SOSVASC

Cardiovascular disease is the most common cause of death in Sweden today and it has been estimated that 1,4 million people are suffering from it . The SOSVASC group constitutes of a group of researchers focusing on arteriosclerotic and degenerative vascular disorders.

Vascular Surgery Research Group KI SÖS

To strengthen the clinical research at KI SÖS we have broadened ongoing projects by networking with other groups at Karolinska Institutet, as well as national and international external departments. The SOSVASC group is the connective link for persons involved in vascular research.

  • Carotid disease
  • Peripheral artery disease (PAD)
  • Aortic disease
  • Trauma
  • Caring science
  • Wound therapy

Research group leader

Group members

Johnny Steuer, Post-doc

Jonas Malmstedt, Post-doc

Anneli Linné, Post-doc

Ann-Mari Fagerdahl, Post-doc

Andreas Älgå, Post-doc

Christian Smedberg, Post-doc

Eva Torbjörnsson, Post-doc

Fredrik Sartipy, Post-doc

Otto Stackelberg, Post-doc

Carin Ottosson, Post-doc

Sara Haile, PhD-student

Victor Mill, PhD-student

Collaborations

Associate professor Rebecka Hultgren, Department of Molecular Medicine and Surgery, STAR-Stockholm Aneurysm Research Group, Karolinska Institutet.

Professor Ulf Hedins Research Group, Department of Molecular Medicine and Surgery, Karolinska Institutet.

Professor Mario Lachat, Universitätsspital Zürich.

Professor Anders Wanhainen, Uppsala University, website.

Professor Johan Frostegård, Unit of Immunology and Chronic Disease, Karolinska Institutet.

MD Klas Österberg, University of Gothenburg, website.

Senior lecturer Johan von Schreeb, Department of Public Health Sciences, Karolinska Institutet.

MD Birgitta Sigvant, Centralsjukhuset i Karlstad.

Professor Andrew Bradbury, University of Birmingham, England, The Basil-2 trial.

Projects

Carotid disease

  1. Methodological aspects on carotid intervention.
  2. Biomarkers and cellular mechanisms to predict unstable arterioscleroses.

Aortic disease

  1. Aneurysm of the abdominal aorta; hereditary aspects and screening.
  2. Ruptured abdominal aortic aneurysm – patient characteristics, x-ray findings and results of treatment.
  3. Mapping of the prevalence and treatment results of aortic dissection.
  4. The results of treatment when branched endovascular grafts are used involving visceral arteries.

Peripheral artery disease (PAD)

  1. PAD and diabetes; mechanisms for ischemia and long term results.
  2. The natural course for patients with PAD.
  3. Risk factors for worsened outcome after amputation preceded by a vascular intervention.
  4. Evaluation of patient centered follow-up program after vascular intervention for claudication.

Trauma

  1. Long term follow-up for patients treated for traumatic aortic injury.
  2. Evaluation and improvement of surgical methods in blast and gun wounds.

National and international studies

  • ACST-2: Asymptomatic Carotid Surgery Trial. Large international randomized trial comparing carotid endarterectomy vs. carotid artery stenting in patients with asymptomatic carotid stenosis. Peter Gillgren is principal investigator in Sweden. Website.
  • Swedpad study: National Swedish randomized study comparing balloons and stents with – and without – drug eluting mechanism for patients with PAD.
  • Basil-2 study: A multi-centre randomised controlled trial to find out if a ‘vein bypass first’ or a ‘best endovascular first’ revascularisation strategy is best in patients with severe limb ischaemia. Website.

Articles that have changed the clinical routines in our patients

  • We have shown that urgent treatment of symptomatic carotid stenting is not associated with an increased risk as compared to later stenting 1
  • In a collaboration with the University hospital in Zurich, Dr Steuer has shown that there is a sub-acute phase in type B aortic dissection 2
  • In a collaboration with the STAR group (name as link) at the Institution of molecular medicine and surgery along with Dr Linné , the SOSVASC group has shown the link between low income, low educational level and immigrant status and non-participating in aortic screening programmes. In addition Dr Linné has shown that results of treatment do not vary between screened and non-screened patients with aortic abdominal aneurysms. 3
  • Dr Sartipy has shown that procalcitonin is a valuable marker when distinguishing infection from inflammation after endovascular treatment for abdominal aneurysms. 4
  • An increase of the marker PCSK6, a protease, is seen in patients with unstable arteriosclerosis. 5

Articles

Mortality with Paclitaxel-Coated Devices in Peripheral Artery Disease.
Nordanstig J, James S, Andersson M, Andersson M, Danielsson P, Gillgren P, Delle M, Engström J, Fransson T, Hamoud M, Hilbertson A, Johansson P, Karlsson L, Kragsterman B, Lindgren H, Ludwigs K, Mellander S, Nyman N, Renlund H, Sigvant B, Skoog P, Starck J, Tegler G, Toivola A, Truedson M, Wahlgren CM, Wallinder J, Öjersjö A, Falkenberg M
N Engl J Med 2020 12;383(26):2538-2546

Limb Graft Occlusion Following Endovascular Aneurysm Repair for Infrarenal Abdominal Aortic Aneurysm with the Zenith Alpha, Excluder, and Endurant Devices: a Multicentre Cohort Study.
Bogdanovic M, Stackelberg O, Lindström D, Ersryd S, Andersson M, Roos H, Siika A, Jonsson M, Roy J
Eur J Vasc Endovasc Surg 2021 Jul;():

Sex differences and temporal trends in aortic dissection: a population-based study of incidence, treatment strategies, and outcome in Swedish patients during 15 years.
Smedberg C, Steuer J, Leander K, Hultgren R
Eur Heart J 2020 07;41(26):2430-2438

Risk factors for amputation are influenced by competing risk of death in patients with critical limb ischemia.
Torbjörnsson E, Blomgren L, Fagerdahl AM, Boström L, Ottosson C, Malmstedt J
J Vasc Surg 2020 04;71(4):1305-1314.e5

Health-related quality of life and prosthesis use among patients amputated due to peripheral arterial disease - a one-year follow-up.
Torbjörnsson E, Ottosson C, Boström L, Blomgren L, Malmstedt J, Fagerdahl AM
Disabil Rehabil 2020 Sep;():1-9

Negative pressure wound therapy versus standard treatment in patients with acute conflict-related extremity wounds: a pragmatic, multisite, randomised controlled trial.
Älgå A, Haweizy R, Bashaireh K, Wong S, Lundgren KC, von Schreeb J, Malmstedt J
Lancet Glob Health 2020 03;8(3):e423-e429

Malondialdehyde Conjugated With Albumin Induces Pro-Inflammatory Activation of T Cells Isolated From Human Atherosclerotic Plaques Both Directly and Via Dendritic Cell-Mediated Mechanism.
Rahman M, Steuer J, Gillgren P, Végvári Á, Liu A, Frostegård J
JACC Basic Transl Sci 2019 Aug;4(4):480-494

Nationwide Study on Treatment of Mycotic Thoracic Aortic Aneurysms.
Sörelius K, Wanhainen A, Wahlgren CM, Langenskiöld M, Roos H, Resch T, Vaccarino R, Arvidsson B, Gillgren P, Bilos L, Pirouzram A, Holsti M, Mani K
Eur J Vasc Endovasc Surg 2019 Feb;57(2):239-246

Long-Term Outcome After Carotid Artery Stenting: A Population-Based Matched Cohort Study.
Jonsson M, Lindström D, Gillgren P, Wanhainen A, Malmstedt J
Stroke 2016 08;47(8):2083-9

Peri-procedural Risk with Urgent Carotid Artery Stenting: A Population based Swedvasc Study.
Jonsson M, Gillgren P, Wanhainen A, Acosta S, Lindström D
Eur J Vasc Endovasc Surg 2015 May;49(5):506-12

Distinction between acute and chronic type B aortic dissection: is there a sub-acute phase?
Steuer J, Björck M, Mayer D, Wanhainen A, Pfammatter T, Lachat M
Eur J Vasc Endovasc Surg 2013 Jun;45(6):627-31

Reasons for non-participation in population-based abdominal aortic aneurysm screening.
Linné A, Leander K, Lindström D, Törnberg S, Hultgren R
Br J Surg 2014 Apr;101(5):481-7

Profiling of atherosclerotic lesions by gene and tissue microarrays reveals PCSK6 as a novel protease in unstable carotid atherosclerosis.
Perisic L, Hedin E, Razuvaev A, Lengquist M, Osterholm C, Folkersen L, Gillgren P, Paulsson-Berne G, Ponten F, Odeberg J, Hedin U
Arterioscler Thromb Vasc Biol 2013 Oct;33(10):2432-43

Low post-operative mortality after surgery on patients with screening-detected abdominal aortic aneurysms: a Swedvasc registry study.
Linné A, Smidfelt K, Langenskiöld M, Hultgren R, Nordanstig J, Kragsterman B, et al
Eur J Vasc Endovasc Surg 2014 Dec;48(6):649-56

Fruit and vegetable consumption with risk of abdominal aortic aneurysm.
Stackelberg O, Björck M, Larsson SC, Orsini N, Wolk A
Circulation 2013 Aug;128(8):795-802