Mara Mennuni

About me
Publications
Grants
CV
Public outreach and news

About me

I am passionate about science, with a background in studying mitochondrial dysfunction and its role in the onset of diseases. Currently, I focus on coordinating research projects and supporting Larsson's team by helping things run smoothly.

Research

Mitochondria in heath and diseases

Articles

Journal article: SCIENCE ADVANCES. 2024;10(44):eadp3481
High mitochondrial DNA levels accelerate lung adenocarcinoma progression
Mennuni M; Wilkie SE; Michon P; Alsina D; Filograna R; Lindberg M; Sanin DE; Rosenberger F; Schaaf A; Larsson E; Pearce EL; Larsson N-G
Article: NATURE METABOLISM. 2024;6(6):1024-1035
Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity
Jiang S; Yuan T; Rosenberger FA; Mourier A; Dragano NRV; Kremer LS; Rubalcava-Gracia D; Hansen FM; Borg M; Mennuni M; Filograna R; Alsina D; Misic J; Koolmeister C; Papadea P; de Angelis MH; Ren L; Andersson O; Unger A; Bergbrede T; Di Lucrezia R; Wibom R; Zierath JR; Krook A; Giavalisco P; Mann M; Larsson N-G
Article: EMBO REPORTS. 2022;23(1):e53054
Metabolic resistance to the inhibition of mitochondrial transcription revealed by CRISPR-Cas9 screen
Mennuni M; Filograna R; Felser A; Bonekamp NA; Giavalisco P; Lytovchenko O; Larsson N-G
Article: NATURE COMMUNICATIONS. 2021;12(1):6997
2-Deoxy-D-glucose couples mitochondrial DNA replication with mitochondrial fitness and promotes the selection of wild-type over mutant mitochondrial DNA
Pantic B; Ives D; Mennuni M; Perez-Rodriguez D; Fernandez-Pelayo U; Lopez de Arbina A; Munoz-Oreja M; Villar-Fernandez M; Dang T-MJ; Vergani L; Johnston IG; Pitceathly RDS; McFarland R; Hanna MG; Taylor RW; Holt IJ; Spinazzola A
Article: PLOS GENETICS. 2021;17(9):e1009822
Mitochondrial dysfunction in adult midbrain dopamine neurons triggers an early immune response
Filograna R; Lee S; Tiklova K; Mennuni M; Jonsson V; Ringner M; Gillberg L; Sopova E; Shupliakov O; Koolmeister C; Olson L; Perlmann T; Larsson N-G
Article: EMBO MOLECULAR MEDICINE. 2018;10(9):e8550
LETM1 couples mitochondrial DNA metabolism and nutrient preference
Durigon R; Mitchell AL; Jones AWE; Manole A; Mennuni M; Hirst EMA; Houlden H; Maragni G; Lattante S; Doronzio PN; Dalla Rosa I; Zollino M; Holt IJ; Spinazzola A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(30):E4276-E4285
Pathological ribonuclease H1 causes R-loop depletion and aberrant DNA segregation in mitochondria
Akman G; Desai R; Bailey LJ; Yasukawa T; Rosa ID; Durigon R; Holmes JB; Moss CF; Mennuni M; Houlden H; Crouch RJ; Hanna MG; Pitceathly RDS; Spinazzola A; Holt IJ

All other publications

Preprint: BIORXIV. 2024
Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice
Kremer L; Gao G; Rigoni G; Filograna R; Mennuni M; Wibom R; Végvári Á; Koolmeister C; Larsson N-G
Preprint: BIORXIV. 2024
The CHCHD2-CHCHD10 protein complex is modulated by mitochondrial dysfunction and alters lipid homeostasis in the mouse brain
Gerlach J; Pireddu P; Zhang X; Wetzel S; Mennuni M; Milenkovic D; Nolte H; Branzell N; Kaya I; Villegas RG; Rubalcava-Gracia D; Alsina D; Feederle R; Andrén PE; Langer T; Svenningsson P; Filograna R
Preprint: BIORXIV. 2023
Inhibition of mammalian mtDNA transcription paradoxically activates liver fatty acid oxidation to reverse diet-induced hepatosteatosis and obesity
Jiang S; Yuan T; Kremer LS; Rosenberger FA; Hansen FM; Borg M; Rubalcava-Gracia D; Mennuni M; Filograna R; Alsina D; Misic J; Koolmeister C; Ren L; Andersson O; Unger A; Bergbrede T; Di Lucrezia R; Wibom R; Zierath JR; Krook A; Giavalisco P; Mann M; Larsson N-G
Review: FEBS LETTERS. 2021;595(8):976-1002
Mitochondrial DNA copy number in human disease: the more the better?
Filograna R; Mennuni M; Alsina D; Larsson N-G
Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2013;14(11):23011-23032
Pathogenesis of Chronic Cardiorenal Syndrome: Is There a Role for Oxidative Stress?
Rubattu S; Mennuni S; Testa M; Mennuni M; Pierelli G; Pagliaro B; Gabriele E; Coluccia R; Autore C; Volpe M

Grants

Approaches to determine the role of mitochondrial alterations in lung cancer in vivo
Alex och Eva Wallström foundation
1 January 2022 - 31 December 2022

Employments

Research Coordinator, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2024-
Postdoctoral Researcher, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2019-2024

About me

Research

Articles

All other publications

Grants

Employments

News from KI

Events from KI