Otto Stackelberg

Otto Stackelberg

Affiliated to Research
Visiting address: Nobels väg 13, 17177 Stockholm
Postal address: C6 Institutet för miljömedicin, C6 Kardiovaskulär- och nutritionsepidemiologi, 171 77 Stockholm
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About me

  • Resident Vascular Surgeon with an interest for epidemiology and
    biostatistics. Withheld a PhD for my project investigating the potential
    impact of modifiable lifestyle related factors on risk of developing
    abdominal aortic aneurysm (AAA). Affiliated to the Unit of Cardiovascular and
    Nutritional Epidemiology (Institute of Environmental Medicine, Karolinska
    Institutet), and the Unit for Vascular Surgery at Stockholm South General
    Hospital (SOSVASC). Engaged in several studies on epidemiological aspects of
    abdominal aortic aneurysm, and evaluation of endovascular treatments of AAA.
    3rd prize oral presentation at the annual conference for the European Society
    of Vascular Surgery (ESVS) 2018
    Best poster abstract award at the Munich Vascular Conference 2015
    Winner of the Swedvasc prize for best article in vascular surgery
    research 2015
    Winner of the best oral presentation of vascular surgical research at the
    annual national conference for Swedish surgeons 2013
    Winner of the IMM poster awards 2013
    *Doctoral Programme in Medical Science *(June 2012 – May 2016)
    Unit of Nutritional Epidemiology, IMM, Karolinska Institutet, Stockholm
    *Medical Doctors Programme* (Aug 2006 – Jan 2012)
    Karolinska Institutet, Stockholm, Sweden

Research

  • *Lifestyle and risk of abdominal aortic aneurysm*
    My PhD-Project aimed to investigate how modifiable lifestyle related
    factors, such as adiposity, diet and physical activity, may affect the risk
    of developing an abdominal aortic aneurysm. To prospectively assess this
    risk, I utilize two large cohorts of middle-aged and elderly men and women
    from Sweden: the Swedish Mammography Cohort (SMC) and the Cohort of Swedish
    Men (COSM).
    Abdominal aortic aneurysm is a pathological dilatation of the abdominal aorta
    and associated with high mortality if this dilatation keeps growing to
    eventually rupture. Since the development of the disease is usually
    asymptomatic and the best way to detect it is by ultrasound screening, it is
    important to identify people at risk of the disease, making surgery to
    prevent rupture possible. The findings of lifestyle related factors affecting
    the risk of disease may also act as future recommendations for patients with
    detected abdominal aortic aneurysm. Smoking is heavily associated with the
    disease but other lifestyle related exposures that possibly could affect
    inflammation and oxidative stress in the aortic wall, are scarcely
    investigated. We observed an inverse assocation between higher intake of
    fruits, moderate intake of beer and wine, and higher levels of physical
    activity, and risk of the disease. We also observed a higher risk of the
    disease amongst those with larger waist circumference.
    After my dissertation, we have continued to investigate other modifiable
    factors associated with the disease, e.g. different types of physical
    activity, hormone replacement therapy, and anti-inflammatory dietary index.
    http://ki.se/en/imm/unit-of-nutritional-epidemiology [1]
    Thesis for doctoral degree (Ph.D.): Lifestyle and Risk of Abdominal Aortic
    Aneurysm [2]
    *Endovascular treatment of aortic disease*
    Abdominal aortic aneurysm can be treated with different endovascular methods.
    These methods became popular in the 1990's and, with technical innovation, we
    are now able to treat more and more complex aneurysms in the thoracic and
    abdominal aorta. Follow-up of new methods are important in order to secure
    the safety of our patients. Amongst other, we have evaulated how different
    types of endovascular treatments do in comparison with others, and how
    treatment of complex endovascular aortic disease in Sweden compares
    internationally. To do these studies, we collaborate with other vascular
    surgical centers in Sweden, such as Karolinska University Hospital and
    Uppsala University Hospital.
    http://ki.se/kisos/sosvasc [3]
    [1] http://ki.se/en/imm/unit-of-nutritional-epidemiology
    [2] http://hdl.handle.net/10616/45107
    [3] http://ki.se/kisos/sosvasc

Articles

All other publications

Employments

  • Affiliated to Research, Institute of Environmental Medicine, Karolinska Institutet, 2022-2025

Degrees and Education

  • Degree Of Doctor Of Philosophy, Institute of Environmental Medicine, Karolinska Institutet, 2016
  • University Medical Degree, Karolinska Institutet, 2012

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