Roberta Filograna

Publications
Public outreach and news

Articles

Article: NATURE METABOLISM. 2024;6(6):1024-1035
Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity
Jiang S; Yuan T; Rosenberger FA; Mourier A; Dragano NRV; Kremer LS; Rubalcava-Gracia D; Hansen FM; Borg M; Mennuni M; Filograna R; Alsina D; Misic J; Koolmeister C; Papadea P; de Angelis MH; Ren L; Andersson O; Unger A; Bergbrede T; Di Lucrezia R; Wibom R; Zierath JR; Krook A; Giavalisco P; Mann M; Larsson N-G
Article: NPJ PARKINSON'S DISEASE. 2024;10(1):93
PARKIN is not required to sustain OXPHOS function in adult mammalian tissues
Filograna R; Gerlach J; Choi H-N; Rigoni G; Barbaro M; Oscarson M; Lee S; Tiklova K; Ringner M; Koolmeister C; Wibom R; Riggare S; Nennesmo I; Perlmann T; Wredenberg A; Wedell A; Motori E; Svenningsson P; Larsson N-G
Article: CELL METABOLISM. 2023;35(10):1799-1813.e7
Preserved respiratory chain capacity and physiology in mice with profoundly reduced levels of mitochondrial respirasomes
Milenkovic D; Misic J; Hevler JF; Molinie T; Chung I; Atanassov I; Li X; Filograna R; Mesaros A; Mourier A; Heck AJR; Hirst J; Larsson N-G
Article: JCI INSIGHT. 2023;8(17):e167656
Antigen receptor stimulation induces purifying selection against pathogenic mitochondrial tRNA mutations
Zhang J; Koolmeister C; Han J; Filograna R; Hanke L; Adori M; Sheward DJ; Teifel S; Gopalakrishna S; Shao Q; Liu Y; Zhu K; Harris RA; Mcinerney G; Murrell B; Aoun M; Baeckdahl L; Holmdahl R; Pekalski M; Wedell A; Engvall M; Wredenberg A; Hedestam GBK; Dopico XC; Rorbach J
Article: PLOS GENETICS. 2023;19(1):e1010573
A role for BCL2L13 and autophagy in germline purifying selection of mtDNA
Kremer LS; Bozhilova LV; Rubalcava-Gracia D; Filograna R; Upadhyay M; Koolmeister C; Chinnery PF; Larsson N-G
Article: NUCLEIC ACIDS RESEARCH (NAR). 2022;50(15):8749-8766
Mammalian RNase H1 directs RNA primer formation for mtDNA replication initiation and is also necessary for mtDNA replication completion
Misic J; Milenkovic D; Al-Behadili A; Xie X; Jiang M; Jiang S; Filograna R; Koolmeister C; Siira SJ; Jenninger L; Filipovska A; Clausen AR; Caporali L; Valentino ML; La Morgia C; Carelli V; Nicholls TJ; Wredenberg A; Falkenberg M; Larsson N-G
Article: EMBO REPORTS. 2022;23(1):e53054
Metabolic resistance to the inhibition of mitochondrial transcription revealed by CRISPR-Cas9 screen
Mennuni M; Filograna R; Felser A; Bonekamp NA; Giavalisco P; Lytovchenko O; Larsson N-G
Article: PLOS GENETICS. 2021;17(9):e1009822
Mitochondrial dysfunction in adult midbrain dopamine neurons triggers an early immune response
Filograna R; Lee S; Tiklova K; Mennuni M; Jonsson V; Ringner M; Gillberg L; Sopova E; Shupliakov O; Koolmeister C; Olson L; Perlmann T; Larsson N-G
Article: SCIENCE ADVANCES. 2021;7(8):eabf0717
The one-carbon pool controls mitochondrial energy metabolism via complex I and iron-sulfur clusters
Schober FA; Moore D; Atanassov I; Moedas MF; Clemente P; Vegvari A; El Fissi N; Filograna R; Bucher A-L; Hinze Y; The M; Hedman E; Chernogubova E; Begzati A; Wibom R; Jain M; Nilsson R; Kall L; Wedell A; Freyer C; Wredenberg A
Article: NEUROTOXICITY RESEARCH. 2019;36(4):746-755
Superoxide Dismutases SOD1 and SOD2 Rescue the Toxic Effect of Dopamine-Derived Products in Human SH-SY5Y Neuroblastoma Cells
Biosa A; De Lazzari F; Masato A; Filograna R; Plotegher N; Beltramini M; Bubacco L; Bisaglia M
Article: PLOS GENETICS. 2019;15(7):e1008240
Defects of mitochondrial RNA turnover lead to the accumulation of double-stranded RNA in vivo
Pajak A; Laine I; Clemente P; El-Fissi N; Schober FA; Maffezzini C; Calvo-Garrido J; Wibom R; Filograna R; Dhir A; Wedell A; Freyer C; Wredenberg A
Article: SCIENCE ADVANCES. 2019;5(4):eaav9824
Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse
Filograna R; Koolmeister C; Upadhyay M; Pajak A; Clemente P; Wibom R; Simard ML; Wredenberg A; Freyer C; Stewart JB; Larsson NG
Article: HUMAN MOLECULAR GENETICS. 2018;27(9):1618-1629
Superoxide dismutating molecules rescue the toxic effects of PINK1 and parkin loss
Biosa A; Sanchez-Martinez A; Filograna R; Terriente-Felix A; Alam SM; Beltramini M; Bubacco L; Bisaglia M; Whitworth AJ
Article: CELL REPORTS. 2016;16(11):2980-2990
A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease
Kauppila JHK; Baines HL; Bratic A; Simard M-L; Freyer C; Mourier A; Stamp C; Filograna R; Larsson N-G; Greaves LC; Stewart JB
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2016;291(17):9257-9267
Superoxide Dismutase (SOD)-mimetic M40403 Is Protective in Cell and Fly Models of Paraquat Toxicity: IMPLICATIONS FOR PARKINSON DISEASE.
Filograna R; Godena VK; Sanchez-Martinez A; Ferrari E; Casella L; Beltramini M; Bubacco L; Whitworth AJ; Bisaglia M
Article: CURRENT NEUROPHARMACOLOGY. 2016;14(3):260-271
Anti-Oxidants in Parkinson's Disease Therapy: A Critical Point of View.
Filograna R; Beltramini M; Bubacco L; Bisaglia M
Article: JOURNAL OF NEUROINFLAMMATION. 2015;12:230
Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells.
Russo I; Berti G; Plotegher N; Bernardo G; Filograna R; Bubacco L; Greggio E
Article: PLOS ONE. 2015;10(8):e0136769
Analysis of the Catecholaminergic Phenotype in Human SH-SY5Y and BE(2)-M17 Neuroblastoma Cell Lines upon Differentiation.
Filograna R; Civiero L; Ferrari V; Codolo G; Greggio E; Bubacco L; Beltramini M; Bisaglia M

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Editorial comment: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2022;10:1018778
Defective macroautophagy in organelle turnover: From basic mechanisms to human disease
Bejarano E; Antonio Rodriguez-Navarro J; Filograna R; Calvo-Garrido J
Review: FEBS LETTERS. 2021;595(8):976-1002
Mitochondrial DNA copy number in human disease: the more the better?
Filograna R; Mennuni M; Alsina D; Larsson N-G
Review: CLINICAL GENITOURINARY CANCER. 2016;14(6):473-484
The Clinical Use of the Neutrophil to Lymphocyte Ratio (NLR) in Urothelial Cancer: A Systematic Review
Marchioni M; Primiceri G; Ingrosso M; Filograna R; Castellan P; De Francesco P; Schips L
Corrigendum: JOURNAL OF NEUROINFLAMMATION. 2016;13(1):70
Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells (vol 12, 230, 2015)
Russo I; Berti G; Plotegher N; Bernardo G; Filograna R; Bubacco L; Greggio E
Review: AGEING RESEARCH REVIEWS. 2014;13:107-114
Are dopamine derivatives implicated in the pathogenesis of Parkinson's disease?
Bisaglia M; Filograna R; Beltramini M; Bubacco L

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