Mikael Lindström
About me
PhD degree in Experimental Oncology 2004 and Docent in Experimental Pathology obtained 2012 at Karolinska Institutet i Stockholm, Sweden.
Research
We are specifically interested in molecular mechanisms underlying the regulation of ribosome biogenesis, how the cell senses errors in the complex process of ribosome biogenesis and how these processes in turn can be used in the development of novel anti-cancer therapies. To investigate ribosome biogenesis and nucleolar structure, the team uses various microscopy technologies, ribosome profiling, rDNA assays, transcriptomics, translatomics, and proteomics. We also work a lot with small molecules and functional screens. Main lines and interests of research: 1. Characterization of ribosome biogenesis regulatory proteins and potential role in cancer development, biomarker discovery for personalized cancer medicine. 2. Regulation of ribosome biogenesis and protein synthesis in normal CNS cells and in glioma, including heterogeneity of ribosome in relation to glioma cellular diversity. 3. Targeting of ribosome biogenesis or mature ribosome function in cancer. 4. Functional studies of ribosomal proteins. 5. Together with Prof Sinisa Volarevic, Univ of Rijeka, Croatia, we investigate the role of RPL24 and p53 in disease.
I have evaluated manuscripts for the following journals among others
Oncogene, Nature, EMBO Rep, EMBO J, Nature Cell Biology, J Biol Chem, Mol Cell Biol, Proteins, J. of Clinical Investigation, Mol Cell, Intl. J of Cancer, Int J Mol Sciences, Cancer, Cancers, J Cytology and Histology, J Mol Biol, PLoS One, FEBS Letters, FEBS J, Future Oncology, Cell Proliferation, Biochem J, Scientific Reports, Tumor Biology, Current Drug Targets, Cytotherapy, Nature Communications, J Cell Science, Cell Reports, Cell Cycle, Chemistry Biology, Blood, Pharmaceuticals, Biochem Soc Trans, Cells, Oncotarget, Int J of Dev Neuroscience, Cellular Physiology and Biochemistry, BMC Biotechnology, BMC Molecular Biology, Bioscience Reports, Cancer Res, Elife, J Cellular Physiology, J Oncology, BBA Mol Cell, Comm Biol, Metabolites, Ebiomedicine, ACS Chemical Biology, BBA Molecular Res, Biomarkers, JCI Insight, BioEssays, Cell Death and Disease, Cell Death and Differentiation, Biomedicines, Breast Cancer Research, Pathogens, Signal Transduction and Targeted Therapies, Biomolecules and Biomedicine, Histology and Histopathology, Epigenetics and Chromatin, Mol Oncol, Nucleic Acids Res Cancer, iScience, Int J Cancer, Discover Oncology, Trends Cell Biology, Cell Proliferation and many others.
Grant evaluator 2010-2024
NWO Vidi Scheme for Innovational Research Incentives Scheme Netherlands, AICR Assoc International Cancer Research UK, YRC Yorkshire Cancer Res UK, Semaphore FRS FNRS BE, Romanian national development and innovation council uefiscdi, German-Israeli Foundation for Scientific Research and Development, Czech Science Foundation GACR, National Science Centre NCN Poland, INCa the French National Cancer Institute France, Fondation contre le Cancer Grant Belgian Foundation against Cancer, Croatian Science Foundation Croatia, Agence Nationale de la Recherche France, Evaluator of Baillet Latour Grant for Medical Research and Baillet Latour Prize GMR NL, European Science Foundation ESF including FWO grants and many others Worldwide Cancer Res, SNSF Innosuisse BRIDGE, UK research and innovation UKRI, INSERM Cancer PCSI France and others.
Teaching
Supervision
Co-supervisor: Dr Tamador Elsir, PhD 2010-06-04, KI
Co-supervisor: Dr Inga Nazarenko, PhD 2011-09-30, KI
Co-supervisor: Dr Karl Holmberg-Olausson, PhD 2015-06-01, KIMain supervisor: Dr Kaveh Moazemi Goudarzi, PhD 2018-04-27, KI
Main supervisor: Dr Asimina Zisi, PhD 2022-10-28, KIService to the universities
Pre-examiner of doctoral dissertation: 16 (2009-2024)
Half time review for PhD: 20 (2012-2024)
Chairman of PhD defense: 8 (2015-2024)
Examiner of MSc or BSc thesis 16 (2012-2018)
Opponent: 1Following courses I have taken
Basic pedagogics for university lecturers GHPH09
Postgraduate supervisor training course KI
Leadership education UGL, KI
Web courses for supervisors
I have over 600 teaching hours in cell biology, oncology, and biochemistry for students at the medical and biomedical programs, including molecular oncology and biostatistics (BioMed), and Molecular Medicine course, cell biology. At the medical program biochemistry in the DFM1 and BV2 courses. I have been teaching also at the postgraduate course level, at the Cancer Cell cycles and Cancer Cell metabolism courses. I have co-organized a course on Brain Tumors. I currently also teach biochemistry at the KI prep course for foreign (non EU) medical doctors that will take knowledge test for licence to practice medicine in Sweden.
Articles
- Article: NATURE COMMUNICATIONS. 2025;16(1):7130Wenson L; Heldin J; Martin M; Erbilgin Y; Salman B; Sundqvist A; Schaal W; Sandbaumhuter FA; Jansson ET; Chen X; Davidsson A; Stenerlow B; Espinoza JA; Lindstrom M; Lennartsson J; Spjuth O; Soderberg O
- Journal article: TUMOR DISCOVERY. 2024;3(4):4904Ye Z; Li X; Xie F; Deng C; Yang D; Li H; Lu Y; Mao Z; Meng Q; Wang L; Wang Z; Xing J; Bai C; Bian Z; Boffano P; Brower S; Chen R; Chen W; Deng J; Deng X; Ding C; Duan J; Duan S; Duzgunes N; Franco P; Fu G; Guo L; Guo Y; Han R; Hao L; He L; He Y; Hu X; Jia J; Jiang Y; Jin W; Kairemo K; Kamal M; Keller ET; Lai R; Li C; Li J; Li L; Li Q; Li W; Li X; Li Y; Li Y; Li Y; Lindström MS; Liu X; Liu Y; Liu Y; Liu Z; Lopes JM; Lu H; Luo X; Ma W; Meng H; Min A; Moya AC; Papavassiliou AG; Pan X; Peng M; Popper HH; Qiu L; Qu D; Schönthal AH; Shelat V; Shi Y; Shtil A; Siddique HR; Song Y; Su H; Tang M; Wang M; Wang Q; Wang S; Wei B; Wu D; Wu L; Xu L; Yan Y; Yang N; Yang Z; Yi Z; Yu S; Zhang H; Zhang H; Zhang L; Zhao J; Zhao Z; Zheng S; Zhou C; Zhou P; Zhou Q; Zhu G; Yan Q; Zhang M; Yin M
- Article: NUCLEIC ACIDS RESEARCH. 2024;52(8):4151-4166Espinoza JA; Kanellis DC; Saproo S; Leal K; Martinez JF; Bartek J; Lindstrom MS
- Article: CELL DEATH AND DIFFERENTIATION. 2023;30(7):1666-1678Kanellis DC; Zisi A; Skrott Z; Lemmens B; Espinoza JA; Kosar M; Bjorkman A; Li X; Arampatzis S; Bartkova J; Andujar-Sanchez M; Fernandez-Capetillo O; Mistrik M; Lindstrom MS; Bartek J
- Article: NEURO-ONCOLOGY. 2023;25(6):1058-1072Zisi A; Kanellis DC; Moussaud S; Karlsson I; Caren H; Braeutigam L; Bartek J; Lindstrom MS
- Article: ONCOGENE. 2021;40(32):5066-5080Guo M; Goudarzi KM; Abedi S; Pieber M; Sjoberg E; Behnan J; Zhang X-M; Harris RA; Bartek J; Lindstrom MS; Nister M; Hagerstrand D
- Article: SCIENCE ADVANCES. 2021;7(32):eabf7561Kanellis DC; Espinoza JA; Zisi A; Sakkas E; Bartkova J; Katsori A-M; Bostrom J; Dyrskjot L; Broholm H; Altun M; Elsasser SJ; Lindstrom MS; Bartek J
- Article: CANCER RESEARCH. 2020;80(7):1538-1550Peuget S; Zhu J; Sanz G; Singh M; Gaetani M; Chen X; Shi Y; Saei AA; Visnes T; Lindstrom MS; Rihani A; Moyano-Galceran L; Carlson JW; Hjerpe E; Joneborg U; Lehti K; Hartman J; Helleday T; Zubarev R; Selivanova G
- Article: CELL DEATH AND DIFFERENTIATION. 2020;27(2):773-789Espinoza JA; Zisi A; Kanellis DC; Carreras-Puigvert J; Henriksson M; Huhn D; Watanabe K; Helleday T; Lindstrom MS; Bartek J
- Article: NEURO-ONCOLOGY ADVANCES. 2020;2(1):vdaa061Guo M; van Vliet M; Zhao J; de Stahl TD; Lindstrom MS; Cheng H; Heller S; Nister M; Hagerstrand D
- Article: CANCER RESEARCH. 2018;78(20):5901-5916Goudarzi KM; Espinoza JA; Guo M; Bartek J; Nister M; Lindstrom MS; Hagerstrand D
- Article: CELL CYCLE. 2018;17(17):2146-2163Bennetzen MV; Kosar M; Bunkenborg J; Payne MR; Bartkova J; Lindstrom MS; Lukas J; Andersen JS; Bartek J; Larsen DH
- Article: ONCOTARGET. 2017;8(57):96536-96552Kostopoulou ON; Wilhelmi V; Raiss S; Ananthaseshan S; Lindstrom MS; Bartek J; Soderberg-Naucler C
- Article: LEUKEMIA. 2017;31(1):213-221Jaako P; Ugale A; Wahlestedt M; Velasco-Hernandez T; Cammenga J; Lindstrom MS; Bryder D
- Article: SCIENTIFIC REPORTS. 2015;5:16495Olausson KH; Elsir T; Goudarzi KM; Nister M; Lindstrom MS
- Article: LEUKEMIA. 2015;29(11):2221-2229Jaako P; Debnath S; Olsson K; Zhang Y; Flygare J; Lindstrom MS; Bryder D; Karlsson S
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2014;289(50):34601-34619Olausson KH; Nister M; Lindstrom MS
- Article: CANCER BIOLOGY & THERAPY. 2014;15(11):1499-1514Goudarzi KM; Nister M; Lindstrom MS
- Article: GENES & DEVELOPMENT. 2014;28(1):58-70Kelly GL; Grabow S; Glaser SP; Fitzsimmons L; Aubrey BJ; Okamoto T; Valente LJ; Robati M; Tai L; Fairlie WD; Lee EF; Lindstrom MS; Wiman KG; Huang DCS; Bouillet P; Rowe M; Rickinson AB; Herold MJ; Strasser A
- Article: PLOS ONE. 2012;7(12):e52476Lindstrom MS
- Article: CELLS. 2012;1(4):774-798Holmberg Olausson K; Nistér M; Lindström MS
- Article: BRITISH JOURNAL OF CANCER. 2011;104(11):1747-1754Elsir T; Qu M; Berntsson SG; Orrego A; Olofsson T; Lindstrom MS; Nister M; von Deimling A; Hartmann C; Ribom D; Smits A
- Article: PLOS ONE. 2011;6(4):e18303Nazarenko I; Hedren A; Sjodin H; Orrego A; Andrae J; Afink GB; Nister M; Lindstrom MS
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011;405(4):581-587Gadalla S-E; Alexandraki A; Lindstrom MS; Nister M; Ericsson C
- Article: JOURNAL OF ONCOLOGY. 2011;2011:852970-11Hede S-M; Nazarenko I; Nister M; Lindstrom AS
- Article: BIOCHEMISTRY RESEARCH INTERNATIONAL. 2011;2011:195209-16Lindstrom MS
- Article: CANCER CELL. 2010;18(3):231-243Macias E; Jin A; Deisenroth C; Bhat K; Mao H; Lindstrom MS; Zhang Y
- Article: PLOS ONE. 2010;5(3):e9578-A129Lindstrom MS; Nister M
- Article: JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. 2010;69(2):129-138Elsir T; Eriksson A; Orrego A; Lindstrom MS; Nister M
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(23):15568-15576Lindstrom MS; Zhang Y
- Article: CANCER CELL. 2007;12(4):355-366Itahana K; Mao H; Jin A; Itahana Y; Clegg HV; Lindstrom MS; Bhat KP; Godfrey VL; Evan GI; Zhang Y
- Article: CELL CYCLE. 2007;6(4):434-437Lindstrom MS; Deisenroth C; Zhang Y
- Article: MOLECULAR AND CELLULAR BIOLOGY. 2007;27(3):1056-1068Lindstrom MS; Jin A; Deisenroth C; Wolf GW; Zhang Y
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(27):18463-18472Enomoto T; Lindstrom MS; Jin A; Ke H; Zhang Y
- Article: ACTA ONCOLOGICA. 2006;45(6):676-684Wang J-L; Andersson S; Li X; Hellstrom A-C; Auer G; Angstrom T; Lindstrom MS; Wallin K-L
- Article: MODERN PATHOLOGY. 2005;18(5):629-637Wang JL; Zheng BY; Li XD; Nokelainen K; Ångström T; Lindström MS; Wallin KL
- Journal article: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER. 2004;14:46158 P16Ink4A and P14Arf Expression Pattern By Immunohistochemistry in HPV Related Cervical NeoplasiaWand J-L; Zheng B-Y; Li X-D; Nokelainen K; Angstrom T; Lindstrom MS; Wallin K-L
- Article: CLINICAL CANCER RESEARCH. 2004;10(7):2407-2414Wang JL; Zheng BY; Li XD; Ångström T; Lindström MS; Wallin KL
- Article: ONCOGENE. 2003;22(32):4993-5005Lindström MS; Wiman KG
- Article: SEMINARS IN CANCER BIOLOGY. 2002;12(5):381-387Lindström MS; Wiman KG
- Article: CANCER LETTERS. 2002;180(2):211-221Hashemi J; Lindström MS; Asker C; Platz A; Hansson J; Wiman KG
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(27):25336-25341Jackson MW; Lindström MS; Berberich SJ
- Article: ONCOGENE. 2001;20(17):2171-2177Lindström MS; Klangby U; Wiman KG
- Article: APOPTOSIS. 2001;6(1-2):133-137Henriksson M; Selivanova G; Lindström M; Wiman KG
- Article: EXPERIMENTAL CELL RESEARCH. 2000;256(2):400-410Lindström MS; Klangby U; Inoue R; Pisa P; Wiman KG; Asker CE
- Show more
All other publications
- Editorial comment: CANCERS. 2025;17(10):1597Lindstrom MS
- Meeting abstract: CANCER RESEARCH. 2024;84(6):4526Saproo S; Papadaki S; Espinoza JA; Bartek J; Lindstrom MS
- Meeting abstract: CANCER RESEARCH. 2024;84(5):pr-002-pr-002Zisi A; Dratkiewicz E; Kanellis DC; Moussaud S; Karlsson I; Caren H; Brautigam L; Bartek J; Lindstrom MS
- Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023Peuget S; Zhu J; Sanz G; Singh M; Gaetani M; Chen X; Shi Y; Saei AA; Visnes T; Lindström MS; Rihani A; Moyano-Galceran L; Carlson JW; Hjerpe E; Joneborg U; Lehti K; Hartman J; Helleday T; Zubarev R; Selivanova G
- Review: CELL DEATH AND DIFFERENTIATION. 2022;29(5):972-982Lindstrom MS; Bartek J; Maya-Mendoza A
- Review: CANCERS. 2022;14(9):2126Zisi A; Bartek J; Lindstrom MS
- Corrigendum: ONCOGENE. 2021;40(32):5153Guo M; Goudarzi KM; Abedi S; Pieber M; Sjoberg E; Behnan J; Zhang X-M; Harris RA; Bartek J; Lindstrom MS; Nister M; Hagerstrand D
- Editorial comment: BIOSCIENCE REPORTS. 2019;39(7):BSR20190770Lindstrom MS
- Review: ONCOGENE. 2018;37(18):2351-2366Lindstrom MS; Jurada D; Bursac S; Orsolic I; Bartek J; Volarevic S
- Review: INTERNATIONAL JOURNAL OF ONCOLOGY. 2016;48(4):1313-1324Goudarzi KM; Lindstrom MS
- Meeting abstract: CANCER RESEARCH. 2015;75:2082Goudarzi KM; Elsir T; Nister M; Lindstrom MS
- Conference publication: EUROPEAN JOURNAL OF CANCER. 2014;50:S72Goudarzi KM; Nister M; Lindstrom MS
- Book chapter: PROTEINS OF THE NUCLEOLUS. 2013;p. 251-273Lindström MS; Latonen L
- Review: CANCER AND METASTASIS REVIEWS. 2012;31(3-4):793-805Elsir T; Smits A; Lindstrom MS; Nister M
- Review: UPSALA JOURNAL OF MEDICAL SCIENCES. 2012;117(2):99-112Nazarenko I; Hede S-M; He X; Hedren A; Thompson J; Lindstrom MS; Nister M
- Conference publication: CANCER RESEARCH. 2012;72:5560Eisir T; Qu M; Berntsson S; Olofsson T; Ribom D; Orrego A; Hedren A; Deimling AV; Hartmann C; Lindstrom M; Smits A; Nister M
- Conference publication: NEURO-ONCOLOGY. 2010;12:51Elsir T; Qu M; Berntsson S; Orrego A; Olofsson T; Lindstrom M; Nister M; Ribom D; Smits A
- Review: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2009;379(2):167-170Lindstrom MS
- Review: CELL BIOCHEMISTRY AND BIOPHYSICS. 2006;46(1):79-90Lindstrom MS; Zhang Y
- Doctoral thesis: 2004Lindström M
- Book chapter: WILEY ENCYCLOPEDIA OF MOLECULAR MEDICINE. 2002;p.Lindström MS; Asker C; Wiman KG
- Show more
Grants
- Interplay between Ribosomal Protein L24 Heterozygosity and p53 in Disease PathogenesisCroatian Science Foundation1 April 2022
- Ribosome biogenesis as a chemotherapy targetStiftelsen Konung Gustaf V:s Jubileumsfond RaH Fonder1 January 2017 - 31 December 2018
- Ribosome biogenesis as a chemotherapy targetStiftelsen Konung Gustaf V:s Jubileumsfond RaH fonder1 January 2014 - 31 December 2015
Employments
- Researcher, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2015-
Degrees and Education
- Docent, Karolinska Institutet, 2012
- Doctor Of Philosophy, Department of Oncology-Pathology, Karolinska Institutet, 2004
- Master Of Medical Science, Karolinska Institutet, 1999
Editorial work
- Tumor Discovery, Editorial board member, 2024
- Frontiers Biophysics, Section editor / academic editor, 2023
- Precision Cancer Medicine, AME HONG KONG, Editorial board member, 2023
- Cancers, Editorial board member, 2020