Mikael Ryden

Mikael Ryden

Professor/Senior Physician
Telephone: +46852482922
Visiting address: C2:94, Karolinska Universitetssjukhuset Huddinge, 14186 Stockholm
Postal address: H7 Medicin, Huddinge, H7 CeRM Rydén&Mejhert, 171 77 Stockholm

About me

  • Professor of Clinical and Experimental Fat Tissue Research since 2013 and Head of the Endocrinology Unit with the Lipid laboratory at the Department of Medicine, Huddinge. Following the merger with BioNut, the unit incorporated several additional research groups and was renamed the Center for Reproduction, Metabolism, and Molecular Medicine (CeRM).

Research

  • Mikael Rydén's research involves cell and molecular biotechnologies in various cell culture systems along with clinical studies.

    The adipose tissue is the most plastic organ in the human body, and its main producer of hormones. While it was previously regarded primarily as an energy-storing tissue, we now know that it plays a central role in the development of insulin resistance, dyslipidemia and atherosclerosis in clinical conditions such as overweight/obesity, type 2 diabetes, familial combined hyperlipidaemia, chronic renal failure, cancer, cachexia and polycystic ovary syndrome.

Articles

All other publications

Grants

  • Swedish Research Council
    1 January 2023 - 31 December 2027
    The main function of white adipose tissue (WAT) is to store (lipogenesis) and release (lipolysis) energy. In humans, both pathways are under hormonal control where insulin stimulates lipogenesis and inhibits lipolysis, whereas catecholamines and atrial natriuretic peptide (ANP) activate lipolysis. The balance between lipogenesis and lipolysis determines WAT lipid turnover and thereby its storage capacity. By comparing WAT from people with and without atherosclerosis, our preliminary data has identified that the two groups differ in their ability to turnover lipids. More specifically, subjects with atherosclerosis display reduced responsiveness not only to insulin, but also to catecholamines and ANP. Based on these observations, we hypothesize that this “multi-hormone resistance” promotes cardiometabolic complications via ectopic lipid deposition and impacts on the response to antidiabetic drugs. However, whether the attenuated response to hormones and drugs depends on a general dysregulation in all fat cells or in specific adipocyte subtypes is unclear. To test this, we will perform detailed phenotyping of clinical intervention studies using spatial transcriptomics and organellar proteomics and perform state-of-the-art experiments in human adipocyte 3D models. By unravelling the mechanisms underlying inter-individual variations in lipid turnover, our project can improve diagnostic and therapeutic precision in people suffering from common cardiometabolic complications.

Employments

  • Professor/Senior Physician, Department of Medicine, Huddinge, Karolinska Institutet, 2013-

Degrees and Education

  • Docent, Karolinska Institutet, 2002
  • University Medical Degree, Karolinska Institutet, 1996

News from KI

Events from KI