Mikael Lindström

Mikael Lindström

Researcher | Docent
Visiting address: Tomtebodavägen 23A, 17165 Solna
Postal address: C2 Medicinsk biokemi och biofysik, C2 Genome biology Bartek, 171 77 Stockholm
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About me

  • PhD degree in Experimental Oncology 2004 and Docent in Experimental Pathology 

  • obtained 2012 at Karolinska Institutet i Stockholm, Sweden.

Research

  • We are specifically interested in molecular mechanisms underlying the regulation of ribosome biogenesis, how the cell senses errors in the complex process of ribosome biogenesis and how these processes in turn can be used in the development of novel anti-cancer therapies. To investigate ribosome biogenesis and nucleolar structure, the team uses various microscopy technologies, ribosome profiling, rDNA assays, transcriptomics, translatomics, and proteomics. We also work a lot with small molecules and functional screens. Main lines and interests of research: 1. Characterization of ribosome biogenesis regulatory proteins and potential role in cancer development, biomarker discovery for precision / 


  • personalized cancer medicine. 2. Regulation of ribosome biogenesis and protein synthesis in normal CNS cells and in glioma, including heterogeneity of ribosome in relation to glioma cellular diversity. 3. Targeting of ribosome biogenesis or mature ribosome function in cancer. 4. Functional studies of ribosomal proteins.

     

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  • I have evaluated manuscripts for the following journals among others

     

  • Oncogene, Nature, EMBO Rep, EMBO J, Nature Cell Biology, J Biol Chem, Mol Cell Biol, Proteins, J. of Clinical Investigation, Mol Cell, Intl. J of Cancer, Int J Mol Sciences, Cancer, Cancers, J Cytology &

  • Histology, J Mol Biol, PLoS One, FEBS Letters, FEBS J, Future Oncology, Cell Proliferation, Biochem J, Scientific Reports, Tumor Biology, Current Drug Targets, Cytotherapy, Nature Communications, J Cell Science, Cell Reports, Cell Cycle, Chemistry Biology, Blood, Pharmaceuticals, Biochem Soc Trans, Cells, Oncotarget, Int J of Dev Neuroscience, Cellular Physiology and Biochemistry, BMC Biotechnology, BMC Molecular Biology, Bioscience Reports, Cancer Res, Elife, J Cellular Physiology, J Oncology, BBA Mol Cell, Comm Biol, Metabolites, Ebiomedicine, ACS Chemical Biology, BBA Molecular Res, Biomarkers, JCI Insight, BioEssays, Cell Death and Disease, Cell Death and Differentiation, Biomedicines, Breast Cancer Research, Pathogens, Signal Transduction and Targeted Therapies, Biomolecules and Biomedicine, Histology &
  • Histopathology, Epigenetics and Chromatin, Mol Oncol, Nucleic Acids Res Cancer, iScience, Int J Cancer, Discover Oncology, Trends Cell Biology, Cell Proliferation and many others

Teaching

  • Supervision

     

  • Co-supervisor: Dr Tamador Elsir, PhD 2010-06-04, KI 


  • Co-supervisor: Dr Inga Nazarenko, PhD 2011-09-30, KI
    Co-supervisor: Dr Karl Holmberg-Olausson, PhD 2015-06-01, KI

    Main supervisor: Dr Kaveh Moazemi Goudarzi, PhD 2018-04-27, KI
    Main supervisor: Dr Asimina Zisi, PhD 2022-10-28, KI

     

  • Service to the universities

     

  • Pre-examiner of doctoral dissertation: 16 (2009-2024)
    Half time review for PhD: 20 (2012-2024)
    Chairman of PhD defense: 8 (2015-2024)
    Examiner of MSc or BSc thesis 16 (2012-2018)
    Opponent: 1

     

  • Following courses I have taken

    Basic pedagogics for university lecturers GHPH09

    Postgraduate supervisor training course KI

    Leadership education UGL, KI

    Web courses for supervisors

     

  • I have over 1000 teaching hours in cell biology, oncology, and biochemistry for students at the medical and biomedical programs, including molecular oncology and biostatistics (BioMed), and Molecular Medicine course, cell biology. At the medical program biochemistry in the DFM1 and BV2 courses. I have been teaching also at the postgraduate course level, at the Cancer Cell cycles and Cancer Cell metabolism courses. I have co-organized a course on Brain Tumors. I currently also teach biochemistry at the KI "prep course" for foreign (non EU) medical doctors that will take knowledge test for licence to practice medicine in Sweden. 

Articles

All other publications

Grants

Employments

  • Researcher, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2015-

Degrees and Education

  • Docent, Karolinska Institutet, 2012
  • Doctor Of Philosophy, Department of Oncology-Pathology, Karolinska Institutet, 2004
  • Master Of Medical Science, Karolinska Institutet, 1999

Supervisor

  • Asimina Zisi, RNA Polymerase I inhibition: mechanism and exploitation in cancer treatment
  • Kaveh Goudarzi, Functional investigation of prognostic biomarkers and therapeutic targets in glioma brain tumors
  • Karl Holmberg Olausson, Molecular subclassification, stem cell markers and growth regulatory pathways in gliomas
  • Inga Nazarenko, Modeling PDGF-driven gliomagenesis in the mouse
  • Tamador Elsir, Transcription factors PROX1 and p53 in cancer development

Editorial work

  • Tumor Discovery, Editorial board member, 2024
  • Frontiers Biophysics, Section editor / academic editor, 2023
  • Precision Cancer Medicine, AME HONG KONG, Editorial board member, 2023
  • Cancers, Editorial board member, 2020

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