Nils-Göran Larsson Group
The mitochondrion is a key player in cellular function and dysfunctional mitochondria have been implicated in a number of disorders as well as in the process of normal ageing. Our research group is interested in fundamental questions related to mitochondrial biology. How is the number and the function of mitochondria regulated? What happens in a cell with dysfunctional mitochondria? How does mitochondrial dysfunction cause human disease?
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Latest grants and publications
New study questions the role of supercomplexes in metabolism and disease
A new study published in Cell Metabolism by the research group of Professor Nils-Göran Larsson, at the Department of Medical Biochemistry and Biophysics, Karolinska Institutet, shows that so-called supercomplexes have no major role in cellular energy production and that altered levels therefore are unlikely to affect physiology and disease.
Young researcher from Karolinska Institutet meets Nobel laureates in Germany
Jelena Misic, PhD in Nils-Göran Larsson Group at the Department of Medical Biochemistry and Biophysics at Karolinska Institutet, has been selected to participate in the Lindau Nobel Laureate Meetings in June 2023. Jelena studies different aspects of mitochondrial gene expression in mammals.
Grants to Roberta Filograna and Nils-Göran Larsson
Professor Nils-Göran Larsson receives a Novo Nordisk Foundation Project Grant of DKK 3 million. Roberta Filograna receives a grant from the Åhlén foundation.
Roberta Filograna awarded grant from the Loo and Hans Osterman Foundation
Roberta Filograna has been awarded a grant from the Loo and Hans Osterman Foundation.
Mara Mennuni awarded grant from the Alex and Eva Wallström foundation
Mara Mennuni, a postdoc with Prof. Nils-Göran Larsson at the division of molecular metabolism has received a grant from the Alex and Eva Wallström foundationworth 300,000 SEK to determine the role of mitochondrial alterations in lung cancer in vivo.
Hjärnfonden grant of SEK 1.2 Million to Prof. Nils-Göran Larsson and Dr. Roberta Filograna
Prof. Nils-Göran Larsson and Dr.Roberta Filograna received a project grant of SEK 1.2 million from Hjärnfonden (the Swedish Brain Foundation). The project investigates the role of mitochondrial dysfunction in Parkinson's disease.
Novel principle for cancer treatment shows promising effect
In a new study in Nature we report that we have developed novel first-in-class inhibitors that compromise mitochondrial function in cancer cells. Treatment with the inhibitors stopped cancer cells from proliferating and reduced tumour growth in mice, without significantly affecting healthy cells.
Novo Nordisk Foundation Project Grant of DKK 2 million
Our group receives a project grant in Endocrinology & Metabolism of DKK 2 million from the Novo Nordisk Foundation. Here's an interview about the project that investigates the role of mitochondria in the development of obesity-associated insulin resistance.
Neurons protect themselves from degeneration by adapting their metabolism
A recent study in Science Advances by the group, in cooperation with Max Planck Institute, shows that neurons can counteract degeneration and promote survival by adapting their metabolism. It challenges the long-standing view that neurons cannot adjust their metabolism and therefore irreversibly degenerate. These findings may contribute to developing therapeutic approaches for patients with mitochondrial diseases and other types of neurodegeneration, such as Parkinson’s Disease.
Outreach and funding
"He wants to boost powerless cells' energy level"
Funding agency Knut and Alice Wallenberg Foundation (KAW) about Nils-Göran's research.
"Nobel Prize in Medicine - about the recycling centres in our cells"
Nils-Göran comments the Nobel Prize in Physiology or Medicine 2016 in Swedish radio.