Publications | Nils-Göran Larsson Group

Find our latest publications as well as all publications by Principal Investigator Nils-Göran Larsson.

Recent original publications

Mice lacking the mitochondrial exonuclease MGME1 develop inflammatory kidney disease with glomerular dysfunction.
Milenkovic D, Sanz-Moreno A, Calzada-Wack J, Rathkolb B, Veronica Amarie O, Gerlini R, Aguilar-Pimentel A, Misic J, Simard ML, Wolf E, Fuchs H, Gailus-Durner V, de Angelis MH, Larsson NG
PLoS Genet 2022 05;18(5):e1010190

Metabolic resistance to the inhibition of mitochondrial transcription revealed by CRISPR-Cas9 screen.
Mennuni M, Filograna R, Felser A, Bonekamp NA, Giavalisco P, Lytovchenko O, Larsson NG
EMBO Rep 2022 Jan 5;23(1):e53054

High levels of TFAM repress mammalian mitochondrial DNA transcription in vivo.
Bonekamp NA, Jiang M, Motori E, Garcia Villegas R, Koolmeister C, Atanassov I, Mesaros A, Park CB, Larsson NG
Life Sci Alliance 2021 11;4(11):

Mitochondrial dysfunction in adult midbrain dopamine neurons triggers an early immune response.
Filograna R, Lee S, Tiklová K, Mennuni M, Jonsson V, Ringnér M, Gillberg L, Sopova E, Shupliakov O, Koolmeister C, Olson L, Perlmann T, Larsson NG
PLoS Genet 2021 09;17(9):e1009822

The mitochondrial single-stranded DNA binding protein is essential for initiation of mtDNA replication.
Jiang M, Xie X, Zhu X, Jiang S, Milenkovic D, Misic J, Shi Y, Tandukar N, Li X, Atanassov I, Jenninger L, Hoberg E, Albarran-Gutierrez S, Szilagyi Z, Macao B, Siira SJ, Carelli V, Griffith JD, Gustafsson CM, Nicholls TJ, Filipovska A, Larsson NG, Falkenberg M
Sci Adv 2021 Jul;7(27):

Small-molecule inhibitors of human mitochondrial DNA transcription.
Bonekamp NA, Peter B, Hillen HS, Felser A, Bergbrede T, Choidas A, Horn M, Unger A, Di Lucrezia R, Atanassov I, Li X, Koch U, Menninger S, Boros J, Habenberger P, Giavalisco P, Cramer P, Denzel MS, Nussbaumer P, Klebl B, Falkenberg M, Gustafsson CM, Larsson NG
Nature 2020 12;588(7839):712-716

Neuronal metabolic rewiring promotes resilience to neurodegeneration caused by mitochondrial dysfunction.
Motori E, Atanassov I, Kochan SMV, Folz-Donahue K, Sakthivelu V, Giavalisco P, Toni N, Puyal J, Larsson NG
Sci Adv 2020 Aug;6(35):eaba8271

Proofreading deficiency in mitochondrial DNA polymerase does not affect total dNTP pools in mouse embryos.
Sharma S, Koolmeister C, Tran P, Nilsson AK, Larsson NG, Chabes A
Nat Metab 2020 08;2(8):673-675

FBXL4 deficiency increases mitochondrial removal by autophagy.
Alsina D, Lytovchenko O, Schab A, Atanassov I, Schober FA, Jiang M, Koolmeister C, Wedell A, Taylor RW, Wredenberg A, Larsson NG
EMBO Mol Med 2020 07;12(7):e11659

Recent reviews

SnapShot: Mitochondrial Nucleoid.
Bonekamp NA, Larsson NG
Cell 2018 01;172(1-2):388-388.e1

The Enigma of the Respiratory Chain Supercomplex.
Milenkovic D, Blaza JN, Larsson NG, Hirst J
Cell Metab. 2017 Apr;25(4):765-776

Mammalian Mitochondria and Aging: An Update.
Kauppila TES, Kauppila JHK, Larsson NG
Cell Metab. 2017 01;25(1):57-71

Maintenance and Expression of Mammalian Mitochondrial DNA.
Gustafsson CM, Falkenberg M, Larsson NG
Annu. Rev. Biochem. 2016 Jun;85():133-60

Keeping mtDNA in shape between generations.
Stewart JB, Larsson NG
PLoS Genet. 2014 Oct;10(10):e1004670

Making proteins in the powerhouse.
Hällberg BM, Larsson NG
Cell Metab. 2014 Aug;20(2):226-40

All publications by Nils-Göran Larsson

Publications by Nils-Göran Larsson on Pubmed