; Andersson DP; Bergstrom IB; Arner P
Article: DIABETES CARE. 2014;37(7):1831-1836
Changes in Subcutaneous Fat Cell Volume and Insulin Sensitivity After Weight Loss
Andersson DP; Hogling DE; Thorell A; Toft E; Qvisth V; Naslund E; Thorne A; Wiren M; Lofgren P; Hoffstedt J; Dahlman I; Mejhert N; Ryden M; Arner E; Arner P
Article: CELL METABOLISM. 2014;19(6):981-992
Early B Cell Factor 1 Regulates Adipocyte Morphology and Lipolysis in White Adipose Tissue
Gao H; Mejhert N; Fretz JA; Arner E; Lorente-Cebrian S; Ehrlund A; Dahlman-Wright K; Gong X; Stromblad S; Douagi I; Laurencikiene J; Dahlman I; Daub CO; Ryden M; Horowitz MC; Arner P
Article: DIABETES. 2014;63(4):1248-1258
Additive Effects of MicroRNAs and Transcription Factors on CCL2 Production in Human White Adipose Tissue
Kulyte A; Belarbi Y; Lorente-Cebrian S; Bambace C; Arner E; Daub CO; Heden P; Ryden M; Mejhert N; Arner P
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2014;306(3):E267-E274
MicroRNA profiling links miR-378 to enhanced adipocyte lipolysis in human cancer cachexia
Kulyte A; Lorente-Cebrian S; Gao H; Mejhert N; Agustsson T; Arner P; Ryden M; Dahlman I
Article: PLOS ONE. 2014;9(1):e86800
MicroRNAs Regulate Human Adipocyte Lipolysis: Effects of miR-145 Are Linked to TNF-α
Lorente-Cebrian S; Mejhert N; Kulyte A; Laurencikiene J; Astrom G; Heden P; Ryden M; Arner P
Article: PLOS ONE. 2014;9(3):e80274
Ceruloplasmin Is a Novel Adipokine Which Is Overexpressed in Adipose Tissue of Obese Subjects and in Obesity-Associated Cancer Cells
Arner E; Forrest ARR; Ehrlund A; Mejhert N; Itoh M; Kawaji H; Lassmann T; Laurencikiene J; Ryden M; Arner P
Article: JOURNAL OF LIPID RESEARCH. 2013;54(10):2909-2913
Adipocyte triglyceride turnover and lipolysis in lean and overweight subjects
Ryden M; Andersson DP; Bernard S; Spalding K; Arner P
Article: DIABETOLOGIA. 2013;56(8):1792-1801
Semaphorin 3C is a novel adipokine linked to extracellular matrix composition
Mejhert N; Wilfling F; Esteve D; Galitzky J; Pellegrinelli V; Kolditz C-I; Viguerie N; Tordjman J; Naslund E; Trayhurn P; Lacasa D; Dahlman I; Stich V; Lang P; Langin D; Bouloumie A; Clement K; Ryden M
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2013;98(5):E897-E901
Variations in the Size of the Major Omentum Are Primarily Determined by Fat Cell Number
Arner P; Andersson DP; Thorne A; Wiren M; Hoffstedt J; Naslund E; Thorell A; Ryden M
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2013;98(3):E503-E508
Characterization of the Wnt Inhibitors Secreted Frizzled-Related Proteins (SFRPs) in Human Adipose Tissue
Ehrlund A; Mejhert N; Lorente-Cebrian S; Astrom G; Dahlman I; Laurencikiene J; Ryden M
Article: PLOS ONE. 2013;8(5):e63493
Elevated Circulating Levels and Tissue Expression of Pentraxin 3 in Uremia: A Reflection of Endothelial Dysfunction
Witasp A; Ryden M; Carrero JJ; Qureshi AR; Nordfors L; Naslund E; Hammarqvist F; Arefin S; Kublickiene K; Stenvinkel P
Article: NUTRITION. 2012;28(9):851-855
Adipose tissue volume is decreased in recently diagnosed cancer patients with cachexia
Agustsson T; Wikrantz P; Ryden M; Brismar T; Isaksson B
Article: DIABETES. 2012;61(8):1986-1993
Adipose Tissue MicroRNAs as Regulators of CCL2 Production in Human Obesity
Arner E; Mejhert N; Kulyte A; Balwierz PJ; Pachkov M; Cormont M; Lorente-Cebrian S; Ehrlund A; Laurencikiene J; Heden P; Dahlman-Wright K; Tanti J-F; Hayashizaki Y; Ryden M; Dahlman I; van Nimwegen E; Daub CO; Arner P
Article: JOURNAL OF INTERNAL MEDICINE. 2012;271(4):414-420
Adipose zinc-a2-glycoprotein is a catabolic marker in cancer and noncancerous states
Ryden M; Agustsson T; Andersson J; Bolinder J; Toft E; Arner P
Article: EUROPEAN JOURNAL OF NUTRITION. 2012;51(3):335-342
Differential effects of 1α,25-dihydroxycholecalciferol on MCP-1 and adiponectin production in human white adipocytes
Lorente-Cebrian S; Eriksson A; Dunlop T; Mejhert N; Dahlman I; Astrom G; Sjolin E; Wahlen K; Carlberg C; Laurencikiene J; Heden P; Arner P; Ryden M
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2011;96(12):E2045-E2049
Regulation of Lipolysis in Small and Large Fat Cells of the Same Subject
Laurencikiene J; Skurk T; Kulyte A; Heden P; Astrom G; Sjolin E; Ryden M; Hauner H; Arner P
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2011;96(10):E1661-E1665
MTCH2 in Human White Adipose Tissue and Obesity
Kulyte A; Ryden M; Mejhert N; Dungner E; Sjolin E; Arner P; Dahlman I
Article: NATURE. 2011;478(7367):110-113
Dynamics of human adipose lipid turnover in health and metabolic disease
Arner P; Bernard S; Salehpour M; Possnert G; Liebl J; Steier P; Buchholz BA; Eriksson M; Arner E; Hauner H; Skurk T; Ryden M; Frayn KN; Spalding KL
Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2011;26(8):2485-2491
Uraemic sera stimulate lipolysis in human adipocytes: role of perilipin
Axelsson J; Astrom G; Sjolin E; Qureshi AR; Lorente-Cebrian S; Stenvinkel P; Ryden M
Article: DIABETES. 2011;60(7):1917-1925
Dipeptidyl Peptidase 4 Is a Novel Adipokine Potentially Linking Obesity to the Metabolic Syndrome
Lamers D; Famulla S; Wronkowitz N; Hartwig S; Lehr S; Ouwens DM; Eckardt K; Kaufman JM; Ryden M; Mueller S; Hanisch F-G; Ruige J; Arner P; Sell H; Eckel J
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2011;96(6):E962-E966
Genetic Association and Gene Expression Analysis Identify FGFR1 as a New Susceptibility Gene for Human Obesity
Jiao H; Arner P; Dickson SL; Vidal H; Mejhert N; Henegar C; Taube M; Hansson C; Hinney A; Galan P; Simon C; Silveira A; Benrick A; Jansson J-O; Bouloumie A; Langin D; Laville M; Debard C; Axelsson T; Ryden M; Kere J; Dahlman-Wright K; Hamsten A; Clement K; Dahlman I
Article: FEBS LETTERS. 2011;585(5):744-748
CIDEA interacts with liver X receptors in white fat cells
Kulyte A; Pettersson AT; Antonson P; Stenson BM; Langin D; Gustafsson J-A; Staels B; Ryden M; Arner P; Laurencikiene J
Article: BRITISH JOURNAL OF CANCER. 2011;104(3):441-447
Enhanced ZAG production by subcutaneous adipose tissue is linked to weight loss in gastrointestinal cancer patients
Mracek T; Stephens NA; Gao D; Bao Y; Ross JA; Ryden M; Arner P; Trayhurn P; Fearon KCH; Bing C
Article: LAKARTIDNINGEN. 2011;108(4):136
[Metformin in type 2 diabetes. An extensive observational study confirms the agent as first choice--so far].
Rydén M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(1):370-379
Liver X Receptor (LXR) Regulates Human Adipocyte Lipolysis
Stenson BM; Ryden M; Venteclef N; Dahlman I; Pettersson AML; Mairal A; Astrom G; Blomqvist L; Wang V; Jocken JWE; Clement K; Langin D; Arner P; Laurencikiene J
Article: OBESITY FACTS. 2011;4(5):365-371
Relationship between Site-Specific HSL Phosphorylation and Adipocyte Lipolysis in Obese Women
Lorente-Cebrian S; Kulyte A; Heden P; Naslund E; Arner P; Ryden M
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2011;96(1):133-141
Twist1 in Human White Adipose Tissue and Obesity
Pettersson AT; Mejhert N; Jernas M; Carlsson LMS; Dahlman I; Laurencikiene J; Arner P; Ryden M
Article: DIABETOLOGIA. 2010;53(12):2496-2503
Regional impact of adipose tissue morphology on the metabolic profile in morbid obesity
Hoffstedt J; Arner E; Wahrenberg H; Andersson DP; Qvisth V; Lofgren P; Ryden M; Thorne A; Wiren M; Palmer M; Thorell A; Toft E; Arner P
Article: INTERNATIONAL JOURNAL OF OBESITY. 2010;34(8):1333-1340
Effects of pain controlling neuropeptides on human fat cell lipolysis
van Harmelen V; Dicker A; Sjolin E; Blomqvist L; Wiren M; Hoffstedt J; Ryden M; Arner P
Article: BRITISH JOURNAL OF CANCER. 2010;102(10):1541-1548
Adipose tissue pathways involved in weight loss of cancer cachexia
Dahlman I; Mejhert N; Linder K; Agustsson T; Mutch DM; Kulyte A; Isaksson B; Permert J; Petrovic N; Nedergaard J; Sjoelin E; Brodin D; Clement K; Dahlman-Wright K; Ryden M; Arner P
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2010;95(5):2451-2457
Mapping of the Fibroblast Growth Factors in Human White Adipose Tissue
Mejhert N; Galitzky J; Pettersson AT; Bambace C; Blomqvist L; Bouloumie A; Frayn KN; Dahlman I; Arner P; Ryden M
Article: DIABETES. 2010;59(3):564-571
A Possible Inflammatory Role of Twist1 in Human White Adipocytes
Pettersson AT; Laurencikiene J; Mejhert N; Naslund E; Bouloumie A; Dahlman I; Arner P; Ryden M
Article: BMC ENDOCRINE DISORDERS. 2010;10:1
Role of Receptor-Interacting Protein 140 in human fat cells
Mejhert N; Laurencikiene J; Pettersson AT; Kaaman M; Stenson BM; Ryden M; Dahlman I
Article: DIABETES. 2010;59(1):105-109
Adipocyte Turnover: Relevance to Human Adipose Tissue Morphology
Arner E; Westermark PO; Spalding KL; Britton T; Ryden M; Frisen J; Bernard S; Arner P
Article: ENDOCRINOLOGY. 2009;150(9):4104-4113
Activation of Liver X Receptor Regulates Substrate Oxidation in White Adipocytes
Stenson BM; Ryden M; Steffensen KR; Wahlen K; Pettersson AT; Jocken JW; Arner P; Laurencikiene J
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2009;94(8):3003-3009
Role of Follistatin in Promoting Adipogenesis in Women
Flanagan JN; Linder K; Mejhert N; Dungner E; Wahlen K; Decaunes P; Ryden M; Bjorklund P; Arver S; Bhasin S; Bouloumie A; Arner P; Dahlman I
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2009;284(27):18282-18291
Contribution of Adipose Triglyceride Lipase and Hormone-sensitive Lipase to Lipolysis in hMADS Adipocytes
Bezaire V; Mairal A; Ribet C; Lefort C; Girousse A; Jocken J; Laurencikiene J; Anesia R; Rodriguez A-M; Ryden M; Stenson BM; Dani C; Ailhaud G; Arner P; Langin D
Article: HORMONE AND METABOLIC RESEARCH. 2009;41(5):350-355
Primary Differences in Lipolysis between Human Omental and Subcutaneous Adipose Tissue Observed Using In Vitro Differentiated Adipocytes
Dicker A; Astrom G; Wahlen K; Hoffstedt J; Naslund E; Wiren M; Ryden M; Arner P; van Harmelen V
Article: CIRCULATION RESEARCH. 2009;104(8):961-968
T Cell-Mediated Inflammation in Adipose Tissue Does Not Cause Insulin Resistance in Hyperlipidemic Mice
Sultan A; Strodthoff D; Robertson A-K; Paulsson-Berne G; Fauconnier J; Parini P; Ryden M; Thierry-Mieg N; Johansson ME; Chibalin AV; Zierath JR; Arner P; Hansson GK
Article: INTERNATIONAL JOURNAL OF OBESITY. 2009;33(1):67-74
Endothelin-1 stimulates human adipocyte lipolysis through the ET_A receptor
Eriksson AKS; van Harmelen V; Stenson BM; Astrom G; Wahlen K; Laurencikiene J; Ryden M
Article: CANCER RESEARCH. 2008;68(22):9247-9254
Evidence for an Important Role of CIDEA in Human Cancer Cachexia
Laurencikiene J; Stenson BM; Nordstrom EA; Agustsson T; Langin D; Isaksson B; Permert J; Ryden M; Arner P
Article: LAKARTIDNINGEN. 2008;105(42):2910-2911
[Intensive glucose control in type 2 diabetes. The benefit greater than the risks?].
Rydén M; Freyschuss B
Article: CANCER. 2008;113(7):1695-1704
Lipolysis -: Not inflammation, cell death, or lipogenesis -: Is involved in adipose tissue loss in cancer cachexia
Ryden M; Agustsson T; Laurencikiene J; Britton T; Sjoelin E; Isaksson B; Permert J; Arner P
Article: INTERNATIONAL JOURNAL OF OBESITY. 2008;32(9):1380-1387
Characterization of the human CIDEA promoter in fat cells
Pettersson AT; Laurencikiene J; Nordstrom EA; Stenson BM; van Harmelen V; Murphy C; Dahlman I; Ryden M
Article: NATURE. 2008;453(7196):783-787
Dynamics of fat cell turnover in humans
Spalding KL; Arner E; Westermark PO; Bernard S; Buchholz BA; Bergmann O; Blomqvist L; Hoffstedt J; Naslund E; Britton T; Concha H; Hassan M; Ryden M; Frisen J; Arner P
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2008;93(6):2249-2254
Expression of six transmembrane protein of prostate 2 in human adipose tissue associates with adiposity and insulin resistance
Arner P; Stenson BM; Dungner E; Naslund E; Hoffstedt J; Ryden M; Dahlman I
Article: FEBS LETTERS. 2008;582(12):1725-1730
FGF21 attenuates lipolysis in human adipocytes -: A possible link to improved insulin sensitivity
Arner P; Pettersson A; Mitchell PJ; Dunbar JD; Kharitonenkov A; Ryden M
Article: PLOS ONE. 2008;3(3):e1713
Monomeric Tartrate Resistant Acid Phosphatase Induces Insulin Sensitive Obesity
Lang P; van Harmelen V; Ryden M; Kaaman M; Parini P; Carneheim C; Cassady AI; Hume DA; Andersson G; Arner P
Article: AMERICAN JOURNAL OF TRANSPLANTATION. 2008;8(2):458-462
Intramuscular autotransplantation of pancreatic islets in a 7-year-old child:: A 2-year follow-up
Rafael E; Tibell A; Ryden M; Lundgren T; Savendhal L; Borgstrom B; Arnelo U; Isaksson B; Nilsson B; Korsgren O; Permert J
Article: DIABETOLOGIA. 2008;51(2):227-232
Optimising islet engraftment is critical for successful clinical islet transplantation
Korsgren O; Lundgren T; Felldin M; Foss A; Isaksson B; Permert J; Persson NH; Rafael E; Ryden M; Salmela K; Tibell A; Tufveson G; Nilsson B
Article: DIABETES. 2008;57(2):378-386
Vascular peptide endothelin-1 links fat accumulation with alterations of visceral adipocyte lipolysis
van Harmelen V; Eriksson A; Astrom G; Wahlen K; Naslund E; Karpe F; Frayn K; Oisson T; Amdersson J; Ryden M; Arner P
Article: PLOS ONE. 2008;3(11):e3771
ApoB100-LDL Acts as a Metabolic Signal from Liver to Peripheral Fat Causing Inhibition of Lipolysis in Adipocytes
Skogsberg J; Dicker A; Ryden M; Astrom G; Nilsson R; Bhuiyan H; Vitols S; Mairal A; Langin D; Alberts P; Walum E; Tegner J; Hamsten A; Arner P; Bjorkegren J
Article: JOURNAL OF INTERNAL MEDICINE. 2007;262(4):431-438
Tumour necrosis factor-α in human adipose tissue -: from signalling mechanisms to clinical implications
Ryden M; Arner P
Article: FERTILITY AND STERILITY. 2007;88(1):100-106
Effects of testosterone and estrogen treatment on lipolysis signaling pathways in subcutaneous adipose tissue of postmenopausal women
Zang H; Ryden M; Wahlen K; Dahlman-Wright K; Arner P; Hirschberg AL
Article: CANCER RESEARCH. 2007;67(11):5531-5537
Mechanism of increased lipolysis in cancer cachexia
Agustsson T; Ryden M; Hoffstedt J; van Harmelen V; Dicker A; Laurencikiene J; Isaksson B; Permert J; Arner P
Article: INTERNATIONAL JOURNAL OF OBESITY. 2007;31(6):900-907
Oestrogen receptor α gene expression levels are reduced in obese compared to normal weight females
Nilsson M; Dahlman I; Ryden M; Nordstrom EA; Gustafsson J-A; Arner P; Dahlman-Wright K
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2007;292(6):E1847-E1855
Comparative studies of the role of hormone-sensitive lipase and adipose triglyceride lipase in human fat cell lipolysis
Ryden M; Jocken J; van Harmelen V; Dicker A; Hoffstedt J; Wiren M; Blomqvist L; Mairal A; Langin D; Blaak E; Arner P
Article: JOURNAL OF LIPID RESEARCH. 2007;48(5):1069-1077
NF-κB is important for TNF-α-induced lipolysis in human adipocytes
Laurencikiene J; van Harmelen V; Nordstrom EA; Dicker A; Blomqvist L; Naslund E; Langin D; Arner P; Ryden M
Article: OBESITY. 2007;15(4):846-852
Differential lipolytic regulation in human embryonic stem cell-derived adipocytes
van Harmelen V; Astroem G; Stroemberg A; Sjoelin E; Dicker A; Hovatta O; Ryden M
Article: JOURNAL OF LIPID RESEARCH. 2007;48(1):201-206
A role of lipin in human obesity and insulin resistance:: relation to adipocyte glucose transport and GLUT4 expression
van Harmelen V; Ryden M; Sjolin E; Hoffstedt J
Article: INTERNATIONAL JOURNAL OF OBESITY. 2006;30(3):447-452
ALOX5AP expression, but not gene haplotypes, is associated with obesity and insulin resistance
Kaaman M; Rydén M; Axelsson T; Nordström E; Sicard A; Bouloumié A; Langin D; Arner P; Dahlman I
Article: INTERNATIONAL JOURNAL OF OBESITY. 2005;29(12):1413-1421
Differential function of the α2A-adrenoceptor and phosphodiesterase-3B in human adipocytes of different origin
Dicker A; Kaaman M; van Harmelen V; Åström G; Blanc KL; Rydén M
Article: DIABETES. 2005;54(11):3190-3197
Adipocyte lipases and defect of lipolysis in human obesity
Langin D; Dicker A; Tavernier G; Hoffstedt J; Mairal A; Rydén M; Arner E; Sicard A; Jenkins CM; Viguerie N; van Harmelen V; Gross RW; Holm C; Arner P
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2005;90(9):5356-5360
Upstream transcription factor-1 gene polymorphism is associated with increased adipocyte lipolysis
Hoffstedt J; Rydén M; Wahrenberg H; van Harmelen V; Arner P
Article: EXPERIMENTAL CELL RESEARCH. 2005;308(2):283-290
Functional studies of mesenchymal stem cells derived from adult human adipose tissue
Dicker A; Le Blanc K; Åström G; van Harmelen V; Götherström C; Blomqvist L; Arner P; Rydén M
Article: DIABETES. 2005;54(6):1726-1734
A human-specific role of cell death-inducing DFFA (DNA fragmentation factor-α-like effector A (CIDEA) in adipocyte lipolysis and obesity
Nordström EA; Rydén M; Backlund EC; Dahlman I; Kaaman M; Blomqvist L; Cannon B; Nedergaard J; Arner P
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2004;318(1):168-175
Targets for TNF-α-induced lipolysis in human adipocytes
Rydén M; Arvidsson E; Blomqvist L; Perbeck L; Dicker A; Arner P
Article: JOURNAL OF NUTRITIONAL BIOCHEMISTRY. 2004;15(5):303-312
Dimethylaminopurine inhibits metabolic effects of insulin in primary adipocytes
Göransson O; Rydén M; Nilsson R; Arner P; Degerman E
Article: JOURNAL OF INTERNAL MEDICINE. 2004;255(5):595-601
Depot-specific differences in perilipin mRNA but not protein expression in obesity
Arvidsson E; Blomqvist L; Rydén M
Article: DIABETOLOGIA. 2004;47(3):420-428
Effect of testosterone on lipolysis in human pre-adipocytes from different fat depots
Dicker A; Rydén M; Näslund E; Muehlen IE; Wirén M; Lafontan M; Arner P
Article: INTERNATIONAL JOURNAL OF OBESITY. 2004;28(2):185-190
Relationship between β-2 adrenoceptor gene haplotypes and adipocyte lipolysis in women
Eriksson P; Dahlman I; Rydén M; Hoffstedt J; Arner P
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2003;311(2):391-397
Functional characterization of human mesenchymal stem cell-derived adipocytes
Rydén M; Dicker A; Götherström C; Åström G; Tammik C; Arner P; Le Blanc K
Article: DIABETOLOGIA. 2003;46(6):789-797
Evidence for an important role of perilipin in the regulation of human adipocyte lipolysis
Mottagui-Tabar S; Rydén M; Löfgren P; Faulds G; Hoffstedt J; Brookes AJ; Andersson I; Arner P
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2003;88(5):2269-2273
Mechanisms behind lipolytic catecholamine resistance of subcutaneous fat cells in the polycystic ovarian syndrome
Faulds G; Rydén M; Ek I; Wahrenberg H; Arner P
Article: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2002;32(12):938-942
The hormone-sensitive lipase i6 gene polymorphism and body fat accumulation
Lavebratt C; Rydén M; Schalling M; Sengul S; Ahlberg S; Hoffstedt J
Article: DIABETES. 2002;51(12):3376-3383
Marked heterogeneity of human skeletal muscle lipolysis at rest
Hagström-Toft E; Qvisth V; Nennesmo I; Rydén M; Bolinder H; Enoksson S; Bolinder J; Arner P
Article: INTERNATIONAL JOURNAL OF OBESITY. 2002;26(10):1379-1385
Effects of obesity and weight loss on the expression of proteins involved in fatty acid metabolism in human adipose tissue
Fisher RM; Hoffstedt J; Hotamisligil GS; Thörne A; Rydén M
Article: DIABETES. 2002;51(7):2029-2036
Increased lipolysis and decreased leptin production by human omental as compared with subcutaneous preadipocytes
van Harmelen V; Dicker A; Rydén M; Hauner H; Lönnqvist F; Näslund E; Arner P
Article: DIABETES. 2002;51(5):1601-1608
Effect of the (C825T) Gβ₃ polymorphism on adrenoceptor-mediated lipolysis in human fat cells
Rydén M; Faulds G; Hoffstedt J; Wennlund A; Arner P
Article: DIABETOLOGIA. 2002;45(2):276-282
Polymorphism in the Calpain 10 gene influences glucose metabolism in human fat cells
Hoffstedt J; Rydén M; Löfgren P; Orho-Melander M; Groop L; Arner P
Article: DIABETES. 2002;51(2):484-492
A unique defect in the regulation of visceral fat cell lipolysis in the polycystic ovary syndrome as an early link to insulin resistance
Ek I; Arner P; Rydén M; Holm C; Thörne A; Hoffstedt J; Wahrenberg H
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2002;87(2):764-771
Major gentler differences in the lipolytic capacity of abdominal subcutaneous fat cells in obesity observed before and after long-term weight reduction
Löfgren P; Hoffstedt J; Rydén M; Thörne A; Holm C; Wahrenberg H; Arner P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(2):1085-1091
Mapping of early signaling events in tumor necrosis factor-α-mediated lipolysis in human fat cells
Rydén M; Dicker A; van Hermelen V; Hauner H; Brunnberg M; Perbeck L; Lönnqvist F; Arner P
Article: INTERNATIONAL JOURNAL OF OBESITY. 2001;25(11):1599-1603
The Arg 389 Gly β₁-adrenergic receptor gene polymorphism and human fat cell lipolysis
Rydén M; Hoffstedt J; Eriksson P; Bringman S; Arner P
Article: DIABETOLOGIA. 2001;44(10):1268-1273
Fatty acid binding protein expression in different adipose tissue depots from lean and obese individuals
Fisher RM; Eriksson P; Hoffstedt J; Hotamisligil GS; Thörne A; Rydén M; Hamsten A; Arner P
Article: INTERNATIONAL JOURNAL OF OBESITY. 2001;25(6):811-815
Increased expression of eNOS protein in omental versus subcutaneous adipose tissue in obese human subjects
Rydén M; Elizalde M; van Harmelen V; Öhlund A; Hoffstedt J; Bringman S; Andersson K
Article: JOURNAL OF LIPID RESEARCH. 2000;41(8):1244-1251
Expression of nitric oxide syntheses in subcutaneous adipose tissue of nonobese and obese humans
Elizalde M; Rydén M; van Harmelen V; Eneroth P; Gyllenhammar H; Holm C; Ramel S; Ölund A; Arner P; Andersson K
Article: DIABETES. 2000;49(5):688-692
Secretion of tumor necrosis factor-α shows a strong relationship to insulin-stimulated glucose transport in human adipose tissue
Löfgren P; van Harmelen V; Reynisdottir S; Näslund E; Rydén M; Rössner S; Arner P
Article: DIABETOLOGIA. 2000;43(1):117-120
Excessive fat accumulation is associated with the TNFα-308 G/A promoter polymorphism in women but not in men
Hoffstedt J; Eriksson P; Hellström L; Rössner S; Rydén M; Arner P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(52):33085-33091
A second determinant of binding to the p75 neurotrophin receptor revealed by alanine-scanning mutagenesis of a conserved loop in nerve growth factor
Rydén M; Ibáñez CF
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(26):16322-16328
Differential modulation of neuron survival during development by nerve growth factor binding to the p75 neurotrophin receptor
Ryden M; Hempstead B; Ibanez CF
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(48):30603-30609
A novel type I receptor serine-threonine kinase predominantly expressed in the adult central nervous system
Ryden M; Imamura T; Jornvall H; Belluardo N; Neveu I; Trupp M; Okadome T; tenDijke P; Ibanez CF
Article: BRITISH JOURNAL OF CANCER. 1996;74(5):773-779
Expression of mRNA for the neurotrophin receptor trkC in neuroblastomas with favourable tumour stage and good prognosis
Ryden M; Sehgal R; Dominici C; Schilling FH; Ibanez CF; Kogner P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(10):5623-5627
Binding of neurotrophin-3 to p75(LNGFR), TrkA, and TrkB mediated by a single functional epitope distinct from that recognized by TrkC
Ryden M; Ibanez CF
Article: JOURNAL OF CELL BIOLOGY. 1995;130(1):137-148
PERIPHERAL EXPRESSION AND BIOLOGICAL-ACTIVITIES OF GDNF, A NEW NEUROTROPHIC FACTOR FOR AVIAN AND MAMMALIAN PERIPHERAL NEURONS
TRUPP M; RYDEN M; JORNVALL H; FUNAKOSHI H; TIMMUSK T; ARENAS E; IBANEZ CF
Article: EMBO JOURNAL. 1995;14(9):1979-1990
FUNCTIONAL-ANALYSIS OF MUTANT NEUROTROPHINS DEFICIENT IN LOW-AFFINITY BINDING REVEALS A ROLE FOR P75(LNGFR) IN NT-4 SIGNALING
RYDEN M; MURRAYRUST J; GLASS D; ILAG LL; TRUPP M; YANCOPOULOS GD; MCDONALD NQ; IBANEZ CF
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All other publications

Review: CLINICAL ENDOCRINOLOGY. 2024;101(1):3-9
Diagnostic challenges in patients with reninomas and extrarenal renin-producing tumours
Fabian B; Ragnarsson O; Prazic A; Ryden M; Volpe C; Lindgren O
Preprint: RES SQ. 2023;RES SQ
Obesity-dependent increase in RalA activity disrupts mitochondrial dynamics in white adipocytes.
Xia W; Veeragandham P; Cao Y; Xu Y; Rhyne T; Qian J; Hung C-W; Zhao P; Jones Y; Gao H; Liddle C; Yu R; Downes M; Evans R; Ryden M; Wabitsch M; Reilly S; Huang J; Saltiel A
Editorial comment: NATURE REVIEWS ENDOCRINOLOGY. 2022;18(5):269-270
Understanding the complexity of insulin resistance
Mejhert N; Ryden M
Review: HANDBOOK OF EXPERIMENTAL PHARMACOLOGY. 2022;274:131-144
Insights from Studies of White Adipose Tissue Using Single-Cell Approaches.
Mejhert N; Rydén M
Review: INTERNATIONAL JOURNAL OF OBESITY. 2021;45(5):934-943
Cellular senescence and its role in white adipose tissue
Smith U; Li Q; Ryden M; Spalding KL
Review: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2021;41(4):1284-1290
Diabetes and Metabolic Drivers of Trained Immunity New Therapeutic Targets Beyond Glucose
Choudhury RP; Edgar L; Ryden M; Fisher EA
Corrigendum: NATURE METABOLISM. 2021;3(2):287
Liver macrophages regulate systemic metabolism through non-inflammatory factors (vol 1, pg 445, 2019)
Morgantini C; Jager J; Li X; Levi L; Azzimato V; Sulen A; Barreby E; Xu C; Tencerova M; Naslund E; Kumar C; Verdeguer F; Straniero S; Hultenby K; Bjorkstrom NK; Ellis E; Ryden M; Kutter C; Hurrell T; Lauschke VM; Boucher J; Tomcala A; Krejcova G; Bajgar A; Aouadi M
Review: CURRENT OPINION IN PHARMACOLOGY. 2020;55:47-52
Novel aspects on the role of white adipose tissue in type 2 diabetes
Mejhert N; Ryden M
Letter: CELL METABOLISM. 2020;32(1):1-3
Age-Induced Reduction in Human Lipolysis: A Potential Role for Adipocyte Noradrenaline Degradation
Gao H; Arner P; Beauchef G; Guere C; Vie K; Dahlman I; Mejhert N; Ryden M
Review: ADIPOCYTE. 2020;9(1):620-625
Glutamine metabolism in adipocytes: a bona fide epigenetic modulator of inflammation
Lecoutre S; Maqdasy S; Petrus P; Ludzki A; Couchet M; Mejhert N; Ryden M
Corrigendum: NATURE METABOLISM. 2019;1(4):497
Liver macrophages regulate systemic metabolism through non-inflammatory factors (vol 1, 497, 2019)
Morgantini C; Jager J; Li X; Levi L; Azzimato V; Sulen A; Barreby E; Xu C; Tencerova M; Naslund E; Kumar C; Verdeguer F; Straniero S; Hultenby K; Bjorkstrom NK; Ellis E; Ryden M; Kutter C; Hurrell T; Lauschke VM; Boucher J; Tomcala A; Krejcova G; Bajgar A; Aouadi M
Review: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2018;29(10):675-685
Transgenerational Epigenetic Mechanisms in Adipose Tissue Development
Lecoutre S; Petrus P; Ryden M; Breton C
Editorial comment: CARDIOVASCULAR RESEARCH (CVR). 2018;114(3):e19-e21
Bariatric surgery helps to reduce blood pressure - insights from GATEWAY trial
Backdahl J; Ryden M
Review: ADIPOCYTE. 2017;6(3):187-192
The contribution of bone marrow-derived cells to the human adipocyte pool
Arner P; Ryden M
Corrigendum: DIABETOLOGIA. 2016;59(12):2728
The epigenetic signature of systemic insulin resistance in obese women (vol 59, pg 2393, 2016)
Arner P; Sahlqvist A-S; Sinha I; Xu H; Yao X; Waterworth D; Rajpal D; Loomis AK; Freudenberg JM; Johnson T; Thorell A; Naslund E; Ryden M; Dahlman I
Editorial comment: ADIPOCYTE. 2016;5(3):312-317
On the origin of human adipocytes and the contribution of bone marrow-derived cells
Ryden M
Review: INTERNATIONAL JOURNAL OF OBESITY. 2012;36(12):1494-1502
Liver X receptors and fat cell metabolism
Laurencikiene J; Ryden M
Review: LAKARTIDNINGEN. 2010;107(45):2810-2814
[Tough glucose reduction necessary in newly diagnosed diabetes].
Rydén M
Letter: NEW ENGLAND JOURNAL OF MEDICINE. 2010;362(12):1151-1153
Tumor Necrosis Factor α and Regulation of Adipose Tissue
Arner E; Ryden M; Arner P
Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2009;66(13):2067-2073
Fibroblast growth factor 21: an overview from a clinical perspective
Ryden M
Review: CLINICAL NUTRITION. 2007;26(1):1-6
Fat loss in cachexia -: is there a role for adipocyte lipolysis?
Ryden M; Arner P
Letter: DIABETOLOGIA. 2001;44(5):654-655
Tumour necrosis factor-α (TNF-α) polymorphisms-857C/A and -863C/A are associated with TNF-α secretion from human adipose tissue
Skoog T; Eriksson P; Hoffstedt J; Rydén M; Hamsten A; Arner P
Published conference paper: EUROPEAN JOURNAL OF CANCER. 1997;33(12):2058-2063
Coexpression of mRNA for the full-length neurotrophin receptor trk-C and trk-A in favourable neuroblastoma
Svensson T; Rydén M; Schilling FH; Dominici C; Sehgal R; Ibáñez CF; Kogner P
Thesis / dissertation: 1997
Neurotrophic factors and their receptors structure-function relationships and signalling mechanisms
Ryden, Mikael
Review: LAKARTIDNINGEN. 1995;92(21):2191-2194
[Nerve growth factors in future therapies. Protein mutation broadens the range of therapeutic possibilities].
Ibáñez CF; Rydén M
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Employments

Professor/Senior Physician, Department of Medicine, Huddinge, Karolinska Institutet, 2013-

Degrees and Education

Docent, Karolinska Institutet, 2002
University Medical Degree, Karolinska Institutet, 1996

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