Publications | Nils-Göran Larsson Group
Find our latest publications as well as all publications by Principal Investigator Nils-Göran Larsson.
Recent original publications
A role for BCL2L13 and autophagy in germline purifying selection of mtDNA.
Kremer LS, Bozhilova LV, Rubalcava-Gracia D, Filograna R, Upadhyay M, Koolmeister C, Chinnery PF, Larsson NG
PLoS Genet 2023 Jan;19(1):e1010573
Preserved respiratory chain capacity and physiology in mice with profoundly reduced levels of mitochondrial respirasomes.
Milenkovic D, Misic J, Hevler JF, Molinié T, Chung I, Atanassov I, Li X, Filograna R, Mesaros A, Mourier A, Heck AJR, Hirst J, Larsson NG
Cell Metab 2023 Aug;():
Mammalian RNase H1 directs RNA primer formation for mtDNA replication initiation and is also necessary for mtDNA replication completion.
Misic J, Milenkovic D, Al-Behadili A, Xie X, Jiang M, Jiang S, Filograna R, Koolmeister C, Siira SJ, Jenninger L, Filipovska A, Clausen AR, Caporali L, Valentino ML, La Morgia C, Carelli V, Nicholls TJ, Wredenberg A, Falkenberg M, Larsson NG
Nucleic Acids Res 2022 Aug;50(15):8749-8766
Mice lacking the mitochondrial exonuclease MGME1 develop inflammatory kidney disease with glomerular dysfunction.
Milenkovic D, Sanz-Moreno A, Calzada-Wack J, Rathkolb B, Veronica Amarie O, Gerlini R, Aguilar-Pimentel A, Misic J, Simard ML, Wolf E, Fuchs H, Gailus-Durner V, de Angelis MH, Larsson NG
PLoS Genet 2022 05;18(5):e1010190
Metabolic resistance to the inhibition of mitochondrial transcription revealed by CRISPR-Cas9 screen.
Mennuni M, Filograna R, Felser A, Bonekamp NA, Giavalisco P, Lytovchenko O, Larsson NG
EMBO Rep 2022 Jan 5;23(1):e53054
High levels of TFAM repress mammalian mitochondrial DNA transcription in vivo.
Bonekamp NA, Jiang M, Motori E, Garcia Villegas R, Koolmeister C, Atanassov I, Mesaros A, Park CB, Larsson NG
Life Sci Alliance 2021 11;4(11):
Mitochondrial dysfunction in adult midbrain dopamine neurons triggers an early immune response.
Filograna R, Lee S, Tiklová K, Mennuni M, Jonsson V, Ringnér M, Gillberg L, Sopova E, Shupliakov O, Koolmeister C, Olson L, Perlmann T, Larsson NG
PLoS Genet 2021 09;17(9):e1009822
The mitochondrial single-stranded DNA binding protein is essential for initiation of mtDNA replication.
Jiang M, Xie X, Zhu X, Jiang S, Milenkovic D, Misic J, Shi Y, Tandukar N, Li X, Atanassov I, Jenninger L, Hoberg E, Albarran-Gutierrez S, Szilagyi Z, Macao B, Siira SJ, Carelli V, Griffith JD, Gustafsson CM, Nicholls TJ, Filipovska A, Larsson NG, Falkenberg M
Sci Adv 2021 Jul;7(27):
Small-molecule inhibitors of human mitochondrial DNA transcription.
Bonekamp NA, Peter B, Hillen HS, Felser A, Bergbrede T, Choidas A, Horn M, Unger A, Di Lucrezia R, Atanassov I, Li X, Koch U, Menninger S, Boros J, Habenberger P, Giavalisco P, Cramer P, Denzel MS, Nussbaumer P, Klebl B, Falkenberg M, Gustafsson CM, Larsson NG
Nature 2020 12;588(7839):712-716
Neuronal metabolic rewiring promotes resilience to neurodegeneration caused by mitochondrial dysfunction.
Motori E, Atanassov I, Kochan SMV, Folz-Donahue K, Sakthivelu V, Giavalisco P, Toni N, Puyal J, Larsson NG
Sci Adv 2020 Aug;6(35):eaba8271
Proofreading deficiency in mitochondrial DNA polymerase does not affect total dNTP pools in mouse embryos.
Sharma S, Koolmeister C, Tran P, Nilsson AK, Larsson NG, Chabes A
Nat Metab 2020 08;2(8):673-675
FBXL4 deficiency increases mitochondrial removal by autophagy.
Alsina D, Lytovchenko O, Schab A, Atanassov I, Schober FA, Jiang M, Koolmeister C, Wedell A, Taylor RW, Wredenberg A, Larsson NG
EMBO Mol Med 2020 07;12(7):e11659
Recent reviews
No role for nuclear transcription regulators in mammalian mitochondria?
Rubalcava-Gracia D, García-Villegas R, Larsson NG
Mol Cell 2022 Sep;():
SnapShot: Mitochondrial Nucleoid.
Bonekamp NA, Larsson NG
Cell 2018 01;172(1-2):388-388.e1
The Enigma of the Respiratory Chain Supercomplex.
Milenkovic D, Blaza JN, Larsson NG, Hirst J
Cell Metab. 2017 Apr;25(4):765-776
Mammalian Mitochondria and Aging: An Update.
Kauppila TES, Kauppila JHK, Larsson NG
Cell Metab. 2017 01;25(1):57-71
Maintenance and Expression of Mammalian Mitochondrial DNA.
Gustafsson CM, Falkenberg M, Larsson NG
Annu. Rev. Biochem. 2016 Jun;85():133-60
Keeping mtDNA in shape between generations.
Stewart JB, Larsson NG
PLoS Genet. 2014 Oct;10(10):e1004670
Making proteins in the powerhouse.
Hällberg BM, Larsson NG
Cell Metab. 2014 Aug;20(2):226-40