Toxicology – Bertrand Joseph´s Research group

Over the years, our team has been working in several fields of research from the investigations of the cell death signaling pathways to the molecular mechanism controlling cell differentiation. In addition, these investigations were performed in various models of human diseases ranging from cancers, neurodevelopmental disorders to neurodegenerative disorders.

Our team has more than 15 years of experience working in the field of microglia, and an international recognition. Highlights of our research include the discovery of a role for killer caspases in microglia pro-inflammatory and tumor-supporting phenotypes and a contribution to the understanding of the transcriptional/epigenetic regulation of microglial activation states and the possibility to reprogram microglia toward distinct phenotypes. Lately, we have been arguing for the concept of microglia diversity, i.e., the existence of microglial subtypes.

Publications

Selected publications

All publications from group members

Staff and contact

Group leader

All members of the group

Visiting address

Institute of Environmental Medicine / Institutet för miljömedicin (IMM), Toxicology, Nobels väg 13, Solna, 17177, Sweden

Postal address

IMM (Karolinska Institutet), Toxicology, Box 210, Stockholm, 17177, Sweden