Jirina Bartkova

Publications
Public outreach and news

Articles

Article: CELL DEATH AND DIFFERENTIATION. 2023;30(7):1666-1678
Actionable cancer vulnerability due to translational arrest, p53 aggregation and ribosome biogenesis stress evoked by the disulfiram metabolite CuET
Kanellis DC; Zisi A; Skrott Z; Lemmens B; Espinoza JA; Kosar M; Bjorkman A; Li X; Arampatzis S; Bartkova J; Andujar-Sanchez M; Fernandez-Capetillo O; Mistrik M; Lindstrom MS; Bartek J
Article: FRONTIERS IN ONCOLOGY. 2023;13:1218297
Investigating chromosomal instability in long-term survivors with glioblastoma and grade 4 astrocytoma
Spoor JKH; den Braber M; Dirven CMF; Pennycuick A; Bartkova J; Bartek J; van Dis V; van den Bosch TPP; Leenstra S; Venkatesan S
Article: BMC CANCER. 2022;22(1):1298
Markers associated with genomic instability, immunogenicity and immune therapy responsiveness in Metaplastic carcinoma of the breast: Expression of γH2AX, pRPA2, P53, PD-L1 and tumor infiltrating lymphocytes in 76 cases
Voutilainen S; Heikkila P; Bartkova J; Nevanlinna H; Blomqvist C; Bartek J; Mattson J
Article: CELL DEATH AND DIFFERENTIATION. 2022;29(8):1639-1653
Human cytomegalovirus hijacks host stress response fueling replication stress and genome instability
Merchut-Maya JM; Bartek JJ; Bartkova J; Galanos P; Pantalone MR; Lee M; Cui HL; Shilling PJ; Brochner CB; Broholm H; Maya-Mendoza A; Soderberg-Naucler C; Bartek J
Article: MOLECULAR CELL. 2021;81(22):4692-4708.e9
Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps
Dias MP; Tripathi V; van der Heijden I; Cong K; Manolika E-M; Bhin J; Gogola E; Galanos P; Annunziato S; Lieftink C; Andujar-Sanchez M; Chakrabarty S; Smith GCM; van de Ven M; Beijersbergen RL; Bartkova J; Rottenberg S; Cantor S; Bartek J; Chaudhuri AR; Jonkers J
Article: CANCER DISCOVERY. 2021;11(10):2456-2473
Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution
Venkatesan S; Angelova M; Puttick C; Zhai H; Caswell DR; Lu W-T; Dietzen M; Galanos P; Evangelou K; Bellelli R; Lim EL; Watkins TBK; Rowan A; Teixeira VH; Zhao Y; Chen H; Ngo B; Zalmas L-P; Al Bakir M; Hobor S; Gronroos E; Pennycuick A; Nigro E; Campbell BB; Brown WL; Akarca AU; Marafioti T; Wu MY; Howell M; Boulton SJ; Bertoli C; Fenton TR; de Bruin RAM; Maya-Mendoza A; Santoni-Rugiu E; Hynds RE; Gorgoulis VG; Jamal-Hanjani M; McGranahan N; Harris RS; Janes SM; Bartkova J; Bakhoum SF; Bartek J; Kanu N; Swanton C
Article: SCIENCE ADVANCES. 2021;7(32):eabf7561
The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output
Kanellis DC; Espinoza JA; Zisi A; Sakkas E; Bartkova J; Katsori A-M; Bostrom J; Dyrskjot L; Broholm H; Altun M; Elsasser SJ; Lindstrom MS; Bartek J
Article: NATURE COMMUNICATIONS. 2021;12(1):3937
The human nucleoporin Tpr protects cells from RNA-mediated replication stress
Kosar M; Giannattasio M; Piccini D; Maya-Mendoza A; Garcia-Benitez F; Bartkova J; Barroso SI; Gaillard H; Martini E; Restuccia U; Ramirez-Otero MA; Garre M; Verga E; Andujar-Sanchez M; Maynard S; Hodny Z; Costanzo V; Kumar A; Bachi A; Aguilera A; Bartek J; Foiani M
Article: CLINICAL NEUROPATHOLOGY. 2021;40(3):151-159
Expression of the stem cell marker CD133 in malignant meningioma
Maier AD; Mirian C; Bartek JJ; Juhler M; Bartkova J; Broholm H; Mathiesen TI
Article: NATURE. 2021;592(7856):799-803
AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity
Maiani E; Milletti G; Nazio F; Holdgaard SG; Bartkova J; Rizza S; Cianfanelli V; Lorente M; Simoneschi D; Di Marco M; D'Acunzo P; Di Leo L; Rasmussen R; Montagna C; Raciti M; De Stefanis C; Gabicagogeascoa E; Rona G; Salvador N; Pupo E; Merchut-Maya JM; Daniel CJ; Carinci M; Cesarini V; O'sullivan A; Jeong Y-T; Bordi M; Russo F; Campello S; Gallo A; Filomeni G; Lanzetti L; Sears RC; Hamerlik P; Bartolazzi A; Hynds RE; Pearce DR; Swanton C; Pagano M; Velasco G; Papaleo E; De Zio D; Maya-Mendoza A; Locatelli F; Bartek J; Cecconi F
Article: CELL CYCLE. 2020;19(7):727-741
Cancer cell stemness, responses to experimental genotoxic treatments, cytomegalovirus protein expression and DNA replication stress in pediatric medulloblastomas
Bartek JJ; Merchut-Maya JM; Maya-Mendoza A; Fornara O; Rahbar A; Brochner CB; Sehested A; Soderberg-Naucler C; Bartek J; Bartkova J
Article: CELL DEATH AND DIFFERENTIATION. 2020;27(3):1134-1153
Autophagy role(s) in response to oncogenes and DNA replication stress
Vanzo R; Bartkova J; Merchut-Maya JM; Hall A; Bouchal J; Dyrskjot L; Frankel LB; Gorgoulis V; Maya-Mendoza A; Jaattela M; Bartek J
Article: PROSTATE. 2019;79(4):352-362
Targeting genotoxic and proteotoxic stress-response pathways in human prostate cancer by clinically available PARP inhibitors, vorinostat and disulfiram
Majera D; Skrott Z; Bouchal J; Bartkova J; Simkova D; Gachechiladze M; Steigerova J; Kurfurstova D; Gursky J; Korinkova G; Cwiertka K; Hodny Z; Mistrik M; Bartek J
Article: CELL CYCLE. 2018;17(17):2146-2163
DNA damage-induced dynamic changes in abundance and cytosol-nuclear translocation of proteins involved in translational processes, metabolism, and autophagy
Bennetzen MV; Kosar M; Bunkenborg J; Payne MR; Bartkova J; Lindstrom MS; Lukas J; Andersen JS; Bartek J; Larsen DH
Article: CANCER CELL. 2018;33(6):1078-1093.e12
Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality
Gogola E; Duarte AA; de Ruiter JR; Wiegant WW; Schmid JA; de Bruijn R; James DI; Llobet SG; Vis DJ; Annunziato S; van den Broek B; Barazas M; Kersbergen A; van de Ven M; Tarsounas M; Ogilvie DJ; van Vugt M; Wessels LFA; Bartkova J; Gromova I; Andujar-Sanchez M; Bartek J; Lopes M; van Attikum H; Borst P; Jonkers J; Rottenberg S
Article: NATURE. 2017;552(7684):194-199
Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4
Skrott Z; Mistrik M; Andersen KK; Friis S; Majera D; Gursky J; Ozdian T; Bartkova J; Turi Z; Moudry P; Kraus M; Michalova M; Vaclavkova J; Dzubak P; Vrobel I; Pouckova P; Sedlacek J; Miklovicova A; Kutt A; Li J; Mattova J; Driessen C; Dou QP; Olsen J; Hajduch M; Cvek B; Deshaies RJ; Bartek J
Article: MOLECULAR ONCOLOGY. 2017;11(8):945-964
Replication stress, DNA damage signalling, and cytomegalovirus infection in human medulloblastomas
Bartek JJ; Fornara O; Merchut-Maya JM; Maya-Mendoza A; Rahbar A; Stragliotto G; Broholm H; Svensson M; Sehested A; Naucler CS; Bartek J; Bartkova J
Article: ONCOGENE. 2017;36(17):2405-2422
Tumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress
Chroma K; Mistrik M; Moudry P; Gursky J; Liptay M; Strauss R; Skrott Z; Vrtel R; Bartkova J; Kramara J; Bartek J
Article: INTERNATIONAL JOURNAL OF CANCER. 2016;139(12):2760-2770
FANCM c.5101C>T mutation associates with breast cancer survival and treatment outcome
Kiiski JI; Fagerholm R; Tervasmaki A; Pelttari LM; Khan S; Jamshidi M; Mantere T; Pylkas K; Bartek J; Bartkova J; Mannermaa A; Tengstrom M; Kosma V-M; Winqvist R; Kallioniemi A; Aittomaki K; Blomqvist C; Nevanlinna H
Article: GENOME BIOLOGY. 2016;17(1):185
DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer
Kanu N; Cerone MA; Goh G; Zalmas L-P; Bartkova J; Dietzen M; McGranahan N; Rogers R; Law EK; Gromova I; Kschischo M; Walton MI; Rossanese OW; Bartek J; Harris RS; Venkatesan S; Swanton C
Article: MOLECULAR ONCOLOGY. 2016;10(6):879-894
DNA damage signalling barrier, oxidative stress and treatment-relevant DNA repair factor alterations during progression of human prostate cancer
Kurfurstova D; Bartkova J; Vrtel R; Mickova A; Burclova A; Majera D; Mistrik M; Kral M; Santer FR; Bouchal J; Bartek J
Article: JOURNAL OF CELL BIOLOGY. 2016;212(3):281-288
TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity
Moudry P; Watanabe K; Wolanin KM; Bartkova J; Wassing IE; Watanabe S; Strauss R; Pedersen RT; Oestergaard VH; Lisby M; Andujar-Sanchez M; Maya-Mendoza A; Esashi F; Lukas J; Bartek J
Article: ONCOGENE. 2015;34(46):5699-5708
SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair.
Kanu N; Grönroos E; Martinez P; Burrell RA; Yi Goh X; Bartkova J; Maya-Mendoza A; Mistrík M; Rowan AJ; Patel H; Rabinowitz A; East P; Wilson G; Santos CR; McGranahan N; Gulati S; Gerlinger M; Birkbak NJ; Joshi T; Alexandrov LB; Stratton MR; Powles T; Matthews N; Bates PA; Stewart A; Szallasi Z; Larkin J; Bartek J; Swanton C
Article: CELL. 2015;162(1):146-159
A Synergistic Interaction between Chk1-and MK2 Inhibitors in KRAS-Mutant Cancer
Dietlein F; Kalb B; Jokic M; Noll EM; Strong A; Tharun L; Ozretic L; Kuenstlinger H; Kambartel K; Randerath WJ; Juengst C; Schmitt A; Torgovnick A; Richters A; Rauh D; Siedek F; Persigehl T; Mauch C; Bartkova J; Bradley A; Sprick MR; Trumpp A; Rad R; Saur D; Bartek J; Wolf J; Buettner R; Thomas RK; Reinhardt HC
Article: NATURE. 2015;521(7553):541-544
REV7 counteracts DNA double-strand break resection and affects PARP inhibition.
Xu G; Chapman JR; Brandsma I; Yuan J; Mistrik M; Bouwman P; Bartkova J; Gogola E; Warmerdam D; Barazas M; Jaspers JE; Watanabe K; Pieterse M; Kersbergen A; Sol W; Celie PHN; Schouten PC; van den Broek B; Salman A; Nieuwland M; de Rink I; de Ronde J; Jalink K; Boulton SJ; Chen J; van Gent DC; Bartek J; Jonkers J; Borst P; Rottenberg S
Article: MOLECULAR ONCOLOGY. 2015;9(3):601-616
Myc and Ras oncogenes engage different energy metabolism programs and evoke distinct patterns of oxidative and DNA replication stress
Maya-Mendoza A; Ostrakova J; Kosar M; Hall A; Duskova P; Mistrik M; Merchut-Maya JM; Hodny Z; Bartkova J; Christensen C; Bartek J
Article: MOLECULAR ONCOLOGY. 2014;8(8):1667-1678
Patterns of DNA damage response in intracranial germ cell tumors versus glioblastomas reflect cell of origin rather than brain environment: implications for the anti-tumor barrier concept and treatment.
Bartkova J; Hoei-Hansen CE; Krizova K; Hamerlik P; Skakkebæk NE; Rajpert-De Meyts E; Bartek J
Article: NATURE COMMUNICATIONS. 2014;5:5348
A short acidic motif in ARF guards against mitochondrial dysfunction and melanoma susceptibility.
Christensen C; Bartkova J; Mistrík M; Hall A; Lange MK; Ralfkiær U; Bartek J; Guldberg P
Article: CELL DEATH AND DISEASE. 2014;5(7):e1351
Immortalised breast epithelia survive prolonged DNA replication stress and return to cycle from a senescent-like state.
Maya-Mendoza A; Merchut-Maya JM; Bartkova J; Bartek J; Streuli CH; Jackson DA
Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2013;20(12):1425-1433
JMJD1C demethylates MDC1 to regulate the RNF8 and BRCA1-mediated chromatin response to DNA breaks.
Watanabe S; Watanabe K; Akimov V; Bartkova J; Blagoev B; Lukas J; Bartek J
Article: ANNALS OF ONCOLOGY. 2013;24(11):2780-2785
Overabundant FANCD2, alone and combined with NQO1, is a sensitive marker of adverse prognosis in breast cancer.
Fagerholm R; Sprott K; Heikkinen T; Bartkova J; Heikkilä P; Aittomäki K; Bartek J; Weaver D; Blomqvist C; Nevanlinna H
Article: CELL DEATH AND DIFFERENTIATION. 2013;20(11):1485-1497
The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis
Evangelou K; Bartkova J; Kotsinas A; Pateras IS; Liontos M; Velimezi G; Kosar M; Liloglou T; Trougakos IP; Dyrskjot L; Andersen CL; Papaioannou M; Drosos Y; Papafotiou G; Hodny Z; Sosa-Pineda B; Wu X-R; Klinakis A; Orntoft T; Lukas J; Bartek J; Gorgoulis VG
Article: NATURE CELL BIOLOGY. 2013;15(8):967-977
Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer.
Velimezi G; Liontos M; Vougas K; Roumeliotis T; Bartkova J; Sideridou M; Dereli-Oz A; Kocylowski M; Pateras IS; Evangelou K; Kotsinas A; Orsolic I; Bursac S; Cokaric-Brdovcak M; Zoumpourlis V; Kletsas D; Papafotiou G; Klinakis A; Volarevic S; Gu W; Bartek J; Halazonetis TD; Gorgoulis VG
Article: ONCOGENE. 2013;32(31):3577-3586
A high resolution genomic portrait of bladder cancer: correlation between genomic aberrations and the DNA damage response.
Schepeler T; Lamy P; Hvidberg V; Laurberg JR; Fristrup N; Reinert T; Bartkova J; Tropia L; Bartek J; Halazonetis TD; Pan C-C; Borre M; Dyrskjøt L; Orntoft TF
Article: CELL CYCLE. 2012;11(20):3837-3850
Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment.
Oplustilova L; Wolanin K; Mistrik M; Korinkova G; Simkova D; Bouchal J; Lenobel R; Bartkova J; Lau A; O'Connor MJ; Lukas J; Bartek J
Article: HUMAN PATHOLOGY. 2012;43(9):1363-1375
Utilization of fluorescence in situ hybridization with cytokeratin discriminators in TOP2A assessment of chemotherapy-treated patients with breast cancer.
Pierceall WE; Sprott KM; Heikkinen T; Heikkila P; Alaparthi L; Aittomaki K; Al-Adhami M; Villegas-Bergazzi V; Meyer JL; Kutok JL; Bartkova J; Bartek J; Nevanlinna H; Weaver DT; Blomqvist C
Article: CELL. 2012;150(4):697-709
TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes.
Gudjonsson T; Altmeyer M; Savic V; Toledo L; Dinant C; Grøfte M; Bartkova J; Poulsen M; Oka Y; Bekker-Jensen S; Mailand N; Neumann B; Heriche J-K; Shearer R; Saunders D; Bartek J; Lukas J; Lukas C
Article: CANCER CELL. 2012;21(4):517-531
DNA damage response and inflammatory signaling limit the MLL-ENL-induced leukemogenesis in vivo.
Takacova S; Slany R; Bartkova J; Stranecky V; Dolezel P; Luzna P; Bartek J; Divoky V
Article: BREAST CANCER RESEARCH AND TREATMENT. 2012;132(3):955-968
NQO1 expression correlates inversely with NFκB activation in human breast cancer.
Jamshidi M; Bartkova J; Greco D; Tommiska J; Fagerholm R; Aittomäki K; Mattson J; Villman K; Vrtel R; Lukas J; Heikkilä P; Blomqvist C; Bartek J; Nevanlinna H
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2012;209(3):507-520
Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth
Hamerlik P; Lathia JD; Rasmussen R; Wu Q; Bartkova J; Lee M; Moudry P; Bartek JJ; Fischer W; Lukas J; Rich JN; Bartek J
Article: PLOS ONE. 2012;7(9):e44156
Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory bowel disease.
Sohn JJ; Schetter AJ; Yfantis HG; Ridnour LA; Horikawa I; Khan MA; Robles AI; Hussain SP; Goto A; Bowman ED; Hofseth LJ; Bartkova J; Bartek J; Wogan GN; Wink DA; Harris CC
Article: GENES & DEVELOPMENT. 2009;23(16):1895-1909
The combined status of ATM and p53 link tumor development with therapeutic response.
Jiang H; Reinhardt HC; Bartkova J; Tommiska J; Blomqvist C; Nevanlinna H; Bartek J; Yaffe MB; Hemann MT
Article: MOLECULAR ONCOLOGY. 2008;2(4):296-316
Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene.
Bartkova J; Tommiska J; Oplustilova L; Aaltonen K; Tamminen A; Heikkinen T; Mistrik M; Aittomäki K; Blomqvist C; Heikkilä P; Lukas J; Nevanlinna H; Bartek J
Article: NATURE GENETICS. 2008;40(7):844-853
NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer.
Fagerholm R; Hofstetter B; Tommiska J; Aaltonen K; Vrtel R; Syrjäkoski K; Kallioniemi A; Kilpivaara O; Mannermaa A; Kosma V-M; Uusitupa M; Eskelinen M; Kataja V; Aittomäki K; von Smitten K; Heikkilä P; Lukas J; Holli K; Bartkova J; Blomqvist C; Bartek J; Nevanlinna H
Article: ONCOGENE. 2008;27(17):2501-2506
The DNA damage signalling kinase ATM is aberrantly reduced or lost in BRCA1/BRCA2-deficient and ER/PR/ERBB2-triple-negative breast cancer.
Tommiska J; Bartkova J; Heinonen M; Hautala L; Kilpivaara O; Eerola H; Aittomäki K; Hofstetter B; Lukas J; von Smitten K; Blomqvist C; Ristimäki A; Heikkilä P; Bartek J; Nevanlinna H
Article: NATURE. 2006;444(7119):633-637
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
Bartkova J; Rezaei N; Liontos M; Karakaidos P; Kletsas D; Issaeva N; Vassiliou L-VF; Kolettas E; Niforou K; Zoumpourlis VC; Takaoka M; Nakagawa H; Tort F; Fugger K; Johansson F; Sehested M; Andersen CL; Dyrskjot L; Orntoft T; Lukas J; Kittas C; Helleday T; Halazonetis TD; Bartek J; Gorgoulis VG
Article: INTERNATIONAL JOURNAL OF CANCER. 2006;118(11):2911-2916
Evaluation of RAD50 in familial breast cancer predisposition.
Tommiska J; Seal S; Renwick A; Barfoot R; Baskcomb L; Jayatilake H; Bartkova J; Tallila J; Kaare M; Tamminen A; Heikkilä P; Evans DG; Eccles D; Aittomäki K; Blomqvist C; Bartek J; Stratton MR; Nevanlinna H; Rahman N
Article: INTERNATIONAL JOURNAL OF CANCER. 2005;113(4):575-580
Correlation of CHEK2 protein expression and c.1100delC mutation status with tumor characteristics among unselected breast cancer patients.
Kilpivaara O; Bartkova J; Eerola H; Syrjäkoski K; Vahteristo P; Lukas J; Blomqvist C; Holli K; Heikkilä P; Sauter G; Kallioniemi O-P; Bartek J; Nevanlinna H
Article: INTERNATIONAL JOURNAL OF CANCER. 2004;111(4):543-547
CHEK2 variant I157T may be associated with increased breast cancer risk.
Kilpivaara O; Vahteristo P; Falck J; Syrjäkoski K; Eerola H; Easton D; Bartkova J; Lukas J; Heikkilä P; Aittomäki K; Holli K; Blomqvist C; Kallioniemi O-P; Bartek J; Nevanlinna H
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2002;71(2):432-438
A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer.
Vahteristo P; Bartkova J; Eerola H; Syrjäkoski K; Ojala S; Kilpivaara O; Tamminen A; Kononen J; Aittomäki K; Heikkilä P; Holli K; Blomqvist C; Bartek J; Kallioniemi O-P; Nevanlinna H
Article: GASTROENTEROLOGY. 2001;120(7):1680-1688
Aberrant expression of G1-phase cell cycle regulators in flat and exophytic adenomas of the human colon
Bartkova J; Thullberg M; Slezak P; Jaramillo E; Rubio C; Thomassen LH; Bartek J
Article: FEBS LETTERS. 2000;470(2):161-166
Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors.
Thullberg M; Bartkova J; Khan S; Hansen K; Rönnstrand L; Lukas J; Strauss M; Bartek J
Article: HYBRIDOMA. 2000;19(1):63-72
Monoclonal antibody probes for p21^WAF1/CIP1 and the INK4 family of cyclin-dependent kinase inhibitors
Thullberg M; Welcker M; Bartkova J; Kjerulff AA; Lukas J; Högberg J; Bartek J
Article: MOLECULAR CANCER RESEARCH. 1996;7(12):1723-1732
Phenotype-related differences in the expression of D-type cyclins in human B cell-derived lines
Pokrovskaja K; EhlinHenriksson B; Bartkova J; Bartek J; Scuderi R; Szekely L; Wiman KG; Klein G
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Meeting abstract: MOLECULAR CANCER RESEARCH. 2017;15:ia13
Replication stress in cancer pathogenesis: Mechanisms and treatment opportunities
Bartek J; Bartkova J

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